{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:43:45Z","timestamp":1778600625386,"version":"3.51.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007831","name":"University of Tabriz","doi-asserted-by":"publisher","award":["2070"],"award-info":[{"award-number":["2070"]}],"id":[{"id":"10.13039\/501100007831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Supercomput"],"DOI":"10.1007\/s11227-025-08078-w","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:28:04Z","timestamp":1771068484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Numerical solutions of two-dimensional weakly singular fractional integro-differential equations"],"prefix":"10.1007","volume":"82","author":[{"given":"Safar","family":"Irandoust-Pakchin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Derakhshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Rezapour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"issue":"12","key":"8078_CR1","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.enganabound.2010.07.002","volume":"34","author":"S Abbasbandy","year":"2010","unstructured":"Abbasbandy S, Shirzadi SA (2010) A meshless method for two-dimensional diffusion equation with an integral condition. Eng Anal Bound Elem 34(12):1031\u20131037","journal-title":"Eng Anal Bound Elem"},{"issue":"3","key":"8078_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3390\/fractalfract5030085","volume":"5","author":"T Akram","year":"2021","unstructured":"Akram T, Ali Z, Rabiei F, Shah K, Kumam P (2021) A numerical study of nonlinear fractional order partial integro-differential equation with a weakly singular kernel. Fractal Fract 5(3):85","journal-title":"Fractal Fract"},{"issue":"1","key":"8078_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/02286203.2021.2015818","volume":"43","author":"KA Abro","year":"2023","unstructured":"Abro KA, Atangana A, G\u00f3mez-Aguilar JF (2023) A comparative analysis of plasma dilution based on fractional integro-differential equation: an application to biological science. Int J Model Simul 43(1):1\u201310","journal-title":"Int J Model Simul"},{"key":"8078_CR4","doi-asserted-by":"publisher","first-page":"116816","DOI":"10.1016\/j.cam.2025.116816","volume":"474","author":"AA Aghaei","year":"2026","unstructured":"Aghaei AA, Nejad AG, Yousefi S, Parand K (2026) A new Chebyshev operational matrix formulation of least-squares support vector regression for solving fractional integro-differential equations. J Comput Appl Math 474:116816","journal-title":"J Comput Appl Math"},{"issue":"1","key":"8078_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.2478\/s13540-012-0005-4","volume":"15","author":"A Aghajani","year":"2012","unstructured":"Aghajani A, Jalilian Y, Trujillo JJ (2012) On the existence of solutions of fractional integro-differential equations. Fract Calcul Appl Anal 15(1):44\u201369","journal-title":"Fract Calcul Appl Anal"},{"issue":"1","key":"8078_CR6","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s12190-024-02279-x","volume":"71","author":"KK Ali","year":"2025","unstructured":"Ali KK, Mohamed MS, Maneea M (2025) Unveiling the dynamics of plasma dilution in medical science through analytical and numerical approaches via fractional integro-differential equations. J Appl Math Comput 71(1):1219\u20131245","journal-title":"J Appl Math Comput"},{"issue":"1","key":"8078_CR7","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/mma.4617","volume":"41","author":"R Almeida","year":"2018","unstructured":"Almeida R, Malinowska AB, Monteiro MTT (2018) Fractional differential equations with a Caputo derivative with respect to a kernel function and their applications. Math Methods Appl Sci 41(1):336\u2013352","journal-title":"Math Methods Appl Sci"},{"issue":"1","key":"8078_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00036811.2022.2036335","volume":"103","author":"M Alotaibi","year":"2023","unstructured":"Alotaibi M, Jleli M, Ragusa MA, Samet