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However, analysing large datasets presents challenges due to the identification of nonlinear gene\u2013gene associations and the need to process an ever-growing number of gene pairs and their potential network connections. These challenges mean that some experiments are discarded because the techniques do not support these intense workloads. This paper presents pyEnGNet, a Python library that can generate gene co-expression networks in High-performance computing environments. To do this, pyEnGNet harnesses CPU and multi-GPU parallel computing resources, efficiently handling large datasets. These implementations have optimised memory management and processing, delivering timely results. We have used synthetic datasets to prove the runtime and intensive workload improvements. 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