{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:44:02Z","timestamp":1784097842912,"version":"3.55.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Grants in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government","award":["24650265"],"award-info":[{"award-number":["24650265"]}]},{"name":"Grants in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government","award":["26282120"],"award-info":[{"award-number":["26282120"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s11517-017-1664-4","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T02:11:59Z","timestamp":1498702319000},"page":"2257-2266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of low-intensity whole-body vibration on bone defect repair and associated vascularization in mice"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-7963","authenticated-orcid":false,"given":"Takeshi","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"1664_CR1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1096\/fj.05-4966.com","volume":"20","author":"RG Bacabac","year":"2006","unstructured":"Bacabac RG, Smit TH, Van Loon JJ, Doulabi BZ, Helder M, Klein-Nulend J (2006) Bone cell responses to high-frequency vibration stress: does the nucleus oscillate within the cytoplasm? FASEB J 20:858\u2013864","journal-title":"FASEB J"},{"key":"1664_CR2","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1152\/japplphysiol.01209.2007","volume":"104","author":"K Baek","year":"2008","unstructured":"Baek K, Barlow A, Allen M, Bloomfield S (2008) Food restriction and simulated microgravity: effects on bone and serum leptin. J Appl Physiol 104:1086\u20131093","journal-title":"J Appl Physiol"},{"key":"1664_CR3","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/jor.22042","volume":"30","author":"JD Boerckel","year":"2012","unstructured":"Boerckel JD, Kolambkar YM, Stevens HY, Lin AS, Dupont KM, Guldberg RE (2012) Effects of in vivo mechanical loading on large bone defect regeneration. J Orthop Res 30:1067\u20131075","journal-title":"J Orthop Res"},{"key":"1664_CR4","doi-asserted-by":"crossref","first-page":"E674","DOI":"10.1073\/pnas.1107019108","volume":"108","author":"JD Boerckel","year":"2011","unstructured":"Boerckel JD, Uhrig BA, Willett NJ, Huebsch N, Guldberg RE (2011) Mechanical regulation of vascular growth and tissue regeneration in vivo. Proc Natl Acad Sci U S A 108:E674\u2013E680","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1664_CR5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s004210050067","volume":"81","author":"C Bosco","year":"2000","unstructured":"Bosco C, Iacovelli M, Tsarpela O, Cardinale M, Bonifazi M, Tihanyi J, Viru M, De Lorenzo A, Viru A (2000) Hormonal responses to whole-body vibration in men. Eur J Appl Physiol 81:449\u2013454","journal-title":"Eur J Appl Physiol"},{"key":"1664_CR6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bone.2015.02.010","volume":"80","author":"M Brotto","year":"2015","unstructured":"Brotto M, Bonewald L (2015) Bone and muscle: interactions beyond mechanical. Bone 80:109\u2013114","journal-title":"Bone"},{"key":"1664_CR7","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S1359-6446(03)02866-6","volume":"8","author":"RA Carano","year":"2003","unstructured":"Carano RA, Filvaroff EH (2003) Angiogenesis and bone repair. Drug Discov Today 8:980\u2013989","journal-title":"Drug Discov Today"},{"key":"1664_CR8","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.ultrasmedbio.2012.07.025","volume":"38","author":"WH Cheung","year":"2012","unstructured":"Cheung WH, Sun MH, Zheng YP, Chu WC, Leung AH, Qin L, Wei FY, Leung KS (2012) Stimulated angiogenesis for fracture healing augmented by low-magnitude, high-frequency vibration in a rat model-evaluation of pulsed-wave doppler, 3-D power Doppler ultrasonography and micro-CT microangiography. Ultrasound Med Biol 38:2120\u20132129","journal-title":"Ultrasound Med