{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:23:06Z","timestamp":1776784986470,"version":"3.51.2"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s11517-020-02185-x","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T22:02:41Z","timestamp":1591740161000},"page":"1831-1843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Coronary arteries hemodynamics: effect of arterial geometry on hemodynamic parameters causing atherosclerosis"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-1105","authenticated-orcid":false,"given":"Kelvin K. L.","family":"Wong","sequence":"first","affiliation":[]},{"given":"Jianhuang","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Guiying","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Wenhua","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Dhanjoo N.","family":"Ghista","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"2185_CR1","doi-asserted-by":"crossref","unstructured":"Wong, K.K.L., Ghista, D.N.,Wu, J., Li, G. Simulation of blood flow in idealized and patient-specific coronary arteries with curvatures, stenoses, dilatations and side-branches, in Cardiology Science and Technology, by Dhanjoo N. Ghista, CRC Press, Taylor & Francis Group, 2016","DOI":"10.1201\/b18553-16"},{"key":"2185_CR2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jcp.2015.11.022","volume":"305","author":"R Mittal","year":"2016","unstructured":"Mittal R, Seo JH, Vedula V, Choi YJ, Liu H, Huang HH, Jain S, Younes L, Abraham T, George RT (2016) Computational modeling of cardiac hemodynamics: current status and future outlook. J Comput Phys 305:1065\u20131082","journal-title":"J Comput Phys"},{"issue":"4","key":"2185_CR3","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jbiomech.2004.12.026","volume":"39","author":"JV Soulis","year":"2006","unstructured":"Soulis JV, Farmakis TM, Giannoglou GD, Louridas GE (2006) Wall shear stress in normal left coronary artery tree. J Biomech Eng 39(4):742\u2013749","journal-title":"J Biomech Eng"},{"key":"2185_CR4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0021-9290(97)00118-8","volume":"31","author":"K Perktold","year":"1998","unstructured":"Perktold K, Hofer M, Rappitsch G, Loew M, Kuban BD, Friedman MH (1998) Validated computation of physiologic flow in a realistic coronary artery branch. J Biomech 31:217\u2013228","journal-title":"J Biomech"},{"key":"2185_CR5","doi-asserted-by":"crossref","first-page":"A15816","DOI":"10.1161\/circ.132.suppl_3.15816","volume":"132","author":"A Starikov","year":"2015","unstructured":"Starikov A, Xiong G, Min JK (2015) Normal distribution of wall shear stress in the coronary arteries. Circulation. 132:A15816","journal-title":"Circulation."},{"issue":"2","key":"2185_CR6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbe.2018.01.004","volume":"38","author":"Z Tyfa","year":"2018","unstructured":"Tyfa Z, Obidowski D, Reorowicz P, Stefa\u0144czyk L, Fortuniak J, J\u00f3\u017awik K (2018) Numerical simulations of the pulsatile blood flow in the different types of arterial fenestrations: comparable analysis of multiple vascular geometries. Biocybernetics Biomed Eng 38(2):228\u2013242","journal-title":"Biocybernetics Biomed Eng"},{"key":"2185_CR7","first-page":"Article number:","volume":"7","author":"Y Yang","year":"2017","unstructured":"Yang Y, Liu X, Xia Y, Liu X et al (2017) Impact of spatial characteristics in the left stenotic coronary artery on the hemodynamics and visualization of 3D replica models. Sci Rep 7:Article number: 15452","journal-title":"Sci Rep"},{"key":"2185_CR8","first-page":"1","volume":"99","author":"M Qian","year":"2014","unstructured":"Qian M, Niu L, Wong KKL, Abbott D, Zhou Q, Zheng H (2014) Pulsatile flow characterization in a vessel phantom with elastic wall using ultrasonic particle image velocimetry technique: the impact of vessel stiffness on flow dynamics. IEEE Trans Biomed Eng 99:1\u20137","journal-title":"IEEE Trans Biomed Eng"},{"issue":"16","key":"2185_CR9","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1080\/10255842.2014.976812","volume":"18","author":"J Wu","year":"2014","unstructured":"Wu J, Liu G, Huang W, Ghista DN, Wong KKL (2014) Transient blood flow in elastic coronary arteries with varying degrees of stenosis and dilatations: CFD modelling and parametric study. Comput