{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T15:52:52Z","timestamp":1769356372079,"version":"3.49.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T00:00:00Z","timestamp":1503100800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s11517-017-1696-9","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T01:17:56Z","timestamp":1503105476000},"page":"491-504","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sensitivity analysis of ventricular activation and electrocardiogram in tailored models of heart-failure patients"],"prefix":"10.1007","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-5403","authenticated-orcid":false,"given":"C.","family":"S\u00e1nchez","sequence":"first","affiliation":[]},{"given":"G.","family":"D\u2019Ambrosio","sequence":"additional","affiliation":[]},{"given":"F.","family":"Maffessanti","sequence":"additional","affiliation":[]},{"given":"E. G.","family":"Caiani","sequence":"additional","affiliation":[]},{"given":"F. W.","family":"Prinzen","sequence":"additional","affiliation":[]},{"given":"R.","family":"Krause","sequence":"additional","affiliation":[]},{"given":"A.","family":"Auricchio","sequence":"additional","affiliation":[]},{"given":"M.","family":"Potse","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,8,19]]},"reference":[{"issue":"1","key":"1696_CR1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pbiomolbio.2011.06.014","volume":"107","author":"J Aguado-Sierra","year":"2011","unstructured":"Aguado-Sierra J, Krishnamurthy A, Villongco C, Chuang J, Howard E, Gonzales MJ, Omens J, Krummen DE, Narayan S, Kerckhoffs RCP, McCulloch AD (2011) Patient-specific modeling of dyssynchronous heart failure: a case study. Prog Biophys Mol Biol 107(1):147\u2013155","journal-title":"Prog Biophys Mol Biol"},{"issue":"9","key":"1696_CR2","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/01.CIR.0000118502.91105.F6","volume":"109","author":"A Auricchio","year":"2004","unstructured":"Auricchio A, Fantoni C, Regoli F, Carbucicchio C, Goette A, Geller C, Kloss M, Klein H (2004) Characterization of left ventricular activation in patients with heart failure and left bundle-branch block. Circulation 109(9):1133\u20131139","journal-title":"Circulation"},{"key":"1696_CR3","unstructured":"Bay\u00e9s de Luna A, Batchvarov VN, Malik M (2006) The morphology of the electrocardiogram. In: Camm AJ, Luscher TF, Serruys PW (eds) The ESC textbook of cardiovascular medicine. Blackwell Publishers, Oxford"},{"issue":"3","key":"1696_CR4","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10439-009-9873-0","volume":"38","author":"M Boulakia","year":"2010","unstructured":"Boulakia M, Cazeau S, Fern\u00e1ndez MA, Gerbeau JF, Zemzemi N (2010) Mathematical modeling of electrocardiograms: a numerical study. Ann Biomed Eng 38(3):1071\u20131097","journal-title":"Ann Biomed Eng"},{"issue":"7","key":"1696_CR5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1114\/1.1289467","volume":"28","author":"CP Bradley","year":"2000","unstructured":"Bradley CP, Pullan AJ, Hunter PJ (2000) Effects of material properties and geometry on electrocardiographic forward simulations. Ann Biomed Eng 28(7):721\u2013741","journal-title":"Ann Biomed Eng"},{"key":"1696_CR6","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","volume":"34","author":"M Brignole","year":"2013","unstructured":"Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Blomstrom-Lundqvist C, Badano LP, Aliyev F, B\u00e4nsch D, Bsata W, Buser P, Charron P, Daubert JC, Dobreanu D, Faerestrand S, Le Heuzey JY, Mavrakis H, McDonagh T, Merino JL, Nawar MM, Nielsen JC, Pieske B, Poposka L, Ruschitzka F, Van Gelder IC, Wilson CM (2013) 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. Eur Heart J 34:2281\u20132329","journal-title":"Eur Heart J"},{"issue":"23","key":"1696_CR7","doi-asserted-by":"crossref","first-page":"E2098","DOI":"10.1073\/pnas.1304382110","volume":"110","author":"OJ Britton","year":"2013","unstructured":"Britton OJ, Bueno-Orovio A, Van Ammel K, Lu HR, Towart R, Gallacher DJ, Rodriguez B (2013) Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology. Proc Natl Acad Sci U S A 