{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:40:49Z","timestamp":1791153649559,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,1,8]],"date-time":"2011-01-08T00:00:00Z","timestamp":1294444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s11517-010-0730-y","type":"journal-article","created":{"date-parts":[[2011,1,7]],"date-time":"2011-01-07T11:14:37Z","timestamp":1294398877000},"page":"453-462","source":"Crossref","is-referenced-by-count":19,"title":["Characterization of cellular elastic modulus using structure based double layer model"],"prefix":"10.1007","volume":"49","author":[{"given":"Yeongjin","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,1,8]]},"reference":[{"key":"730_CR1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nnano.2007.388","volume":"2","author":"SE Cross","year":"2007","unstructured":"Cross SE, Jin YS, Rao J, Gimzewski JK (2007) Nanomechanical analysis of cells from cancer patients. Nat Nano 2:780\u2013783","journal-title":"Nat Nano"},{"key":"730_CR2","first-page":"279","volume":"37","author":"ZZ Wu","year":"2000","unstructured":"Wu ZZ, Zhang G, Long M, Wang HB, Song GB, Cai SX (2000) Comparison of the viscoelastic properties of normal hepatocytes and hepatocellular carcinoma cells under cytoskeletal perturbation. Biorheology 37:279\u2013290","journal-title":"Biorheology"},{"key":"730_CR3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3748\/wjg.v8.i2.243","volume":"8","author":"G Zhang","year":"2002","unstructured":"Zhang G, Long M, Wu ZZ, Yu WQ (2002) Mechanical properties of hepatocellular carcinoma cells. World J Gastroenterol 8:243\u2013246","journal-title":"World J Gastroenterol"},{"key":"730_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0006-3495(89)82660-8","volume":"56","author":"E Evans","year":"1989","unstructured":"Evans E, Yeung A (1989) Apparent viscosity and cortical tension of blood granulocytes determined by micropipet aspiration. Biophys J 56:151\u2013160","journal-title":"Biophys J"},{"key":"730_CR5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1155\/2004\/482680","volume":"19","author":"KD Costa","year":"2003","unstructured":"Costa KD (2003) Single-cell elastography: probing for disease with the atomic force microscope. Dis Markers 19:139\u2013154","journal-title":"Dis Markers"},{"key":"730_CR6","doi-asserted-by":"crossref","first-page":"C1475","DOI":"10.1152\/ajpcell.2001.280.6.C1475","volume":"280","author":"JX Chen","year":"2001","unstructured":"Chen JX, Fabry B, Schiffrin EL, Wang N (2001) Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells. Am J Physiol Cell Physiol 280:C1475\u2013C1484","journal-title":"Am J Physiol Cell Physiol"},{"key":"730_CR7","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1152\/jappl.2001.91.3.1152","volume":"91","author":"M Puig-De-Morales","year":"2001","unstructured":"Puig-De-Morales M, Grabulosa M, Alcaraz J, Mullol J, Maksym GN, Fredberg JJ, Navajas D (2001) Measurement of cell microrheology by magnetic twisting cytometry with frequency domain demodulation. J Appl Physiol 91:1152\u20131159","journal-title":"J Appl Physiol"},{"key":"730_CR8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0006-3495(79)85238-8","volume":"26","author":"RM Hochmuth","year":"1979","unstructured":"Hochmuth RM, Worthy PR, Evans EA (1979) Red cell extensional recovery and the determination of membrane viscosity. Biophys J 26:101\u2013114","journal-title":"Biophys J"},{"key":"730_CR9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0006-3495(84)84034-5","volume":"46","author":"S Chien","year":"1984","unstructured":"Chien S, Sung KL (1984) Effect of colchicine on viscoelastic properties of neutrophils. Biophys J 46:383\u2013386","journal-title":"Biophys J"},{"key":"730_CR10","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1114\/1.1476017","volume":"30","author":"JY Shao","year":"2002","unstructured":"Shao JY (2002) Finite element analysis of imposing Femtonewton forces with micropipette aspiration. Ann Biomed Eng 30:546\u2013554","journal-title":"Ann Biomed Eng"},{"key":"730_CR11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-3495(81)84726-1","volume":"36","author":"GW Schmid-Schonbein","year":"1981","unstructured":"Schmid-Schonbein GW, Sung