{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:16:33Z","timestamp":1740143793826,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100010665","name":"H2020 Marie Skłodowska-Curie Actions","doi-asserted-by":"publisher","award":["No 722022 \u201dAffecTech"],"award-info":[{"award-number":["No 722022 \u201dAffecTech"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012958","name":"Minist\u00e8re de l\u2019Education Nationale, de la Formation professionnelle, de l\u2019Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","award":["CrossLab"],"award-info":[{"award-number":["CrossLab"]}],"id":[{"id":"10.13039\/100012958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s11517-020-02311-9","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:04:46Z","timestamp":1614902686000},"page":"775-785","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantifying multidimensional control mechanisms of cardiovascular dynamics during multiple concurrent stressors"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-9489","authenticated-orcid":false,"given":"Shadi","family":"Ghiasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Greco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Faes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Javorka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo Pasquale","family":"Scilingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Valenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"unstructured":"Hainsworth R (1995) The control and physiological importance of heart rate. Heart Rate Var 3\u20139","key":"2311_CR1"},{"issue":"25","key":"2311_CR2","doi-asserted-by":"publisher","first-page":"10 503","DOI":"10.1523\/JNEUROSCI.1103-13.2013","volume":"33","author":"F Beissner","year":"2013","unstructured":"Beissner F, Meissner K, B\u00e4r K-J, Napadow V (2013) The autonomic brain: an activation likelihood estimation meta-analysis for central processing of autonomic function. J Neurosci 33(25):10 503\u201310 511","journal-title":"J Neurosci"},{"key":"2311_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.brainres.2017.12.024","volume":"1681","author":"L Wei","year":"2018","unstructured":"Wei L, Chen H, Wu G-R (2018) Heart rate variability associated with grey matter volumes in striatal and limbic structures of the central autonomic network. Brain Res 1681:14\u201320","journal-title":"Brain Res"},{"issue":"10","key":"2311_CR4","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/S0025-6196(12)62272-1","volume":"68","author":"EE Benarroch","year":"1993","unstructured":"Benarroch EE (1993) The central autonomic network: functional organization, dysfunction, and perspective. Mayo Clin Proc 68(10):988\u20131001. Elsevier","journal-title":"Mayo Clin Proc"},{"doi-asserted-by":"crossref","unstructured":"de la Cruz F, Schumann A, K\u00f6hler S, Reichenbach JR, Wagner G, B\u00e4r K-J (2019) The relationship between heart rate and functional connectivity of brain regions involved in autonomic control. NeuroImage","key":"2311_CR5","DOI":"10.1016\/j.neuroimage.2019.04.014"},{"unstructured":"Sklerov M, Dayan E, Browner N (2018) Functional neuroimaging of the central autonomic network: recent developments and clinical implications. Clin Auton Res 1\u201312","key":"2311_CR6"},{"issue":"2","key":"2311_CR7","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.neubiorev.2011.11.009","volume":"36","author":"JF Thayer","year":"2012","unstructured":"Thayer JF, \u00c5hs F, Fedrikson M, Sollers JJ III, Wager TD (2012) A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev 36(2):747\u2013756","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"2311_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.neubiorev.2008.08.004","volume":"33","author":"JF Thayer","year":"2009","unstructured":"Thayer JF, Lane RD (2009) Claude bernard and the heart\u2013brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev 33(2):81\u201388","journal-title":"Neurosci Biobehav Rev"},{"issue":"16","key":"2311_CR9","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1161\/01.CIR.103.16.2072","volume":"103","author":"MT La Rovere","year":"2001","unstructured":"La Rovere MT, et al. (2001) Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials. Circulation 103(16):2072\u20132077","journal-title":"Circulation"},{"issue":"4","key":"2311_CR10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1046\/j.1440-1681.2002.03640.x","volume":"29","author":"R Dampney","year":"2002","unstructured":"Dampney R, Coleman M, Fontes M, Hirooka Y, Horiuchi J, Li Y. -W., Polson J, Potts P, Tagawa T (2002) Central mechanisms underlying short-and long-term regulation of the cardiovascular system. Clin Exp Pharmacol Physiol 