{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:59:29Z","timestamp":1768618769737,"version":"3.49.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s11517-015-1352-1","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T12:46:20Z","timestamp":1438346780000},"page":"607-617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Longan polysaccharides on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro"],"prefix":"10.1007","volume":"54","author":[{"given":"Shuyu","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,1]]},"reference":[{"key":"1352_CR1","first-page":"845","volume":"21","author":"H Akiyama","year":"2011","unstructured":"Akiyama H (2011) Transcriptional regulation in chondrogenesis by Sox9. Clin Calcium 21:845\u2013851","journal-title":"Clin Calcium"},{"key":"1352_CR2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0092-8674(82)90027-7","volume":"30","author":"PD Benya","year":"1982","unstructured":"Benya PD, Shaffer JD (1982) Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30:215\u2013224","journal-title":"Cell"},{"key":"1352_CR3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/8792","volume":"22","author":"W Bi","year":"1999","unstructured":"Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B (1999) Sox9 is required for cartilage formation. Nat Genet 22:85\u201389","journal-title":"Nat Genet"},{"key":"1352_CR4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11655-013-1511-x","volume":"21","author":"YL Cao","year":"2015","unstructured":"Cao YL, Liu T, Pang J, Gao NY, Zhan HS, Shi YY, Wang X, Wang SC (2015) Glucan HBP-A increase type II collagen expression of chondrocytes in vitro and tissue engineered cartilage in vivo. Chin J Integr Med 21:196\u2013203","journal-title":"Chin J Integr Med"},{"key":"1352_CR5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/joca.1999.0309","volume":"8","author":"A Carranza-Bencano","year":"2000","unstructured":"Carranza-Bencano A, Garc\u00eda-Paino L, Armas Padr\u00f3n JR, Cayuela Dominguez A (2000) Neochondrogenesis in repair of full-thickness articular cartilage defects using free autogenous periosteal grafts in the rabbit. A follow-up in 6\u00a0months. Osteoarthr Cartil 8:351\u2013358","journal-title":"Osteoarthr Cartil"},{"key":"1352_CR6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3109\/02699052.2010.546824","volume":"25","author":"J Chen","year":"2011","unstructured":"Chen J, Chen X, Qin J (2011) Effects of polysaccharides of the Euphoria Longan (Lour.). Steud on focal cerebral ischemia\/reperfusion injury and its underlying mechanism. Brain Inj 25:292\u2013299","journal-title":"Brain Inj"},{"key":"1352_CR7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.addr.2007.08.027","volume":"60","author":"C Chung","year":"2008","unstructured":"Chung C, Burdick JA (2008) Engineering cartilage tissue. Adv Drug Deliv Rev 60:243\u2013262","journal-title":"Adv Drug Deliv Rev"},{"key":"1352_CR8","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1101\/gr.6224007","volume":"17","author":"SR Davies","year":"2007","unstructured":"Davies SR, Chang LW, Patra D, Xing X, Posey K, Hecht J, Stormo GD, Sandell LJ (2007) Computational identification and functional validation of regulatory motifs in cartilage-expressed genes. Genome Res 17:1438\u20131447","journal-title":"Genome Res"},{"key":"1352_CR9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/307521a0","volume":"307","author":"J Downward","year":"1984","unstructured":"Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD (1984) Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 307:521\u2013527","journal-title":"Nature"},{"key":"1352_CR10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.carbpol.2005.10.005","volume":"63","author":"A Forabosco","year":"2006","unstructured":"Forabosco A, Bruno G, Sparapano L, Liut G, Marino D, Delben F (2006) Pullulans produced by strains of Cryphonectria parasitica\u2014I. Production and characterisation of the exopolysaccharides. Carbohydr Polym 63:535\u2013544","journal-title":"Carbohydr Polym"},{"key":"1352_CR11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3928\/0147-7447-20030401-17","volume":"26","author":"PC Hsieh","year":"2003","unstructured":"Hsieh PC, Thanapipatsiri S, Anderson PC, Wang GJ, Balian G (2003) Repair of full-thickness cartilage defects in rabbit knees with free periosteal graft preincubated with transforming growth factor. Orthopedics 26:393\u2013402","journal-title":"Orthopedics"},{"key":"1352_CR12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijbiomac.2014.03.030","volume":"67C","author":"J Jiang","year":"2014","unstructured":"Jiang J, Meng FY, He Z Ning YL, Li XH, Song H, Wang J, Zhou R (2014) Sulfated modification of Longan polysaccharide and its immunomodulatory and antitumor activity in vitro. Int J Biol Macromol 