KL, Tozeren H, Skalak R, Chien S (1981) Passive mechanical properties of human leukocytes. Biophys J 36:243\u2013256","journal-title":"Biophys J"},{"key":"730_CR12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1139\/o95-041","volume":"73","author":"N Wang","year":"1995","unstructured":"Wang N, Ingber DE (1995) Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry. Biochem Cell Biol 73:327\u2013335","journal-title":"Biochem Cell Biol"},{"key":"730_CR13","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511809217","volume-title":"Introductory biomechanics: from cells to organisms","author":"CR Ethier","year":"2007","unstructured":"Ethier CR, Simmons CA (2007) Introductory biomechanics: from cells to organisms. Cambridge University Press, Cambridge, New York"},{"key":"730_CR14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/excr.1996.0223","volume":"226","author":"WH Goldmann","year":"1996","unstructured":"Goldmann WH, Ezzell RM (1996) Viscoelasticity in wild-type and vinculin-deficient embryonic carcinoma cells examined by atomic force microscopy and rheology. Exp Cell Res 226:234\u2013237","journal-title":"Exp Cell Res"},{"key":"730_CR15","doi-asserted-by":"crossref","first-page":"C286","DOI":"10.1152\/ajpcell.1995.269.1.C286","volume":"38","author":"SG Shroff","year":"1995","unstructured":"Shroff SG, Saner DR, Lal R (1995) Dynamic micromechanical properties of cultured rat atrial myocytes measured by atomic-force microscopy. Am J Physiol Cell Physiol 38:C286\u2013C292","journal-title":"Am J Physiol Cell Physiol"},{"key":"730_CR16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jbiotec.2006.02.016","volume":"124","author":"TS Lanero","year":"2006","unstructured":"Lanero TS, Cavalleri O, Krol S, Rolandi R, Gliozzi A (2006) Mechanical properties of single living cells encapsulated in polyelectrolyte matrixes. J Biotechnol 124:723\u2013731","journal-title":"J Biotechnol"},{"key":"730_CR17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1088\/0031-9155\/50\/1\/007","volume":"50","author":"TK Berdyyeva","year":"2005","unstructured":"Berdyyeva TK, Woodworth CD, Sokolov I (2005) Human epithelial cells increase their rigidity with ageing in vitro: direct measurements. Phys Med Biol 50:81\u201392","journal-title":"Phys Med Biol"},{"key":"730_CR18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1385\/CBB:39:3:257","volume":"39","author":"A Ikai","year":"2003","unstructured":"Ikai A, Afrin R (2003) Toward mechanical manipulations of cell membranes and membrane proteins using an atomic force microscope\u2014an invited review. Cell Biochem Biophys 39:257\u2013277","journal-title":"Cell Biochem Biophys"},{"issue":"2","key":"730_CR19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1115\/1.2165690","volume":"128","author":"KD Costa","year":"2006","unstructured":"Costa KD, Sim AJ, Yin FCP (2006) Non-Hertzian approach to analyzing mechanical properties of endothelial cells probed by atomic force microscopy. J Biomech Eng 128(2):176\u2013184","journal-title":"J Biomech Eng"},{"key":"730_CR20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1115\/1.2720908","volume":"129","author":"GU Unnikrishnan","year":"2007","unstructured":"Unnikrishnan GU, Unnikirishnan VU, Reddy JN (2007) Constitutive material modeling of cell: a micromechanics approach. J Biomech Eng Trans ASME 129:315\u2013323","journal-title":"J Biomech Eng Trans ASME"},{"key":"730_CR21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1115\/1.2746374","volume":"129","author":"A Kamgoue","year":"2007","unstructured":"Kamgoue A, Ohayon J, Tracqui P (2007) Estimation of cell young\u2019s modulus of adherent cells probed by optical and magnetic tweezers: influence of cell thickness and bead immersion. J Biomech Eng Trans ASME 129:523\u2013530","journal-title":"J Biomech Eng Trans ASME"},{"key":"730_CR22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0021-9290(01)00201-9","volume":"35","author":"N Caille","year":"2002","unstructured":"Caille N, Thoumine O, Tardy Y, Meister JJ (2002) Contribution of the nucleus to the mechanical properties of endothelial cells. J Biomech 35:177\u2013187","journal-title":"J Biomech"},{"key":"730_CR23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3233\/BIR-1991-28607","volume":"28","author":"C