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The relation between quantitative EEG parameters in pre-thrombolysis hyper-acute phase and outcomes has still to be investigated. Hence, possible correlations between early EEG biomarkers, measured on bedside wireless EEG, and short-term\/long-term functional and morphological outcomes were investigated in thrombolysis-treated strokes. EEG with a wireless device was performed in 20 patients with hyper-acute (&lt;\u20094.5\u00a0h from onset) anterior ischemic stroke before reperfusion treatment. The correlations between outcome parameters (i.e., 7-day\/12-month National Institutes of Health Stroke Scale NIHSS, 12-month modified Rankin Scale mRS, final infarct volume) and the\u00a0pre-treatment EEG parameters were studied. Relative delta power and alpha power, delta\/alpha (DAR), and (delta+theta)\/(alpha+beta) (DTABR) ratios significantly correlated with NIHSS 7-day (rho\u2009=\u20090.80, \u2212\u20090.81, 0.76, 0.75, respectively) and NIHSS 12-month (0.73, \u2212\u20090.78, 0.74, 0.73, respectively), as well as with final infarct volume (0.75, \u2212\u20090.70, 0.78, 0.62, respectively). A good outcome in terms of mRS\u2009\u2264\u20092 at 12\u00a0months was associated with DAR parameter (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). The neurophysiological biomarkers obtained by non-invasive and portable technique as wireless EEG in the early pre-treatment phase may contribute as objective parameters to the short\/long-term outcome prediction pivotal to better establish the treatment strategies.<\/jats:p><jats:p>Graphical abstract<\/jats:p>","DOI":"10.1007\/s11517-020-02280-z","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T02:02:30Z","timestamp":1607047350000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Hyper-acute EEG alterations predict functional and morphological outcomes in thrombolysis-treated ischemic stroke: a wireless EEG study"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-4360","authenticated-orcid":false,"given":"Milo\u0161","family":"Aj\u010devi\u0107","sequence":"first","affiliation":[]},{"given":"Giovanni","family":"Furlanis","sequence":"additional","affiliation":[]},{"given":"Marcello","family":"Naccarato","sequence":"additional","affiliation":[]},{"given":"Aleksandar","family":"Miladinovi\u0107","sequence":"additional","affiliation":[]},{"given":"Alex","family":"Buoite Stella","sequence":"additional","affiliation":[]},{"given":"Paola","family":"Caruso","sequence":"additional","affiliation":[]},{"given":"Tommaso","family":"Cillotto","sequence":"additional","affiliation":[]},{"given":"Agostino","family":"Accardo","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Manganotti","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"2280_CR1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1212\/wnl.53.1.126","volume":"53","author":"HPJ Adams","year":"1999","unstructured":"Adams HPJ, Davis PH, Leira EC et al (1999) Baseline NIH Stroke Scale score strongly predicts outcome after stroke: a report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). 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