110(23):E2098\u20132105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1696_CR8","first-page":"57","volume":"40","author":"BM Burton","year":"2013","unstructured":"Burton BM, Erem B, Potter K, Rosen P, Johnson CR, Brooks DH, Macleod RS (2013) Uncertainty visualization in forward and inverse cardiac models. Comput Cardiol 40:57\u201360","journal-title":"Comput Cardiol"},{"issue":"03","key":"1696_CR9","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4208\/cicp.230909.160310s","volume":"9","author":"GT Buzzard","year":"2011","unstructured":"Buzzard GT, Xiu D (2011) Variance-based global sensitivity analysis via sparse-grid interpolation and cubature. Commun Comput Phys 9(03):542\u2013567","journal-title":"Commun Comput Phys"},{"issue":"1954","key":"1696_CR10","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1098\/rsta.2011.0127","volume":"369","author":"J Carro","year":"2011","unstructured":"Carro J, Rodr\u00edguez JF, Laguna P, Pueyo E (2011) A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions. Philos Trans R Soc A 369(1954):4205\u20134232","journal-title":"Philos Trans R Soc A"},{"issue":"6","key":"1696_CR11","doi-asserted-by":"crossref","first-page":"e0130252","DOI":"10.1371\/journal.pone.0130252","volume":"10","author":"ETY Chang","year":"2015","unstructured":"Chang ETY, Strong M, Clayton RH (2015) Bayesian sensitivity analysis of a cardiac cell model using a gaussian process emulator. PLoS ONE 10(6):e0130252","journal-title":"PLoS ONE"},{"issue":"3","key":"1696_CR12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1098\/rsfs.2010.0029","volume":"1","author":"CA Conti","year":"2011","unstructured":"Conti CA, Votta E, Corsi C, De Marchi D, Tarroni G, Stevanella M, Lombardi M, Parodi O, Caiani EG, Redaelli A (2011) Left ventricular modelling: a quantitative functional assessment tool based on cardiac magnetic resonance imaging. Interface Focus 1(3):384\u2013395","journal-title":"Interface Focus"},{"key":"1696_CR13","doi-asserted-by":"crossref","unstructured":"Elshrif MM, Shi P, Cherry EM (2014) Electrophysiological properties under heart failure conditions in a human ventricular cell: a modeling study. In: Conference proceedings: annual international conference of the IEEE engineering in medicine and biology society 2014, pp 4324\u20134329","DOI":"10.1109\/EMBC.2014.6944581"},{"issue":"14","key":"1696_CR14","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0002-9149(96)00160-9","volume":"77","author":"GJ Fahy","year":"1996","unstructured":"Fahy GJ, Pinski SL, Miller DP, McCabe N, Pye C, Walsh MJ, Robinson K (1996) Natural history of isolated bundle branch block. Am J Cardiol 77(14):1185\u20131190","journal-title":"Am J Cardiol"},{"key":"1696_CR15","doi-asserted-by":"crossref","unstructured":"Geerts L, Kerckhoffs R, Bovendeerd P, Arts T (2003) Towards patient specific models of cardiac mechanics: a sensitivity study. In: Proceedings of the 2nd international conference on functional imaging and modeling of the heart. Springer, Berlin, FIMH\u201903, pp 81\u201390","DOI":"10.1007\/3-540-44883-7_9"},{"issue":"5","key":"1696_CR16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.pcad.2006.02.001","volume":"48","author":"AH Gradman","year":"2006","unstructured":"Gradman AH, Alfayoumi F (2006) From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease. Prog Cardiovasc Dis 48(5):326\u2013341","journal-title":"Prog Cardiovasc Dis"},{"issue":"9","key":"1696_CR17","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/CIRCRESAHA.111.253955","volume":"109","author":"E Grandi","year":"2011","unstructured":"Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM (2011) Human atrial action potential and Ca2 + model: sinus rhythm and chronic atrial fibrillation. Circ Res 109(9):1055\u20131066","journal-title":"Circ Res"},{"key":"1696_CR18","doi-asserted-by":"crossref","unstructured":"Kalayciyan R, Keller DUJ, Seemann G, D\u00f6ssel O (2009) Creation of a realistic endocardial stimulation profile for the visible man dataset. In: D\u00f6ssel O, Schlegel WC (eds) World congress on medical physics and biomedical engineering, 2009, Munich, Germany, no. 25\/4 in IFMBE Proceedings. Springer, Berlin, pp 