{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:05:18Z","timestamp":1775070318404,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Stat Comput"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this work, the uncertainty associated with the finite element discretization error is modeled following the Bayesian paradigm. First, a continuous formulation is derived, where a Gaussian process prior over the solution space is updated based on observations from a finite element discretization. To avoid the computation of intractable integrals, a second, finer, discretization is introduced that is assumed sufficiently dense to represent the true solution field. A prior distribution is assumed over the fine discretization, which is then updated based on observations from the coarse discretization. This yields a posterior distribution with a mean that serves as an estimate of the solution, and a covariance that models the uncertainty associated with this estimate. Two particular choices of prior are investigated: a prior defined implicitly by assigning a white noise distribution to the right-hand side term, and a prior whose covariance function is equal to the Green\u2019s function of the partial differential equation. The former yields a posterior distribution with a mean close to the reference solution, but a covariance that contains little information regarding the finite element discretization error. The latter, on the other hand, yields posterior distribution with a mean equal to the coarse finite element solution, and a covariance with a close connection to the discretization error. For both choices of prior a contradiction arises, since the discretization error depends on the right-hand side term, but the posterior covariance does not. We demonstrate how, by rescaling the eigenvalues of the posterior covariance, this independence can be avoided.<\/jats:p>","DOI":"10.1007\/s11222-024-10463-z","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T18:03:10Z","timestamp":1723226590000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Bayesian approach to modeling finite element discretization error"],"prefix":"10.1007","volume":"34","author":[{"given":"Anne","family":"Poot","sequence":"first","affiliation":[]},{"given":"Pierre","family":"Kerfriden","sequence":"additional","affiliation":[]},{"given":"Iuri","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Frans","family":"van der Meer","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"10463_CR1","doi-asserted-by":"publisher","first-page":"112100","DOI":"10.1016\/j.jcp.2023.112100","volume":"486","author":"A Alberts","year":"2023","unstructured":"Alberts, A., Bilionis, I.: Physics-informed information field theory for modeling physical systems with uncertainty quantification. J. Comput. Phys. 486, 112100 (2023). https:\/\/doi.org\/10.1016\/j.jcp.2023.112100","journal-title":"J. Comput. Phys."},{"key":"10463_CR2","doi-asserted-by":"crossref","unstructured":"Akyildiz, \u00d6.D., Duffin, C., Sabanis, S., Girolami, M.: Statistical finite elements via Langevin dynamics. arXiv:2110.11131 [cs, math, stat] (2021)","DOI":"10.1137\/21M1463094"},{"issue":"4","key":"10463_CR3","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s11222-020-09926-w","volume":"30","author":"A Abdulle","year":"2020","unstructured":"Abdulle, A., Garegnani, G.: Random time step probabilistic methods for uncertainty quantification in chaotic and geometric numerical integration. Stat. Comput. 30(4), 907\u2013932 (2020). https:\/\/doi.org\/10.1007\/s11222-020-09926-w","journal-title":"Stat. Comput."