{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T18:10:03Z","timestamp":1748369403338,"version":"3.41.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Syst Sci Complex"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s11424-015-4021-4","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T18:17:32Z","timestamp":1430331452000},"page":"592-605","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Statistical diagnosis for HIV dynamics based on mean shift outlier model"],"prefix":"10.1007","volume":"28","author":[{"given":"Ting","family":"Wu","sequence":"first","affiliation":[]},{"given":"Sanyang","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"4021_CR1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/373123a0","volume":"373","author":"D D Ho","year":"1995","unstructured":"Ho D D, Neumann A U, Perelson A S, Chen W, Leonard J M, and Markowitz M, Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection, Nature, 1995, 373: 123\u2013126.","journal-title":"Nature"},{"key":"4021_CR2","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1126\/science.271.5255.1582","volume":"271","author":"A S Perelson","year":"1996","unstructured":"Perelson A S, Neumann A U, Markowitz M, Leonard J M, and Ho D D, HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time, Science, 1996, 271: 1582\u20131586.","journal-title":"Science"},{"key":"4021_CR3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/387188a0","volume":"387","author":"A S Perelson","year":"1997","unstructured":"Perelson A S, Essunger P, Cao Y Z, Vesanen M, Hurley A, Saksela K, Markowitz M, and Ho D D, Decay characteristics of HIV-1-infected compartments during combination therapy, Nature, 1997, 387: 181\u2013191.","journal-title":"Nature"},{"key":"4021_CR4","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1097\/00002030-199812000-00010","volume":"12","author":"D W Notermans","year":"1998","unstructured":"Notermans D W, Goudsmit J, Danner S A, de Wolf F, Perelson A S, and Mitter J, Rate of HIV-1 decline following antiretroviral therapy is related to viral load at baseline and drug regimen, AIDS, 1998, 12: 1483\u20131490.","journal-title":"AIDS"},{"key":"4021_CR5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.0006-341X.1999.00410.x","volume":"55","author":"H Wu","year":"1999","unstructured":"Wu H and Ding A, Population HIV-1 dynamics in vivo: Applicable models and inferential tools for virological data from AIDS clinical trials, Biometrics, 1999, 55: 410\u2013418.","journal-title":"Biometrics"},{"key":"4021_CR6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1137\/S0036144598335107","volume":"41","author":"A S Perelson","year":"1999","unstructured":"Perelson A S and Nelson P W, Mathematical analysis of HIV-1 dynamics in vivo, SIAM Rev., 1999, 41: 3\u201344.","journal-title":"SIAM Rev."},{"key":"4021_CR7","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198504184.001.0001","volume-title":"Virus Dynamics: Mathematical Principles of Immunology and Virology","author":"M A Nowak","year":"2000","unstructured":"Nowak M A and May W H, Virus Dynamics: Mathematical Principles of Immunology and Virology, Oxford University Press, Oxford, 2000."},{"key":"4021_CR8","doi-asserted-by":"crossref","DOI":"10.1142\/5737","volume-title":"Deterministic and Stochastic Model of AIDS Epidemics and HIV Infections with Intervention","author":"W Y Tan","year":"2005","unstructured":"Tan W Y and Wu H, Deterministic and Stochastic Model of AIDS Epidemics and HIV Infections with Intervention, World Scientific, Singapore, 2005."},{"key":"4021_CR9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1541-0420.2005.00447.x","volume":"62","author":"Y Huang","year":"2006","unstructured":"Huang Y, Liu D, and Wu H, Hierarchical Bayesian methods for estimation of parameters in a longitudinal HIV dynamic system, Biometrics, 2006, 62: 413\u2013423.","journal-title":"Biometrics"},{"issue":"484","key":"4021_CR10","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1198\/016214508000000797","volume":"103","author":"H Liang","year":"2008","unstructured":"Liang H and Wu H L, Parameter estimation for differential equation models using a framework of measurement error in regression models, J. Am. Stat. Assoc., 2008, 103(484): 1570\u20131583.","journal-title":"J. Am. Stat. Assoc."},{"key":"4021_CR11","volume-title":"Nonlinear Parameter Estimation","author":"Y Bard","year":"1974","unstructured":"Bard Y, Nonlinear Parameter Estimation, London, Academic, 1974."},{"key":"4021_CR12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/aic.690320105","volume":"32","author":"L Biegler","year":"1986","unstructured":"Biegler L, Damiano J J, and Blau G E, Nonlinear parameter estimation: A case study comparison, AICHE Journal, 1986, 32: 29\u201345.","journal-title":"AICHE Journal"},{"key":"4021_CR13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1198\/016214507000001382","volume":"103","author":"J Chen","year":"2008","unstructured":"Chen J and Wu H, Efficient local estimation for time-varying coefficients in deterministic dynamic models with applications to HIV-1 dynamics, J. Amer. Statist. Assoc., 2008, 103: 369\u2013384.","journal-title":"J. Amer. Statist. Assoc."},{"key":"4021_CR14","first-page":"987","volume":"18","author":"J Chen","year":"2008","unstructured":"Chen J and Wu H, Estimation of time-varying parameters in deterministic dynamic models, Statist. Sinica, 2008, 18: 987\u20131006.","journal-title":"Statist. Sinica"},{"key":"4021_CR15","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1214\/07-EJS132","volume":"2","author":"N Brunel","year":"2008","unstructured":"Brunel N, Parameter estimatin of ODE\u2019s via nonparametric estimators, Electronic J. Statist., 2008, 2: 1242\u20131267.","journal-title":"Electronic J. Statist."},{"key":"4021_CR16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1467-9868.2007.00610.x","volume":"69","author":"J O Ramsay","year":"2007","unstructured":"Ramsay J O, Hooker G, Campbell D, and Cao J, Parameter estimation for differential equations: A generalized smoothing approach, Journal of Royal Statistical Society, 2007, 69: 741\u2013796.","journal-title":"Journal of Royal Statistical Society"},{"key":"4021_CR17","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1198\/jasa.2010.tm10555","volume":"492","author":"H Liang","year":"2010","unstructured":"Liang H and Wu H L, Correction, Journal of the American Statistical Association, 2010, 492: 1636\u20131636.","journal-title":"Journal of the American Statistical Association"}],"container-title":["Journal of Systems Science and Complexity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11424-015-4021-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11424-015-4021-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11424-015-4021-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T17:50:54Z","timestamp":1748368254000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11424-015-4021-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["4021"],"URL":"https:\/\/doi.org\/10.1007\/s11424-015-4021-4","relation":{},"ISSN":["1009-6124","1559-7067"],"issn-type":[{"type":"print","value":"1009-6124"},{"type":"electronic","value":"1559-7067"}],"subject":[],"published":{"date-parts":[[2015,4,30]]}}}