67C:323\u2013329","journal-title":"Int J Biol Macromol"},{"key":"1352_CR13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.6318322","volume":"223","author":"SF Josephs","year":"1984","unstructured":"Josephs SF, Guo C, Ratner L, Wong-Staal F (1984) Human-proto-oncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus. Science 223:487\u2013491","journal-title":"Science"},{"key":"1352_CR14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1089\/ten.tec.2010.0200","volume":"17","author":"TA Karlsen","year":"2010","unstructured":"Karlsen TA, Shahdadfar A, Brinchmann JE (2010) Human primary articular chondrocytes, chondroblasts-like cells, and dedifferentiated chondrocytes: differences in gene, microRNA, and protein expression and phenotype. Tissue Eng Part C Methods 17:219\u2013227","journal-title":"Tissue Eng Part C Methods"},{"key":"1352_CR15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.136.2.459","volume":"136","author":"KM Kwan","year":"1997","unstructured":"Kwan KM, Pang MK, Zhou S, Cowan SK, Kong RY, Pfordte T, Olsen BR, Sillence DO, Tam PP, Cheah KS (1997) Abnormal compartmentalization of cartilage matrix components in mice lacking collagen X: implications for function. J Cell Biol 136:459\u2013471","journal-title":"J Cell Biol"},{"key":"1352_CR16","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3892\/ijmm.2013.1527","volume":"32","author":"H Li","year":"2013","unstructured":"Li H, Li X, Liu G, Chen J, Weng X, Liu F, Xu H, Liu X, Ye H (2013) Bauhinia championi (Benth.) Benth. polysaccharides upregulate Wnt\/\u03b2-catenin signaling in chondrocytes. Int J Mol Med 32:1329\u20131336","journal-title":"Int J Mol Med"},{"key":"1352_CR17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/mgme.2000.3081","volume":"71","author":"OJ Marshall","year":"2000","unstructured":"Marshall OJ, Harley VR (2000) Molecular mechanisms of SOX9 action. Mol Gene Metab 71:455\u2013462","journal-title":"Mol Gene Metab"},{"key":"1352_CR18","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.3390\/ijms15035140","volume":"15","author":"FY Meng","year":"2014","unstructured":"Meng FY, Ning YL, Qi J, He Z, Jie J, Lin JJ, Huang YJ, Li FS, Li XH (2014) Structure and antitumor and immunomodulatory activities of a water-soluble polysaccharide from dimocarpus Longan pulp. Int J Mol Sci 15:5140\u20135162","journal-title":"Int J Mol Sci"},{"key":"1352_CR19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/dbio.1996.8487","volume":"183","author":"LJ Ng","year":"1997","unstructured":"Ng LJ, Wheatley S, Muscat GE, Conway-Campbell J, Bowles J, Wright E, Bell DM, Tam PP, Cheah KS, Koopman P (1997) SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse. Dev Biol 183:108\u2013121","journal-title":"Dev Biol"},{"key":"1352_CR20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jep.2006.11.020","volume":"111","author":"AM Panico","year":"2007","unstructured":"Panico AM, Cardile V, Garufi F, Puglia C, Bonina F, Ronsisvalle S (2007) Effect of hyaluronic acid and polysaccharides from Opuntia ficus indica (L.) cladodes on the metabolism of humanchondrocyte cultures. J Ethnopharmacol 111:315\u2013321","journal-title":"J Ethnopharmacol"},{"key":"1352_CR21","first-page":"755","volume":"28","author":"R Paul","year":"2003","unstructured":"Paul R, Haydon RC, Cheng H, Ishikawa A, Nenadovich N, Jiang W, Zhou L, Breyer B, Feng T, Gupta P, He TC, Phillips FM (2003) Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. Spine 28:755\u2013763","journal-title":"Spine"},{"key":"1352_CR22","author":"EG Popa","year":"2014","unstructured":"Popa EG, Reis RL, Gomes ME (2014) Seaweed polysaccharide-based hydrogels used for the regeneration of articular cartilage. Crit Rev Biotechnol. doi: 10.3109\/07388551.2014.889079","journal-title":"rit Rev Biotechnol"},{"key":"1352_CR23","first-page":"794","volume":"2013","author":"J Qin","year":"2013","unstructured":"Qin J, Liu YS, Liu J, Li J, Tan Y, Li XJ, Magdalou J, Mei QB, Wang H, Chen LB (2013) Effect of Angelica sinensis polysaccharides on osteoarthritis in vivo and in vitro: a possible mechanism to promote proteoglycans synthesis. Evid Based Complement Altern Med. doi: 10.1155\/2013\/794761","journal-title":"Evid Based Complement Altern Med"},{"key":"1352_CR24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/0363546506294078","volume":"35","author":"M S\u00e1nchez","year":"2007","unstructured":"S\u00e1nchez M, Anitua E, Azofra J, And\u00eda I, Padilla S, Mujika I (2007) Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 35:245\u2013251","journal-title":"Am J Sports Med"},{"key":"1352_CR25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/joca.2001.0482","volume":"10","author":"M Schnabel","year":"2002","unstructured":"Schnabel M, Marlovits S, Eckhoff G, Fichtel I, Gotzen L, V\u00e9csei V, Schlegel J (2002) Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture. Osteoarthr Cartil 10:62\u201370","journal-title":"Osteoarthr Cartil"},{"key":"1352_CR26","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1089\/ten.tea.2010.0579","volume":"17","author":"SR Tew","year":"2011","unstructured":"Tew SR, Clegg PD (2011) Analysis of post transcriptional regulation of SOX9 mRNA during In vitro chondrogenesis. Tissue Eng Part A 17:1801\u20131807","journal-title":"Tissue Eng Part A"},{"key":"1352_CR27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.joca.2004.10.011","volume":"13","author":"SR Tew","year":"2005","unstructured":"Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE (2005) Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes. Osteoarthr Cartil 13:80\u201389","journal-title":"Osteoarthr Cartil"},{"key":"1352_CR28","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0006-291X(02)03026-7","volume":"301","author":"H Tsuchiya","year":"2003","unstructured":"Tsuchiya H, Kitoh H, Sugiura F, Ishiguro N (2003) Chondrogenesis enhanced by overexpression of Sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 301:338\u2013343","journal-title":"Biochem Biophys Res Commun"},{"key":"1352_CR29","first-page":"1663","volume":"26","author":"G Verbruggen","year":"1999","unstructured":"Verbruggen G, Cornelissen M, Elewaut D, Broddelez C, De Ridder L, Veys EM (1999) Influence of polysulfated polysaccharides on aggrecans synthesized by differentiated human articular chondrocytes. J Rheumatol 26:1663\u20131671","journal-title":"J Rheumatol"},{"key":"1352_CR30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/304035a0","volume":"304","author":"MD Waterfield","year":"1983","unstructured":"Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin CH, Huang JS, Deuel TF (1983) Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 304:35\u201339","journal-title":"Nature"},{"key":"1352_CR31","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.foodchem.2008.01.067","volume":"110","author":"B Yang","year":"2008","unstructured":"Yang B, Zhao MM, Jiang YM (2008) Optimization of tyrosinase inhibition activity of ultrasonic-extracted polysaccharides from Longan fruit pericarp. Food Chem 110:294\u2013300","journal-title":"Food Chem"},{"key":"1352_CR32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.foodchem.2008.09.099","volume":"114","author":"B Yang","year":"2009","unstructured":"Yang B, Zhao MM, Jiang YM (2009) Anti-glycated activity of polysaccharides of Longan (Dimocarpus longan Lour.) fruit pericarp treated by ultrasonic wave. Food Chem 114:629\u2013633","journal-title":"Food Chem"},{"key":"1352_CR33","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.foodchem.2009.04.128","volume":"118","author":"B Yang","year":"2010","unstructured":"Yang B, Zhao MM, Prasad KN, Jiang GX, Jiang YM (2010) Effect of methylation on the structure and radical scavenging activity of polysaccharides from Longan (Dimocarpus longan Lour.) fruit pericarp. Food Chem 118:364\u2013368","journal-title":"Food Chem"},{"key":"1352_CR34","doi-asserted-by":"crossref","first-page":"935","DOI":"10.3892\/mmr.2013.1286","volume":"7","author":"F Yu","year":"2013","unstructured":"Yu F, Li X, Cai L, Li H, Chen J, Wong X, Xu H, Zheng C, Liu X, Ye H (2013) Achyranthes bidentata polysaccharides induce chondrocyte proliferation via the promotion of the G1\/S cell cycle transition. Mol Med Rep 7:935\u2013940","journal-title":"Mol Med Rep"},{"key":"1352_CR35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.carbpol.2009.10.066","volume":"80","author":"K Zhong","year":"2010","unstructured":"Zhong K, Wang Q (2010) Optimization of ultrasonic extraction of polysaccharides from dried Longan pulp using response surface methodology. Carbohydr Polym 80:19\u201325","journal-title":"Carbohydr Polym"},{"key":"1352_CR36","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijbiomac.2010.05.022","volume":"47","author":"K Zhong","year":"2010","unstructured":"Zhong K, Wang Q, He Y, He X (2010) Evaluation of radicals scavenging, immunity-modulatory and antitumor activities of Longan polysaccharides with ultrasonic extraction on in S180 tumor mice models. Int J Biol Macromol 47:356\u2013360","journal-title":"Int J Biol Macromol"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-015-1352-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-015-1352-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-015-1352-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T19:54:40Z","timestamp":1652990080000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-015-1352-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,1]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["1352"],"URL":"https:\/\/doi.org\/10.1007\/s11517-015-1352-1","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,1]]}}}