B (2023) On the absence of global weak solutions for a nonlinear time-fractional Schr\u00f6dinger equation. Appl Anal 103(1):1\u201315","journal-title":"Appl Anal"},{"issue":"1","key":"8078_CR9","doi-asserted-by":"publisher","first-page":"22347","DOI":"10.1038\/s41598-023-49577-1","volume":"13","author":"SA Alsallami","year":"2023","unstructured":"Alsallami SA, Maneea M, Khalil EM, Abdel-Khalek S, Ali KK (2023) Insights into time fractional dynamics in the Belousov\u2013Zhabotinsky system through singular and non-singular kernels. Sci Rep 13(1):22347","journal-title":"Sci Rep"},{"issue":"8","key":"8078_CR10","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s40314-023-02491-8","volume":"42","author":"J Alavi","year":"2023","unstructured":"Alavi J, Aminikhah H (2023) An efficient parametric finite difference and orthogonal spline approximation for solving the weakly singular nonlinear time-fractional partial integro-differential equation. Comput Appl Math 42(8):350","journal-title":"Comput Appl Math"},{"key":"8078_CR11","doi-asserted-by":"crossref","unstructured":"Baleanu D, Diethelm K, Scalas E, Trujillo JJ (2012) Fractional calculus: models and numerical methods, vol 3. World Scientific","DOI":"10.1142\/8180"},{"key":"8078_CR12","volume":"494","author":"IA Bhat","year":"2025","unstructured":"Bhat IA, Mishra LN, Mishra VN (2025) Comparative analysis of nonlinear Urysohn functional integral equations via Nystr\u00f6m method. Appl Math Comput 494:129287","journal-title":"Appl Math Comput"},{"issue":"12","key":"8078_CR13","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.1108\/HFF-06-2024-0459","volume":"34","author":"IA Bhat","year":"2024","unstructured":"Bhat IA, Mishra LN, Mishra VN, Tun\u00e7 C (2024) Analysis of efficient discretization technique for nonlinear integral equations of Hammerstein type. Int J Numer Methods Heat Fluid Flow 34(12):4257\u20134280","journal-title":"Int J Numer Methods Heat Fluid Flow"},{"key":"8078_CR14","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.aej.2024.08.017","volume":"104","author":"IA Bhat","year":"2024","unstructured":"Bhat IA, Mishra LN, Mishra VN, Abdel-Aty M, Qasymeh M (2024) A comprehensive analysis for weakly singular nonlinear functional Volterra integral equations using discretization techniques. Alex Eng J 104:564\u2013575","journal-title":"Alex Eng J"},{"key":"8078_CR15","volume":"470","author":"IA Bhat","year":"2024","unstructured":"Bhat IA, Mishra LN (2024) A comparative study of discretization techniques for augmented Urysohn type nonlinear functional Volterra integral equations and their convergence analysis. Appl Math Comput 470:128555","journal-title":"Appl Math Comput"},{"issue":"1","key":"8078_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmaa.2023.127342","volume":"526","author":"H Boujemaa","year":"2023","unstructured":"Boujemaa H, Oulgiht B, Ragusa MA (2023) A new class of fractional Orlicz\u2013Sobolev space and singular elliptic problems. J Math Anal Appl 526(1):127342. https:\/\/doi.org\/10.1016\/j.jmaa.2023.127342","journal-title":"J Math Anal Appl"},{"issue":"3","key":"8078_CR17","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1515\/fca-2015-0045","volume":"18","author":"J Cao","year":"2015","unstructured":"Cao J, Li C, Chen Y (2015) High-order approximation to Caputo derivatives and Caputo-type advection-diffusion equations (II). Fract Calcul Appl Anal 18(3):735\u2013761","journal-title":"Fract Calcul Appl Anal"},{"issue":"4","key":"8078_CR18","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1007\/s11075-024-01854-4","volume":"98","author":"Y Chakir","year":"2025","unstructured":"Chakir Y, Safouhi H (2025) On solving 2D weakly singular Volterra integral equations of the second kind. Numer Algorithms 98(4):1827\u20131847","journal-title":"Numer Algorithms"},{"issue":"3","key":"8078_CR19","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1137\/130933447","volume":"52","author":"M