Biol"},{"key":"1664_CR9","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s10439-006-9133-5","volume":"34","author":"BA Christiansen","year":"2006","unstructured":"Christiansen BA, Silva MJ (2006) The effect of varying magnitudes of whole-body vibration on several skeletal sites in mice. Ann Biomed Eng 34:1149\u20131156","journal-title":"Ann Biomed Eng"},{"key":"1664_CR10","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1242\/jcs.167783","volume":"128","author":"P Dan","year":"2015","unstructured":"Dan P, Velot \u00c9, Decot V, Menu P (2015) The role of mechanical stimuli in the vascular differentiation of mesenchymal stem cells. J Cell Sci 128:2415\u20132422","journal-title":"J Cell Sci"},{"key":"1664_CR11","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.bone.2010.08.023","volume":"47","author":"M Doube","year":"2010","unstructured":"Doube M, K\u0142osowski MM, Arganda-Carreras I, Cordeli\u00e8res FP, Dougherty RP, Jackson JS, Schmid B, Hutchinson JR, Shefelbine SJ (2010) BoneJ: free and extensible bone image analysis in ImageJ. Bone 47:1076\u20131079","journal-title":"Bone"},{"key":"1664_CR12","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1073\/pnas.92.17.7657","volume":"92","author":"CJ Drake","year":"1995","unstructured":"Drake CJ, Little CD (1995) Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc Natl Acad Sci U S A 92:7657\u20137661","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1664_CR13","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4252\/wjsc.v7.i3.568","volume":"7","author":"JH Edwards","year":"2015","unstructured":"Edwards JH, Reilly GC (2015) Vibration stimuli and the differentiation of musculoskeletal progenitor cells: review of results in vitro and in vivo. World J Stem Cells 7:568\u2013582","journal-title":"World J Stem Cells"},{"key":"1664_CR14","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1118\/1.1617353","volume":"30","author":"NL Ford","year":"2003","unstructured":"Ford NL, Thornton MM, Holdsworth DW (2003) Fundamental image quality limits for microcomputed tomography in small animals. Med Phys 30:2869\u20132877","journal-title":"Med Phys"},{"key":"1664_CR15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2106\/JBJS.J.00795","volume":"94","author":"P Garcia","year":"2012","unstructured":"Garcia P, Pieruschka A, Klein M, Tami A, Histing T, Holstein JH, Scheuer C, Pohlemann T, Menger MD (2012) Temporal and spatial vascularization patterns of unions and nonunions: role of vascular endothelial growth factor and bone morphogenetic proteins. J Bone Joint Surg Am 94:49\u201358","journal-title":"J Bone Joint Surg Am"},{"key":"1664_CR16","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/jor.20354","volume":"25","author":"R Garman","year":"2007","unstructured":"Garman R, Gaudette G, Donahue LR, Rubin C, Judex S (2007) Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation. J Orthop Res 25:732\u2013740","journal-title":"J Orthop Res"},{"key":"1664_CR17","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1371\/journal.pone.0000653","volume":"2","author":"R Garman","year":"2007","unstructured":"Garman R, Rubin C, Judex S (2007) Small oscillatory accelerations, independent of matrix deformations, increase osteoblast activity and enhance bone morphology. PLoS One 2:e653","journal-title":"PLoS One"},{"key":"1664_CR18","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/aje\/kws554","volume":"178","author":"TM Gill","year":"2013","unstructured":"Gill TM, Murphy TE, Gahbauer EA, Allore HG (2013) Association of injurious falls with disability outcomes and nursing home admissions in community-living older persons. Am J Epidemiol 178:418\u2013425","journal-title":"Am J Epidemiol"},{"key":"1664_CR19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.bone.2010.05.026","volume":"47","author":"A Groothuis","year":"2010","unstructured":"Groothuis A, Duda G, Wilson C, Thompson M, Hunter M, Simon P, Bail H, van Scherpenzeel K, Kasper G (2010) Mechanical stimulation of the pro-angiogenic