{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:05:40Z","timestamp":1769216740956,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:00:00Z","timestamp":1228176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1007\/s11517-008-0425-9","type":"journal-article","created":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T08:42:53Z","timestamp":1228120973000},"page":"357-366","source":"Crossref","is-referenced-by-count":21,"title":["Mechanobiological bone growth: comparative analysis of two biomechanical modeling approaches"],"prefix":"10.1007","volume":"47","author":[{"given":"Hui","family":"Lin","sequence":"first","affiliation":[]},{"given":"Carl-\u00c9ric","family":"Aubin","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Parent","sequence":"additional","affiliation":[]},{"given":"Isabelle","family":"Villemure","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,12,2]]},"reference":[{"key":"425_CR1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3109\/17453679308993665","volume":"64","author":"A Alberty","year":"1993","unstructured":"Alberty A, Peltonen J, Ritsila V (1993) Effects of distraction and compression on proliferation of growth plate chondrocytes. A study in rabbits. Acta Orthop Scand 64:449\u2013455","journal-title":"Acta Orthop Scand"},{"key":"425_CR2","first-page":"145","volume":"37","author":"GS Beaupre","year":"2000","unstructured":"Beaupre GS, Stevens SS, Carter DR (2000) Mechanobiology in the development, maintenance and degeneration of articular cartilage. J Rehabil R D 37:145\u2013151","journal-title":"J Rehabil R D"},{"key":"425_CR3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01811214","volume":"6","author":"F Bonnel","year":"1984","unstructured":"Bonnel F, Dimeglio A, Baldet P, Rabischong P (1984) Biomechanical activity of the growth plate. Clinical incidences. Anat Clin 6:53\u201361. doi: 10.1007\/BF01811214","journal-title":"Anat Clin"},{"issue":"4","key":"425_CR4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/BF02350997","volume":"42","author":"J Carrier","year":"2004","unstructured":"Carrier J, Aubin CE, Villemure I, Labelle H (2004) Biomechanical modeling of growth modulation following rib shortening or lengthening in adolescent idiopathic scoliosis. Med Biol Eng Comput 42(4):541\u2013548. doi: 10.1007\/BF02350997","journal-title":"Med Biol Eng Comput"},{"key":"425_CR5","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/jor.1100060604","volume":"6","author":"DR Carter","year":"1988","unstructured":"Carter DR, Wong M (1988) The role of mechanical loading histories in the development of diarthrodial joint. J Orthop Res 6:804\u2013816. doi: 10.1002\/jor.1100060604","journal-title":"J Orthop Res"},{"issue":"1","key":"425_CR6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jor.1100060120","volume":"6","author":"DR Carter","year":"1988","unstructured":"Carter DR, Wong M (1988) Mechanical stresses and endochondral ossification in the chondroepiphysis. J Orthop Res 6(1):148\u2013154. doi: 10.1002\/jor.1100060120","journal-title":"J Orthop Res"},{"key":"425_CR7","first-page":"453","volume-title":"Le rachis en croissance","author":"A Dimeglio","year":"1990","unstructured":"Dimeglio A, Bonnel F (1990) Le rachis en croissance. Springer, Paris, p 453"},{"key":"425_CR8","first-page":"203","volume-title":"Skeletal growth and development","author":"CE Farnum","year":"1998","unstructured":"Farnum CE, Wilsman NJ (1998) Growth plate cellular function. In: Buckwalter JA, Ehrlich MG, Sandell LJ, Trippel SB (eds) Skeletal growth and development. AAOS, Rosemont, pp 203\u2013243"},{"key":"425_CR9","first-page":"517","volume-title":"Skeletal growth and development","author":"CE Farnum","year":"1998","unstructured":"Farnum CE, Wilsman NJ (1998) Effects of distraction and compression on growth plate function. In: Buckwalter JA, Ehrlich MG, Sandell LJ, Trippel SB (eds) Skeletal growth and development. AAOS, Rosemont, pp 517\u2013530"},{"issue":"4","key":"425_CR10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000016787","volume":"167","author":"CE Farnum","year":"2000","unstructured":"Farnum CE, Nixon