{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:25:44Z","timestamp":1775096744383,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Comput"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s11047-014-9436-7","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T06:53:55Z","timestamp":1403506435000},"page":"421-430","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Topology driven modeling: the IS metaphor"],"prefix":"10.1007","volume":"14","author":[{"given":"Emanuela","family":"Merelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Marco","family":"Pettini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]},{"given":"Mario","family":"Rasetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocab":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"9436_CR1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0550-3213(85)90356-6","volume":"B257","author":"J Ambj\u00f8rn","year":"1985","unstructured":"Ambj\u00f8rn J, Durhuus B, Fr\u00f6hlich J (1985) Diseases of triangulated random surface models, and possible cures. Nucl Phys B257:433\u2013449","journal-title":"Nucl Phys"},{"issue":"1505","key":"9436_CR2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1098\/rsta.1983.0017","volume":"308","author":"MF Atiyah","year":"1983","unstructured":"Atiyah MF, Bott R (1983) The Yang\u2013Mills equations over Riemann surfaces. Philos Trans R Soc Lond Ser A 308(1505):523\u2013615","journal-title":"Philos Trans R Soc Lond Ser A"},{"key":"9436_CR3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0375-9601(03)00679-0","volume":"313","author":"D Battaglia","year":"2003","unstructured":"Battaglia D, Rasetti M (2003) Quantumlike diffusion over discrete sets. Phys Lett A 313:8\u201315","journal-title":"Phys Lett A"},{"issue":"124018","key":"9436_CR4","first-page":"1","volume":"59","author":"E Bittner","year":"1999","unstructured":"Bittner E, Hauke A, Markum H, Riedler J, Holm C, Janke W (1999) $$Z_2$$ Z 2 -Regge versus standard Regge calculus in two dimensions. Phys Rev D 59(124018):1\u20139","journal-title":"Phys Rev D"},{"issue":"2","key":"9436_CR5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1090\/S0273-0979-09-01249-X","volume":"46","author":"G Carlsson","year":"2009","unstructured":"Carlsson G (2009) Topology of data. Bull New Ser AMS 46(2):255\u2013308","journal-title":"Bull New Ser AMS"},{"issue":"3","key":"9436_CR7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF01430963","volume":"216","author":"UV Desale","year":"1975","unstructured":"Desale UV, Ramanan S (1975) Poincar\u00e9 polynomials of the variety of stable bundles. Math Ann 216(3):233\u2013244","journal-title":"Math Ann"},{"key":"9436_CR8","volume-title":"Computational topology, an introduction","author":"H Edelsbrunner","year":"2010","unstructured":"Edelsbrunner H, Harer J (2010) Computational topology, an introduction. American Mathematical Society, Providence"},{"key":"9436_CR9","first-page":"187","volume":"D22","author":"J Farmer","year":"1986","unstructured":"Farmer J, Packard N, Perelson A (1986) The immune system, adaptation, and machine learning. Physica D22:187\u2013204","journal-title":"Physica"},{"key":"9436_CR11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-7643-7978-0_9","volume-title":"Quantum gravity: mathematical models and experimental bounds","author":"D Giulini","year":"2007","unstructured":"Giulini D (2007) Mapping class groups of 3-manifolds. In: Fauser B, Tolksdorf J, Zeidler E (eds) Quantum gravity: mathematical models and experimental bounds. Birkhuser Verlag, Basel, pp 161\u2013201"},{"key":"9436_CR12","doi-asserted-by":"crossref","unstructured":"Harder G, Narasimhan MS (1974\/75) On the cohomology groups of moduli spaces of vector bundles on curves. Math Ann 212:215\u2013248","DOI":"10.1007\/BF01357141"},{"key":"9436_CR13","unstructured":"Hart E, Bersini H, Santos F (2009) Structure versus function: a topological perspective on immune networks. Natural Computing 9138(8):603\u2013624"},{"key":"9436_CR14","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/eji.1830050912","volume":"5","author":"GW Hoffmann","year":"1975","unstructured":"Hoffmann GW (1975) A network theory of the immune system. Eur J Immunol 5:638\u2013647","journal-title":"Eur J Immunol"},{"key":"9436_CR15","unstructured":"Hoffmann GW (2010) An improved version of the symmetrical immune network theory. www.arXiv.org\/abs\/1004.5107"},{"issue":"8","key":"9436_CR16","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1073\/pnas.79.8.2554","volume":"79","author":"JJ Hopfield","year":"1982","unstructured":"Hopfield JJ (1982) Neural networks and physical systems with emergent collective computational abilities. Proc Natl Acad Sci USA 79(8):2554\u20132558","journal-title":"Proc Natl Acad Sci USA"},{"key":"9436_CR17","first-page":"373","volume":"125C","author":"N Jerne","year":"1974","unstructured":"Jerne N (1974) Towards a network theory of the immune system. Ann Immunol Inst Pasteur 125C:373\u2013389","journal-title":"Ann Immunol Inst Pasteur"},{"key":"9436_CR18","doi-asserted-by":"crossref","unstructured":"Knizhnik V, Polyakov A, Zamolodchikov A (1988) Fractal structure of 2d-quantum gravity. Mod Phys Lett A 3(8):819\u2013826","DOI":"10.1142\/S0217732388000982"},{"issue":"3","key":"9436_CR19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0550-3213(98)00124-2","volume":"523","author":"P Menotti","year":"1998","unstructured":"Menotti P (1998) Group theoretical derivation of Liouville action for Regge surfaces. Nucl Phys B 523(3):611\u2013619","journal-title":"Nucl Phys B"},{"key":"9436_CR20","unstructured":"Merelli E, Paoletti N, Tesei L (2013) Adaptability checking in multi-level complex systems. http:\/\/arxiv.org\/abs\/1404.0698"},{"key":"9436_CR21","doi-asserted-by":"crossref","unstructured":"Merelli E, Rasetti M (2013) Non-locality, topology, formal languages: new global tools to handle large data sets. Procedia Comput Sci 18:90\u201399","DOI":"10.1016\/j.procs.2013.05.172"},{"key":"9436_CR22","volume-title":"Statistical field theory","author":"G Parisi","year":"1998","unstructured":"Parisi G (1998) Statistical field theory. Westview Press, Boulder"},{"key":"9436_CR23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1073\/pnas.87.1.429","volume":"87","author":"G Parisi","year":"1990","unstructured":"Parisi G (1990) A simple model for the immune network. Proc Natl Acad Sci USA 87:429\u2013433","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"9436_CR24","doi-asserted-by":"crossref","first-page":"e66506","DOI":"10.1371\/journal.pone.0066506","volume":"8","author":"G Petri","year":"2013","unstructured":"Petri G, Scolamiero M, Donato I, Vaccarino F (2013) Topological strata of weighted complex networks. PLoS One 8(6):e66506","journal-title":"PLoS One"},{"key":"9436_CR25","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/BF02733251","volume":"19","author":"T Regge","year":"1961","unstructured":"Regge T (1961) General relativity without coordinates. Nuovo Cimento 19:558\u2013571","journal-title":"General relativity without coordinates. Nuovo Cimento"},{"issue":"3","key":"9436_CR26","first-page":"315","volume":"1","author":"S Stepney","year":"2005","unstructured":"Stepney S, Smith RE, Timmis J, Tyrrell AM, Neal MJ, Hone ANW (2005) Conceptual frameworks for artificial immune systems. Int J Unconv Comput 1(3):315\u2013338","journal-title":"Int J Unconv Comput"},{"key":"9436_CR28","unstructured":"TOPDRIM. Topology driven methods of complex systems project, Future Emerging Technologies (FET) programme within Seventh Framework Programme (FP7), www.topdrim.eu"},{"key":"9436_CR27","unstructured":"Varela F, Coutinho A, Dupire B, Vaz N (1988) Cognitive networks: immune, neural and otherwise. In: Perelson A (ed) Theoretical immunology: part two, SFI studies in science of complexity, vol 2. Addison Wesley, Reading, pp 359\u2013371"}],"container-title":["Natural Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11047-014-9436-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11047-014-9436-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11047-014-9436-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T23:14:29Z","timestamp":1553642069000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11047-014-9436-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,24]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["9436"],"URL":"https:\/\/doi.org\/10.1007\/s11047-014-9436-7","relation":{},"ISSN":["1567-7818","1572-9796"],"issn-type":[{"value":"1567-7818","type":"print"},{"value":"1572-9796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,24]]}}}