{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:10:49Z","timestamp":1777180249844,"version":"3.51.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["228415"],"award-info":[{"award-number":["228415"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNINETT Sigma2 AS","award":["NN9371K FEM"],"award-info":[{"award-number":["NN9371K FEM"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s11517-018-1884-2","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:15:17Z","timestamp":1534378517000},"page":"311-324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparison of titanium dioxide scaffold with commercial bone graft materials through micro-finite element modelling in flow perfusion"],"prefix":"10.1007","volume":"57","author":[{"given":"Xianbin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Tiainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-7233","authenticated-orcid":false,"given":"H\u00e5vard J.","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"key":"1884_CR1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1115\/1.2891235","volume":"113","author":"VC Mow","year":"1991","unstructured":"Mow VC, Ratcliffe A, Rosenwasser MP, Buckwalter JA (1991) Experimental studies on repair of large osteochondral defects at a high weight bearing area of the knee-joint\u2014a tissue engineering study. J Biomech Eng 113:198\u2013207. \n                    https:\/\/doi.org\/10.1115\/1.2891235","journal-title":"J Biomech Eng"},{"key":"1884_CR2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/jbm.a.35556","volume":"104","author":"HR Yan","year":"2016","unstructured":"Yan HR, Liu X, Zhu MH, Luo GL, Sun T, Peng Q, Zeng Y, Chen TJ, Wang YY, Liu KL, Feng B, Weng J, Wang JX (2016) Hybrid use of combined and sequential delivery of growth factors and ultrasound stimulation in porous multilayer composite scaffolds to promote both vascularization and bone formation in bone tissue engineering. J Biomed Mater Res A 104:195\u2013208. \n                    https:\/\/doi.org\/10.1002\/jbm.a.35556","journal-title":"J Biomed Mater Res A"},{"key":"1884_CR3","doi-asserted-by":"publisher","first-page":"5390","DOI":"10.1016\/j.actbio.2012.09.009","volume":"9","author":"HJ Haugen","year":"2013","unstructured":"Haugen HJ, Monjo M, Rubert M, Verket A, Lyngstadaas SP, Ellingsen JE, Ronold HJ, Wohlfahrt JC (2013) Porous ceramic titanium dioxide scaffolds promote bone formation in rabbit peri-implant cortical defect model. Acta Biomater 9:5390\u20135399. \n                    https:\/\/doi.org\/10.1016\/j.actbio.2012.09.009","journal-title":"Acta Biomater"},{"key":"1884_CR4","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","volume":"21","author":"DW Hutmacher","year":"2000","unstructured":"Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529\u20132543. \n                    https:\/\/doi.org\/10.1016\/S0142-9612(00)00121-6","journal-title":"Biomaterials"},{"key":"1884_CR5","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1096\/fj.04-2210fje","volume":"18","author":"JG McGarry","year":"2004","unstructured":"McGarry JG, Klein-Nulend J, Mullender MG, Prendergast PJ (2004) A comparison of strain and fluid shear stress in stimulating bone cell responses\u2014a computational and experimental study. FASEB J 18:482\u2013484. \n                    https:\/\/doi.org\/10.1096\/fj.04-2210fje","journal-title":"FASEB J"},{"key":"1884_CR6","doi-asserted-by":"publisher","first-page":"5544","DOI":"10.1016\/j.biomaterials.2007.09.003","volume":"28","author":"DP Byrne","year":"2007","unstructured":"Byrne DP, Lacroix D, Planell JA, Kelly DJ, Prendergast PJ (2007) Simulation of tissue differentiation in a scaffold as a function of porosity, Young\u2019s modulus and dissolution rate: application of mechanobiological models in tissue engineering. Biomaterials 28:5544\u20135554. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2007.09.003","journal-title":"Biomaterials"},{"key":"1884_CR7","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.jbiomech.2009.10.037","volume":"43","author":"AJF Stops","year":"2010","unstructured":"Stops AJF, Heraty KB, Browne M, O'Brien FJ, McHugh PE (2010) A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow. J Biomech 43:618\u2013626. \n                    https:\/\/doi.org\/10.1016\/j.jbiomech.2009.10.037","journal-title":"J Biomech"},{"key":"1884_CR8","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s10237-010-0256-0","volume":"10","author":"C Sandino","year":"2011","unstructured":"Sandino C, Lacroix D (2011) A dynamical study of the mechanical stimuli and tissue differentiation within a CaP scaffold based on micro-CT finite element models. Biomech Model Mechanobiol 10:565\u2013576. \n                    https:\/\/doi.org\/10.1007\/s10237-010-0256-0","journal-title":"Biomech Model Mechanobiol"},{"key":"1884_CR9","doi-asserted-by":"publisher","first-page":"011006","DOI":"10.1115\/1.4028985","volume":"137","author":"TA Metzger","year":"2015","unstructured":"Metzger TA, Kreipke TC, Vaughan TJ, McNamara LM, Niebur GL (2015) The in situ mechanics of trabecular bone marrow: the potential for mechanobiological response. J Biomech Eng 137:011006. \n                    https:\/\/doi.org\/10.1115\/1.4028985","journal-title":"J Biomech Eng"},{"key":"1884_CR10","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1016\/j.biomaterials.2009.04.026","volume":"30","author":"JL Milan","year":"2009","unstructured":"Milan JL, Planell JA, Lacroix D (2009) Computational modelling of the mechanical environment of osteogenesis within a polylactic acid-calcium phosphate glass scaffold. Biomaterials 30:4219\u20134226. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2009.04.026","journal-title":"Biomaterials"},{"key":"1884_CR11","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.1016\/j.biomaterials.2009.07.041","volume":"30","author":"AL Olivares","year":"2009","unstructured":"Olivares AL, Marshal E, Planell JA, Lacroix D (2009) Finite element study of scaffold architecture design and culture conditions for tissue engineering. Biomaterials 30:6142\u20136149. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2009.07.041","journal-title":"Biomaterials"},{"key":"1884_CR12","doi-asserted-by":"publisher","unstructured":"Lin LL, Lu YJ, Fang ML (2015) Computational modeling of the fluid mechanical environment of regular and irregular scaffolds. Int J Control Autom 12:529\u2013539. \n                    https:\/\/doi.org\/10.1007\/s11633-014-0873-7","DOI":"10.1007\/s11633-014-0873-7"},{"key":"1884_CR13","doi-asserted-by":"publisher","first-page":"8320","DOI":"10.1016\/j.ceramint.2015.03.004","volume":"41","author":"A Farzadi","year":"2015","unstructured":"Farzadi A, Waran V, Solati-Hashjin M, Rahman ZAA, Asadi M, Abu Osman NA (2015) Effect of layer printing delay on mechanical properties and dimensional accuracy of 3D printed porous prototypes in bone tissue engineering. Ceram Int 41:8320\u20138330. \n                    https:\/\/doi.org\/10.1016\/j.ceramint.2015.03.004","journal-title":"Ceram Int"},{"key":"1884_CR14","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.actbio.2010.02.002","volume":"6","author":"S Eshraghi","year":"2010","unstructured":"Eshraghi S, Das S (2010) Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering. Acta Biomater 6:2467\u20132476. \n                    https:\/\/doi.org\/10.1016\/j.actbio.2010.02.002","journal-title":"Acta Biomater"},{"key":"1884_CR15","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1016\/j.jeurceramsoc.2009.03.017","volume":"29","author":"G Fostad","year":"2009","unstructured":"Fostad G, Hafell B, Forde A, Dittmann R, Sabetrasekh R, Will J, Ellingsen JE, Lyngstadaas SP, Haugen HJ (2009) Loadable TiO2 scaffolds-a correlation study between processing parameters, micro CT analysis and mechanical strength. J Eur Ceram Soc 29:2773\u20132781. \n                    https:\/\/doi.org\/10.1016\/j.jeurceramsoc.2009.03.017","journal-title":"J Eur Ceram Soc"},{"key":"1884_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jeurceramsoc.2012.08.016","volume":"33","author":"H Tiainen","year":"2013","unstructured":"Tiainen H, Wiedmer D, Haugen HJ (2013) Processing of highly porous TiO2 bone scaffolds with improved compressive strength. J Eur Ceram Soc 33:15\u201324. \n                    https:\/\/doi.org\/10.1016\/j.jeurceramsoc.2012.08.016","journal-title":"J Eur Ceram Soc"},{"key":"1884_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5277\/Abb-00129-2014-02","volume":"17","author":"L Rumian","year":"2015","unstructured":"Rumian L, Reczynska K, Wrona M, Tiainen H, Haugen