{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T07:25:28Z","timestamp":1745479528493},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T00:00:00Z","timestamp":1437782400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Comput"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s11047-015-9508-3","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T08:47:25Z","timestamp":1437727645000},"page":"15-30","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Halting the hallmarks: a cellular automaton model of early cancer growth inhibition"],"prefix":"10.1007","volume":"15","author":[{"given":"Jenna","family":"Butler","sequence":"first","affiliation":[]},{"given":"Frances","family":"Mackay","sequence":"additional","affiliation":[]},{"given":"Colin","family":"Denniston","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Daley","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,7,25]]},"reference":[{"issue":"12","key":"9508_CR1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1162\/artl.2006.12.4.617","volume":"4","author":"R Abbott","year":"2006","unstructured":"Abbott R, Forrest S, Pienta K (2006) Simulating the hallmarks of cancer. Artif Life 4(12):617\u201334","journal-title":"Artif Life"},{"key":"9508_CR2","doi-asserted-by":"crossref","unstructured":"Anderson ARA, Quaranta V (2008) Integrative mathematical oncology. Nat Rev Cancer 8(3):227\u2013234. doi: 10.1038\/nrc2329 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18273038","DOI":"10.1038\/nrc2329"},{"key":"9508_CR3","doi-asserted-by":"crossref","unstructured":"Anderson ARA, Weaver AM, Cummings PT, Quaranta V (2006) Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127(5):905\u2013915. doi: 10.1016\/j.cell.2006.09.042 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17129778","DOI":"10.1016\/j.cell.2006.09.042"},{"key":"9508_CR4","doi-asserted-by":"crossref","unstructured":"Anderson ARA, Rejniak KA, Gerlee P, Quaranta V (2008) Modelling of cancer growth, evolution and invasion: bridging scales and models. Math Model Nat Phenom 2(3):1\u201329. doi: 10.1051\/mmnp:2007001 , http:\/\/www.mmnp-journal.org\/10.1051\/mmnp:2007001","DOI":"10.1051\/mmnp:2007001"},{"issue":"1","key":"9508_CR5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/carcin\/bgp268","volume":"31","author":"SE Artandi","year":"2010","unstructured":"Artandi SE, DePinho RA (2010) Telomeres and telomerase in cancer. Carcinogenesis 31(1):9\u201318","journal-title":"Carcinogenesis"},{"key":"9508_CR6","doi-asserted-by":"crossref","unstructured":"Basanta D, Ribba B, Watkin E, You B, Deutsch A (2011) Computational analysis of the influence of the microenvironment on carcinogenesis. Math Biosci 229(1):22\u201329. doi: 10.1016\/j.mbs.2010.10.005 , http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0025556410001616","DOI":"10.1016\/j.mbs.2010.10.005"},{"key":"9508_CR7","doi-asserted-by":"crossref","unstructured":"Bello L, Lucini V, Costa F, Pluderi M, Giussani C, Acerbi F, Carrabba G, Pannacci M, Caronzolo D, Grosso S, Shinkaruk S, Colleoni F, Canron X, Tomei G, Deleris G, Bikfalvi A (2004) Combinatorial administration of molecules that simultaneously inhibit angiogenesis and invasion leads to increased therapeutic efficacy in mouse models of malignant glioma combinatorial administration of molecules that simultaneously inhibit angiogenesis. Clin Cancer Res 10(13):4527\u20134537","DOI":"10.1158\/1078-0432.CCR-04-0194"},{"key":"9508_CR8","volume-title":"Selected topics in cancer modeling: genesis, evolution, immune competition, and therapy","author":"N Bellomo","year":"2008","unstructured":"Bellomo N, De Angelis E (2008) Selected topics in cancer modeling: genesis, evolution, immune competition, and therapy. Springer, Berlin"},{"key":"9508_CR9","unstructured":"Bentley