29(4):261\u2013268","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1","key":"2311_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10558-007-9046-4","volume":"8","author":"JM Karemaker","year":"2008","unstructured":"Karemaker JM, Wesseling KH (2008) Variability in cardiovascular control: the baroreflex reconsidered. Cardiovasc Eng 8(1):23\u201329","journal-title":"Cardiovasc Eng"},{"issue":"9","key":"2311_CR12","doi-asserted-by":"publisher","first-page":"822","DOI":"10.4065\/84.9.822","volume":"84","author":"N Charkoudian","year":"2009","unstructured":"Charkoudian N, Rabbitts JA (2009) Sympathetic neural mechanisms in human cardiovascular health and disease. Mayo Clin Proc 84(9):822\u2013830. Elsevier","journal-title":"Mayo Clin Proc"},{"key":"2311_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-58709-7","volume-title":"Complexity and nonlinearity in cardiovascular signals","author":"R Barbieri","year":"2017","unstructured":"Barbieri R, Scilingo E, Valenza G (2017) Complexity and nonlinearity in cardiovascular signals. Springer, Berlin"},{"issue":"1","key":"2311_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0008-6363(02)00851-9","volume":"58","author":"J Hayano","year":"2003","unstructured":"Hayano J, Yasuma F (2003) Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system. Cardiovasc Res 58(1):1\u20139","journal-title":"Cardiovasc Res"},{"issue":"2","key":"2311_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.biopsycho.2005.11.014","volume":"74","author":"P Grossman","year":"2007","unstructured":"Grossman P, Taylor EW (2007) Toward understanding respiratory sinus arrhythmia: relations to cardiac vagal tone, evolution and biobehavioral functions. Biol Psychol 74(2):263\u2013285","journal-title":"Biol Psychol"},{"issue":"3","key":"2311_CR16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1136\/hrt.46.3.311","volume":"46","author":"J Atterh\u00f6g","year":"1981","unstructured":"Atterh\u00f6g J, Eliasson K, Hjemdahl P (1981) Sympathoadrenal and cardiovascular responses to mental stress, isometric handgrip, and cold pressor test in asymptomatic young men with primary t wave abnormalities in the electrocardiogram. Br Heart J 46(3):311","journal-title":"Br Heart J"},{"issue":"3","key":"2311_CR17","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1088\/0967-3334\/36\/3\/441","volume":"36","author":"R-C Peng","year":"2015","unstructured":"Peng R-C, Yan W-R, Zhou X-L, Zhang N-L, Lin W-H, Zhang Y-T (2015) Time-frequency analysis of heart rate variability during the cold pressor test using a time-varying autoregressive model. Physiol Meas 36(3):441","journal-title":"Physiol Meas"},{"issue":"1","key":"2311_CR18","doi-asserted-by":"publisher","first-page":"H702","DOI":"10.1152\/ajpheart.00006.2007","volume":"293","author":"A Porta","year":"2007","unstructured":"Porta A, Tobaldini E, Guzzetti S, Furlan R, Montano N, Gnecchi-Ruscone T (2007) Assessment of cardiac autonomic modulation during graded head-up tilt by symbolic analysis of heart rate variability. Am J Physiol Heart Circ Physiol 293(1):H702\u2013H708","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"2311_CR19","doi-asserted-by":"publisher","first-page":"R582","DOI":"10.1152\/ajpregu.00180.2016","volume":"311","author":"HF Posada-Quintero","year":"2016","unstructured":"Posada-Quintero HF, Florian JP, Orjuela-Ca\u00f1\u00f3n \u00c1D, Chon KH (2016) Highly sensitive index of sympathetic activity based on time-frequency spectral analysis of electrodermal activity, American Journal of Physiology-Regulatory. Integr Comp Physiol 311(3):R582\u2013R591","journal-title":"Integr Comp Physiol"},{"issue":"1","key":"2311_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-62225-2","volume":"10","author":"S Ghiasi","year":"2020","unstructured":"Ghiasi S, Greco A, Barbieri R, Scilingo E, Valenza G (2020) Assessing autonomic function from electrodermal activity and heart rate variability during cold-pressor test and emotional challenge. Sci Rep 10(1):1\u201313","journal-title":"Sci Rep"},{"issue":"3","key":"2311_CR21","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/psyp.12332","volume":"52","author":"JJ McGinley","year":"2015","unstructured":"McGinley JJ, Friedman BH (2015) Autonomic responses to lateralized cold pressor and facial cooling tasks. Psychophysiology 52(3):416\u2013424","journal-title":"Psychophysiology"},{"issue":"1","key":"2311_CR22","doi-asserted-by":"publisher","first-page":"83","DOI":"10.33549\/physiolres.931360","volume":"58","author":"L Mourot","year":"2009","unstructured":"Mourot L, Bouhaddi M, Regnard J (2009) Effects of the cold pressor test on cardiac autonomic control in normal subjects. Physiol Res 58(1):83","journal-title":"Physiol