Methods Biomech Biomed Eng 18(16):1835\u20131845","journal-title":"Comput Methods Biomech Biomed Eng"},{"key":"2185_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1166\/jmihi.2014.1215","volume":"4","author":"G Liu","year":"2014","unstructured":"Liu G, Wu J, Huang W, Wu W, Zhang H, Wong KKL, Ghista DN (2014) Numerical simulation of flow in curved coronary arteries with progressive amounts of stenosis using fluid-structure interaction modelling. J Med Imaging Health Inform 4:1\u20137","journal-title":"J Med Imaging Health Inform"},{"key":"2185_CR11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.compbiomed.2015.06.009","volume":"64","author":"G Liu","year":"2015","unstructured":"Liu G, Wu J, Ghista DN, Huang W, Wong KKL (2015) Hemodynamic characterization of transient blood flow in right coronary arteries with varying curvature and side-branch bifurcation angles. Comput Biol Med 64:117\u2013126","journal-title":"Comput Biol Med"},{"issue":"2","key":"2185_CR12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0021-9150(99)00386-X","volume":"150","author":"SG Worthley","year":"2000","unstructured":"Worthley SG, Helft G, Fuster V, Fayad ZA, Fallon JT, Osende JI, Roque M, Shinnar M, Zaman AG, Rodriguez OJ (2000) High resolution ex vivo magnetic resonance imaging of in situ coronary and aortic atherosclerotic plaque in a porcine model. Atherosclerosis. 150(2):321\u2013329","journal-title":"Atherosclerosis."},{"issue":"6","key":"2185_CR13","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/01.CIR.101.6.586","volume":"101","author":"SG Worthley","year":"2000","unstructured":"Worthley SG, Helft G, Fuster V, Zaman AG, Fayad ZA, Fallon JT, Badimon JJ (2000) Serial in vivo mri documents arterial remodeling in experimental atherosclerosis. Circulation. 101(6):586\u2013589","journal-title":"Circulation."},{"issue":"1","key":"2185_CR14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1444-2892.2002.00107.x","volume":"11","author":"SG Worthley","year":"2002","unstructured":"Worthley SG, Omar-Farouque HM, Helft G, Meredith IT (2002) Coronary artery imaging in the new millennium. Heart Lung Circ 11(1):19\u201325","journal-title":"Heart Lung Circ"},{"key":"2185_CR15","first-page":"549","volume":"8","author":"AA Kalanuria","year":"2012","unstructured":"Kalanuria AA, Nyquist P, Ling G (2012) The prevention and regression of atherosclerotic plaques: emerging treatments. Vasc Health Risk Manag 8:549\u2013561","journal-title":"Vasc Health Risk Manag"},{"issue":"8","key":"2185_CR16","first-page":"927","volume":"5","author":"M Rafieian-Kopaei","year":"2014","unstructured":"Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H (2014) Atherosclerosis: process, indicators, risk factors and new hopes. Int J Prev Med 5(8):927\u2013946","journal-title":"Int J Prev Med"},{"issue":"1","key":"2185_CR17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1172\/JCI43713","volume":"122","author":"MR Alexander","year":"2012","unstructured":"Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK (2012) Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 122(1):70\u201379","journal-title":"J Clin Invest"},{"key":"2185_CR18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1115\/1.2798319","volume":"121","author":"JA Moore","year":"1999","unstructured":"Moore JA, Steinman DA, Prakash KW et al (1999) Numerical study of blood flow patterns in anatomically realistic and simplified end-to-side anastomoses. J Biomech Eng 121:265\u2013272","journal-title":"J Biomech Eng"},{"issue":"4","key":"2185_CR19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1055\/s-0034-1393964","volume":"31","author":"MA Bailey","year":"2014","unstructured":"Bailey MA, Griffin KJ, Scott DJA (2014) Clinical assessment of patients with peripheral arterial disease. Semin Interv Radiol 31(4):292\u2013299","journal-title":"Semin Interv Radiol"},{"issue":"2","key":"2185_CR20","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.surg.2014.03.035","volume":"156","author":"MS de Vos","year":"2014","unstructured":"de Vos MS, Bol BJ, Gravereaux EC, Hamming JF, Nguyen LL (2014) Treatment planning for peripheral arterial disease based on duplex ultrasonography and computed tomography angiography: consistency, confidence and the value of additional imaging. Surgery. 