Dong","year":"1991","unstructured":"Dong C, Skalak R, Sung KL (1991) Cytoplasmic rheology of passive neutrophils. Biorheology 28:557\u2013567","journal-title":"Biorheology"},{"key":"730_CR24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1073\/pnas.94.3.849","volume":"94","author":"AJ Maniotis","year":"1997","unstructured":"Maniotis AJ, Chen CS, Ingber DE (1997) Demonstration of mechanical connections between integrins cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci USA 94:849\u2013854","journal-title":"Proc Natl Acad Sci USA"},{"key":"730_CR25","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1557\/jmr.2006.0262","volume":"21","author":"A Vaziri","year":"2006","unstructured":"Vaziri A, Lee H, Mofrad MRK (2006) Deformation of the cell nucleus under indentation: mechanics and mechanisms. J Mater Res 21:2126\u20132135","journal-title":"J Mater Res"},{"key":"730_CR26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1109\/51.582176","volume":"16","author":"M Radmacher","year":"1997","unstructured":"Radmacher M (1997) Measuring the elastic properties of biological samples with the AFM. IEEE Eng Med Biol Mag 16:47\u201357","journal-title":"IEEE Eng Med Biol Mag"},{"key":"730_CR27","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1103\/PhysRevLett.85.880","volume":"85","author":"RE Mahaffy","year":"2000","unstructured":"Mahaffy RE, Shih CK, Mackintosh FC, Kas J (2000) Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells. Phys Rev Lett 85:880\u2013883","journal-title":"Phys Rev Lett"},{"key":"730_CR28","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0021-9290(01)00149-X","volume":"34","author":"AB Mathur","year":"2001","unstructured":"Mathur AB, Collinsworth AM, Reichert WM, Kraus WE, Truskey GA (2001) Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy. J Biomech 34:1545\u20131553","journal-title":"J Biomech"},{"key":"730_CR29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1115\/1.2835074","volume":"121","author":"KD Costa","year":"1999","unstructured":"Costa KD, Yin FCP (1999) Analysis of indentation: implications for measuring mechanical properties with atomic force microscopy. J Biomech Eng Trans ASME 121:462\u2013471","journal-title":"J Biomech Eng Trans ASME"},{"key":"730_CR30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1515\/crll.1882.92.156","volume":"92","author":"H Hertz","year":"1882","unstructured":"Hertz H (1882) U\u00a8 ber Die beru\u00a8hrung fester elastischer ko\u00a8rper. J Reine Angew Math 92:156\u2013171","journal-title":"J Reine Angew Math"},{"key":"730_CR31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0020-7225(65)90019-4","volume":"3","author":"IN Sneddon","year":"1965","unstructured":"Sneddon IN (1965) The relation between load and penetration in the axisymmetric Boussinesq problem for a punch of arbitrary profile. Int J Eng Sci 3:47\u201357","journal-title":"Int J Eng Sci"},{"key":"730_CR32","unstructured":"Ottensmeyer MP (2001) Minimally invasive instrument for in vivo measurement of solid organ mechanical impedance. PhD Thesis. Massachusetts Institute of Technology, Boston, USA"},{"key":"730_CR33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3991(00)00076-0","volume":"86","author":"GT Charras","year":"2001","unstructured":"Charras GT, Lehenkari PP, Horton MA (2001) Atomic force microscopy can be used to mechanically stimulate osteoblasts and evaluate cellular strain distributions. Ultramicroscopy 86:85\u201395","journal-title":"Ultramicroscopy"},{"key":"730_CR34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0021-9290(98)00166-3","volume":"32","author":"WR Jones","year":"1999","unstructured":"Jones WR, Ting-Beall PT, Lee GM, Kelly SS, Hochmuth RM, Guilak F (1999) Alterations in the Young\u2019s modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. J Biomech 32:119\u2013127","journal-title":"J Biomech"},{"key":"730_CR35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jbiomech.2004.11.006","volume":"39","author":"WR Trickey","year":"2006","unstructured":"Trickey WR, Baaijens FPT, Laursen TA, Alexopoulos LG, Guilak F (2006) Determination of the Poisson\u2019s ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. J Biomech 