},{"key":"10463_CR4","doi-asserted-by":"publisher","first-page":"113961","DOI":"10.1016\/j.cma.2021.113961","volume":"384","author":"A Abdulle","year":"2021","unstructured":"Abdulle, A., Garegnani, G.: A probabilistic finite element method based on random meshes: a posteriori error estimators and Bayesian inverse problems. Comput. Methods Appl. Mech. Eng. 384, 113961 (2021). https:\/\/doi.org\/10.1016\/j.cma.2021.113961","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"10463_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/0470047429","volume-title":"Mathematical Methods in Science and Engineering","author":"S Bayin","year":"2006","unstructured":"Bayin, S.: Mathematical Methods in Science and Engineering, 2nd edn. John Wiley & Sons, Hoboken (2006)","edition":"2"},{"issue":"1","key":"10463_CR6","doi-asserted-by":"publisher","first-page":"122","DOI":"10.2307\/1990053","volume":"49","author":"AC Berry","year":"1941","unstructured":"Berry, A.C.: The accuracy of the Gaussian approximation to the sum of independent variates. Trans. Am. Math. Soc. 49(1), 122\u2013136 (1941). https:\/\/doi.org\/10.2307\/1990053","journal-title":"Trans. Am. Math. Soc."},{"key":"10463_CR7","unstructured":"Bilionis, I.: Probabilistic solvers for partial differential equations. arXiv:1607.03526 [math] (2016)"},{"issue":"1","key":"10463_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0045-7825(87)90114-9","volume":"61","author":"I Babu\u0161ka","year":"1987","unstructured":"Babu\u0161ka, I., Miller, A.: A feedback finite element method with a posteriori error estimation: part I. The finite element method and some basic properties of the a posteriori error estimator. Comput. Methods Appl. Mech. Eng. 61(1), 1\u201340 (1987). https:\/\/doi.org\/10.1016\/0045-7825(87)90114-9","journal-title":"Comput. Methods Appl. Mech. Eng."},{"issue":"1","key":"10463_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1214\/18-STS660","volume":"34","author":"F-X Briol","year":"2017","unstructured":"Briol, F.-X., Oates, C.J., Girolami, M., Osborne, M.A., Sejdinovic, D.: Probabilistic integration: a role in statistical computation? Stat. Sci. 34(1), 1\u201322 (2017). https:\/\/doi.org\/10.1214\/18-STS660","journal-title":"Stat. Sci."},{"issue":"146","key":"10463_CR10","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2307\/2006290","volume":"33","author":"I Babu\u0161ka","year":"1979","unstructured":"Babu\u0161ka, I., Rheinboldt, W.C.: Analysis of optimal finite-element meshes in $$\\mathbb{R} ^1$$. Math. Comput. 33(146), 435\u2013463 (1979). https:\/\/doi.org\/10.2307\/2006290","journal-title":"Math. Comput."},{"issue":"4","key":"10463_CR11","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1214\/16-BA1017","volume":"11","author":"OA Chkrebtii","year":"2016","unstructured":"Chkrebtii, O.A., Campbell, D.A., Calderhead, B., Girolami, M.: Bayesian solution uncertainty quantification for differential equations. Bayesian Anal. 11(4), 1239\u20131267 (2016). https:\/\/doi.org\/10.1214\/16-BA1017","journal-title":"Bayesian Anal."},{"issue":"4","key":"10463_CR12","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s11222-016-9671-0","volume":"27","author":"PR Conrad","year":"2017","unstructured":"Conrad, P.R., Girolami, M., S\u00e4rkk\u00e4, S., Stuart, A.M., Zygalakis, K.: Statistical analysis of differential equations: introducing probability measures on numerical solutions. Stat. Comput. 27(4), 1065\u20131082 (2017). https:\/\/doi.org\/10.1007\/s11222-016-9671-0","journal-title":"Stat. Comput."},{"issue":"3","key":"10463_CR13","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1214\/19-BA1145","volume":"14","author":"J Cockayne","year":"2019","unstructured":"Cockayne, J., Oates, C.J., Ipsen, I.C.F., Girolami, M.: A Bayesian conjugate gradient method (with discussion). Bayesian Anal. 14(3), 937\u20131012 (2019). https:\/\/doi.org\/10.1214\/19-BA1145","journal-title":"Bayesian Anal."},{"key":"10463_CR14","unstructured":"Cockayne, J., Oates, C.J., Sullivan, T.J., Girolami, M.: Probabilistic numerical methods for partial differential equations and Bayesian inverse problems. arXiv:1605.07811 [cs, math, stat] (2017)"},{"issue":"4","key":"10463_CR15","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1137\/17M1139357","volume":"61","author":"J Cockayne","year":"2019","unstructured":"Cockayne, J., Oates, C.J., Sullivan, T.J., Girolami, M.: Bayesian probabilistic numerical methods. SIAM Rev. 61(4), 756\u2013789 (2019). https:\/\/doi.org\/10.1137\/17M1139357","journal-title":"SIAM Rev."