934\u2013937","DOI":"10.1007\/978-3-642-03882-2_249"},{"issue":"7","key":"1696_CR19","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1109\/TBME.2010.2046485","volume":"57","author":"D Keller","year":"2010","unstructured":"Keller D, Weber F, Seemann G, D\u00f6ssel O (2010) Ranking the influence of tissue conductivities on forward-calculated ECGs. IEEE Trans Biomed Eng 57(7):1568\u20131576","journal-title":"IEEE Trans Biomed Eng"},{"key":"1696_CR20","doi-asserted-by":"crossref","unstructured":"Kharche S, L\u00fcdtke N, Panzeri S, Zhang H (2009) A global sensitivity index for biophysically detailed cardiac cell models: a computational approach. In: Ayache N, Delingette H, Sermesant M (eds) Functional imaging and modeling of the heart. Lecture Notes in Computer Science. Springer, Berlin, pp 366\u2013375","DOI":"10.1007\/978-3-642-01932-6_40"},{"issue":"4, Supplement","key":"1696_CR21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jelectrocard.2005.06.096","volume":"38","author":"P Kohl","year":"2005","unstructured":"Kohl P, Camelliti P, Burton FL, Smith GL (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. J Electrocardiol 38(4, Supplement):45\u201350","journal-title":"J Electrocardiol"},{"key":"1696_CR22","unstructured":"Krause D, Potse M, Dickopf T, Krause R, Auricchio A, Prinzen F (2012) Poster: hybrid parallelization of a realistic heart model. In: Keller R, Kramer D, Weiss J-P (eds) Facing the multicore - challenge II; Aspects of new paradigms and technologies in parallel computing. Lecture Notes in Computer Science, vol 7174"},{"key":"1696_CR23","unstructured":"Krueger MW, Rhode K, Weber FM, Keller DUJ, Caulfield D, Seemann G, Knowles BR, Razavi R, D\u00f6ssel O (2010) Patient-specific volumetric atrial models with electrophysiological components: a comparison of simulations and measurements. In: Biomedizinische Technik\/Biomedical Engineering, vol 55 (Suppl. 1)"},{"issue":"20","key":"1696_CR24","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/jama.1996.03530440037034","volume":"275","author":"D Levy","year":"1996","unstructured":"Levy D, Larson MG, Vasan RS, Kannel WB, Ho KK (1996) The progression from hypertension to congestive heart failure. JAMA 275(20):1557\u20131562","journal-title":"JAMA"},{"issue":"1896","key":"1696_CR25","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1098\/rsta.2008.0314","volume":"367","author":"RS MacLeod","year":"2009","unstructured":"MacLeod RS, Stinstra JG, Lew S, Whitaker RT, Swenson DJ, Cole MJ, Kr\u00fcger J, Brooks DH, Johnson CR (2009) Subject-specific, multiscale simulation of electrophysiology: a software pipeline for image-based models and application examples. Phil Trans R Soc A 367(1896):2293\u20132310","journal-title":"Phil Trans R Soc A"},{"issue":"5","key":"1696_CR26","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1109\/TBME.2010.2097597","volume":"58","author":"A Minchol\u00e9","year":"2011","unstructured":"Minchol\u00e9 A, Pueyo E, Rodr\u00edguez JF, Zacur E, Doblar\u00e9 M, Laguna P (2011) Quantification of restitution dispersion from the dynamic changes of the T-wave peak to end, measured at the surface ECG. IEEE Trans Biomed Eng 58(5):1172\u20131182","journal-title":"IEEE Trans Biomed Eng"},{"issue":"1","key":"1696_CR27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.RES.42.1.27","volume":"42","author":"RJ Myerburg","year":"1978","unstructured":"Myerburg RJ, Gelband H, Nilsson K, Castellanos A, Morales AR, Bassett AL (1978) The role of canine superficial ventricular muscle fibers in endocardial impulse distribution. Circ Res 42(1):27\u201335","journal-title":"Circ Res"},{"issue":"1","key":"1696_CR28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/bib\/bbp049","volume":"11","author":"ML Neal","year":"2010","unstructured":"Neal ML, Kerckhoffs R (2010) Current progress in patient-specific modeling. Brief Bioinform 11(1):111\u2013126","journal-title":"Brief Bioinform"},{"issue":"4","key":"1696_CR29","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jelectrocard.2015.05.004","volume":"48","author":"UC Nguy\u00ean","year":"2015","unstructured":"Nguy\u00ean UC, Potse M, Regoli F, Caputo ML, Conte G, Murzilli R, Muzzarelli S, Moccetti T, Caiani EG, Prinzen FW, Krause R, Auricchio A (2015) An in-silico analysis