{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:04:56Z","timestamp":1770915896729,"version":"3.50.1"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T00:00:00Z","timestamp":1458864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81202378"],"award-info":[{"award-number":["81202378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81311140268"],"award-info":[{"award-number":["81311140268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Fundamental Research Funds for the Central South Universities","award":["7601110178"],"award-info":[{"award-number":["7601110178"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s11517-016-1475-z","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T14:33:02Z","timestamp":1458916382000},"page":"1317-1330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A novel technology: microfluidic devices for microbubble ultrasound contrast agent generation"],"prefix":"10.1007","volume":"54","author":[{"given":"Hangyu","family":"Lin","sequence":"first","affiliation":[]},{"given":"Junfang","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Chuanpin","family":"Chen","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,3,25]]},"reference":[{"key":"1475_CR1","doi-asserted-by":"crossref","first-page":"046306","DOI":"10.1103\/PhysRevE.74.046306","volume":"74","author":"V Barbier","year":"2006","unstructured":"Barbier V, Willaime H, Tabeling P et al (2006) Producing droplets in parallel microfluidic systems. Phys Rev E 74:046306","journal-title":"Phys Rev E"},{"key":"1475_CR2","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1039\/c1lc20615j","volume":"11","author":"D Bardin","year":"2011","unstructured":"Bardin D, Martz TD, Sheeran PS et al (2011) High-speed, clinical-scale microfluidic generation of stable phase-change droplets for gas embolotherapy. Lab Chip 11:3990\u20133998","journal-title":"Lab Chip"},{"key":"1475_CR3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1081\/DDC-100101308","volume":"26","author":"K Bjerknes","year":"2000","unstructured":"Bjerknes K, Dyrstad K, Smistad G et al (2000) Preparation of polymeric microcapsules: formulation studies. Drug Dev Ind Pharm 26:847\u2013856","journal-title":"Drug Dev Ind Pharm"},{"key":"1475_CR4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.7150\/thno.3464","volume":"2","author":"XW Cai","year":"2012","unstructured":"Cai XW, Yang F, Gu N (2012) Applications of magnetic microbubbles for theranostics. Theranostics 2:103\u2013112","journal-title":"Theranostics"},{"key":"1475_CR5","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1039\/c0lc00731e","volume":"11","author":"E Castro-Hernandez","year":"2011","unstructured":"Castro-Hernandez E, Hoeve WV, Lohse D et al (2011) Microbubble generation in a co-flow device operated in a new regime. Lab Chip 11:2023\u20132029","journal-title":"Lab Chip"},{"key":"1475_CR6","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2174\/156802610791384180","volume":"10","author":"F Cavalieri","year":"2010","unstructured":"Cavalieri F, Zhou M, Ashokkumar M (2010) The design of multifunctional microbubbles for ultrasound image-guided cancer therapy. Curr Top Med Chem 10:1198\u20131210","journal-title":"Curr Top Med Chem"},{"key":"1475_CR7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ijpharm.2013.08.041","volume":"456","author":"R Cavalli","year":"2013","unstructured":"Cavalli R, Bisazza A, Lembo D (2013) Micro- and nanobubbles: a versatile non-viral platform for gene delivery. Int J Pharm 456:437\u2013445","journal-title":"Int J Pharm"},{"key":"1475_CR8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ultsonch.2012.06.015","volume":"20","author":"S Chang","year":"2013","unstructured":"Chang S, Guo J, Sun J et al (2013) Targeted microbubbles for ultrasound mediated gene transfection and apoptosis induction in ovarian cancer cells. Ultrason Sonochem 20:171\u2013179","journal-title":"Ultrason Sonochem"},{"key":"1475_CR9","doi-asserted-by":"crossref","first-page":"144101","DOI":"10.1063\/1.3242019","volume":"95","author":"C Chen","year":"2009","unstructured":"Chen C, Zhu Y, Leech PW et al (2009) Production of monodispersed micron-sized bubbles at high rates in a microfluidic device. Appl Phys Lett 95:144101","journal-title":"Appl Phys Lett"},{"key":"1475_CR10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1039\/C2SM26992A","volume":"9","author":"H Chen","year":"2013","unstructured":"Chen H, Li J, Wan J et al (2013) Gas-core triple emulsions for ultrasound triggered release. Soft Matter 9:38\u201342","journal-title":"Soft Matter"},{"key":"1475_CR11","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1021\/la5004929","volume":"30","author":"H Chen","year":"2014","unstructured":"Chen H, Li J, Zhou W et al (2014) Sonication-microfluidics for fabrication of nanoparticle-stabilized microbubbles. Langmuir 30:4262\u20134266","journal-title":"Langmuir"},{"key":"1475_CR12","first-page":"160","volume":"2011","author":"JL Chen","year":"2011","unstructured":"Chen JL, Dhanaliwala AH, Wang S et al (2011) Parallel output, liquid flooded flow-focusing microfluidic device for generating monodisperse microbubbles within a catheter. IEEE Ultrason Symp 2011:160\u2013163","journal-title":"IEEE Ultrason Symp"},{"key":"1475_CR13","first-page":"1150","volume":"2013","author":"JL Chen","year":"2013","unstructured":"Chen JL, Dhanaliwala AH, Dixon AJ et al. (2013) Synthesis of albumin microbubbles using a microfluidic device for real-time imaging and therapeutics. IEEE Ultrason Symp 2013:1150\u20131153","journal-title":"IEEE Ultrason Symp"},{"key":"1475_CR14","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1039\/c2lc40387k","volume":"12","author":"R Chen","year":"2012","unstructured":"Chen R, Dong PF, Xu JH et al (2012) Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin polymer shells. Lab Chip 12:3858","journal-title":"Lab Chip"},{"key":"1475_CR15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijpharm.2011.05.030","volume":"414","author":"MC Cochran","year":"2011","unstructured":"Cochran MC, Eisenbrey J, Ouma RO et al (2011) Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery. Int J Pharm 414:161\u2013170","journal-title":"Int J Pharm"},{"key":"1475_CR16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ejrad.2006.06.022","volume":"60","author":"D Cosgrove","year":"2006","unstructured":"Cosgrove D (2006) Ultrasound contrast agents: an overview. Eur J Radiol 60:324\u2013330","journal-title":"Eur J Radiol"},{"key":"1475_CR17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s11517-009-0434-3","volume":"47","author":"D Cosgrove","year":"2009","unstructured":"Cosgrove D, Harvey C (2009) Clinical uses of microbubbles in diagnosis and treatment. Med Biol Eng Comput 47:813\u2013826","journal-title":"Med Biol Eng Comput"},{"key":"1475_CR18","first-page":"1663","volume":"2008","author":"Y Cui","year":"2008","unstructured":"Cui Y, Campbell PA (2008) Towards monodisperse microbubble populations via microfluidic chip flow-focusing. IEEE Ultrason Symp 2008:1663\u20131666","journal-title":"IEEE Ultrason Symp"},{"key":"1475_CR19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10404-012-1064-x","volume":"14","author":"AH Dhanaliwala","year":"2013","unstructured":"Dhanaliwala AH, Chen JL, Wang S et al (2013) Liquid flooded flow-focusing microfluidic device for in situ generation of monodisperse microbubbles. Microfluid Nanofluidics 14:457\u2013467","journal-title":"Microfluid Nanofluidics"},{"key":"1475_CR20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10544-014-9914-9","volume":"17","author":"AH Dhanaliwala","year":"2015","unstructured":"Dhanaliwala AH, Dixon AJ, Lin D et al (2015) In vivo imaging of microfluidic-produced microbubbles. Biomed Microdevices 17:23","journal-title":"Biomed Microdevices"},{"key":"1475_CR21","doi-asserted-by":"crossref","first-page":"12391","DOI":"10.1021\/la502822v","volume":"30","author":"AR Duarte","year":"2014","unstructured":"Duarte AR, Unal B, Mano JF et al (2014) Microfluidic production of perfluorocarbon-alginate core-shell microparticles for ultrasound therapeutic applications. Langmuir 30:12391\u201312399","journal-title":"Langmuir"},{"key":"1475_CR22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1039\/B712917C","volume":"4","author":"W Edmond","year":"2008","unstructured":"Edmond W (2008) Simultaneous generation of droplets with different dimensions in parallel integrated microfluidic droplet generators. Soft Matter 4:258\u2013262","journal-title":"Soft Matter"},{"key":"1475_CR23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1109\/TUFFC.2013.2533","volume":"60","author":"T Faez","year":"2013","unstructured":"Faez T, Emmer M, Kooiman K et al (2013) 20\u00a0years of ultrasound contrast agent modeling. IEEE Trans Ultrason Ferroelectr Freq Control 60:7\u201320","journal-title":"IEEE Trans Ultrason Ferroelectr Freq Control"},{"key":"1475_CR24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s11517-007-0210-1","volume":"45","author":"U Farook","year":"2007","unstructured":"Farook U, Stride E, Edirisinghe M et al (2007) Microbubbling by co-axial electrohydrodynamic atomization. Med Biol Eng Comput 45:781\u2013789","journal-title":"Med Biol Eng Comput"},{"key":"1475_CR25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.medengphy.2006.08.009","volume":"29","author":"U Farook","year":"2007","unstructured":"Farook U, Zhang H, Edirisinghe M et al (2007) Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization. Med Eng