capacity of human fracture haematoma: involvement of VEGF mechano-regulation. Bone 47:438\u2013444","journal-title":"Bone"},{"key":"1664_CR20","doi-asserted-by":"crossref","first-page":"16689","DOI":"10.1073\/pnas.0407429101","volume":"101","author":"Y Han","year":"2004","unstructured":"Han Y, Cowin SC, Schaffler MB, Weinbaum S (2004) Mechanotransduction and strain amplification in osteocyte cell processes. Proc Natl Acad Sci U S A 101:16689\u201316694","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1664_CR21","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S8756-3282(01)00608-1","volume":"29","author":"MR Hausman","year":"2001","unstructured":"Hausman MR, Schaffler MB, Majeska RJ (2001) Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone 29:560\u2013564","journal-title":"Bone"},{"key":"1664_CR22","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.bone.2011.03.720","volume":"48","author":"YX He","year":"2011","unstructured":"He YX, Zhang G, Pan XH, Liu Z, Zheng LZ, Chan CW, Lee KM, Cao YP, Li G, Wei L, Hung LK, Leung KS, Qin L (2011) Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: a drill-hole defect model. Bone 48:1388\u20131400","journal-title":"Bone"},{"key":"1664_CR23","first-page":"2185","volume":"307","author":"WW Hung","year":"2012","unstructured":"Hung WW, Egol KA, Zuckerman JD, Siu AL (2012) Hip fracture management: tailoring care for the older patient. JAMA 307:2185\u20132194","journal-title":"JAMA"},{"key":"1664_CR24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s11999-008-0552-5","volume":"467","author":"SJ Hwang","year":"2009","unstructured":"Hwang SJ, Lublinsky S, Seo YK, Kim IS, Judex S (2009) Extremely small-magnitude accelerations enhance bone regeneration: a preliminary study. Clin Orthop Relat Res 467:1083\u20131091","journal-title":"Clin Orthop Relat Res"},{"key":"1664_CR25","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1096\/fj.01-0913fje","volume":"16","author":"S Judex","year":"2002","unstructured":"Judex S, Donahue LR, Rubin C (2002) Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J 16:1280\u20131282","journal-title":"FASEB J"},{"key":"1664_CR26","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/gerona\/58.11.M1042","volume":"58","author":"HK Kamel","year":"2003","unstructured":"Kamel HK, Iqbal MA, Mogallapu R, Maas D, Hoffmann RG (2003) Time to ambulation after hip fracture surgery: relation to hospitalization outcomes. J Gerontol A Biol Sci Med Sci 58:1042\u20131045","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"1664_CR27","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.bone.2003.12.024","volume":"34","author":"DE Komatsu","year":"2004","unstructured":"Komatsu DE, Hadjiargyrou M (2004) Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone 34:680\u2013688","journal-title":"Bone"},{"key":"1664_CR28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","volume":"507","author":"AP Kusumbe","year":"2014","unstructured":"Kusumbe AP, Ramasamy SK, Adams RH (2014) Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 507:323\u2013328","journal-title":"Nature"},{"key":"1664_CR29","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/jor.20753","volume":"27","author":"KS Leung","year":"2009","unstructured":"Leung KS, Shi HF, Cheung WH, Qin L, Ng WK, Tam KF, Tang N (2009) Low-magnitude high-frequency vibration accelerates callus formation, mineralization, and fracture healing in rats. J Orthop Res 27:458\u2013465","journal-title":"J Orthop Res"},{"key":"1664_CR30","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1002\/jcb.23287","volume":"112","author":"GL Lin","year":"2011","unstructured":"Lin GL, Hankenson KD (2011) Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem 112:3491\u20133501","journal-title":"J Cell Biochem"},{"key":"1664_CR31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","volume":"19","author":"C Maes","year":"2010","unstructured":"Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, Carmeliet