{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:18:29Z","timestamp":1761675509570},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T00:00:00Z","timestamp":1191542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Bio Eng Comput"],"published-print":{"date-parts":[[2007,11,20]]},"DOI":"10.1007\/s11517-007-0260-4","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T10:26:13Z","timestamp":1191493573000},"page":"1023-1028","source":"Crossref","is-referenced-by-count":19,"title":["Automated live cell screening system based on a 24-well-microplate with integrated micro fluidics"],"prefix":"10.1007","volume":"45","author":[{"given":"V.","family":"Lob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Geisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Brischwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Uhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,10,5]]},"reference":[{"key":"260_CR1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.snb.2005.07.056","volume":"B113","author":"S Arain","year":"2006","unstructured":"Arain S et al (2006) Characterization of microtiterplates with integrated optical sensors for oxygen and pH, and their applications to enzyme activity screening, respirometry, and toxicological assays. Sen Actuators B113:639\u2013648","journal-title":"Sen Actuators"},{"key":"260_CR2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2818.1983.tb04158.x","volume":"129","author":"D Axelrod","year":"1983","unstructured":"Axelrod D (1983) Total internal inflection fluorescent microscopy. J Microsc 129:19\u201328","journal-title":"J Microsc"},{"key":"260_CR3","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1016\/S0006-3495(03)75126-1","volume":"84","author":"C Berney","year":"2003","unstructured":"Berney C, Danuser G (2003) FRET or no FRET: a quantitative comparison. Biophys J 84:3992\u20134010","journal-title":"Biophys J"},{"key":"260_CR4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2818.1979.tb01178.x","volume":"117","author":"GJ Brakenhoff","year":"1979","unstructured":"Brakenhoff GJ et al (1979) Confocal scanning light microscopy with high aperture immersion lenses. J Microsc 117:219\u2013232","journal-title":"J Microsc"},{"key":"260_CR5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-662-05204-4_7","volume-title":"Ul-trathin electrochemical chemo- and biosensors","author":"M Brischwein","year":"2004","unstructured":"Brischwein M, Grothe H, Otto AM, Stepper C, Motrescu E, Weyh T, Wolf B (2004) Living cells on chip: bioanalytical applications. In: Mirsky VM (ed) Ul-trathin electrochemical chemo- and biosensors. Springer, Berlin, pp 159\u2013180"},{"issue":"4","key":"260_CR6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1039\/b308888j","volume":"3","author":"M Brischwein","year":"2003","unstructured":"Brischwein M, Motrescu ER, Otto AM, Cabala E, Grothe H, Wolf B (2003) Functional cellular assays with multiparametric silicon sensor chips. Lab Chip 3(4):234\u2013240","journal-title":"Lab Chip"},{"key":"260_CR7","first-page":"41","volume":"18","author":"A Constans","year":"2004","unstructured":"Constans A (2004) Automated microscopy gets a new shape. Scientist 18:41\u201343","journal-title":"Scientist"},{"key":"260_CR8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.2321027","volume":"248","author":"W Denk","year":"1990","unstructured":"Denk W et al (1990) Two-photon laser scanning fluorescence microscopy. Science 248:73\u201376","journal-title":"Science"},{"key":"260_CR9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0956-5663(96)89087-7","volume":"12","author":"R Ehret","year":"1996","unstructured":"Ehret R et al (1996) Monitoring of cellular behavior by impedance measurements on interdigititated electrode structures. Biosens Bioelectron 12:29\u201341","journal-title":"Biosens Bioelectron"},{"key":"260_CR10","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S1471-4892(03)00088-2","volume":"3","author":"M Entzeroth","year":"2003","unstructured":"Entzeroth M (2003) Emerging trends in high-throughput screening. Curr Opin Pharmacol 3:522\u2013529","journal-title":"Curr Opin Pharmacol"},{"key":"260_CR11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1109\/TASE.2006.871476","volume":"3","author":"T Geisler","year":"2006","unstructured":"Geisler T et al (2006) Automated multiparametric platform for high-content and high-throughput analytical screening on living cells. IEEE Trans Autom Sci Eng 3:169\u2013176","journal-title":"IEEE Trans Autom Sci Eng"},{"key":"260_CR12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1367-5931(00)00110-1","volume":"4","author":"RP Hertzberg","year":"2000","unstructured":"Hertzberg RP et al (2000) High-throughput screening: new technology for the 21st century. Curr Opin Chem Biol 4:445\u2013451","journal-title":"Curr Opin Chem Biol"},{"key":"260_CR13","volume-title":"Structured biological modelling\u2014a new approach to biophysical cell biology","author":"M Kraus","year":"1995","unstructured":"Kraus M, Wolf B (1995) Structured biological modelling\u2014a new approach to biophysical cell biology. CRC Press, Boca Raton"},{"key":"260_CR14","first-page":"511","volume":"11","author":"V Lob","year":"2005","unstructured":"Lob V et al (2005) Cell-based assays: mikrosensorarray-basiertes screening an lebenden Zellen und Geweben. Biospektrum 11:511\u2013512","journal-title":"Biospektrum"},{"key":"260_CR15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/nadc.20060540210","volume":"54","author":"V Lob","year":"2006","unstructured":"Lob V et al (2006) Chip statt Maus: Mikrosensor-arrays zur Chemikalienpr\u00fcfung. Nachrichten aus der Chemie 54:115\u2013120","journal-title":"Nachrichten aus der Chemie"},{"key":"260_CR16","first-page":"69","volume":"6","author":"K Moore","year":"2001","unstructured":"Moore K et al (2001) Cell-based versus isolated target screening: how lucky do you feel? J Biomol Screen 6:69\u201374","journal-title":"J Biomol Screen"},{"key":"260_CR17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1051\/medsci\/200420111027","volume":"20","author":"G Trugnan","year":"2004","unstructured":"Trugnan G et al (2004) FRAP, FLIP, FRET, BRET, FLIM, PRIM...new techniques for a colourful life. Med Sci (Paris) 20:1027\u20131034","journal-title":"Med Sci (Paris)"},{"key":"260_CR18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2533\/000942905777676623","volume":"59","author":"J Wiest et a","year":"2005","unstructured":"Wiest J et al (2005) Cellular assays with multiparametric bioelectronic sensor chips Chimia 59:243\u2013246","journal-title":"Chimia"}],"container-title":["Medical &amp; Biological Engineering &amp; Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-007-0260-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-007-0260-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-007-0260-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T12:06:54Z","timestamp":1559390814000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-007-0260-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,5]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11,20]]}},"alternative-id":["260"],"URL":"https:\/\/doi.org\/10.1007\/s11517-007-0260-4","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,5]]}}}