},{"key":"10463_CR16","unstructured":"Davis, T.A.: User Guide for CHOLMOD: a sparse Cholesky factorization and modification package. Technical Report (2013)"},{"key":"10463_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/978-1-4613-8768-8_20","volume-title":"Statistical Decision Theory and Related Topics IV","author":"P Diaconis","year":"1988","unstructured":"Diaconis, P.: Bayesian numerical analysis. In: Berger, J.O., Gupta, S.S. (eds.) Statistical Decision Theory and Related Topics IV, pp. 163\u2013175. Springer, New York (1988)"},{"key":"10463_CR18","doi-asserted-by":"publisher","first-page":"113533","DOI":"10.1016\/j.cma.2020.113533","volume":"375","author":"M Girolami","year":"2021","unstructured":"Girolami, M., Febrianto, E., Yin, G., Cirak, F.: The statistical finite element method (statFEM) for coherent synthesis of observation data and model predictions. Comput. Methods Appl. Mech. Eng. 375, 113533 (2021). https:\/\/doi.org\/10.1016\/j.cma.2020.113533","journal-title":"Comput. Methods Appl. Mech. Eng."},{"issue":"1","key":"10463_CR19","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1137\/140955501","volume":"25","author":"P Hennig","year":"2015","unstructured":"Hennig, P.: Probabilistic interpretation of linear solvers. SIAM J. Optim. 25(1), 234\u2013260 (2015). https:\/\/doi.org\/10.1137\/140955501","journal-title":"SIAM J. Optim."},{"key":"10463_CR20","unstructured":"Hennig, P., Hauberg, S.: Probabilistic solutions to differential equations and their application to Riemannian statistics. In: Proceedings of the Seventeenth International Conference on Artificial Intelligence and Statistics, pp. 347\u2013355. PMLR, Reykjavik (2014). https:\/\/proceedings.mlr.press\/v33\/hennig14.html"},{"issue":"2179","key":"10463_CR21","doi-asserted-by":"publisher","first-page":"20150142","DOI":"10.1098\/rspa.2015.0142","volume":"471","author":"P Hennig","year":"2015","unstructured":"Hennig, P., Osborne, M.A., Girolami, M.: Probabilistic numerics and uncertainty in computations. Proc. R. Soc. A Math. Phys. Eng. Sci. 471(2179), 20150142 (2015). https:\/\/doi.org\/10.1098\/rspa.2015.0142","journal-title":"Proc. R. Soc. A Math. Phys. Eng. Sci."},{"key":"10463_CR22","doi-asserted-by":"publisher","DOI":"10.1017\/9781316681411","volume-title":"Probabilistic Numerics: Computation as Machine Learning","author":"P Hennig","year":"2022","unstructured":"Hennig, P., Osborne, M.A., Kersting, H.P.: Probabilistic Numerics: Computation as Machine Learning. Cambridge University Press, Cambridge (2022)"},{"key":"10463_CR23","unstructured":"Kersting, H.P., Hennig, P.: Active uncertainty calibration in Bayesian ODE solvers. arXiv:1605.03364 [cs, math, stat] (2018)"},{"key":"10463_CR24","doi-asserted-by":"publisher","unstructured":"Karvonen, T., S\u00e4rkk\u00e4, S.: Classical quadrature rules via Gaussian processes. In: 2017 IEEE 27th International Workshop on Machine Learning for Signal Processing (MLSP), pp. 1\u20136 (2017). https:\/\/doi.org\/10.1109\/MLSP.2017.8168195","DOI":"10.1109\/MLSP.2017.8168195"},{"issue":"3","key":"10463_CR25","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1216\/RMJ-1972-2-3-379","volume":"2","author":"FM Larkin","year":"1972","unstructured":"Larkin, F.M.: Gaussian measure in Hilbert space and applications in numerical analysis. Rocky Mt. J. Math. 2(3), 379\u2013421 (1972). https:\/\/doi.org\/10.1216\/RMJ-1972-2-3-379","journal-title":"Rocky Mt. J. Math."},{"key":"10463_CR26","series-title":"Texts in Computational Science and Engineering","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33287-6","volume-title":"The Finite Element Method: Theory, Implementation, and Applications","author":"MG Larson","year":"2013","unstructured":"Larson, M.G., Bengzon, F.: The Finite Element Method: Theory, Implementation, and Applications. Texts in Computational Science and Engineering, Springer, Berlin, Heidelberg (2013)"},{"issue":"6","key":"10463_CR27","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s11222-019-09898-6","volume":"29","author":"HC Lie","year":"2019","unstructured":"Lie, H.C., Stuart, A.M., Sullivan, T.J.: Strong convergence rates of probabilistic integrators for ordinary differential equations. Stat. Comput. 