HJ, Pamula E (2015) The influence of sintering conditions on microstructure and mechanical properties of titanium dioxide scaffolds for the treatment of bone tissue defects. Acta Bioeng Biomech 17:3\u20139. \n                    https:\/\/doi.org\/10.5277\/Abb-00129-2014-02","journal-title":"Acta Bioeng Biomech"},{"key":"1884_CR18","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1177\/0885328214559859","volume":"29","author":"B Muller","year":"2015","unstructured":"Muller B, Reseland JE, Haugen HJ, Tiainen H (2015) Cell growth on pore-graded biomimetic TiO2 bone scaffolds. J Biomater Appl 29:1284\u20131295. \n                    https:\/\/doi.org\/10.1177\/0885328214559859","journal-title":"J Biomater Appl"},{"key":"1884_CR19","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1111\/clr.12725","volume":"27","author":"A Verket","year":"2016","unstructured":"Verket A, Muller B, Wohlfahrt JC, Lyngstadaas SP, Ellingsen JE, Jostein Haugen H, Tiainen H (2016) TiO2 scaffolds in peri-implant dehiscence defects: an experimental pilot study. Clin Oral Implants Res 27:1200\u20131206. \n                    https:\/\/doi.org\/10.1111\/clr.12725","journal-title":"Clin Oral Implants Res"},{"key":"1884_CR20","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1177\/0885328209354925","volume":"25","author":"R Sabetrasekh","year":"2011","unstructured":"Sabetrasekh R, Tiainen H, Lyngstadaas SP, Reseland J, Haugen H (2011) A novel ultra-porous titanium dioxide ceramic with excellent biocompatibility. J Biomater Appl 25:559\u2013580. \n                    https:\/\/doi.org\/10.1177\/0885328209354925","journal-title":"J Biomater Appl"},{"key":"1884_CR21","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.1016\/j.biomaterials.2005.02.002","volume":"26","author":"V Karageorgiou","year":"2005","unstructured":"Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26:5474\u20135491. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2005.02.002","journal-title":"Biomaterials"},{"key":"1884_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bone.2015.07.007","volume":"81","author":"E Garcia-Gareta","year":"2015","unstructured":"Garcia-Gareta E, Coathup MJ, Blunn GW (2015) Osteoinduction of bone grafting materials for bone repair and regeneration. Bone 81:112\u2013121. \n                    https:\/\/doi.org\/10.1016\/j.bone.2015.07.007","journal-title":"Bone"},{"key":"1884_CR23","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1111\/clr.12722","volume":"27","author":"JE Mate Sanchez de Val","year":"2016","unstructured":"Mate Sanchez de Val JE, Calvo-Guirado JL, Gomez-Moreno G, Perez-Albacete Martinez C, Mazon P, De Aza PN (2016) Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reaction in vivo. Part A: synthesis, characterization of the materials, and SEM analysis. Clin Oral Implants Res 27:1331\u20131338. \n                    https:\/\/doi.org\/10.1111\/clr.12722","journal-title":"Clin Oral Implants Res"},{"key":"1884_CR24","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1016\/j.actbio.2012.02.020","volume":"8","author":"H Tiainen","year":"2012","unstructured":"Tiainen H, Wohlfahrt JC, Verket A, Lyngstadaas SP, Haugen HJ (2012) Bone formation in TiO2 bone scaffolds in extraction sockets of minipigs. Acta Biomater 8:2384\u20132391. \n                    https:\/\/doi.org\/10.1016\/j.actbio.2012.02.020","journal-title":"Acta Biomater"},{"key":"1884_CR25","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/bit.22277","volume":"103","author":"F Maes","year":"2009","unstructured":"Maes F, Ransbeeck P, Van Oosterwyck H, Verdonck P (2009) Modeling fluid flow through irregular scaffolds for perfusion bioreactors. Biotechnol Bioeng 103:621\u2013630. \n                    https:\/\/doi.org\/10.1002\/bit.22277","journal-title":"Biotechnol Bioeng"},{"key":"1884_CR26","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/bit.21955","volume":"101","author":"RM Schulz","year":"2008","unstructured":"Schulz RM, Wustneck N, van Donkelaar CC, Shelton JC, Bader A (2008) Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnol Bioeng 101:714\u2013728. \n                    https:\/\/doi.org\/10.1002\/bit.21955","journal-title":"Biotechnol Bioeng"},{"key":"1884_CR27","doi-asserted-by":"publisher","unstructured":"Zhang XB, Gong H (2015) Simulation on tissue differentiations for different architecture designs in bone tissue engineering scaffold based on cellular structure model. J Mech Med Biol 15. \n                    https:\/\/doi.org\/10.1142\/S0219519415500281","DOI":"10.1142\/S0219519415500281"},{"key":"1884_CR28","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0021-9290(97)00016-X","volume":"30","author":"MJ Grimm","year":"1997","unstructured":"Grimm MJ, Williams JL (1997) Measurements of permeability in human calcaneal trabecular bone. J Biomech 30:743\u2013745. \n                    https:\/\/doi.org\/10.1016\/S0021-9290(97)00016-X","journal-title":"J Biomech"},{"key":"1884_CR29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1114\/1.195","volume":"27","author":"EA Nauman","year":"1999","unstructured":"Nauman EA, Fong KE, Keaveny TM (1999) Dependence of intertrabecular permeability on flow direction and anatomic site. Ann Biomed Eng 27:517\u2013524. \n                    https:\/\/doi.org\/10.1114\/1.195","journal-title":"Ann Biomed Eng"},{"key":"1884_CR30","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1016\/j.jbiomech.2012.06.020","volume":"45","author":"TR Coughlin","year":"2012","unstructured":"Coughlin TR, Niebur GL (2012) Fluid shear stress in trabecular bone marrow due to low-magnitude high-frequency vibration. J Biomech 45:2222\u20132229. \n                    https:\/\/doi.org\/10.1016\/j.jbiomech.2012.06.020","journal-title":"J Biomech"},{"key":"1884_CR31","doi-asserted-by":"publisher","unstructured":"Miranda P, Pajares A, Guiberteau F (2008) Finite element modeling as a tool for predicting the fracture behaviour of robocast scaffolds. Acta Biomater 4:1715\u20131724. \n                    https:\/\/doi.org\/10.1016\/j.actbio.2008.05.020","DOI":"10.1016\/j.actbio.2008.05.020"},{"key":"1884_CR32","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1007\/s10439-014-1135-0","volume":"43","author":"E Birmingham","year":"2015","unstructured":"Birmingham E, Kreipke TC, Dolan EB, Coughlin TR, Owens P, McNamara LM, Niebur GL, McHugh PE (2015) Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants. Ann Biomed Eng 43:1036\u20131050. \n                    https:\/\/doi.org\/10.1007\/s10439-014-1135-0","journal-title":"Ann Biomed Eng"},{"key":"1884_CR33","doi-asserted-by":"publisher","unstructured":"Ebrahimian-Hosseinabadi M, Ashrafizadeh F, Etemadifar M, Venkatraman SS (2011) Evaluating and modeling the mechanical properties of the prepared PLGA\/nano-BCP composite scaffolds for bone tissue engineering. J Mater Sci Technol 27:1105\u20131112. \n                    https:\/\/doi.org\/10.1016\/S1005-0302(12)60004-8","DOI":"10.1016\/S1005-0302(12)60004-8"},{"key":"1884_CR34","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.jbiomech.2007.12.011","volume":"41","author":"C Sandino","year":"2008","unstructured":"Sandino C, Planell JA, Lacroix D (2008) A finite element study of mechanical stimuli in scaffolds for bone tissue engineering. J Biomech 41:1005\u20131014. \n                    https:\/\/doi.org\/10.1016\/j.jbiomech.2007.12.011","journal-title":"J Biomech"},{"key":"1884_CR35","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/10255842.2010.539563","volume":"15","author":"JCM Teo","year":"2012","unstructured":"Teo JCM, Teoh SH (2012) Permeability study of vertebral cancellous bone using micro-computational fluid dynamics. Comput Methods Biomech Biomed Engin 15:417\u2013423. \n                    https:\/\/doi.org\/10.1080\/10255842.2010.539563","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"1884_CR36","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s10439-012-0714-1","volume":"41","author":"E Birmingham","year":"2013","unstructured":"Birmingham E, Grogan JA, Niebur GL, McNamara LM, McHugh PE (2013) Computational modelling of the mechanics of trabecular bone and marrow using fluid structure interaction techniques. Ann Biomed Eng 41:814\u2013826. \n                    https:\/\/doi.org\/10.1007\/s10439-012-0714-1","journal-title":"Ann Biomed Eng"},{"key":"1884_CR37","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.actbio.2014.12.021","volume":"15","author":"FJ Martinez-Vazquez","year":"2015","unstructured":"Martinez-Vazquez FJ, Cabanas MV, Paris JL, Lozano D, Vallet-Regi M (2015) Fabrication