A, Lee AO, Kwan DT, Belanger L, Wilsman NJ (2000) Quantitative three-dimensional analysis of chondrocytic kinetic responses to short-term stapling of the rat proximal tibial growth plate. Cells Tissues Organs 167(4):247\u2013258. doi: 10.1159\/000016787","journal-title":"Cells Tissues Organs"},{"issue":"4","key":"425_CR11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ar.1092260404","volume":"226","author":"HM Frost","year":"1990","unstructured":"Frost HM (1990) Skeletal structural adaptations to mechanical usage (SATMU): 3. The hyaline cartilage modeling problem. Anat Rec 226(4):423\u2013432. doi: 10.1002\/ar.1092260404","journal-title":"Anat Rec"},{"issue":"5","key":"425_CR12","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bone.2006.05.017","volume":"39","author":"CH Kim","year":"2006","unstructured":"Kim CH, You L, Yellowley CE, Jacobs CR (2006) Oscillatory fluid flow induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone 39(5):1043\u20131047. doi: 10.1016\/j.bone.2006.05.017","journal-title":"Bone"},{"key":"425_CR13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0021-9290(98)00015-3","volume":"31","author":"AL Lerner","year":"1998","unstructured":"Lerner AL, Kuhn JL, Hollister SL (1998) Are regional variations in bone growth related to mechanical stress and strain parameters. J Biomech 31:327\u2013335. doi: 10.1016\/S0021-9290(98)00015-3","journal-title":"J Biomech"},{"key":"425_CR14","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1093\/ptj\/64.12.1874","volume":"64","author":"BF Leveau","year":"1984","unstructured":"Leveau BF, Bernhardt DB (1984) Developmental biomechanics. Effect of forces on the growth, development, and maintenance of the human body. Phys Ther 64:1874\u20131882","journal-title":"Phys Ther"},{"issue":"6","key":"425_CR15","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ajodo.2003.08.024","volume":"125","author":"JJ Mao","year":"2004","unstructured":"Mao JJ, Nah HD (2004) Growth and development: hereditary and mechanical modulations. Am J Orthod Dentofacial Orthop 125(6):676\u2013689. doi: 10.1016\/j.ajodo.2003.08.024","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"11","key":"425_CR16","first-page":"798","volume":"26","author":"CT Mehlman","year":"1997","unstructured":"Mehlman CT, Araghi A, Roy DR (1997) Hyphenated history: the Hueter\u2013Volkmann Law. Am J Orthop 26(11):798\u2013800","journal-title":"Am J Orthop"},{"issue":"2","key":"425_CR17","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1302\/0301-620X.62B2.6988435","volume":"62-B","author":"MS Moreland","year":"1980","unstructured":"Moreland MS (1980) Morphological effect of torsion applied to growing bone. J Bone Joint Surg Br 62-B(2):230\u2013237","journal-title":"J Bone Joint Surg Br"},{"issue":"suppl 1","key":"425_CR18","first-page":"131","volume":"48","author":"JS Price","year":"1994","unstructured":"Price JS, Oyajobi BO, Russell RGG (1994) The cell biology of bone growth. Eur J Clin Nutr 48(suppl 1):131\u2013149","journal-title":"Eur J Clin Nutr"},{"issue":"suppl 1","key":"425_CR19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2106\/JBJS.F.00314","volume":"89","author":"J Sarwark","year":"2007","unstructured":"Sarwark J, Aubin CE (2007) Growth considerations of the immature spine. J Bone Joint Surg Am 89(suppl 1):8\u201313. doi: 10.2106\/JBJS.F.00314","journal-title":"J Bone Joint Surg Am"},{"issue":"7","key":"425_CR20","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/01.brs.0000259059.90430.c2","volume":"32","author":"H Schmidt","year":"2007","unstructured":"Schmidt H, Kettler A, Heuter F, Simon U, Claes L, Wilke HJ (2007) Intradiscal pressure, shear strain, and fiber strain in the intervertebral disc under combined loading. Spine 32(7):748\u2013755. doi: 10.1097\/01.brs.0000259059.90430.c2","journal-title":"Spine"},{"issue":"1","key":"425_CR21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0306-9877(03)00102-6","volume":"61","author":"L Schwartz","year":"2003","unstructured":"Schwartz L, Maitournam H, Stolz C, Steayert JM, Ho Ba Tho MC, Halphen B (2003) Growth and cellular differentiation: a