29(6), 1265\u20131283 (2019). https:\/\/doi.org\/10.1007\/s11222-019-09898-6","journal-title":"Stat. Comput."},{"key":"10463_CR28","series-title":"Texts in Applied Mathematics","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-20325-6","volume-title":"Data Assimilation: A Mathematical Introduction","author":"K Law","year":"2015","unstructured":"Law, K., Stuart, A.M., Zygalakis, K.: Data Assimilation: A Mathematical Introduction. Texts in Applied Mathematics, Springer, Cham (2015)"},{"key":"10463_CR29","series-title":"Mathematics and its Applications","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-0909-0","volume-title":"Bayesian Approach to Global Optimization: Theory and Applications","author":"J Mockus","year":"1989","unstructured":"Mockus, J.: Bayesian Approach to Global Optimization: Theory and Applications. Mathematics and its Applications, Springer, Dordrecht (1989)"},{"issue":"3","key":"10463_CR30","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0378-3758(91)90002-V","volume":"29","author":"A O\u2019Hagan","year":"1991","unstructured":"O\u2019Hagan, A.: Bayes-Hermite quadrature. J. Stat. Plan. Inference 29(3), 245\u2013260 (1991). https:\/\/doi.org\/10.1016\/0378-3758(91)90002-V","journal-title":"J. Stat. Plan. Inference"},{"issue":"3","key":"10463_CR31","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1137\/140974596","volume":"13","author":"H Owhadi","year":"2015","unstructured":"Owhadi, H.: Bayesian numerical homogenization. Multiscale Model. Simul. 13(3), 812\u2013828 (2015). https:\/\/doi.org\/10.1137\/140974596","journal-title":"Multiscale Model. Simul."},{"key":"10463_CR32","unstructured":"Peker, U.: Analyzing the influence of prior covariances on a Bayesian finite element method. Master\u2019s Thesis, TU Delft (2023). http:\/\/resolver.tudelft.nl\/uuid:880758ca-6a09-4fd8-b95d-8cfb3283cca6"},{"key":"10463_CR33","unstructured":"Pf\u00f6rtner, M., Steinwart, I., Hennig, P., Wenger, J.: Physics-informed gaussian process regression generalizes linear PDE solvers. arXiv:2212.12474 [cs, math, stat] (2023)"},{"issue":"2","key":"10463_CR34","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3934\/ipi.2014.8.561","volume":"8","author":"L Roininen","year":"2014","unstructured":"Roininen, L., Huttunen, J.M.J., Lasanen, S.: Whittle-Mat\u00e9rn priors for Bayesian statistical inversion with applications in electrical impedance tomography. Inverse Probl. Imaging 8(2), 561\u2013586 (2014). https:\/\/doi.org\/10.3934\/ipi.2014.8.561","journal-title":"Inverse Probl. Imaging"},{"key":"10463_CR35","unstructured":"Rouse, J.P., Kerfriden, P., Hamadi, M.: A probabilistic hierarchical sub-modelling approach through a posteriori Bayesian state estimation of finite element error fields (2021). https:\/\/hal.archives-ouvertes.fr\/hal-03462530"},{"issue":"1","key":"10463_CR36","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1137\/17M1120762","volume":"40","author":"M Raissi","year":"2018","unstructured":"Raissi, M., Perdikaris, P., Karniadakis, G.E.: Numerical Gaussian processes for time-dependent and nonlinear partial differential equations. SIAM J. Sci. Comput. 40(1), 172\u2013198 (2018). https:\/\/doi.org\/10.1137\/17M1120762","journal-title":"SIAM J. Sci. Comput."},{"key":"10463_CR37","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.jcp.2018.10.045","volume":"378","author":"M Raissi","year":"2019","unstructured":"Raissi, M., Perdikaris, P., Karniadakis, G.E.: Physics-informed neural networks: a deep learning framework for solving forward and inverse problems involving nonlinear partial differential equations. J. Comput. Phys. 378, 686\u2013707 (2019). https:\/\/doi.org\/10.1016\/j.jcp.2018.10.045","journal-title":"J. Comput. Phys."