of novel si-doped hydroxyapatite\/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration. Acta Biomater 15:200\u2013209. \n                    https:\/\/doi.org\/10.1016\/j.actbio.2014.12.021","journal-title":"Acta Biomater"},{"key":"1884_CR38","doi-asserted-by":"publisher","first-page":"4208","DOI":"10.1016\/j.actbio.2010.06.012","volume":"6","author":"FPW Melchels","year":"2010","unstructured":"Melchels FPW, Barradas AMC, van Blitterswijk CA, de Boer J, Feijen J, Grijpma DW (2010) Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing. Acta Biomater 6:4208\u20134217. \n                    https:\/\/doi.org\/10.1016\/j.actbio.2010.06.012","journal-title":"Acta Biomater"},{"key":"1884_CR39","doi-asserted-by":"publisher","first-page":"5892","DOI":"10.1016\/j.biomaterials.2006.08.013","volume":"27","author":"B Otsuki","year":"2006","unstructured":"Otsuki B, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T (2006) Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: three-dimensional micro-CT based structural analyses of porous bioactive titanium implants. Biomaterials 27:5892\u20135900. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2006.08.013","journal-title":"Biomaterials"},{"key":"1884_CR40","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.biomaterials.2008.10.056","volume":"30","author":"AC Jones","year":"2009","unstructured":"Jones AC, Arns CH, Hutmacher DW, Milthorpe BK, Sheppard AP, Knackstedt MA (2009) The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth. Biomaterials 30:1440\u20131451. \n                    https:\/\/doi.org\/10.1016\/j.biomaterials.2008.10.056","journal-title":"Biomaterials"},{"key":"1884_CR41","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1093\/oxfordjournals.jbchem.a021589","volume":"121","author":"E Tsuruga","year":"1997","unstructured":"Tsuruga E, Takita H, Itoh H, Wakisaka Y, Kuboki Y (1997) Pore size of porous hydroxyapatite as the cell-substratum controls BMP-induced osteogenesis. J Biochem 121:317\u2013324. \n                    https:\/\/doi.org\/10.1093\/oxfordjournals.jbchem.a021589","journal-title":"J Biochem"},{"key":"1884_CR42","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10856-008-3597-9","volume":"20","author":"JR Jones","year":"2009","unstructured":"Jones JR, Atwood RC, Poologasundarampillai G, Yue S, Lee PD (2009) Quantifying the 3D macrostructure of tissue scaffolds. J Mater Sci Mater Med 20:463\u2013471. \n                    https:\/\/doi.org\/10.1007\/s10856-008-3597-9","journal-title":"J Mater Sci Mater Med"},{"key":"1884_CR43","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1089\/ten.tea.2010.0560","volume":"17","author":"AG Mitsak","year":"2011","unstructured":"Mitsak AG, Kemppainen JM, Harris MT, Hollister SJ (2011) Effect of polycaprolactone scaffold permeability on bone regeneration in vivo. Tissue Eng Part A 17:1831\u20131839. \n                    https:\/\/doi.org\/10.1089\/ten.tea.2010.0560","journal-title":"Tissue Eng Part A"},{"key":"1884_CR44","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1089\/ten.tec.2010.0069","volume":"16","author":"S Impens","year":"2010","unstructured":"Impens S, Chen YT, Mullens S, Luyten F, Schrooten J (2010) Controlled cell-seeding methodologies: a first step toward clinically relevant bone tissue engineering strategies. Tissue Eng Part C Methods 16:1575\u20131583. \n                    https:\/\/doi.org\/10.1089\/ten.tec.2010.0069","journal-title":"Tissue Eng Part C Methods"},{"key":"1884_CR45","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/jbm.b.31568","volume":"93b","author":"CG Jeong","year":"2010","unstructured":"Jeong CG, Hollister SJ (2010) Mechanical, permeability, and degradation properties of 3D designed poly(1,8 octanediol-co-citrate) scaffolds for soft tissue engineering. J Biomed Mater Res B 93b:141\u2013149. \n                    https:\/\/doi.org\/10.1002\/jbm.b.31568","journal-title":"J Biomed Mater Res B"},{"key":"1884_CR46","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0021-9290(95)00010-0","volume":"29","author":"PW Hui","year":"1996","unstructured":"Hui PW, Leung PC, Sher A (1996) Fluid conductance of cancellous bone graft as a predictor for graft-host interface healing. J Biomech 29:123\u2013132. \n                    