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We tested the hypothesis that an intervention to reduce work-related screen time during a weekend off reduces stress in healthcare workers in a pragmatic parallel design randomized controlled trial between November 2021 and November 2023. Healthcare workers using a smartphone with a work email application were eligible. Randomization was 1:1 to no treatment or a threefold educational intervention to: 1) activate automated responses to emails received, 2) reduce screen time, and 3) uninstall work applications from personal devices. The primary outcome was the change in participants\u2019 stress from pre- to post-weekend, measured with the Perceived Stress Scale-10. The secondary outcome was device screen time. Among 815 enrolled participants, 520 responded to the post-intervention survey. The median [Q1, Q3] change from baseline Perceived Stress Scale-10 scores was -2 [-7, 0] in controls and -4 [-9, 0] in the intervention group. The mean difference (intervention \u2013 control) in post-intervention Perceived Stress Scale-10 scores, adjusted for baseline stress, was -1.6 (95% CI: -2.6, -0.6;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002). The median [Q1, Q3] change from baseline screen time was 0 [-2, 1] hours in the controls and -1 [-3, 0] hours in the intervention group. A three-pronged educational intervention targeting work-related screen time among healthcare workers doubled stress reduction during a non-work weekend. Stress reduction in the intervention group was mediated by reduced screen time. Future research should investigate long-term effects and broader implementation of such interventions to promote well-being in the healthcare workforce. Trial Registration:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05106647\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/study\/NCT05106647<\/jats:ext-link>\n                    . Identifier: NCT05106647, Registration date: November 4, 2021.\n                  <\/jats:p>","DOI":"10.1007\/s10916-026-02338-9","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:04:22Z","timestamp":1768608262000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reducing Work-Related Screen-Time in Healthcare Workers During Leisure Time (REDUCE SCREEN) \u2013 A Randomized Controlled Trial"],"prefix":"10.1007","volume":"50","author":[{"given":"Karsten","family":"Bartels","sequence":"first","affiliation":[]},{"given":"Karan","family":"Shah","sequence":"additional","affiliation":[]},{"given":"Emelind","family":"Sanchez Rodriguez","sequence":"additional","affiliation":[]},{"given":"Julie T.","family":"Hoffman","sequence":"additional","affiliation":[]},{"given":"Megan L.","family":"Rolfzen","sequence":"additional","affiliation":[]},{"given":"Juana","family":"Mora Valdovinos","sequence":"additional","affiliation":[]},{"given":"Afton L.","family":"Hassett","sequence":"additional","affiliation":[]},{"given":"Daniel I.","family":"Sessler","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2026,1,17]]},"reference":[{"key":"2338_CR1","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1016\/s0140-6736(02)08915-8","volume":"359","author":"IC McManus","year":"2002","unstructured":"McManus IC, Winder BC, Gordon D (2002) The causal links between stress and burnout in a longitudinal study of UK doctors. 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