K, Bates P, Gerhardt H (2008) Artificial life as cancer research: embodied agent modelling of blood vessel growth in tumours. In: Proceedings of artifical life XI"},{"issue":"5","key":"9508_CR10","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.devcel.2010.10.005","volume":"19","author":"M Berdasco","year":"2010","unstructured":"Berdasco M, Esteller M (2010) Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Dev Cell 19(5):698\u2013711","journal-title":"Dev Cell"},{"key":"9508_CR11","doi-asserted-by":"crossref","unstructured":"Bhatnagar E, Gross E, Krook M (1954) A model for collision processes in gases. I. Small amplitude processes in charged and neutral one-component systems. Phys Rev 94(3):511","DOI":"10.1103\/PhysRev.94.511"},{"key":"9508_CR12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.fluid.30.1.329","volume":"30","author":"S Chen","year":"1998","unstructured":"Chen S, Doolen GD (1998) Lattice boltzmann method for fluid flows. Annu Rev Fluid Mech 30:329\u201364","journal-title":"Annu Rev Fluid Mech"},{"key":"9508_CR13","unstructured":"Chinese Academy of Medical Sciences (2014) Efficacy and safety study of recombinant endostatic combined with chemotherapy to treat advanced colorectal cancer. ClinicalTrials.gov Bethesda (MD): National Library of Medicine (US)"},{"issue":"2","key":"9508_CR14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1158\/1078-0432.CCR-09-1924","volume":"16","author":"KM Detjen","year":"2010","unstructured":"Detjen KM, Rieke S, Deters A, Schulz P, Rexin A, Vollmer S, Hauff P, Wiedenmann B, Pavel M, Scholz A (2010) Angiopoietin-2 promotes disease progression of neuroendocrine tumors. Clin Cancer Res 16(2):420\u2013429","journal-title":"Clin Cancer Res"},{"key":"9508_CR15","doi-asserted-by":"crossref","unstructured":"Ebos JML, Lee CR, Cruz-Munoz W, Bjarnason Ga, Christensen JG, Kerbel RS (2009) Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15(3):232\u2013239. doi: 10.1016\/j.ccr.2009.01.021 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19249681","DOI":"10.1016\/j.ccr.2009.01.021"},{"key":"9508_CR16","doi-asserted-by":"crossref","unstructured":"Erbertseder K, Reichold J, Flemisch B, Jenny P, Helmig R (2012) A coupled discrete\/continuum model for cancer-therapeutic transport in the lung. PloS One 7(3)","DOI":"10.1371\/journal.pone.0031966"},{"issue":"5381","key":"9508_CR17","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.281.5381.1317","volume":"281","author":"G Evan","year":"1998","unstructured":"Evan G, Littlewood T (1998) A matter of life and cell death. Science 281(5381):1317\u20131322","journal-title":"Science"},{"key":"9508_CR18","unstructured":"Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D (2008) Globocan2008 cancer incidence and mortality worldwide: Iarc cancerbase no. 10"},{"key":"9508_CR19","doi-asserted-by":"crossref","first-page":"L529","DOI":"10.1056\/NEJM197109022851001","volume":"285","author":"J Folkman","year":"1971","unstructured":"Folkman J (1971) Tumor angiogenesis: therapeutic implications. Nat Engl J Med 285:L529\u2013L533","journal-title":"Nat Engl J Med"},{"issue":"4","key":"9508_CR20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1084\/jem.138.4.745","volume":"138","author":"J Folkman","year":"1973","unstructured":"Folkman J, Hochberg M (1973) Self-regulation of growth in three dimensions. J Exp Med 138(4):745\u2013753","journal-title":"J Exp Med"},{"key":"9508_CR21","doi-asserted-by":"crossref","unstructured":"Gerlee P, Anderson ARA (2007) An evolutionary hybrid cellular automaton model of solid tumour growth. J Theor Biol 246(4):583\u2013603. doi: 10.1016\/j.jtbi.2007.01.027 , http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2652069\/?tool=pmcentrez","DOI":"10.1016\/j.jtbi.2007.01.027"},{"key":"9508_CR22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jtbi.2007.10.038","volume":"250","author":"P Gerlee","year":"2008","unstructured":"Gerlee P, Anderson ARA (2008) A hybrid cellular automaton model of clonal evolution in cancer: the emergence of the glycolytic phenotype. J Theor Biol 250:705\u2013722","journal-title":"J Theor Biol"},{"issue":"1","key":"9508_CR23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jtbi.2009.03.005","volume":"259","author":"P Gerlee","year":"2009","unstructured":"Gerlee P, Anderson ARA (2009) Evolution of cell motility in an individual-based model of tumour growth. J Theor Biol 259(1):67\u201383. doi: 10.1016\/j.jtbi.2009.03.005","journal-title":"J Theor Biol"},{"key":"9508_CR24","doi-asserted-by":"crossref","unstructured":"Gevertz JL, Gillies GT, Torquato S (2008) Simulating tumor growth in confined heterogeneous environments. Phys Biol 5(3):036010. doi: 10.1088\/1478-3975\/5\/3\/036010 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18824788","DOI":"10.1088\/1478-3975\/5\/3\/036010"},{"issue":"1","key":"9508_CR25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg R (2000) The hallmarks of cancer. Cell 100(1):57\u201370","journal-title":"Cell"},{"issue":"5","key":"9508_CR26","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg R (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"key":"9508_CR27","unstructured":"Hellenic Oncology Research Group (2014) Paclitaxel plus bevacizumab for older patients with breast cancer. ClinicalTrials.gov Bethesda (MD): National Library of Medicine (US)"},{"issue":"12","key":"9508_CR28","first-page":"2272","volume":"29","author":"E Henderson","year":"1969","unstructured":"Henderson E, Samaha R (1969) Evidence that drugs in multiple combinations have materially advanced the treatment of human malignancies. Cancer Res 29(12):2272\u20132280","journal-title":"Cancer Res"},{"key":"9508_CR29","doi-asserted-by":"crossref","unstructured":"Hirata Y, Bruchovsky N, Aihara K (2010) Development of a mathematical model that predicts the outcome of hormone therapy for prostate cancer. J Theor Biol 264(2):517\u2013527. doi: 10.1016\/j.jtbi.2010.02.027 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20176032","DOI":"10.1016\/j.jtbi.2010.02.027"},{"key":"9508_CR30","unstructured":"Hoffmann-La Roche (2014) A study of avastin (bevacizumab) in combination with chemotherapy in patients with breast cancer progressing after first-line therapy with avastin and chemotherapy (tania). ClinicalTrials.gov Bethesda (MD): National Library of Medicine (US)"},{"key":"9508_CR31","unstructured":"International breast cancer study group (2014) Combination chemotherapy after surgery in treating patients with stage I, stage II or stage III breast cancer. ClinicalTrials.gov Bethesda (MD): National Library of Medicine (US)"},{"issue":"4","key":"9508_CR32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","volume":"128","author":"PA Jones","year":"2007","unstructured":"Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128(4):683\u2013692","journal-title":"Cell"},{"issue":"11","key":"9508_CR33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrc2728","volume":"9","author":"MR Junttila","year":"2009","unstructured":"Junttila MR, Evan GI (2009) p53\u2014a Jack of all trades but master of none. Nat Rev Cancer 9(11):821\u2013829","journal-title":"Nat Rev Cancer"},{"key":"9508_CR34","doi-asserted-by":"crossref","unstructured":"Kam Y, Rejniak KA, Anderson ARA (2012) Cellular modeling of cancer invasion: integration of in silico and in vitro approaches. J Cell Physiol 227(2):431\u2013438. doi: 10.1002\/jcp.22766 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21465465","DOI":"10.1002\/jcp.22766"},{"issue":"1","key":"9508_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02587.x","volume":"121","author":"R