physica-biochemical conundrum? The example of the hand. Med Hypotheses 61(1):45\u201351. doi: 10.1016\/S0306-9877(03)00102-6","journal-title":"Med Hypotheses"},{"key":"425_CR22","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.orthres.2003.08.004","volume":"22","author":"SJ Shefelbine","year":"2004","unstructured":"Shefelbine SJ, Carter DS (2004) Mechanobiological prediction of growth front morphology in development hip dysplasia. J Orthop Res 22:346\u2013352. doi: 10.1016\/j.orthres.2003.08.004","journal-title":"J Orthop Res"},{"issue":"2","key":"425_CR23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/B:ABME.0000012750.73170.ba","volume":"32","author":"SJ Shefelbine","year":"2004","unstructured":"Shefelbine SJ, Carter DS (2004) Mechnobiological predictions of femoral anteversion in cerebral palsy. Ann Biomed Eng 32(2):297\u2013305. doi: 10.1023\/B:ABME.0000012750.73170.ba","journal-title":"Ann Biomed Eng"},{"issue":"5","key":"425_CR24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S8756-3282(02)00700-7","volume":"30","author":"SJ Shefelbine","year":"2002","unstructured":"Shefelbine SJ, Tardieu C, Carter DR (2002) Development of the femoral bicondylar angle in hominid bipedalism. Bone 30(5):765\u2013770. doi: 10.1016\/S8756-3282(02)00700-7","journal-title":"Bone"},{"issue":"5","key":"425_CR25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/jor.1100170505","volume":"17","author":"SS Stevens","year":"1999","unstructured":"Stevens SS, Beaupre GS, Carter DS (1999) Computer model of endochondral growth and ossification in long bones: biological and mechanobiological Influences. J Orthop Res 17(5):646\u2013653. doi: 10.1002\/jor.1100170505","journal-title":"J Orthop Res"},{"key":"425_CR26","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s00586-007-0442-7","volume":"16","author":"IAF Stokes","year":"2007","unstructured":"Stokes IAF (2007) Analysis and simulation of progressive adolescent scoliosis by biomechanical growth modulation. Eur Spine J 16:1621\u20131628. doi: 10.1007\/s00586-007-0442-7","journal-title":"Eur Spine J"},{"issue":"6","key":"425_CR27","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0021-9290(90)90051-4","volume":"23","author":"IAF Stokes","year":"1990","unstructured":"Stokes IAF, Laible JP (1990) Three-dimension osseo-ligamentous model of the thorax representing initiation of scoliosis by asymmetric growth. J Biomech 23(6):589\u2013595. doi: 10.1016\/0021-9290(90)90051-4","journal-title":"J Biomech"},{"key":"425_CR28","first-page":"51","volume":"3","author":"IAF Stokes","year":"1994","unstructured":"Stokes IAF, Aronsson DD, Urban JPG (1994) Biomechanical factors influencing progression of angular skeletal deformities during growth. Eur J Musculoskelet Res 3:51\u201360","journal-title":"Eur J Musculoskelet Res"},{"key":"425_CR29","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.2106\/00004623-200210000-00016","volume":"84","author":"IAF Stokes","year":"2002","unstructured":"Stokes IAF, Mebte PL, Iatridis JC, Farnum CE, Aronsson DD (2002) Enlargement of growth plate chondrocytes modulated by sustained mechanical loading. J Bone Joint Surg Am 84:1842\u20131848","journal-title":"J Bone Joint Surg Am"},{"key":"425_CR30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.orthres.2004.06.012","volume":"23","author":"IAF Stokes","year":"2005","unstructured":"Stokes IAF, Gwadera J, Dimock AN, Farnum CE, Aronsson DD (2005) Modulation of vertebral and tibial growth by compression loading: diurnal versus full-time loading. J Orthop Res 23:188\u2013195. doi: 10.1016\/j.orthres.2004.06.012","journal-title":"J Orthop Res"},{"issue":"6","key":"425_CR31","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/jor.20189","volume":"24","author":"IAF Stokes","year":"2006","unstructured":"Stokes IAF, Aronsson DD, Dimock AN, Cortright V, Beck S (2006) Endochondral growth in growth plates of three species at two anatomical locations modulated by mechanical compression and tension. J Orthop Res 24(6):1327\u20131334. doi: 10.1002\/jor.20189","journal-title":"J Orthop Res"},{"key":"425_CR32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bone.2007.04.180","volume":"41","author":"IAF