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The growing demands for documentation, quality assurance, and secondary use of medical data for research purposes has underscored the necessity for solutions that are more flexible, straightforward to maintain and interoperable. In this context, modular systems have the potential to act as a catalyst for change, offering the capacity to encapsulate and combine functionalities in an adaptable manner. The objective of this scoping review is to determine the extent to which modular systems are employed in the medical field. The review will provide a detailed overview of the effectiveness of service-oriented or microservice architectures, the challenges that should be addressed during implementation, and the lessons that can be learned from countries with productive use of such modular architectures. The review shows a rise in the use of microservices, indicating a shift towards encapsulated autonomous functions. The implementation should use HL7 FHIR as communication standard, deploy RESTful interfaces and standard protocols for technical data exchange, and apply HIPAA security rule for security purposes. User involvement is essential, as is integrating services into existing workflows. Modular architectures can facilitate flexibility and scalability. However, there are well-documented performance issues associated with microservice architectures, namely a high communication demand. One potential solution to this problem may be to integrate modular architectures into a cloud computing environment, which would require further investigation.<\/jats:p>","DOI":"10.1007\/s10916-025-02158-3","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T06:52:09Z","timestamp":1739861529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Application of Modular Architectures in the Medical Domain - a Scoping Review"],"prefix":"10.1007","volume":"49","author":[{"given":"Franziska","family":"Bathelt","sequence":"first","affiliation":[]},{"given":"Stephan","family":"Lorenz","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Weidner","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Sedlmayr","sequence":"additional","affiliation":[]},{"given":"Ines","family":"Reinecke","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"2158_CR1","unstructured":"Newman, S., Building microservices: Designing fine-grained systems First edition edn (O\u2019Reilly Media, Beijing Sebastopol, CA, 2015). 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