Phys 29:749\u2013754","journal-title":"Med Eng Phys"},{"key":"1475_CR26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev.bioeng.8.061505.095852","volume":"9","author":"K Ferrara","year":"2007","unstructured":"Ferrara K, Pollard R, Borden M (2007) Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng 9:415\u2013447","journal-title":"Annu Rev Biomed Eng"},{"key":"1475_CR27","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0041-624X(97)00123-6","volume":"36","author":"F Forsberg","year":"1998","unstructured":"Forsberg F, Merton DA, Liu JB et al (1998) clinical applications of ultrasonic contrasts. Ultrasonics 36:695\u2013701","journal-title":"Ultrasonics"},{"key":"1475_CR28","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1016\/j.ces.2010.03.012","volume":"65","author":"T Fu","year":"2010","unstructured":"Fu T, Ma Y, Funfschilling D et al (2010) Squeezing-to-dripping transition for bubble formation in a microfluidic T-junction. Chem Eng Sci 65:3739\u20133748","journal-title":"Chem Eng Sci"},{"key":"1475_CR29","doi-asserted-by":"crossref","first-page":"274501","DOI":"10.1103\/PhysRevLett.87.274501","volume":"87","author":"AM Ga\u00f1\u00e1n-Calvo","year":"2001","unstructured":"Ga\u00f1\u00e1n-Calvo AM, Gordillo JM (2001) Perfectly monodisperse microbubbling by capillary flow focusing. Phys Rev Lett 87:274501","journal-title":"Phys Rev Lett"},{"key":"1475_CR30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1039\/b510841a","volume":"6","author":"P Garstecki","year":"2006","unstructured":"Garstecki P, Fuerstman MJ, Stone HA et al (2006) Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up. Lab Chip 6:437\u2013446","journal-title":"Lab Chip"},{"key":"1475_CR31","first-page":"1964","volume":"2009","author":"Y Gong","year":"2009","unstructured":"Gong Y, Cabodi M, Porter TM (2009) Measurement of the attenuation coefficient for monodisperse populations of ultrasound contrast agents. Conf Proc IEEE Eng Med Biol Soc 2009:1964\u20131966","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"1475_CR32","first-page":"1932","volume":"2010","author":"Y Gong","year":"2010","unstructured":"Gong Y, Cabodi M, Porter T (2010) Pressure-dependent resonance frequency for lipid-coated microbubbles at low acoustic pressures. IEEE Ultrason Symp 2010:1932\u20131935","journal-title":"IEEE Ultrason Symp"},{"key":"1475_CR33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00004424-196809000-00011","volume":"3","author":"R Gramiak","year":"1968","unstructured":"Gramiak R, Shah PM (1968) Echocardiography of the aortic root. Invest Radiol 3:356\u2013366","journal-title":"Invest Radiol"},{"key":"1475_CR34","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.1073\/pnas.88.17.7708","volume":"88","author":"MW Grinstaff","year":"1991","unstructured":"Grinstaff MW, Suslick KS (1991) Air-filled proteinaceous microbubbles: synthesis of an echo-contrast agent. Proc Natl Acad Sci 88:7708\u20137710","journal-title":"Proc Natl Acad Sci"},{"key":"1475_CR35","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/smll.200800591","volume":"4","author":"M Hashimoto","year":"2008","unstructured":"Hashimoto M, Shevkoplyas SS, Zaso\u0144ska B et al (2008) Formation of bubbles and droplets in parallel, coupled flow-focusing geometries. Small 4:1795\u20131805","journal-title":"Small"},{"key":"1475_CR36","doi-asserted-by":"crossref","first-page":"033027","DOI":"10.1103\/PhysRevE.88.033027","volume":"88","author":"MA Herrada","year":"2013","unstructured":"Herrada MA, Ga\u00f1\u00e1n-Calvo AM, Montanero JM (2013) Theoretical investigation of a technique to produce microbubbles by a microfluidic T junction. Phys Rev E 88:033027","journal-title":"Phys Rev E"},{"key":"1475_CR37","first-page":"1302","volume":"2009","author":"K Hettiarachchi","year":"2009","unstructured":"Hettiarachchi K, Lee AP (2009) Ultrasonic analysis of precision-engineered acoustically active lipospheres produced by microfluidic. IEEE Ultrason Symp 2009:1302\u20131305","journal-title":"IEEE Ultrason Symp"},{"key":"1475_CR38","unstructured":"Hettiarachchi K, Dayton PA, Lee AP (2008) Multimodal particles for biological detection and therapy. Twelfth international conference on miniaturized systems for chemistry and life sciences, pp 1765\u20131767"},{"key":"1475_CR39","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1039\/b701481n","volume":"7","author":"K Hettiarachchi","year":"2007","unstructured":"Hettiarachchi K, Talu E, Longo ML et al (2007) On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging. Lab Chip 7:463\u2013468","journal-title":"Lab Chip"},{"key":"1475_CR40","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/btpr.214","volume":"25","author":"K Hettiarachchi","year":"2009","unstructured":"Hettiarachchi