G, Kronenberg HM (2010) Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell 19:329\u2013344","journal-title":"Dev Cell"},{"key":"1664_CR32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1109\/42.563664","volume":"16","author":"F Maes","year":"1997","unstructured":"Maes F, Collignon A, Vandermeulen D, Marchal G, Suetens P (1997) Multimodality image registration by maximization of mutual information. IEEE Trans Med Imaging 16:187\u2013198","journal-title":"IEEE Trans Med Imaging"},{"key":"1664_CR33","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/labinvest.2013.87","volume":"93","author":"T Matsumoto","year":"2013","unstructured":"Matsumoto T, Goto D, Sato S (2013) Subtraction micro-computed tomography of angiogenesis and osteogenesis during bone repair using synchrotron radiation with a novel contrast agent. Lab Investig 93:1054\u20131063","journal-title":"Lab Investig"},{"key":"1664_CR34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00223-015-0104-4","volume":"98","author":"T Matsumoto","year":"2016","unstructured":"Matsumoto T, Itamochi S, Hashimoto Y (2016) Effect of concurrent use of whole-body vibration and parathyroid hormone on bone structure and material properties of ovariectomized mice. Calcif Tissue Int 98:520\u2013529","journal-title":"Calcif Tissue Int"},{"key":"1664_CR35","doi-asserted-by":"crossref","first-page":"e12335","DOI":"10.14814\/phy2.12335","volume":"3","author":"T Matsumoto","year":"2015","unstructured":"Matsumoto T, Sato S (2015) Stimulating angiogenesis mitigates the unloading-induced reduction in osteogenesis in early-stage bone repair in rats. Physiol Rep 3:e12335","journal-title":"Physiol Rep"},{"key":"1664_CR36","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s10237-010-0285-8","volume":"10","author":"TM Maul","year":"2011","unstructured":"Maul TM, Chew DW, Nieponice A, Vorp DA (2011) Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation. Biomech Model Mechanobiol 10:939\u2013953","journal-title":"Biomech Model Mechanobiol"},{"key":"1664_CR37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.actaastro.2012.04.016","volume":"92","author":"N McCabe","year":"2013","unstructured":"McCabe N, Androjna C, Hill E, Globus R, Midura R (2013) Simulated microgravity alters the expression of key genes involved in fracture healing. Acta Astronaut 92:65\u201372","journal-title":"Acta Astronaut"},{"key":"1664_CR38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00223-009-9314-y","volume":"86","author":"L Monfoulet","year":"2010","unstructured":"Monfoulet L, Rabier B, Chassande O, Fricain JC (2010) Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration. Calcif Tissue Int 86:72\u201381","journal-title":"Calcif Tissue Int"},{"key":"1664_CR39","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0736-0266(02)00234-6","volume":"21","author":"D Moore","year":"2003","unstructured":"Moore D, Leblanc C, Muller R, Crisco J, Ehrlich M (2003) Physiologic weight-bearing increases new vessel formation during distraction osteogenesis: a micro-tomographic imaging study. J Orthop Res 21:489\u2013496","journal-title":"J Orthop Res"},{"key":"1664_CR40","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jsams.2013.01.004","volume":"16","author":"J Muir","year":"2013","unstructured":"Muir J, Kiel DP, Rubin CT (2013) Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults. J Sci Med Sport 16:526\u2013531","journal-title":"J Sci Med Sport"},{"key":"1664_CR41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/A:1010015309973","volume":"2","author":"GR Mundy","year":"2001","unstructured":"Mundy GR, Chen D, Zhao M, Dallas S, Xu C, Harris S (2001) Growth regulatory factors and bone. Rev Endocr Metab Disord 2:105\u2013115","journal-title":"Rev Endocr Metab Disord"},{"key":"1664_CR42","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1152\/japplphysiol.01135.2004","volume":"98","author":"WL Murfee","year":"2005","unstructured":"Murfee