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This study aims to present a computationally inexpensive algorithm based on the difference in pixel intensity between USI frames. During an offline experiment, where data was analyzed after the study, participants performed isometric contractions of the gastrocnemius medialis (GM) muscle, as executed (30% of maximum contraction) or attempted (low force contraction up to a point when the participant is aware of exerting force or contracting the muscle) movements, while USI, EMG, and force data were recorded. The algorithm achieved 99% agreement with EMG and force measurements for executed movements and 93% for attempted movements, with USI detecting 1.9% more contractions than the other methods. In the online study, participants performed GM muscle contractions at 10% and 30% of maximum contraction, while the algorithm provided visual feedback proportional to the muscle activity (based on USI recordings during the maximum contraction) in less than 3\u00a0s following each contraction. We show that the participants reached the target consistently, learning to perform precise contractions. The algorithm is reliable and computationally very efficient, allowing real-time applications on standard computing hardware. It is a suitable method for automated detection, quantification of muscle contraction, and to provide biofeedback which can be used for training of targeted muscles, making it suitable for rehabilitation.<\/jats:p>\n                <jats:p><jats:bold>Graphical abstract<\/jats:bold><\/jats:p>\n                <jats:p>Biofeedback session based on ultrasound imaging (USI) during muscle training. Novel, computationally inexpensive algorithm based on the difference in pixel intensity between USI frames is used to process the video and provide quantitative feedback on the strength of muscle contraction.<\/jats:p>","DOI":"10.1007\/s11517-021-02407-w","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T05:02:41Z","timestamp":1629090161000},"page":"1961-1971","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Automated semi-real-time detection of muscle activity with ultrasound imaging"],"prefix":"10.1007","volume":"59","author":[{"given":"Anna J.","family":"Sosnowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Vuckovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Gollee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"2407_CR1","doi-asserted-by":"crossref","unstructured":"Whittaker JL, Teyhen DS, Elliott JM, Cook K, Langevin HM, Dahl HH, Stokes M (2007) Rehabilitative ultrasound imaging: understanding the technology and its applications. 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