K, Feingold S, Zhang S et al (2009) Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy. Biotechnol Prog 25:938\u2013945","journal-title":"Biotechnol Prog"},{"key":"1475_CR41","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00396-005-1415-1","volume":"284","author":"B Jiang","year":"2006","unstructured":"Jiang B, Gao C, Shen J (2006) Polylactide hollow spheres fabricated by interfacial polymerization in an oil-in-water emulsion system. Colloid Polym Sci 284:513\u2013519","journal-title":"Colloid Polym Sci"},{"key":"1475_CR42","first-page":"1","volume":"2010","author":"C Jiang","year":"2010","unstructured":"Jiang C, Li X, Jin Q et al. (2010) Mass production of monodisperse ultrasound contrast microbubbles in integrated microfluidic devices. IEEE Bioinform Biomed Eng 2010:1\u20134","journal-title":"IEEE Bioinform Biomed Eng"},{"key":"1475_CR43","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s11517-009-0497-1","volume":"47","author":"N Jong","year":"2009","unstructured":"Jong N, Emmer M, Wamel A et al (2009) Ultrasonic characterization of ultrasound contrast agents. Med Biol Eng Comput 47:861\u2013873","journal-title":"Med Biol Eng Comput"},{"key":"1475_CR44","first-page":"125","volume":"35","author":"ST Kang","year":"2012","unstructured":"Kang ST, Yeh CK (2012) Ultrasound microbubble contrast agents for diagnostic and therapeutic applications: current status and future design. Chang Gung Med J 35:125\u2013138","journal-title":"Chang Gung Med J"},{"key":"1475_CR45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0927-7757(00)00498-2","volume":"179","author":"T Kawakatsu","year":"2001","unstructured":"Kawakatsu T, Tr\u00e4g\u00e5rdh G, Tr\u00e4g\u00e5rdh C et al (2001) The effect of the hydrophobicity of microchannels and components in water and oil phases on droplet formation in microchannel water-in-oil emulsification. Colloids Surf A 179:29\u201337","journal-title":"Colloids Surf A"},{"key":"1475_CR46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1179\/175889610X12779105661532","volume":"2","author":"M Kaya","year":"2010","unstructured":"Kaya M, Feingold S, Hettiarachchi K et al (2010) Acoustic responses of monodisperse lipid encapsulated microbubble contrast agents produced by flow focusing. Bubble Sci Eng Technol 2:33\u201340","journal-title":"Bubble Sci Eng Technol"},{"key":"1475_CR47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1179\/1758897912Y.0000000004","volume":"4","author":"MR Kendall","year":"2012","unstructured":"Kendall MR, Bardin D, Shih R et al (2012) Scaled-up production of monodisperse, dual layer microbubbles using multi-array microfluidic module for medical imaging and drug delivery. Bubble Sci Eng Technol 4:12\u201320","journal-title":"Bubble Sci Eng Technol"},{"key":"1475_CR48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7150\/thno\/v01p0127","volume":"1","author":"F Kiessling","year":"2011","unstructured":"Kiessling F, Gaetjens J, Palmowski M (2011) Application of molecular ultrasound for imaging integrin expression. Theranostics 1:127","journal-title":"Theranostics"},{"key":"1475_CR49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2967\/jnumed.111.099754","volume":"53","author":"F Kiessling","year":"2012","unstructured":"Kiessling F, Fokong S, Koczera P et al (2012) Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics. J Nucl Med 53:345\u2013348","journal-title":"J Nucl Med"},{"key":"1475_CR50","doi-asserted-by":"crossref","first-page":"010510","DOI":"10.1117\/1.3302808","volume":"15","author":"C Kim","year":"2010","unstructured":"Kim C, Qin R, Xu JS et al (2010) Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging. J Biomed Opt 15:010510","journal-title":"J Biomed Opt"},{"key":"1475_CR51","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s11517-009-0498-0","volume":"47","author":"AL Klibanov","year":"2009","unstructured":"Klibanov AL (2009) Preparation of targeted microbubbles: ultrasound contrast agents for molecular imaging. Med Biol Eng Comput 47:875\u2013882","journal-title":"Med Biol Eng Comput"},{"key":"1475_CR52","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.colsurfa.2006.09.042","volume":"296","author":"M Kukizaki","year":"2007","unstructured":"Kukizaki M, Goto M (2007) Spontaneous formation behavior of uniform-sized microbubbles from Shirasu porous glass (SPG) membranes in the absence of water-phase flow. Colloids Surf A 296:174\u2013181","journal-title":"Colloids Surf A"},{"key":"1475_CR53","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1039\/C5SM00113G","volume":"11","author":"M Lee","year":"2015","unstructured":"Lee M, Lee EY, Lee D et al (2015) Stabilization and fabrication of microbubbles: applications for medical purposes and functional materials. Soft