WL, Hammett LA, Evans C, Xie L, Squire M, Rubin C, Judex S, Skalak TC (2005) High-frequency, low-magnitude vibrations suppress the number of blood vessels per muscle fiber in mouse soleus muscle. J Appl Physiol (1985) 98:2376\u20132380","journal-title":"J Appl Physiol (1985)"},{"key":"1664_CR43","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.joms.2008.01.048","volume":"66","author":"H Omar","year":"2008","unstructured":"Omar H, Shen G, Jones AS, Zoellner H, Petocz P, Darendeliler MA (2008) Effect of low magnitude and high frequency mechanical stimuli on defects healing in cranial bones. J Oral Maxillofac Surg 66:1104\u20131111","journal-title":"J Oral Maxillofac Surg"},{"key":"1664_CR44","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1748-1716.2008.01869.x","volume":"194","author":"T Otsuki","year":"2008","unstructured":"Otsuki T, Takanami Y, Aoi W, Kawai Y, Ichikawa H, Yoshikawa T (2008) Arterial stiffness acutely decreases after whole-body vibration in humans. Acta Physiol (Oxf) 194:189\u2013194","journal-title":"Acta Physiol (Oxf)"},{"key":"1664_CR45","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0031-3203(95)00111-5","volume":"29","author":"N Pal","year":"1996","unstructured":"Pal N (1996) On minimum cross-entropy thresholding. Pattern Recogn 29:575\u2013580","journal-title":"Pattern Recogn"},{"key":"1664_CR46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2013.03.013","volume":"55","author":"M Pasqualini","year":"2013","unstructured":"Pasqualini M, Lavet C, Elbadaoui M, Vanden-Bossche A, Laroche N, Gnyubkin V, Vico L (2013) Skeletal site-specific effects of whole body vibration in mature rats: from deleterious to beneficial frequency-dependent effects. Bone 55:69\u201377","journal-title":"Bone"},{"key":"1664_CR47","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1172\/JCI15153","volume":"110","author":"H Peng","year":"2002","unstructured":"Peng H, Wright V, Usas A, Gearhart B, Shen HC, Cummins J, Huard J (2002) Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 110:751\u2013759","journal-title":"J Clin Invest"},{"key":"1664_CR48","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S8756-3282(02)00871-2","volume":"31","author":"AG Robling","year":"2002","unstructured":"Robling AG, Turner CH (2002) Mechanotransduction in bone: genetic effects on mechanosensitivity in mice. Bone 31:562\u2013569","journal-title":"Bone"},{"key":"1664_CR49","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1097\/01.BRS.0000102682.61791.C9","volume":"28","author":"C Rubin","year":"2003","unstructured":"Rubin C, Pope M, Fritton JC, Magnusson M, Hansson T, McLeod K (2003) Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis. Spine (Phila Pa 1976) 28:2621\u20132627","journal-title":"Spine (Phila Pa 1976)"},{"key":"1664_CR50","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1359\/jbmr.090602","volume":"24","author":"E Schipani","year":"2009","unstructured":"Schipani E, Maes C, Carmeliet G, Semenza GL (2009) Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res 24:1347\u20131353","journal-title":"J Bone Miner Res"},{"key":"1664_CR51","first-page":"R623","volume":"288","author":"JM Stewart","year":"2005","unstructured":"Stewart JM, Karman C, Montgomery LD, McLeod KJ (2005) Plantar vibration improves leg fluid flow in perimenopausal women. Am J Phys Regul Integr Comp Phys 288:R623\u2013R629","journal-title":"Am J Phys Regul Integr Comp Phys"},{"key":"1664_CR52","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","volume":"99","author":"J Street","year":"2002","unstructured":"Street J, Bao M, de Guzman L, Bunting S, Peale FV, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, van Bruggen N, Redmond HP, Carano RA, Filvaroff EH (2002) Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci U S A 99:9656\u20139661","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1664_CR53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00223-010-9381-0","volume":"87","author":"EK