Res"},{"issue":"5","key":"2311_CR23","doi-asserted-by":"publisher","first-page":"H1717","DOI":"10.1152\/ajpheart.00899.2001","volume":"282","author":"J Cui","year":"2002","unstructured":"Cui J, Wilson TE, Crandall CG (2002) Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans. Am J Physiol Heart Circ Physiol 282(5):H1717\u2013H1723","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2311_CR24","doi-asserted-by":"publisher","first-page":"140 990","DOI":"10.1109\/ACCESS.2019.2944001","volume":"7","author":"PJ Bota","year":"2019","unstructured":"Bota PJ, Wang C, Fred AL, Da Silva HP (2019) A review, current challenges, and future possibilities on emotion recognition using machine learning and physiological signals. IEEE Access 7:140 990\u2013141 020","journal-title":"IEEE Access"},{"issue":"1","key":"2311_CR25","doi-asserted-by":"publisher","first-page":"H202","DOI":"10.1152\/ajpheart.00865.2009","volume":"298","author":"AE Aubert","year":"2009","unstructured":"Aubert AE, et al. (2009) Effects of mental stress on autonomic cardiac modulation during weightlessness. Am J Physiol Heart Circ Physiol 298(1):H202\u2013H209","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"2311_CR26","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s11517-016-1492-y","volume":"55","author":"M Javorka","year":"2017","unstructured":"Javorka M, et al. (2017) Causal analysis of short-term cardiovascular variability: state-dependent contribution of feedback and feedforward mechanisms. Med Biol Eng Comput 55(2):179\u2013190","journal-title":"Med Biol Eng Comput"},{"issue":"6","key":"2311_CR27","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1037\/h0077714","volume":"39","author":"JA Russell","year":"1980","unstructured":"Russell JA (1980) A circumplex model of affect. J Pers Soc Psychol 39(6):1161","journal-title":"J Pers Soc Psychol"},{"key":"2311_CR28","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1109\/TBME.1985.325532","volume":"3","author":"J Pan","year":"1985","unstructured":"Pan J, Tompkins WJ (1985) A real-time qrs detection algorithm. IEEE Trans Biomed Eng 3:230\u2013236","journal-title":"IEEE Trans Biomed Eng"},{"doi-asserted-by":"crossref","unstructured":"Valenza G, Greco A, Gentili C, Lanata A, Sebastiani L, Menicucci D, Gemignani A, Scilingo E (2016) Combining electroencephalographic activity and instantaneous heart rate for assessing brain\u2013heart dynamics during visual emotional elicitation in healthy subjects, vol 374","key":"2311_CR29","DOI":"10.1098\/rsta.2015.0176"},{"issue":"1","key":"2311_CR30","doi-asserted-by":"publisher","first-page":"H424","DOI":"10.1152\/ajpheart.00482.2003","volume":"288","author":"R Barbieri","year":"2005","unstructured":"Barbieri R et al (2005) A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability. Am J Physiol Heart Circ Physiol 288(1):H424\u2013H435","journal-title":"Am J Physiol Heart Circ Physiol"},{"doi-asserted-by":"crossref","unstructured":"Ghiasi S, Greco A, Faes L, Javorka M, Barbieri R, Scilingo E, Valenza G (2019) Quantification of different regulatory pathways contributing to heartbeat dynamics during multiple stimuli: a proof of the concept. In: 2019 41st Annual international conference of the IEEE engineering in medicine and biology society (EMBC). IEEE, pp 4934\u20134937","key":"2311_CR31","DOI":"10.1109\/EMBC.2019.8856461"},{"issue":"3","key":"2311_CR32","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1109\/TBME.2011.2180379","volume":"59","author":"A Porta","year":"2011","unstructured":"Porta A, Bassani T, Bari V, Pinna GD, Maestri R, Guzzetti S (2011) Accounting for respiration is necessary to reliably infer granger causality from cardiovascular variability series. IEEE Trans Biomed Eng 59(3):832\u2013841","journal-title":"IEEE Trans Biomed Eng"},{"doi-asserted-by":"crossref","unstructured":"Valenza G, Citi L, Saul JP, Barbieri R (2018) Measures of sympathetic and parasympathetic autonomic outflow from heartbeat dynamics. J Appl Physiol","key":"2311_CR33","DOI":"10.1152\/japplphysiol.00842.2017"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-020-02311-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11517-020-02311-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-020-02311-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T02:26:05Z","timestamp":1618885565000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11517-020-02311-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["2311"],"URL":"https:\/\/doi.org\/10.1007\/s11517-020-02311-9","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"type":"print","value":"0140-0118"},{"type":"electronic","value":"1741-0444"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"22 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}