Chen","year":"2014","unstructured":"Chen M, Deng W (2014) Fourth order accurate scheme for the space fractional diffusion equations. SIAM J Numer Anal 52(3):1418\u20131438","journal-title":"SIAM J Numer Anal"},{"key":"8078_CR20","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s12220-025-02166-2","volume":"35","author":"NC Eddine","year":"2025","unstructured":"Eddine NC, Ragusa MA (2025) The compact embeddings and the concentration-compactness principles for anisotropic variable exponent Sobolev spaces and applications. J Geom Anal 35:338. https:\/\/doi.org\/10.1007\/s12220-025-02166-2","journal-title":"J Geom Anal"},{"key":"8078_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.matcom.2022.03.008","volume":"199","author":"I Fahimi-khalilabad","year":"2022","unstructured":"Fahimi-khalilabad I, Irandoust-Pakchin S, Abdi-Mazraeh S (2022) High-order finite difference method based on linear barycentric rational interpolation for Caputo type sub-diffusion equation. Math Comput Simul 199:60\u201380. https:\/\/doi.org\/10.1016\/j.matcom.2022.03.008","journal-title":"Math Comput Simul"},{"issue":"10","key":"8078_CR22","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1080\/10255842.2023.2239976","volume":"27","author":"B Fatima","year":"2024","unstructured":"Fatima B, Rahman MU, Althobaiti S, Althobaiti A, Arfan M (2024) Analysis of age wise fractional order problems for the Covid-19 under non-singular kernel of Mittag\u2013Leffler law. Comput Methods Biomech Biomed Engin 27(10):1303\u20131321","journal-title":"Comput Methods Biomech Biomed Engin"},{"issue":"1","key":"8078_CR23","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s12190-023-01981-6","volume":"70","author":"B Ghosh","year":"2024","unstructured":"Ghosh B, Mohapatra J (2024) Efficient numerical schemes based on the cubic B-spline collocation method for time-fractional partial integro-differential equations of Volterra type. J Appl Math Comput 70(1):741\u2013769","journal-title":"J Appl Math Comput"},{"key":"8078_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cam.2025.116506","volume":"463","author":"MH Heydari","year":"2025","unstructured":"Heydari MH, Navari J, Hosseininia M, Razzaghi M (2025) A numerical method based on the hat functions to solve a category of nonlinear fractional integro-differential equations involving Caputo-Hadamard derivative. J Comput Appl Math 463:116506","journal-title":"J Comput Appl Math"},{"issue":"2","key":"8078_CR25","doi-asserted-by":"publisher","first-page":"505","DOI":"10.2298\/FIL2402505I","volume":"38","author":"S Irandoust-Pakchin","year":"2024","unstructured":"Irandoust-Pakchin S, Abdi-Mazraeh S, Fahimi-khalilabad I (2024) Higher order class of finite difference method for time-fractional Liouville-Caputo and space-Riesz fractional diffusion equation. Filomat 38(2):505\u2013521. https:\/\/doi.org\/10.2298\/FIL2402505I","journal-title":"Filomat"},{"issue":"1","key":"8078_CR26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1134\/S0965542516010103","volume":"56","author":"S Irandoust-Pakchin","year":"2016","unstructured":"Irandoust-Pakchin S, Javidi M, Kheiri H (2016) Analytical solutions for the fractional nonlinear cable equation using a modified homotopy perturbation and separation of variables methods. Comput Math Math Phys 56(1):116\u2013131. https:\/\/doi.org\/10.1134\/S0965542516010103","journal-title":"Comput Math Math Phys"},{"issue":"12","key":"8078_CR27","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1134\/S0965542517120120","volume":"57","author":"S Irandoust-Pakchin","year":"2017","unstructured":"Irandoust-Pakchin S, Abdi-Mazraeh S, Khani A (2017) Numerical solution for a variable-order fractional nonlinear cable equation via Chebyshev cardinal functions. Comput Math Math Phys 57(12):2047\u20132056. https:\/\/doi.org\/10.1134\/S0965542517120120","journal-title":"Comput Math Math