Matter 11:2067\u20132079","journal-title":"Soft Matter"},{"key":"1475_CR54","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1039\/c0sm00449a","volume":"6","author":"MH Lee","year":"2010","unstructured":"Lee MH, Lee D (2010) Elastic instability of polymer-shelled bubbles formed from air-in-oil-in-water compound bubbles. Soft Matter 6:4326","journal-title":"Soft Matter"},{"key":"1475_CR55","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1021\/la904425v","volume":"26","author":"MH Lee","year":"2010","unstructured":"Lee MH, Prasad V, Lee D (2010) Microfluidic fabrication of stable nanoparticle-shelled bubbles. Langmuir 26:2227\u20132230","journal-title":"Langmuir"},{"key":"1475_CR56","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1039\/b823051j","volume":"5","author":"I Lentacker","year":"2009","unstructured":"Lentacker I, Smedt SD, Sanders NN (2009) Drug loaded microbubble design for ultrasound triggered delivery. Soft Matter 5:2161","journal-title":"Soft Matter"},{"key":"1475_CR57","doi-asserted-by":"crossref","first-page":"015019","DOI":"10.1088\/0960-1317\/24\/1\/015019","volume":"24","author":"EQ Li","year":"2014","unstructured":"Li EQ, Zhang JM, Thoroddsen ST (2014) Simple and inexpensive microfluidic devices for the generation of monodisperse multiple emulsions. J Micromech Microeng 24:015019","journal-title":"J Micromech Microeng"},{"issue":"10","key":"1475_CR58","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s11517-015-1307-6","volume":"53","author":"S Li","year":"2015","unstructured":"Li S, Xiao C, Duan L et al. (2015) CT image-based computer-aided system for orbital prosthesis rehabilitation. Med Biol Eng Comput 53(10):943\u2013950","journal-title":"Med Biol Eng Comput"},{"issue":"Suppl 2","key":"1475_CR59","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1259\/bjr\/57063872","volume":"76","author":"H Liang","year":"2003","unstructured":"Liang H, Blomley M (2003) The role of ultrasound in molecular imaging. Br J Radiol 76(Suppl 2):S140\u2013S150","journal-title":"Br J Radiol"},{"key":"1475_CR60","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrd1417","volume":"3","author":"JR Lindner","year":"2004","unstructured":"Lindner JR (2004) Microbubbles in medical imaging: current applications and future directions. Nat Rev Drug Discov 3:527\u2013532","journal-title":"Nat Rev Drug Discov"},{"key":"1475_CR61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jconrel.2006.05.018","volume":"114","author":"Y Liu","year":"2006","unstructured":"Liu Y, Miyoshi H, Nakamura M (2006) Encapsulated ultrasound microbubbles: therapeutic application in drug\/gene delivery. J Control Release 114:89\u201399","journal-title":"J Control Release"},{"key":"1475_CR62","doi-asserted-by":"crossref","first-page":"097103","DOI":"10.1063\/1.2353799","volume":"18","author":"E Lorenceau","year":"2006","unstructured":"Lorenceau E, Sang YYC, H\u00f6hler R et al (2006) A high rate flow-focusing foam generator. Phys Fluids 18:097103","journal-title":"Phys Fluids"},{"key":"1475_CR63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ultras.2004.04.001","volume":"43","author":"CA Macdonald","year":"2004","unstructured":"Macdonald CA, Sboros V, Gomatam J et al (2004) A numerical investigation of the resonance of gas-filled microbubbles: resonance dependence on acoustic pressure amplitude. Ultrasonics 43:113\u2013122","journal-title":"Ultrasonics"},{"key":"1475_CR64","doi-asserted-by":"crossref","first-page":"6694","DOI":"10.1021\/la5011715","volume":"30","author":"S Mahalingam","year":"2014","unstructured":"Mahalingam S, Meinders MBJ, Edirisinghe M (2014) Formation, stability, and mechanical properties of bovine serum albumin stabilized air bubbles produced using coaxial electrohydrodynamic atomization. Langmuir 30:6694\u20136703","journal-title":"Langmuir"},{"key":"1475_CR65","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1179\/175889709X446561","volume":"1","author":"CJ Martinez","year":"2009","unstructured":"Martinez CJ (2009) Bubble generation in microfluidic devices. Bubble Sci Eng Technol 1:40\u201352","journal-title":"Bubble Sci Eng Technol"},{"key":"1475_CR66","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10404-012-0941-7","volume":"13","author":"MK Mulligan","year":"2012","unstructured":"Mulligan MK, Rothstein JP (2012) Scale-up and control of droplet production in coupled microfluidic flow-focusing geometries. Microfluid Nanofluidics 13:65\u201373","journal-title":"Microfluid Nanofluidics"},{"key":"1475_CR67","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.biomaterials.2012.12.003","volume":"34","author":"C Niu","year":"2013","unstructured":"Niu C, Wang Z, Lu G et al (2013) Doxorubicin loaded superparamagnetic PLGA-iron oxide