Kim","year":"2007","unstructured":"Kim R, Emi M, Tanabe K (2007) Cancer immunoediting from immune surveillance to immune escape. Immunology 121(1):1\u201314","journal-title":"Immunology"},{"issue":"1","key":"9508_CR36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.gde.2009.11.005","volume":"20","author":"J Korkola","year":"2010","unstructured":"Korkola J, Gray JW (2010) Breast cancer genomes\u2014form and function. Curr Opin Genet Dev 20(1):4\u201314","journal-title":"Curr Opin Genet Dev"},{"key":"9508_CR37","doi-asserted-by":"crossref","unstructured":"Lloyd BA, Szczerba D, Rudin M, Sz\u00e9kely G (2008) A computational framework for modelling solid tumour growth. Philos Trans Ser A Math Phys Eng Sci 366(1879):3301\u20133318. doi: 10.1098\/rsta.2008.0092 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18593664","DOI":"10.1098\/rsta.2008.0092"},{"issue":"7015","key":"9508_CR38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature03098","volume":"432","author":"SW Lowe","year":"2004","unstructured":"Lowe SW, Cepero E, Evan G (2004) Intrinsic tumour suppression. Nature 432(7015):307\u2013315","journal-title":"Nature"},{"key":"9508_CR39","doi-asserted-by":"crossref","unstructured":"Macklin P, Edgerton ME, Thompson A, Cristini V (2012) Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS) I: model formulation and analysis. J Theor Biol 301:122\u2013140","DOI":"10.1016\/j.jtbi.2012.02.002"},{"issue":"4","key":"9508_CR40","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1162\/106454600300103665","volume":"6","author":"C Maley","year":"2000","unstructured":"Maley C, Forrest S (2000) Exploring the relationship between neutral and selective mutations in cancer. Artif Life 6(4):325\u2013345","journal-title":"Artif Life"},{"key":"9508_CR41","volume-title":"Essentials of exercise physiology","author":"WD McArdle","year":"2005","unstructured":"McArdle WD, Katch FI, Katch VL (2005) Essentials of exercise physiology, 3rd edn. Lippincott Williams & Wilkins, Philadelphia","edition":"3"},{"key":"9508_CR42","unstructured":"Medical University of Vienna (2014) Metronomic and targeted anti-angiogenesis therapy for children with recurrent\/progressive medulloblastoma (memmat). ClinicalTrials.gov Bethesda (MD): National Library of Medicine (US)"},{"key":"9508_CR43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-642-28839-5_17","volume":"154","author":"A Monteagudo","year":"2012","unstructured":"Monteagudo A, Santos J (2012) A cellular automaton model for tumor growth simulation. Adv Intell Soft Comput 154:147\u2013155","journal-title":"Adv Intell Soft Comput"},{"key":"9508_CR44","first-page":"21","volume":"7931","author":"A Monteagudo","year":"2013","unstructured":"Monteagudo A, Santos J (2013) Cancer stem cell modeling using a cellular automaton. IWINAC LNCS 7931:21\u201331","journal-title":"IWINAC LNCS"},{"key":"9508_CR45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biosystems.2013.11.001","volume":"115","author":"A Monteagudo","year":"2014","unstructured":"Monteagudo A, Santos J (2014) Studying the capability of different cancer hallmarks to initiate tumor growth using a cellular automaton simulation. Application in a cancer stem cell context. Biosystems 115:46\u201358","journal-title":"Biosystems"},{"issue":"5933","key":"9508_CR46","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.1171362","volume":"324","author":"KP Olive","year":"2009","unstructured":"Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D et al (2009) Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933):1457\u20131461","journal-title":"Science"},{"issue":"6","key":"9508_CR47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1209\/0295-5075\/32\/6\/001","volume":"32","author":"E