Phys"},{"issue":"3","key":"8078_CR28","doi-asserted-by":"publisher","first-page":"650","DOI":"10.4208\/cicp.OA-2016-0136","volume":"21","author":"S Jiang","year":"2017","unstructured":"Jiang S, Zhang J, Zhang Q, Zhang Z (2017) Fast evaluation of the Caputo fractional derivative and its applications to fractional diffusion equations. Commun Comput Phys 21(3):650\u2013678","journal-title":"Commun Comput Phys"},{"issue":"24","key":"8078_CR29","doi-asserted-by":"publisher","first-page":"9819","DOI":"10.1016\/j.apm.2013.06.010","volume":"37","author":"MM Khader","year":"2013","unstructured":"Khader MM, Sweilam NH (2013) On the approximate solutions for system of fractional integro-differential equations using Chebyshev pseudo-spectral method. Appl Math Model 37(24):9819\u20139828","journal-title":"Appl Math Model"},{"issue":"2","key":"8078_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00033-025-02451-8","volume":"76","author":"S Kumar","year":"2025","unstructured":"Kumar S, Das S, Singh VK (2025) Product integration techniques for generalized fractional integro-differential equations. Z Angew Math Phys 76(2):1\u201330","journal-title":"Z Angew Math Phys"},{"issue":"3","key":"8078_CR31","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1137\/17M1160318","volume":"50","author":"L Li","year":"2018","unstructured":"Li L, Liu JG (2018) A generalized definition of Caputo derivatives and its application to fractional ODEs. SIAM J Math Anal 50(3):2867\u20132900","journal-title":"SIAM J Math Anal"},{"issue":"3","key":"8078_CR32","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10915-025-02999-7","volume":"104","author":"S Li","year":"2025","unstructured":"Li S, Ding H (2025) Numerical analysis of two-dimensional time-fractional Allen\u2013Cahn equation on a new non-uniform mesh construction strategy. J Sci Comput 104(3):81","journal-title":"J Sci Comput"},{"issue":"5","key":"8078_CR33","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1080\/01630563.2017.1402346","volume":"39","author":"WH Luo","year":"2018","unstructured":"Luo WH, Li C, Huang TZ, Gu XM, Wu GC (2018) A high-order accurate numerical scheme for the Caputo derivative with applications to fractional diffusion problems. Numer Funct Anal Optim 39(5):600\u2013622","journal-title":"Numer Funct Anal Optim"},{"key":"8078_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnsns.2025.108824","volume":"147","author":"J Ma","year":"2025","unstructured":"Ma J, Sun T, Chen H (2025) An efficient numerical scheme for two-dimensional nonlinear time fractional Schr\u00f6dinger equation. Commun Nonlinear Sci Numer Simul 147:108824","journal-title":"Commun Nonlinear Sci Numer Simul"},{"issue":"3","key":"8078_CR35","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.cnsns.2010.05.027","volume":"16","author":"JT Machado","year":"2011","unstructured":"Machado JT, Kiryakova V, Mainardi F (2011) Recent history of fractional calculus. Commun Nonlinear Sci Numer Simul 16(3):1140\u20131153","journal-title":"Commun Nonlinear Sci Numer Simul"},{"issue":"Suppl 2","key":"8078_CR36","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00366-020-01261-y","volume":"38","author":"A Majeed","year":"2022","unstructured":"Majeed A, Kamran M, Asghar N, Baleanu D (2022) Numerical approximation of inhomogeneous time fractional Burgers\u2013Huxley equation with B-spline functions and Caputo derivative. Eng Comput 38(Suppl 2):885\u2013900","journal-title":"Eng Comput"},{"issue":"Suppl 1","key":"8078_CR37","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12190-025-02490-4","volume":"71","author":"Z Odibat","year":"2025","unstructured":"Odibat Z (2025) On two-parameter Mittag\u2013Leffler type fractional derivative models with non-singular and singular kernels. J Appl Math Comput 71(Suppl 1):217\u2013234","journal-title":"J Appl Math Comput"},{"key":"8078_CR38","unstructured":"Petras I (2012) Fractional calculus and its applications. Math Model Multidiscipl Appl John Wiley & Sons: Hoboken, NJ, USA, 