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The capability to detect and adapt to changes in data stream mining methods is thus a necessity. While methods for multi-target prediction on data streams have recently appeared, they have largely remained without such capability. In this paper, we propose novel methods for change detection and adaptation in the context of incremental online learning of decision trees for multi-target regression. One of the approaches we propose is ensemble based, while the other uses the Page\u2013Hinckley test. We perform an extensive evaluation of the proposed methods on real-world and artificial data streams and show their effectiveness. 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