multifunctional microbubbles for dual-mode US\/MR imaging and therapy of metastasis in lymph nodes. Biomaterials 34:2307\u20132317","journal-title":"Biomaterials"},{"key":"1475_CR68","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0301-5629(00)00333-1","volume":"27","author":"WL Nyborg","year":"2001","unstructured":"Nyborg WL (2001) Biological effects of ultrasound: development of safety guidelines. Part II: general review. Ultrasound Med Biol 27:301\u2013333","journal-title":"Ultrasound Med Biol"},{"key":"1475_CR69","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/10611860802184884","volume":"16","author":"K Pancholi","year":"2008","unstructured":"Pancholi K, Stride E, Edirisinghe M (2008) Generation of microbubbles for diagnostic and therapeutic applications using a novel device. J Drug Target 16:494\u2013501","journal-title":"J Drug Target"},{"key":"1475_CR70","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1021\/la703849x","volume":"24","author":"K Pancholi","year":"2008","unstructured":"Pancholi K, Stride E, Edirisinghe M (2008) Dynamics of bubble formation in highly viscous liquids. Langmuir 24:4388\u20134393","journal-title":"Langmuir"},{"key":"1475_CR71","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00249-007-0211-x","volume":"37","author":"K Pancholi","year":"2008","unstructured":"Pancholi K, Farook U, Moaleji R et al (2008) Novel methods for preparing phospholipid coated microbubbles. Eur Biophys J 37:515\u2013520","journal-title":"Eur Biophys J"},{"key":"1475_CR72","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s10404-012-1098-0","volume":"14","author":"M Parhizkar","year":"2012","unstructured":"Parhizkar M, Edirisinghe M, Stride E (2012) Effect of operating conditions and liquid physical properties on the size of monodisperse microbubbles produced in a capillary embedded T-junction device. Microfluid Nanofluidics 14:797\u2013808","journal-title":"Microfluid Nanofluidics"},{"key":"1475_CR73","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/marc.200900551","volume":"31","author":"JI Park","year":"2010","unstructured":"Park JI, Tumarkin E, Kumacheva E (2010) Small, stable, and monodispersed bubbles encapsulated with biopolymers. Macromol Rapid Commun 31:222\u2013227","journal-title":"Macromol Rapid Commun"},{"key":"1475_CR74","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1039\/B914572A","volume":"6","author":"JI Park","year":"2010","unstructured":"Park JI, Nie Z, Kumachev A et al (2010) A microfluidic route to small CO2microbubbles with narrow size distribution. Soft Matter 6:630\u2013634","journal-title":"Soft Matter"},{"key":"1475_CR75","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-matsci-070909-104514","volume":"40","author":"JI Park","year":"2010","unstructured":"Park JI, Saffari A, Kumar S et al (2010) Microfluidic synthesis of polymer and inorganic particulate materials. Annu Rev Mater Res 40:415\u2013443","journal-title":"Annu Rev Mater Res"},{"key":"1475_CR76","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.1002\/ange.200805204","volume":"121","author":"JI Park","year":"2009","unstructured":"Park JI, Nie Z, Kumachev A et al (2009) A microfluidic approach to chemically driven assembly of colloidal particles at gas\u2013liquid interfaces. Angew Chem 121:5404\u20135408","journal-title":"Angew Chem"},{"key":"1475_CR77","first-page":"6579","volume":"4","author":"JI Park","year":"2010","unstructured":"Park JI, Jagadeesan D, Williams R et al (2010) Microbubbles loaded with nanoparticles: a route to multiple imaging modalities. Acsnano 4:6579\u20136586","journal-title":"Acsnano"},{"key":"1475_CR78","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1021\/la204510h","volume":"28","author":"Y Park","year":"2012","unstructured":"Park Y, Luce AC, Whitaker RD et al (2012) Tunable diacetylene polymerized shell microbubbles as ultrasound contrast agents. Langmuir 28:3766\u20133772","journal-title":"Langmuir"},{"key":"1475_CR79","doi-asserted-by":"crossref","unstructured":"Park YC, Zhang C, Mohamedi G et al (2014) Ultrasound-assisted drug delivery with targeted-microbubbles in blood vessels on a chip. Bioengineering conference, pp 1\u20132","DOI":"10.1109\/NEBEC.2014.6972899"},{"key":"1475_CR80","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.colsurfa.2014.12.016","volume":"468","author":"H Peng","year":"2015","unstructured":"Peng H, Xu Z, Chen S et al (2015) An easily assembled double T-shape microfluidic devices for the preparation of submillimeter-sized polyacronitrile (PAN) microbubbles and polystyrene (PS) double emulsions. Colloids Surf A 468:271\u2013279","journal-title":"Colloids Surf A"},{"key":"1475_CR81","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1039\/c2lc40634a","volume":"12","author":"SA