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Going beyond the specifics of t-SNE, there are two substantial limitations of any such approach: (1) not all information can be captured in a single two-dimensional embedding, and (2) to well-informed users, the salient structure of such an embedding is often already known, preventing that any real new insights can be obtained. Currently, it is not known how to extract the remaining information in a similarly effective manner. We introduce <jats:italic>conditional t-SNE<\/jats:italic> (ct-SNE), a generalization of t-SNE that discounts prior information in the form of labels. This enables obtaining more informative and more relevant embeddings. To achieve this, we propose a conditioned version of the t-SNE objective, obtaining an elegant method with a single integrated objective. We show how to efficiently optimize the objective and study the effects of the extra parameter that ct-SNE has over t-SNE. Qualitative and quantitative empirical results on synthetic and real data show ct-SNE is scalable, effective, and achieves its goal: it allows complementary structure to be captured in the embedding and provided new insights into real data.<\/jats:p>","DOI":"10.1007\/s10994-020-05917-0","type":"journal-article","created":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T15:03:15Z","timestamp":1607266995000},"page":"2905-2940","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Conditional t-SNE: more informative t-SNE embeddings"],"prefix":"10.1007","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-9927","authenticated-orcid":false,"given":"Bo","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dar\u00edo","family":"Garc\u00eda Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jefrey","family":"Lijffijt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Santos-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tijl","family":"De Bie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,6]]},"reference":[{"issue":"7","key":"5917_CR1","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.patrec.2011.02.002","volume":"32","author":"B Alipanahi","year":"2011","unstructured":"Alipanahi, B., & Ghodsi, A. 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