39:78\u201387","journal-title":"J Biomech"},{"key":"730_CR36","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1073\/pnas.96.3.921","volume":"96","author":"C Rotsch","year":"1999","unstructured":"Rotsch C, Jacobson K, Radmacher M (1999) Dimensional and mechanical dynamics of active and stable edges in motile fibroblasts investigated by using atomic force microscopy. Proc Natl Acad Sci USA 96:921\u2013926","journal-title":"Proc Natl Acad Sci USA"},{"key":"730_CR37","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.7684161","volume":"260","author":"N Wang","year":"1993","unstructured":"Wang N, Butler JP, Ingber DE (1993) Mechanotransduction across the cell surface and through the cytoskeleton. Science 260:1124\u20131127","journal-title":"Science"},{"key":"730_CR38","volume-title":"The Levenberg-Marquardt algorithm: implementation and analysis","author":"JJ Mor","year":"1977","unstructured":"Mor JJ (1977) The Levenberg-Marquardt algorithm: implementation and analysis. Springer, Berlin"},{"key":"730_CR39","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.jbiomech.2009.07.035","volume":"42","author":"R Zhao","year":"2009","unstructured":"Zhao R, Wyss K, Simmons CA (2009) Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. J Biomech 42:2768\u20132773","journal-title":"J Biomech"},{"key":"730_CR40","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1529\/biophysj.104.049965","volume":"88","author":"D Pesen","year":"2005","unstructured":"Pesen D, Hoh JH (2005) Micromechanical architecture of the endothelial cell cortex. Biophys J 88:670\u2013679","journal-title":"Biophys J"},{"key":"730_CR41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0304-3991(99)00157-6","volume":"82","author":"H Haga","year":"2000","unstructured":"Haga H, Sasaki S, Kawabata K, Ito E, Ushiki T, Sambongi T (2000) Elasticity mapping of living fibroblasts by AFM and immunofluorescence observation of the cytoskeleton. Ultramicroscopy 82:253\u2013258","journal-title":"Ultramicroscopy"},{"key":"730_CR42","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0041-0101(96)00025-6","volume":"34","author":"C Fiorentini","year":"1996","unstructured":"Fiorentini C, Matarrese P, Fattorossi A, Donelli G (1996) Okadaic acid induces changes in the organization of F-actin in intestinal cells. Toxicon 34:937\u2013945","journal-title":"Toxicon"},{"key":"730_CR43","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/excr.1995.1187","volume":"218","author":"H Blankson","year":"1995","unstructured":"Blankson H, Holen I, Seglen PO (1995) Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid. Exp Cell Res 218:522\u2013530","journal-title":"Exp Cell Res"},{"key":"730_CR44","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1126\/science.1095087","volume":"304","author":"ML Gardel","year":"2004","unstructured":"Gardel ML, Shin JH, Mackintosh FC, Mahadevan L, Matsudaira P, Weitz DA (2004) Elastic behavior of cross-linked and bundled actin networks. Science 304:1301\u20131305","journal-title":"Science"},{"key":"730_CR45","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0091-679X(07)83007-X","volume":"83","author":"JC Crocker","year":"2007","unstructured":"Crocker JC, Hoffman BD (2007) Multiple-particle tracking and two-point microrheology in cells. Cell Mech 83:141\u2013178","journal-title":"Cell Mech"},{"key":"730_CR46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1679\/aohc.69.329","volume":"69","author":"T Kazutaka","year":"2006","unstructured":"Kazutaka T, Takehito T, Ryusuke M, Ichiro N, Takuro M, Aiji O (2006) Human erythrocytes possess a cytoplasmic endoskeleton containing \u03b2-actin and neurofilament protein. Arch Histol Cytol 69:329\u2013340","journal-title":"Arch Histol Cytol"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-010-0730-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-010-0730-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-010-0730-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T17:27:33Z","timestamp":1559928453000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-010-0730-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["730"],"URL":"https:\/\/doi.org\/10.1007\/s11517-010-0730-y","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,8]]}}}