of the effect of heart position and orientation on the ECG morphology and vectorcardiogram parameters in patients with heart failure and intraventricular conduction defects. J Electrocardiol 48(4):617\u2013625","journal-title":"J Electrocardiol"},{"issue":"5","key":"1696_CR30","doi-asserted-by":"crossref","first-page":"e1002061","DOI":"10.1371\/journal.pcbi.1002061","volume":"7","author":"T O\u2019Hara","year":"2011","unstructured":"O\u2019Hara T, Vir\u00e1g L, Varr\u00f3 A, Rudy Y (2011) Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. PLoS Comput Biol 7(5):e1002061","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"1696_CR31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.hrthm.2016.10.010","volume":"14","author":"T Opthof","year":"2017","unstructured":"Opthof T, Remme CA, Jorge E, Noriega F, Wiegerinck RF, Tasiam A, Beekman L, Alvarez-Garcia J, Munoz-Guijosa C, Coronel R, Cinca J (2017) Cardiac activation-repolarization patterns and ion channel expression mapping in intact isolated normal human hearts. Heart Rhythm 14(2):265\u2013272","journal-title":"Heart Rhythm"},{"issue":"1","key":"1696_CR32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jacc.2004.09.058","volume":"45","author":"MV Pitzalis","year":"2005","unstructured":"Pitzalis MV, Iacoviello M, Romito R, Guida P, De Tommasi E, Luzzi G, Anaclerio M, Forleo C, Rizzon P (2005) Ventricular asynchrony predicts a better outcome in patients with chronic heart failure receiving cardiac resynchronization therapy. J Am Coll Cardiol 45(1):65\u201369","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"1696_CR33","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1109\/TBME.2006.880875","volume":"53","author":"M Potse","year":"2006","unstructured":"Potse M, Dub\u00e9 B, Richer J, Vinet A, Gulrajani R (2006) A comparison of monodomain and bidomain reaction-diffusion models for action potential propagation in the human heart. IEEE Trans Biomed Eng 53(12):2425\u20132435","journal-title":"IEEE Trans Biomed Eng"},{"issue":"7","key":"1696_CR34","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s11517-009-0472-x","volume":"47","author":"M Potse","year":"2009","unstructured":"Potse M, Dub\u00e9 B, Vinet A (2009) Cardiac anisotropy in boundary-element models for the electrocardiogram. Med Biol Eng Comput 47(7):719\u2013729","journal-title":"Med Biol Eng Comput"},{"issue":"suppl 4","key":"1696_CR35","doi-asserted-by":"crossref","first-page":"iv56","DOI":"10.1093\/europace\/euu257","volume":"16","author":"M Potse","year":"2014","unstructured":"Potse M, Krause D, Kroon W, Murzilli R, Muzzarelli S, Regoli F, Caiani E, Prinzen FW, Krause R, Auricchio A (2014) Patient-specific modelling of cardiac electrophysiology in heart-failure patients. Europace 16(suppl 4):iv56\u2013iv61","journal-title":"Europace"},{"issue":"5","key":"1696_CR36","doi-asserted-by":"crossref","first-page":"H1577","DOI":"10.1152\/ajpheart.00936.2009","volume":"298","author":"E Pueyo","year":"2010","unstructured":"Pueyo E, Husti Z, Hornyik T, Baczk\u00f3 I, Laguna P, Varr\u00f3 A, Rodr\u00edguez B (2010) Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk. Am J Physiol Heart Circ Physiol 298(5):H1577\u20131587","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"1696_CR37","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1016\/j.bpj.2011.09.060","volume":"101","author":"E Pueyo","year":"2011","unstructured":"Pueyo E, Corrias A, Vir\u00e1g L, Jost N, Sz\u00e9l T, Varr\u00f3 A, Szentandr\u00e1ssy N, N\u00e1n\u00e1si PP, Burrage K, Rodr\u00edguez B (2011) A multiscale investigation of repolarization variability and its role in cardiac arrhythmogenesis. Biophys J 101(12):2892\u20132902","journal-title":"Biophys J"},{"issue":"2","key":"1696_CR38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1540-8167.2003.02421.x","volume":"14","author":"LM Rodriguez","year":"2003","unstructured":"Rodriguez LM, Timmermans C, Nabar A, Beatty G, Wellens HJ (2003) Variable patterns of septal activation in patients with left bundle branch block and heart failure. J Cardiovasc Electrophysiol 14(2):135\u2013141","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"4","key":"1696_CR39","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1161\/CIR.0b013e3182009701","volume":"123","author":"VL