355\u2013396"},{"issue":"1","key":"8078_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/nla.70005","volume":"32","author":"W Qu","year":"2025","unstructured":"Qu W, Huang YY, Hon S, Lei SL (2025) A novel fourth-order scheme for two-dimensional Riesz space fractional nonlinear reaction?diffusion equations and its optimal preconditioned Solver. Numer Linear Algebra Appl 32(1):e70005","journal-title":"Numer Linear Algebra Appl"},{"key":"8078_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.chaos.2025.116025","volume":"192","author":"P Rahimkhani","year":"2025","unstructured":"Rahimkhani P, Ordokhani Y, Razzaghi M (2025) Fractional-order clique functions to solve left-sided Bessel fractional integro-differential equations. Chaos Solitons Fractals 192:116025","journal-title":"Chaos Solitons Fractals"},{"issue":"2","key":"8078_CR41","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s11075-024-01804-0","volume":"98","author":"P Roul","year":"2025","unstructured":"Roul P, Sundar S (2025) Novel numerical methods based on graded, adaptive and uniform meshes for a time-fractional advection-diffusion equation subjected to weakly singular solution. Numer Algorithms 98(2):531\u2013561","journal-title":"Numer Algorithms"},{"issue":"13","key":"8078_CR42","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1177\/1077546310395977","volume":"17","author":"A Saadatmandi","year":"2011","unstructured":"Saadatmandi A, Dehghan M (2011) A Legendre collocation method for fractional integro-differential equations. J Vib Control 17(13):2050\u20132058","journal-title":"J Vib Control"},{"issue":"1","key":"8078_CR43","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1002\/mma.9654","volume":"47","author":"A Singh","year":"2024","unstructured":"Singh A, Kumar S, VigoAguiar J (2024) On new approximations of Caputo-Prabhakar fractional derivative and their application to reaction-diffusion problems with variable coefficients. Math Methods Appl Sci 47(1):268\u2013296","journal-title":"Math Methods Appl Sci"},{"key":"8078_CR44","volume":"15","author":"M Saleem","year":"2025","unstructured":"Saleem M, Ali A, Haq F, Khan H (2025) Numerical approximation of time-fractional nonlinear partial integro-differential equation using fractional Euler and cubic trigonometric B-Spline methods. Part Differ Equ Appl Math 15:101223","journal-title":"Part Differ Equ Appl Math"},{"issue":"2","key":"8078_CR45","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s00366-024-02054-3","volume":"41","author":"T Taheri","year":"2025","unstructured":"Taheri T, Aghaei AA, Parand K (2025) A new kernel-based approach for solving general fractional (integro)-differential-algebraic equations. Eng Comput 41(2):845\u2013864","journal-title":"Eng Comput"},{"issue":"4","key":"8078_CR46","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.4208\/cicp.OA-2017-0019","volume":"22","author":"Y Yan","year":"2017","unstructured":"Yan Y, Sun ZZ, Zhang J (2017) Fast evaluation of the Caputo fractional derivative and its applications to fractional diffusion equations: a second-order scheme. Commun Comput Phys 22(4):1028\u20131048","journal-title":"Commun Comput Phys"}],"container-title":["The Journal of Supercomputing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11227-025-08078-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11227-025-08078-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11227-025-08078-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:28:05Z","timestamp":1771068485000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11227-025-08078-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["8078"],"URL":"https:\/\/doi.org\/10.1007\/s11227-025-08078-w","relation":{},"ISSN":["1573-0484"],"issn-type":[{"value":"1573-0484","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,14]]},"assertion":[{"value":"13 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no Conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"165"}}