156(2):492\u2013502","journal-title":"Surgery."},{"issue":"Suppl 7","key":"2185_CR21","doi-asserted-by":"crossref","first-page":"M58","DOI":"10.1007\/s10406-006-0197-y","volume":"16","author":"D Fleischmann","year":"2006","unstructured":"Fleischmann D, Lammer J (2006) Peripheral CT angiography for interventional treatment planning. Eur Radiol 16(Suppl 7):M58\u2013M64","journal-title":"Eur Radiol"},{"key":"2185_CR22","first-page":"187","volume":"4","author":"B Pincombe","year":"2003","unstructured":"Pincombe B, Mazumdar JN (2003) Techniques for the study of blood flow through both constrictions and post-stenotic dilatations in arteries. Comput Methods Biophys Biomater Biotechnol Med Syst Algorithmic Develop Math Anal Diagn 4:187\u2013246","journal-title":"Comput Methods Biophys Biomater Biotechnol Med Syst Algorithmic Develop Math Anal Diagn"},{"issue":"5","key":"2185_CR23","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s10237-014-0563-y","volume":"13","author":"MU Qureshi","year":"2014","unstructured":"Qureshi MU, Vaughan GDA, Sainsbury C, Johnson M, Peskin CS, Olufsen MS, Hill NA (2014) Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation. Biomech Model Mechanobiol 13(5):1137\u20131154","journal-title":"Biomech Model Mechanobiol"},{"issue":"4","key":"2185_CR24","doi-asserted-by":"crossref","first-page":"e002543","DOI":"10.1161\/JAHA.112.002543","volume":"1","author":"P Eshtehardi","year":"2012","unstructured":"Eshtehardi P, McDaniel MC, Suo J, Dhawan SS, Timmins LH, Binongo J, Golub LJ, Corban MT, Finn AV, Oshinski JN, Quyyumi AA, Giddens DP, Samady H (2012) Association of coronary wall shear stress with atherosclerotic plaque burden, composition, and distribution in patients with coronary artery disease. J Am Heart Assoc 1(4):e002543","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"2185_CR25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3174\/ajnr.A2339","volume":"32","author":"Z Kulcs\u00e1r","year":"2011","unstructured":"Kulcs\u00e1r Z, Ugron \u00c1, Marosf\u0151i M, Berentei Z, Pa\u00e1l G, Szikora I (2011) Hemodynamics of cerebral aneurysm initiation: the role of wall shear stress and spatial wall shear stress gradient. Am J Neuroradiol 32(3):587\u2013594","journal-title":"Am J Neuroradiol"},{"issue":"3","key":"2185_CR26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1115\/1.3138280","volume":"103","author":"B Fox","year":"1981","unstructured":"Fox B, Seed W (1981) Location of early atheroma in the human coronary arteries. J Biomech Eng 103(3):208\u2013212","journal-title":"J Biomech Eng"},{"issue":"4","key":"2185_CR27","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/01.RES.66.4.1045","volume":"66","author":"T Asakura","year":"1990","unstructured":"Asakura T, Karino T (1990) Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ Res 66(4):1045\u20131066","journal-title":"Circ Res"},{"issue":"1","key":"2185_CR28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9150(00)00759-0","volume":"158","author":"ML Ojha","year":"2001","unstructured":"Ojha ML, Leask R, Butany J, Johnston KW (2001) Distribution of intimal and medial thickening in the human right coronary artery: a study of 17 RCAs. Atherosclerosis. 158(1):147\u2013153","journal-title":"Atherosclerosis."},{"issue":"4","key":"2185_CR29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1114\/1.1467679","volume":"30","author":"DA Steinman","year":"2002","unstructured":"Steinman DA (2002) Image-based CFD modeling in realistic arterial geometries. Ann Biomed Eng 30(4):483\u2013497","journal-title":"Ann Biomed Eng"},{"issue":"5","key":"2185_CR30","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1067\/mva.2003.122","volume":"37","author":"DA Steinman","year":"2003","unstructured":"Steinman DA, Vorp DA, Ethier CR (2003) Computational modeling of arterial biomechanics: insights into pathogenesis and treatment of vascular disease. J Vasc Surg 37(5):1118\u20131128","journal-title":"J Vasc Surg"},{"key":"2185_CR31","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/ejcts\/ezv480","volume":"49","author":"M Markl","year":"2016","unstructured":"Markl M, Wagner GJ, Barker AJ (2016) Re: blood flow analysis of the aortic arch using computational fluid dynamics. Eur J Cardiothorac Surg 49:1586\u20131587","journal-title":"Eur J Cardiothorac