Roger","year":"2011","unstructured":"Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ, Hailpern SM, Heit JA, Ho PM, Howard V J, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar D B, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Rosamond WD, Sorlie P D, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J, American Heart Association Statistics Committee and Stroke Statistics Subcommittee (2011) Heart disease and stroke statistics\u20132011 update: a report from the American Heart Association. Circulation 123(4):e18\u2013e209","journal-title":"Circulation"},{"issue":"4","key":"1696_CR40","doi-asserted-by":"crossref","first-page":"H1436\u20141445","DOI":"10.1152\/ajpheart.00263.2009","volume":"297","author":"L Romero","year":"2009","unstructured":"Romero L, Pueyo E, Fink M, Rodr\u00edguez B (2009) Impact of ionic current variability on human ventricular cellular electrophysiology. Am J Physiol Heart Circ Physiol 297(4):H1436\u20141445","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"1696_CR41","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.jbiomech.2015.12.025","volume":"49","author":"F Sahli Costabal","year":"2016","unstructured":"Sahli Costabal F, Hurtado DE, Kuhl E (2016) Generating Purkinje networks in the human heart. J Biomech 49(12):2455\u20132465","journal-title":"J Biomech"},{"issue":"5","key":"1696_CR42","doi-asserted-by":"crossref","first-page":"H1146","DOI":"10.1152\/ajpheart.00668.2011","volume":"302","author":"C S\u00e1nchez","year":"2012","unstructured":"S\u00e1nchez C, Corrias A, Bueno-Orovio A, Davies M, Swinton J, Jacobson I, Laguna P, Pueyo E, Rodr\u00edguez B (2012) The Na + \/K + pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue. Am J Physiol Heart Circ Physiol 302(5):H1146\u20131159","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"1696_CR43","doi-asserted-by":"crossref","first-page":"e105897","DOI":"10.1371\/journal.pone.0105897","volume":"9","author":"C S\u00e1nchez","year":"2014","unstructured":"S\u00e1nchez C, Bueno-Orovio A, Wettwer E, Loose S, Simon J, Ravens U, Pueyo E, Rodriguez B (2014) Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation. PLoS ONE 9(8):e105897","journal-title":"PLoS ONE"},{"issue":"11","key":"1696_CR44","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/j.hrthm.2011.05.023","volume":"8","author":"AX Sarkar","year":"2011","unstructured":"Sarkar AX, Sobie EA (2011) Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. Heart Rhythm 8(11):1749\u20131755","journal-title":"Heart Rhythm"},{"issue":"Pt 11","key":"1696_CR45","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1113\/jphysiol.2011.223313","volume":"590","author":"AX Sarkar","year":"2012","unstructured":"Sarkar AX, Christini DJ, Sobie EA (2012) Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol 590(Pt 11):2555\u20132567","journal-title":"J Physiol"},{"key":"1696_CR46","doi-asserted-by":"crossref","unstructured":"Sobie EA, Sarkar AX (2011) Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms. In: Annual international conference of the IEEE EMBS 2011, pp 4657\u20134660","DOI":"10.1109\/IEMBS.2011.6091153"},{"issue":"5","key":"1696_CR47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCEP.108.798660","volume":"1","author":"DG Strauss","year":"2008","unstructured":"Strauss DG, Selvester RH, Lima JAC, Arheden H, Miller JM, Gerstenblith G, Marb\u00e1n E, Weiss RG, Tomaselli GF, Wagner GS, Wu KC (2008) ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol 1(5):327\u2013336","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"6","key":"1696_CR48","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2010.11.010","volume":"107","author":"DG Strauss","year":"2011","unstructured":"Strauss DG, Selvester RH, Wagner GS (2011) Defining left bundle branch block in the era of cardiac resynchronization therapy. Am J Cardiol 107(6):927\u2013934","journal-title":"Am J Cardiol"},{"issue":"11","key":"1696_CR49","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jacc.2008.12.013","volume":"53","author":"B Surawicz","year":"2009","unstructured":"Surawicz B, Childers R, Deal BJ, Gettes