Orlandini","year":"1995","unstructured":"Orlandini E, Swift MR, Yeomans J (1995) A lattice boltzmann model of binary-fluid mixtures. EPL (Europhysics Letters) 32(6):463","journal-title":"EPL (Europhysics Letters)"},{"issue":"2","key":"9508_CR48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12094-006-0162-1","volume":"8","author":"R Perona","year":"2006","unstructured":"Perona R (2006) Cell signalling: growth factors and tyrosine kinase receptors. Clin Transl Oncol 8(2):77\u201382","journal-title":"Clin Transl Oncol"},{"issue":"11","key":"9508_CR49","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.ejca.2009.04.007","volume":"45","author":"M Raica","year":"2009","unstructured":"Raica M, Cimpean AM, Ribatti D (2009) Angiogenesis in pre-malignant conditions. Eur J Cancer 45(11):1924\u20131934","journal-title":"Eur J Cancer"},{"key":"9508_CR50","doi-asserted-by":"crossref","unstructured":"Ramis-Conde I, Chaplain M AJ, Anderson ARA (2008) Mathematical modelling of cancer cell invasion of tissue. Math Comput Model 47(5\u20136):533\u2013545. doi: 10.1016\/j.mcm.2007.02.034 , http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0895717707001823","DOI":"10.1016\/j.mcm.2007.02.034"},{"key":"9508_CR51","doi-asserted-by":"crossref","unstructured":"Rejniak KA, Anderson ARA (2011) Hybrid models of tumor growth. Wiley Interdiscip Rev Syst Biol Med 3(1):115\u2013125. doi: 10.1002\/wsbm.102 , http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3057876\/?tool=pmcentrez","DOI":"10.1002\/wsbm.102"},{"key":"9508_CR52","doi-asserted-by":"crossref","unstructured":"Rejniak KA, Anderson ARA (2012) State of the art in computational modelling of cancer. Math Med Biol 29(1):1\u20132. doi: 10.1093\/imammb\/dqr029 , http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22200587","DOI":"10.1093\/imammb\/dqr029"},{"key":"9508_CR53","doi-asserted-by":"crossref","unstructured":"Ribba B, Alarc\u00f3n T, Marron K, Maini PK, Agur Z (2004) The use of hybrid cellular automaton models for improving cancer therapy. In: Sloot PMA, Chopard B, Hoekstra AG (eds) Cellular automata. Lecture notes in computer science, vol 3305. Springer, Hiedelberg, pp 444\u2013453","DOI":"10.1007\/978-3-540-30479-1_46"},{"key":"9508_CR54","doi-asserted-by":"crossref","unstructured":"Santos J, Monteagudo \u00c1 (2012) Study of cancer hallmarks relevance using a cellular automaton tumor growth model. In: Parallel problem solving from nature-PPSN XII, pp 489\u2013499","DOI":"10.1007\/978-3-642-32937-1_49"},{"issue":"1","key":"9508_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1072-7515(99)00075-7","volume":"189","author":"S Sener","year":"1999","unstructured":"Sener S, Fremgen A, Menck H, Winchester D (1999) Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985\u20131995, using the national cancer database. J Am Coll Surg 189(1):1\u20137","journal-title":"J Am Coll Surg"},{"issue":"4","key":"9508_CR56","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/cnm.2539","volume":"29","author":"SMB Shrestha","year":"2013","unstructured":"Shrestha SMB, Joldes GR, Wittek A, Miller K (2013) Cellular automata coupled with steady-state nutrient solution permit simulation of large-scale growth of tumours. Int J Numer Methods Biomed Eng 29(4):542\u2013559","journal-title":"Int J Numer Methods Biomed Eng"},{"key":"9508_CR57","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jtbi.2004.07.006","volume":"231","author":"SL Spencer","year":"2004","unstructured":"Spencer SL, Berryman MJ, Garcia JA, Abbott D (2004) An ordinary differential equation model for the multistep transformation to cancer. J Theor Biol 231:515\u2013524","journal-title":"J Theor Biol"},{"key":"9508_CR58","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198503989.001.0001","volume-title":"The