Surg"},{"issue":"3","key":"2185_CR32","first-page":"H1198","volume":"295","author":"N Hadjiloizou","year":"2008","unstructured":"Hadjiloizou N, Davies JE, Malik IS, Aguado-Sierra J, Willson K, Foale RA, Parker KH, Hughes AD, Francis DP, Mayet J (2008) Differences in cardiac microcirculatory wave patterns between the proximal left main stem and proximal RCA. Am J Phys Heart Circ Phys 295(3):H1198\u2013HH205","journal-title":"Am J Phys Heart Circ Phys"},{"issue":"5","key":"2185_CR33","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/cnm.1231","volume":"25","author":"R Torii","year":"2009","unstructured":"Torii R, Wood NB, Hadjiloizou N, Dowsey AW, Wright AR, Hughes AD, Davies J, Francis DP, Mayet J, Yang GZ (2009) Fluid\u2013structure interaction analysis of a patient-specific right coronary artery with physiological velocity and pressure waveforms. Commun Numer Methods Eng 25(5):565\u2013580","journal-title":"Commun Numer Methods Eng"},{"issue":"5","key":"2185_CR34","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jbiomech.2007.11.029","volume":"41","author":"D Bluestein","year":"2008","unstructured":"Bluestein D, Alemu Y, Avrahami I, Gharib M, Dumont K, Ricotta JJ, Einav S (2008) Influence of microcalcifications on vulnerable plaque mechanics using FSI modeling. J Biomech 41(5):1111\u20131118","journal-title":"J Biomech"},{"issue":"1","key":"2185_CR35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/01.CIR.0000078637.21322.D3","volume":"108","author":"JJ Wentzel","year":"2003","unstructured":"Wentzel JJ, Janssen E, Vos J, Schuurbiers JC, Krams R, Serruys PW, de Feyter PJ, Slager CJ (2003) Extension of increased atherosclerotic wall thickness into high shear stress regions is associated with loss of compensatory remodeling. Circulation. 108(1):17\u201323","journal-title":"Circulation."},{"issue":"17","key":"2185_CR36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.csbj.2014.07.004","volume":"10","author":"P Assemat","year":"2014","unstructured":"Assemat P, Siu KK, Armitage JA, Hokke SN, Dart A, Chin-Dusting J, Hourigan K (2014) Haemodynamical stress in mouse aortic arch with atherosclerotic plaques: preliminary study of plaque progression. Comput Struct Biotechnol J 10(17):98\u2013106","journal-title":"Comput Struct Biotechnol J"},{"issue":"7","key":"2185_CR37","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3174\/ajnr.A3558","volume":"35","author":"H Meng","year":"2014","unstructured":"Meng H, Tutino VM, Xiang J, Siddiqui A (2014) High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture: toward a unifying hypothesis. Am J Neuroradiol 35(7):1254\u20131262","journal-title":"Am J Neuroradiol"},{"issue":"11","key":"2185_CR38","doi-asserted-by":"crossref","first-page":"e0141880","DOI":"10.1371\/journal.pone.0141880","volume":"10","author":"A Millon","year":"2015","unstructured":"Millon A, Sigovan M, Boussel L, Mathevet J-L, Louzier V, Paquet C, Geloen A, Provost N, Majd Z, Patsouris D, Serusclat A, Canet-Soulas E (2015) Low WSS induces intimal thickening, while large WSS variation and inflammation induce medial thinning, in an animal model of atherosclerosis. PLoS One 10(11):e0141880","journal-title":"PLoS One"},{"issue":"4","key":"2185_CR39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1586\/erc.10.28","volume":"8","author":"SS Dhawan","year":"2010","unstructured":"Dhawan SS, Nanjundappa RPA, Branch JR, Taylor WR, Quyyumi AA, Jo H, McDaniel MC, Suo J, Giddens D, Samady H (2010) Shear stress and plaque development. Expert Rev Cardiovasc Ther 8(4):545\u2013556","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"7","key":"2185_CR40","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s10439-012-0695-0","volume":"41","author":"JM Dolan","year":"2013","unstructured":"Dolan JM, Kolega J, Meng H (2013) High wall shear stress and spatial gradients in vascular pathology: a review. Ann Biomed Eng 41(7):1411\u20131427","journal-title":"Ann Biomed Eng"},{"issue":"11","key":"2185_CR41","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/01.ATV.12.11.1254","volume":"12","author":"N DePaola","year":"1992","unstructured":"DePaola N, Gimbrone M, Davies PF, Dewey C (1992) Vascular endothelium responds to fluid shear stress gradients. Arterioscler Thromb Vasc Biol 