Stuermer","year":"2010","unstructured":"Stuermer EK, Komrakova M, Werner C, Wicke M, Kolios L, Sehmisch S, Tezval M, Utesch C, Mangal O, Zimmer S, Dullin C, Stuermer KM (2010) Musculoskeletal response to whole-body vibration during fracture healing in intact and ovariectomized rats. Calcif Tissue Int 87:168\u2013180","journal-title":"Calcif Tissue Int"},{"key":"1664_CR54","first-page":"525","volume":"39","author":"SE Szczesny","year":"2010","unstructured":"Szczesny SE, Lee CS, Soslowsky LJ (2010) Remodeling and repair of orthopedic tissue: role of mechanical loading and biologics. Am J Orthop 39:525\u2013530","journal-title":"Am J Orthop"},{"key":"1664_CR55","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11914-008-0012-x","volume":"6","author":"DA Towler","year":"2008","unstructured":"Towler DA (2008) The osteogenic-angiogenic interface: novel insights into the biology of bone formation and fracture repair. Curr Osteoporos Rep 6:67\u201371","journal-title":"Curr Osteoporos Rep"},{"key":"1664_CR56","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/jor.1100070414","volume":"7","author":"Y Usui","year":"1989","unstructured":"Usui Y, Zerwekh JE, Vanharanta H, Ashman RB, Mooney V (1989) Different effects of mechanical vibration on bone ingrowth into porous hydroxyapatite and fracture healing in a rabbit model. J Orthop Res 7:559\u2013567","journal-title":"J Orthop Res"},{"key":"1664_CR57","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.jbiomech.2013.06.008","volume":"46","author":"G Uzer","year":"2013","unstructured":"Uzer G, Pongkitwitoon S, Ete Chan M, Judex S (2013) Vibration induced osteogenic commitment of mesenchymal stem cells is enhanced by cytoskeletal remodeling but not fluid shear. J Biomech 46:2296\u20132302","journal-title":"J Biomech"},{"key":"1664_CR58","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/stem.2004","volume":"33","author":"G Uzer","year":"2015","unstructured":"Uzer G, Thompson WR, Sen B, Xie Z, Yen SS, Miller S, Bas G, Styner M, Rubin CT, Judex S, Burridge K, Rubin J (2015) Cell mechanosensitivity to extremely low-magnitude signals is enabled by a LINCed nucleus. Stem Cells 33:2063\u20132076","journal-title":"Stem Cells"},{"key":"1664_CR59","doi-asserted-by":"crossref","first-page":"613","DOI":"10.33549\/physiolres.931288","volume":"57","author":"A Wagatsuma","year":"2008","unstructured":"Wagatsuma A (2008) Effect of hindlimb unweighting on expression of hypoxia-inducible factor-1alpha vascular endothelial growth factor, angiopoietin, and their receptors in mouse skeletal muscle. Physiol Res 57:613\u2013620","journal-title":"Physiol Res"},{"key":"1664_CR60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bone.2008.09.010","volume":"44","author":"GR Wohl","year":"2009","unstructured":"Wohl GR, Towler DA, Silva MJ (2009) Stress fracture healing: fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair. Bone 44:320\u2013330","journal-title":"Bone"},{"key":"1664_CR61","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.medengphy.2011.08.011","volume":"34","author":"LC Wong","year":"2012","unstructured":"Wong LC, Chiu WK, Russ M, Liew S (2012) Review of techniques for monitoring the healing fracture of bones for implementation in an internally fixated pelvis. Med Eng Phys 34:140\u2013152","journal-title":"Med Eng Phys"}],"container-title":["Medical &amp; Biological Engineering &amp; Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-017-1664-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-017-1664-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-017-1664-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T03:56:16Z","timestamp":1659153376000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-017-1664-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,29]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["1664"],"URL":"https:\/\/doi.org\/10.1007\/s11517-017-1664-4","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,29]]}}}