},{"key":"10463_CR38","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/3206.001.0001","volume-title":"Gaussian Processes for Machine Learning","author":"CE Rasmussen","year":"2005","unstructured":"Rasmussen, C.E., Williams, C.K.I.: Gaussian Processes for Machine Learning. MIT Press, Cambridge (2005)"},{"key":"10463_CR39","first-page":"739","volume-title":"Advances in Neural Information Processing Systems","author":"M Schober","year":"2014","unstructured":"Schober, M., Duvenaud, D.K., Hennig, P.: Probabilistic ODE solvers with Runge\u2013Kutta means. In: Advances in Neural Information Processing Systems, pp. 739\u2013747. Curran Associates Inc, New York (2014)"},{"key":"10463_CR40","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-94-017-2219-3_2","volume-title":"Maximum Entropy and Bayesian Methods","author":"J Skilling","year":"1992","unstructured":"Skilling, J.: Bayesian solution of ordinary differential equations. In: Maximum Entropy and Bayesian Methods, pp. 23\u201337. Springer, Dordrecht (1992)"},{"key":"10463_CR41","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1017\/S0962492910000061","volume":"19","author":"AM Stuart","year":"2010","unstructured":"Stuart, A.M.: Inverse problems: a Bayesian perspective. Acta Numer. 19, 451\u2013559 (2010). https:\/\/doi.org\/10.1017\/S0962492910000061","journal-title":"Acta Numer."},{"key":"10463_CR42","volume-title":"Advances in Neural Information Processing Systems","author":"O Teymur","year":"2016","unstructured":"Teymur, O., Zygalakis, K., Calderhead, B.: Probabilistic linear multistep methods. In: Advances in Neural Information Processing Systems. Curran Associates Inc, New York (2016)"},{"key":"10463_CR43","doi-asserted-by":"publisher","unstructured":"Wang, J., Cockayne, J., Chkrebtii, O.A., Sullivan, T.J., Oates, C.J.: Bayesian numerical methods for nonlinear partial differential equations. Stat. Comput. 31(5), 1\u201320 (2021). https:\/\/doi.org\/10.1007\/s11222-021-10030-w","DOI":"10.1007\/s11222-021-10030-w"},{"key":"10463_CR44","first-page":"6731","volume-title":"Advances in Neural Information Processing Systems","author":"J Wenger","year":"2020","unstructured":"Wenger, J., Hennig, P.: Probabilistic linear solvers for machine learning. In: Advances in Neural Information Processing Systems, pp. 6731\u20136742. Curran Associates Inc, New York (2020)"},{"key":"10463_CR45","unstructured":"Wenger, J., Pleiss, G., Pf\u00f6rtner, M., Hennig, P., Cunningham, J.P.: Posterior and computational uncertainty in Gaussian processes. arXiv:2205.15449 [cs, math, stat] (2023)"},{"key":"10463_CR46","doi-asserted-by":"publisher","first-page":"109913","DOI":"10.1016\/j.jcp.2020.109913","volume":"425","author":"L Yang","year":"2021","unstructured":"Yang, L., Meng, X., Karniadakis, G.E.: B-PINNs: Bayesian physics-informed neural networks for forward and inverse PDE problems with noisy data. J. Comput. Phys. 425, 109913 (2021). https:\/\/doi.org\/10.1016\/j.jcp.2020.109913","journal-title":"J. Comput. Phys."},{"key":"10463_CR47","doi-asserted-by":"publisher","unstructured":"Zienkiewicz, O.C., Zhu, J.Z.: A simple error estimator and adaptive procedure for practical engineering analysis. Int. J. Numer. Meth. Eng. 24(2), 337\u2013357 (1987). https:\/\/doi.org\/10.1002\/nme.1620240206","DOI":"10.1002\/nme.1620240206"}],"container-title":["Statistics and Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11222-024-10463-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11222-024-10463-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11222-024-10463-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T15:07:49Z","timestamp":1727968069000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11222-024-10463-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10463"],"URL":"https:\/\/doi.org\/10.1007\/s11222-024-10463-z","relation":{},"ISSN":["0960-3174","1573-1375"],"issn-type":[{"value":"0960-3174","type":"print"},{"value":"1573-1375","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]},"assertion":[{"value":"12 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"167"}}