12(11):1254\u20131257","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"16","key":"2185_CR42","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1016\/j.jbiomech.2007.06.023","volume":"40","author":"MX Li","year":"2007","unstructured":"Li MX, Beech-Brandt JJ, John LR, Hoskins PR, Easson WJ (2007) Numerical analysis of pulsatile blood flow and vessel wall mechanics in different degrees of stenoses. J Biomech 40(16):3715\u20133724","journal-title":"J Biomech"},{"issue":"1","key":"2185_CR43","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s11517-006-0113-6","volume":"44","author":"KKL Wong","year":"2006","unstructured":"Wong KKL, Mazumdar JN, Pincombe B, Worthley SG, Sanders P, Abbott D (2006) Theoretical modeling of micro-scale biological phenomena in human coronary arteries. Med Biol Eng Comput 44(1):971\u2013982","journal-title":"Med Biol Eng Comput"},{"issue":"22","key":"2185_CR44","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1161\/CIRCULATIONAHA.115.021168","volume":"133","author":"S Bangalore","year":"2016","unstructured":"Bangalore S, Guo Y, Samadashvili Z et al (2016) Revascularization in patients with multivessel coronary artery disease and severe left ventricular systolic dysfunction: everolimus-eluting stents versus coronary artery bypass graft surgery. Circulation 133(22):2132\u20132140","journal-title":"Circulation"},{"issue":"1","key":"2185_CR45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.amjcard.2017.03.261","volume":"120","author":"SH Kang","year":"2017","unstructured":"Kang SH, Lee CW, Baek S et al (2017) Comparison of outcomes of coronary artery bypass grafting versus drug-eluting stent implantation in patients with severe left ventricular dysfunction. Am J Cardiol 120(1):69\u201374","journal-title":"Am J Cardiol"},{"issue":"8","key":"2185_CR46","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jacc.2017.12.024","volume":"71","author":"J Nagendran","year":"2018","unstructured":"Nagendran J, Bozso SJ, Norris CM et al (2018) Coronary artery bypass surgery improves outcomes in patients with diabetes and left ventricular dysfunction. J Am Coll Cardiol 71(8):819\u2013827","journal-title":"J Am Coll Cardiol"},{"key":"2185_CR47","doi-asserted-by":"publisher","first-page":"105163","DOI":"10.1016\/j.cmpb.2019.105163","volume":"185","author":"B Arindam","year":"2019","unstructured":"Arindam B, Adel A, Himadri C et al (2019) Three dimensional numerical analysis of hemodynamic of Stenosed artery considering realistic outlet boundary conditions. Comput Methods Prog Biomed 185:105163. https:\/\/doi.org\/10.1016\/j.cmpb.2019.105163","journal-title":"Comput Methods Prog Biomed"},{"key":"2185_CR48","doi-asserted-by":"crossref","unstructured":"Tang D, Yang C, Zheng J, Woodard PK, Saffitz JE, Petruccelli JD, Sicard GA, Yuan C (2005) Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment. Ann Biomed Eng 33(12):1789\u20131801","DOI":"10.1007\/s10439-005-8267-1"},{"key":"2185_CR49","doi-asserted-by":"crossref","unstructured":"Severin J, Beckert K, Herwig H (2001) Spatial development of disturbances in plane Poiseuille flow: a direct numerical simulation using a commercial CFD code. Int J Heat Mass Transf 44(22):4359\u20134367","DOI":"10.1016\/S0017-9310(01)00074-6"}],"container-title":["Medical &amp; Biological Engineering &amp; Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-020-02185-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11517-020-02185-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-020-02185-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T13:10:46Z","timestamp":1666876246000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11517-020-02185-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["2185"],"URL":"https:\/\/doi.org\/10.1007\/s11517-020-02185-x","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"assertion":[{"value":"9 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This study was approved by the Research Ethics Committee in our institution. All ethical procedures conformed to the principles of 1964 Declaration of Helsinki and its latest 2008 amendments. All eligible patients were informed of the purpose and nature of the study, and the written informed consent was obtained from all participants beforehand.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that there is no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}