lattice Boltzmann equation for fluid dynamics and beyond","author":"S Succi","year":"2001","unstructured":"Succi S (2001) The lattice Boltzmann equation for fluid dynamics and beyond. Oxford University Press, Oxford"},{"key":"9508_CR59","doi-asserted-by":"crossref","unstructured":"Sun X, Zhang L, Tan H, Bao J, Strouthos C, Zhou X (2012) Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis. BMC Bioinform 13(1):218. doi: 10.1186\/1471-2105-13-218 , http:\/\/www.biomedcentral.com\/1471-2105\/13\/218","DOI":"10.1186\/1471-2105-13-218"},{"issue":"10","key":"9508_CR60","first-page":"5320","volume":"46","author":"R Sutherland","year":"1986","unstructured":"Sutherland R, Sordat B, Bamat J, Gabbert H, Bourrat B, Mueller-Klieser W (1986) Oxygenation and differentiation in multicellular spheroids of human colon carcinoma. Cancer Res 46(10):5320\u20135329","journal-title":"Cancer Res"},{"key":"9508_CR61","doi-asserted-by":"crossref","unstructured":"Swift M, Orlandini E, Osborn W, Yeomans J (1996) Lattice Boltzmann simulations of liquid\u2013gas and binary fluid systems. Phys Rev E 54(5):5041\u20135052. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9965683","DOI":"10.1103\/PhysRevE.54.5041"},{"issue":"4","key":"9508_CR62","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1189\/jlb.1107774","volume":"84","author":"MW Teng","year":"2008","unstructured":"Teng MW, Swann JB, Koebel CM, Schreiber RD, Smyth MJ (2008) Immune-mediated dormancy: an equilibrium with cancer. J Leukoc Biol 84(4):988\u2013993","journal-title":"J Leukoc Biol"},{"issue":"3","key":"9508_CR63","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF02796440","volume":"12","author":"BH Tom","year":"1976","unstructured":"Tom BH, Rutzky LP, Jakstys MM, Oyasu R, Kaye CI, Kahan BD (1976) Human colonic adenocarcinoma cells. In Vitro 12(3):180\u2013191","journal-title":"In Vitro"},{"issue":"8","key":"9508_CR64","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/ijc.24439","volume":"125","author":"CM Vajdic","year":"2009","unstructured":"Vajdic CM, van Leeuwen MT (2009) Cancer incidence and risk factors after solid organ transplantation. Int J Cancer 125(8):1747\u20131754","journal-title":"Int J Cancer"},{"key":"9508_CR65","doi-asserted-by":"crossref","unstructured":"Valvano JW, Cochran JR, Diller KR (1985) Thermal conductivity and diffusivity of biomaterials measured with self heated thermistors. Int J Thermophys 6(3):301\u2013311","DOI":"10.1007\/BF00522151"},{"issue":"2","key":"9508_CR66","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1152\/physiol.00045.2009","volume":"25","author":"E Witsch","year":"2010","unstructured":"Witsch E, Sela M, Yarden Y (2010) Roles for growth factors in cancer progression. Physiology 25(2):85\u2013101","journal-title":"Physiology"},{"key":"9508_CR67","unstructured":"World Health Organization (2008) The global burden of disease: 2004 update. http:\/\/www.who.int\/healthinfo\/global_burden_disease\/2004_report_update\/en\/"}],"container-title":["Natural Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11047-015-9508-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11047-015-9508-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11047-015-9508-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T04:57:58Z","timestamp":1717995478000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11047-015-9508-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,25]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["9508"],"URL":"https:\/\/doi.org\/10.1007\/s11047-015-9508-3","relation":{},"ISSN":["1567-7818","1572-9796"],"issn-type":[{"value":"1567-7818","type":"print"},{"value":"1572-9796","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,25]]}}}