LS, Bailey JJ, Gorgels A, Hancock EW, Josephson M, Kligfield P, Kors JA, Macfarlane P, Mason JW, Mirvis DM, Okin P, Pahlm O, Rautaharju PM, van Herpen G, Wagner GS, Wellens H, American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology, American College of Cardiology Foundation, Heart Rhythm Society (2009) AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology. J Am Coll Cardiol 53(11):976\u2013981","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1696_CR50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/CIRCEP.108.777904","volume":"1","author":"MO Sweeney","year":"2008","unstructured":"Sweeney MO, Prinzen FW (2008) Ventricular pump function and pacing; physiological and clinical integration. Circ Arrhythm Electrophysiol 1(2):127\u2013139","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"1696_CR51","unstructured":"Swenson D, Levine J, Fu Z, Tate J, MacLeod R (2010) The effect of non-conformal finite element boundaries on electrical monodomain and Bidomain simulations. In: 2010 Computing in Cardiology, pp 97\u2013100"},{"issue":"2","key":"1696_CR52","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0008-6363(99)00017-6","volume":"42","author":"GF Tomaselli","year":"1999","unstructured":"Tomaselli GF, Marb\u00e1n E (1999) Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42(2):270\u2013283","journal-title":"Cardiovasc Res"},{"key":"1696_CR53","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chemolab.2012.10.006","volume":"120","author":"K Tondel","year":"2013","unstructured":"Tondel K, Vik JO, Martens H, Indahl UG, Smith N, Omholt SW (2013) Hierarchical multivariate regression-based sensitivity analysis reveals complex parameter interaction patterns in dynamic models. Chemom Intell Lab 120:25\u201341","journal-title":"Chemom Intell Lab"},{"issue":"3","key":"1696_CR54","doi-asserted-by":"crossref","first-page":"e32659","DOI":"10.1371\/journal.pone.0032659","volume":"7","author":"B Trenor","year":"2012","unstructured":"Trenor B, Cardona K, Gomez JF, Rajamani S, Ferrero JM, Belardinelli L, Saiz J (2012) Simulation and mechanistic investigation of the arrhythmogenic role of the late sodium current in human heart failure. PloS One 7(3):e32659","journal-title":"PloS One"},{"issue":"3","key":"1696_CR55","doi-asserted-by":"crossref","first-page":"H1088","DOI":"10.1152\/ajpheart.00109.2006","volume":"291","author":"KHWJ ten Tusscher","year":"2006","unstructured":"ten Tusscher KHWJ, Panfilov AV (2006) Alternans and spiral breakup in a human ventricular tissue model. Am J Physiol Heart Circ Physiol 291(3):H1088\u20131100","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"1696_CR56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10334-015-0520-5","volume":"29","author":"L Wang","year":"2016","unstructured":"Wang L, Chitiboi T, Meine H, G\u00fcnther M, Hahn HK (2016) Principles and methods for automatic and semi-automatic tissue segmentation in MRI data. Magn Reson Mater Phys 29(2):95\u2013110","journal-title":"Magn Reson Mater Phys"},{"issue":"10","key":"1696_CR57","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCULATIONAHA.110.960898","volume":"123","author":"W Zareba","year":"2011","unstructured":"Zareba W, Klein H, Cygankiewicz I, Hall WJ, McNitt S, Brown M, Cannom D, Daubert JP, Eldar M, Gold MR, Goldberger JJ, Goldenberg I, Lichstein E, Pitschner H, Rashtian M, Solomon S, Viskin S, Wang P, Moss AJ, Investigators MADIT-CRT (2011) Effectiveness of cardiac resynchronization therapy by QRS morphology in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT). Circulation 123(10):1061\u20131072","journal-title":"Circulation"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-017-1696-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-017-1696-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-017-1696-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T23:25:18Z","timestamp":1520033118000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-017-1696-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,19]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["1696"],"URL":"https:\/\/doi.org\/10.1007\/s11517-017-1696-9","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,19]]}}}