Stokes","year":"2007","unstructured":"Stokes IAF, Clark KC, Farnum CE, Aronsson DD (2007) Alterations in the growth plate associated with growth modulation by sustained compression or distraction. Bone 41:197\u2013205. doi: 10.1016\/j.bone.2007.04.180","journal-title":"Bone"},{"issue":"10","key":"425_CR33","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s11517-007-0220-z","volume":"45","author":"PL Sylvestre","year":"2007","unstructured":"Sylvestre PL, Villemure I, Aubin CE (2007) Finite element modeling of the growth plate in a detailed spine model. Med Biol Eng Comput 45(10):977\u2013988. doi: 10.1007\/s11517-007-0220-z","journal-title":"Med Biol Eng Comput"},{"key":"425_CR34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bone.2006.10.011","volume":"40","author":"B Trepczik","year":"2007","unstructured":"Trepczik B, Lienau J, Schell H, Epari DR, Thompson MS, Hoffmann JE, Anke KR, Mundlos S, Dudam GN (2007) Endochondral ossification in vitro is influenced by mechanical bending. Bone 40:597\u2013603. doi: 10.1016\/j.bone.2006.10.011","journal-title":"Bone"},{"key":"425_CR35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0021-9290(01)00184-1","volume":"35","author":"MCH Meulen Van Der","year":"2002","unstructured":"Van Der Meulen MCH, Huiskes R (2002) Why mechanobiology? A survey article. J Biomech 35:401\u2013414. doi: 10.1016\/S0021-9290(01)00184-1","journal-title":"J Biomech"},{"key":"425_CR36","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1115\/1.1516198","volume":"124","author":"I Villemure","year":"2002","unstructured":"Villemure I, Aubin CE, Dansereau J, Labelle H (2002) Simulation of progressive deformities in adolescent idiopathic scoliosis using a biomechanical model integrating vertebral growth modulation. ASME J Biomech Eng 124:784\u2013790. doi: 10.1115\/1.1516198","journal-title":"ASME J Biomech Eng"},{"issue":"1","key":"425_CR37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00586-003-0565-4","volume":"13","author":"I Villemure","year":"2004","unstructured":"Villemure I, Aubin CE, Dansereau J, Labelle H (2004) Biomechancial simulations of the spine deformation process in adolescent idiopathic scoliosis from different pathogenesis hypotheses. Eur Spine J 13(1):83\u201390. doi: 10.1007\/s00586-003-0565-4","journal-title":"Eur Spine J"},{"issue":"4\u20135","key":"425_CR38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/03008200500344058","volume":"46","author":"I Villemure","year":"2005","unstructured":"Villemure I, Chung MA, Seck CS, Kimm M, Matyas JR, Duncan NA (2005) Static compressive loading reduces the mRNA expression of type II and X collagen in rat growth-plate chondrocytes during post-natal growth. Connect Tissue Res 46(4\u20135):211\u2013219. doi: 10.1080\/03008200500344058","journal-title":"Connect Tissue Res"},{"key":"425_CR39","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1177\/154405910208101009","volume":"81","author":"X Wang","year":"2002","unstructured":"Wang X, Mao JJ (2002) Chondrocyte proliferation of the cranial base cartilage upon in vivo mechanical stresses. J Dent Res 81:701\u2013705","journal-title":"J Dent Res"},{"key":"425_CR40","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bone.2004.09.009","volume":"35","author":"Y Wang","year":"2004","unstructured":"Wang Y, Middlecton F, Horton JA, Reichel L, Farnum CE, Damron TA (2004) Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone 35:1273\u20131293. doi: 10.1016\/j.bone.2004.09.009","journal-title":"Bone"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-008-0425-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-008-0425-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-008-0425-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T07:00:41Z","timestamp":1589266841000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-008-0425-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,2]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["425"],"URL":"https:\/\/doi.org\/10.1007\/s11517-008-0425-9","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,2]]}}}