Peyman","year":"2012","unstructured":"Peyman SA, Abou-Saleh RH, McLaughlan JR et al (2012) Expanding 3D geometry for enhanced on-chip microbubble production and single step formation of liposome modified microbubbles. Lab Chip 12:4544\u20134552","journal-title":"Lab Chip"},{"key":"1475_CR82","doi-asserted-by":"crossref","first-page":"13855","DOI":"10.1021\/la102272d","volume":"26","author":"M Seo","year":"2010","unstructured":"Seo M, Gorelikov I, Williams R et al (2010) Microfluidic assembly of monodisperse, nanoparticle-incorporated perfluorocarbon microbubbles for medical imaging and therapy. Langmuir 26:13855\u201313860","journal-title":"Langmuir"},{"key":"1475_CR83","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jconrel.2013.01.028","volume":"167","author":"CP Shih","year":"2013","unstructured":"Shih CP, Chen HC, Chen HK et al (2013) Ultrasound-aided microbubbles facilitate the delivery of drugs to the inner ear via the round window membrane. J Control Release 167:167\u2013174","journal-title":"J Control Release"},{"key":"1475_CR84","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1039\/c3lc51016f","volume":"13","author":"R Shih","year":"2013","unstructured":"Shih R, Bardin D, Martz TD et al (2013) Flow-focusing regimes for accelerated production of monodisperse drug-loadable microbubbles toward clinical-scale applications. Lab Chip 13:4816\u20134826","journal-title":"Lab Chip"},{"key":"1475_CR85","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s11517-014-1197-z","volume":"52","author":"LC Sousa","year":"2014","unstructured":"Sousa LC, Castro CF, Antonio CC et al (2014) Toward hemodynamic diagnosis of carotid artery stenosis based on ultrasound image data and computational modeling. Med Biol Eng Comput 52:971\u2013983","journal-title":"Med Biol Eng Comput"},{"key":"1475_CR86","first-page":"87","volume":"9","author":"JE Streeter","year":"2010","unstructured":"Streeter JE, Gessner R, Miles I et al (2010) Improving sensitivity in ultrasound molecular imaging by tailoring contrast agent size distribution: in vivo studies. NIH Public Access 9:87\u201395","journal-title":"NIH Public Access"},{"key":"1475_CR87","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1039\/b809517p","volume":"4","author":"E Stride","year":"2008","unstructured":"Stride E, Edirisinghe M (2008) Novel microbubble preparation technologies. Soft Matter 4:2350\u20132359","journal-title":"Soft Matter"},{"key":"1475_CR88","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s11517-009-0510-8","volume":"47","author":"E Stride","year":"2009","unstructured":"Stride E, Edirisinghe M (2009) Special issue on microbubbles: from contrast enhancement to cancer therapy. Med Biol Eng Comput 47:809\u2013811","journal-title":"Med Biol Eng Comput"},{"key":"1475_CR89","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s11517-009-0490-8","volume":"47","author":"E Stride","year":"2009","unstructured":"Stride E, Edirisinghe M (2009) Novel preparation techniques for controlling microbubble uniformity: a comparison. Med Biol Eng Comput 47:883\u2013892","journal-title":"Med Biol Eng Comput"},{"key":"1475_CR90","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1098\/rsif.2008.0005","volume":"5","author":"E Stride","year":"2008","unstructured":"Stride E, Pancholi K, Edirisinghe MJ et al (2008) Increasing the nonlinear character of microbubble oscillations at low acoustic pressures. J R Soc Interface 5:807\u2013811","journal-title":"J R Soc Interface"},{"key":"1475_CR91","doi-asserted-by":"crossref","unstructured":"Sud A, Dindyal S (2012) Microbubble therapies. The delivery of nanoparticles, pp 243\u2013262","DOI":"10.5772\/32783"},{"key":"1475_CR92","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jconrel.2014.03.002","volume":"182","author":"RR Sun","year":"2014","unstructured":"Sun RR, Noble ML, Sun SS et al (2014) Development of therapeutic microbubbles for enhancing ultrasound-mediated gene delivery. J Control Release 182:111\u2013120","journal-title":"J Control Release"},{"key":"1475_CR93","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/adma.200401738","volume":"17","author":"S Takeuchi","year":"2005","unstructured":"Takeuchi S, Garstecki P, Weibel DB et al (2005) An axisymmetric flow-focusing microfluidic device. Adv Mater 17:1067\u20131072","journal-title":"Adv Mater"},{"key":"1475_CR94","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1021\/la062095+","volume":"22","author":"E Talu","year":"2006","unstructured":"Talu E, Lozano MM, Powell RL et al (2006) Long-term stability by lipid coating monodisperse microbubbles formed by a flow-focusing device. Langmuir 22:9487\u20139490","journal-title":"Langmuir"},{"key":"1475_CR95","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1021\/la703065v","volume":"24","author":"E