https:\/\/doi.org\/10.1016\/0021-9290(95)00010-0","journal-title":"J Biomech"},{"key":"1884_CR47","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.bjoms.2005.05.001","volume":"44","author":"U Meyer","year":"2006","unstructured":"Meyer U, Buchter A, Nazer N, Wiesmann HP (2006) Design and performance of a bioreactor system for mechanically promoted three-dimensional tissue engineering. Brit J Oral Maxillofac Surg 44:134\u2013140. \n                    https:\/\/doi.org\/10.1016\/j.bjoms.2005.05.001","journal-title":"Brit J Oral Maxillofac Surg"},{"key":"1884_CR48","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.jbiomech.2004.12.022","volume":"39","author":"F Boschetti","year":"2006","unstructured":"Boschetti F, Raimondi MT, Migliavacca F, Dubini G (2006) Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors. J Biomech 39:418\u2013425. \n                    https:\/\/doi.org\/10.1016\/j.jbiomech.2004.12.022","journal-title":"J Biomech"},{"key":"1884_CR49","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00223-010-9448-y","volume":"88","author":"N Case","year":"2011","unstructured":"Case N, Sen B, Thomas JA, Styner M, Xie Z, Jacobs CR, Rubin J (2011) Steady and oscillatory fluid flows produce a similar osteogenic phenotype. Calcif Tissue Int 88:189\u2013197. \n                    https:\/\/doi.org\/10.1007\/s00223-010-9448-y","journal-title":"Calcif Tissue Int"},{"key":"1884_CR50","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10237-002-0007-y","volume":"1","author":"MT Raimondi","year":"2002","unstructured":"Raimondi MT, Boschetti F, Falcone L, Fiore GB, Remuzzi A, Marinoni E, Marazzi M, Pietrabissa R (2002) Mechanobiology of engineered cartilage cultured under a quantified fluid-dynamic environment. Biomech Model Mechanobiol 1:69\u201382. \n                    https:\/\/doi.org\/10.1007\/s10237-002-0007-y","journal-title":"Biomech Model Mechanobiol"},{"key":"1884_CR51","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1089\/10763270360728107","volume":"9","author":"SH Cartmell","year":"2003","unstructured":"Cartmell SH, Porter BD, Garcia AJ, Guldberg RE (2003) Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro. Tissue Eng 9:1197\u20131203. \n                    https:\/\/doi.org\/10.1089\/10763270360728107","journal-title":"Tissue Eng"},{"key":"1884_CR52","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1902\/jop.2000.71.6.1015","volume":"71","author":"Z Artzi","year":"2000","unstructured":"Artzi Z, Tal H, Dayan D (2000) Porous bovine bone mineral in healing of human extraction sockets. Part 1: Histomorphometric evaluations at 9 months. J Periodontol 71:1015\u20131023. \n                    https:\/\/doi.org\/10.1902\/jop.2000.71.6.1015","journal-title":"J Periodontol"},{"key":"1884_CR53","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1600-051X.2005.00692.x","volume":"32","author":"G Cardaropoli","year":"2005","unstructured":"Cardaropoli G, Ara\u00fajo M, Hayacibara R, Sukekava F, Lindhe J (2005) Healing of extraction sockets and surgically produced-augmented and non-augmented-defects in the alveolar ridge. An experimental study in the dog. J Clin Periodontol 32:435\u2013440. \n                    https:\/\/doi.org\/10.1111\/j.1600-051X.2005.00692.x","journal-title":"J Clin Periodontol"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-018-1884-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-018-1884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-018-1884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T01:42:40Z","timestamp":1569289360000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-018-1884-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["1884"],"URL":"https:\/\/doi.org\/10.1007\/s11517-018-1884-2","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,16]]},"assertion":[{"value":"25 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Tiainen and Haugen hold patents behind the technology for the TiO\n            2\n            scaffolds (EP Patent 2,121,053, US Patent 9,629,941, US Patent App. 14\/427,901, US Patent App. 14\/427,683 and US Patent App. 14\/427,854). The rights for these patents are shared between the University of Oslo and Corticalis AS. Haugen is a shareholder and board member of Corticalis AS.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}