Talu","year":"2008","unstructured":"Talu E, Hettiarachchi K, Powell RL et al (2008) Maintaining monodispersity in a microbubble population formed by flow-focusing. Langmuir 24:1745\u20131749","journal-title":"Langmuir"},{"key":"1475_CR96","unstructured":"Talu E, Hettiarachchi K, Nguyen H et al (2006) Lipid-stabilized monodisperse microbubbles produced by flow focusing for use as ultrasound contrast agents. IEEE ultrasonics symposium, pp 1568\u20131571"},{"key":"1475_CR97","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2310\/7290.2007.00034","volume":"6","author":"E Talu","year":"2007","unstructured":"Talu E, Hettiarachchi K, Zhao S et al (2007) Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging. Mol Imaging 6:384\u2013392","journal-title":"Mol Imaging"},{"key":"1475_CR98","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1039\/b715524g","volume":"8","author":"SY Teh","year":"2008","unstructured":"Teh SY, Lin R, Hung LH et al (2008) Droplet microfluidics. Lab Chip 8:198\u2013220","journal-title":"Lab Chip"},{"key":"1475_CR99","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1039\/c1lc20240e","volume":"11","author":"AB Wang","year":"2011","unstructured":"Wang AB, Lin IC, Hsieh YW et al (2011) Effective pressure and bubble generation in a microfluidic T-junction. Lab Chip 11:3499\u20133507","journal-title":"Lab Chip"},{"key":"1475_CR100","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/aic.10824","volume":"52","author":"JH Xu","year":"2006","unstructured":"Xu JH, Li SW, Chen GG et al (2006) Formation of monodisperse microbubbles in a microfluidic device. AIChE J 52:2254\u20132259","journal-title":"AIChE J"},{"key":"1475_CR101","doi-asserted-by":"crossref","first-page":"133506","DOI":"10.1063\/1.2189570","volume":"88","author":"JH Xu","year":"2006","unstructured":"Xu JH, Li SW, Wang YJ et al (2006) Controllable gas-liquid phase flow patterns and monodisperse microbubbles in a microfluidic T-junction device. Appl Phys Lett 88:133506","journal-title":"Appl Phys Lett"},{"key":"1475_CR102","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1039\/c2lc21193a","volume":"12","author":"JH Xu","year":"2012","unstructured":"Xu JH, Chen R, Wang YD et al (2012) Controllable gas\/liquid\/liquid double emulsions in a dual-coaxial microfluidic device. Lab Chip 12:2029\u20132036","journal-title":"Lab Chip"},{"key":"1475_CR103","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/cmmi.442","volume":"6","author":"RX Xu","year":"2011","unstructured":"Xu RX (2011) Multifunctional microbubbles and nanobubbles for photoacoustic imaging. Contrast Media Mol Imaging 6:401\u2013411","journal-title":"Contrast Media Mol Imaging"},{"key":"1475_CR104","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1586\/erd.10.9","volume":"7","author":"RX Xu","year":"2010","unstructured":"Xu RX, Povoski SP, Edward WMJ (2010) Targeted delivery of microbubbles and nanobubbles for image-guided thermal ablation therapy of tumors. Exp Rev Med Dev 7:303\u2013306","journal-title":"Exp Rev Med Dev"},{"key":"1475_CR105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4236\/eng.2013.510B031","volume":"05","author":"H Zhang","year":"2013","unstructured":"Zhang H, Meng H, Sun Q et al (2013) Multi-layer microbubbles by microfluidics. Engineering 05:146\u2013148","journal-title":"Engineering"},{"key":"1475_CR106","doi-asserted-by":"crossref","first-page":"035008","DOI":"10.1088\/0960-1317\/24\/3\/035008","volume":"24","author":"JM Zhang","year":"2014","unstructured":"Zhang JM, Li EQ, Thoroddsen ST (2014) A co-flow-focusing monodisperse microbubble generator. J Micromech Microeng 24:035008","journal-title":"J Micromech Microeng"},{"key":"1475_CR107","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.ultrasmedbio.2005.05.007","volume":"31","author":"YZ Zhao","year":"2005","unstructured":"Zhao YZ, Liang HD, Mei XG et al (2005) Preparation, characterization and in vivo observation of phospholipid-based gas-filled microbubbles containing hirudin. Ultrasound Med Biol 31:1237\u20131243","journal-title":"Ultrasound Med Biol"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-016-1475-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-016-1475-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-016-1475-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T08:40:48Z","timestamp":1718440848000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-016-1475-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,25]]},"references-count":107,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["1475"],"URL":"https:\/\/doi.org\/10.1007\/s11517-016-1475-z","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,25]]}}}