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In order to handle large simulation models of human bone, it is crucial to homogenize the trabecular structure regarding the mechanical behavior without losing information about the realistic material properties. Accordingly, morphology and fabric measurements of 60 vertebral cancellous bone samples from three osteoporotic lumbar spines were performed on the basis of X-ray microtomography (\u03bcCT) images to determine anisotropic elastic parameters as a function of bone density in the area of pedicle screw anchorage. The fabric tensor was mapped in cubic bone volumes by a 3D mean-intercept-length method. Fabric measurements resulted in a high degree of anisotropy (<jats:italic>D<\/jats:italic><jats:italic>A<\/jats:italic> =\u20090.554). For the Young\u2019s and shear moduli as a function of bone volume fraction (BV\/TV, bone volume\/total volume), an individually fit function was determined and high correlations were found (97.3 \u2264 <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> \u2264\u200999.1,<jats:italic>p<\/jats:italic> &lt;\u20090.005). The results suggest that the mathematical formulation for the relationship between anisotropic elastic constants and BV\/TV is applicable to current \u03bcCT data of cancellous bone in the osteoporotic lumbar spine. In combination with the obtained results and findings, the developed routine allows determination of elastic constants of osteoporotic lumbar spine. Based on this, the elastic constants determined using homogenization theory can enable efficient investigation of human bone using finite element analysis (FEA).<\/jats:p>","DOI":"10.1007\/s11517-021-02465-0","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T06:02:41Z","timestamp":1638165761000},"page":"263-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Determination of anisotropic elastic parameters from morphological parameters of cancellous bone for osteoporotic lumbar spine"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-6227","authenticated-orcid":false,"given":"Christoph","family":"Oefner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5988-2907","authenticated-orcid":false,"given":"Elena","family":"Riemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Funke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-9446","authenticated-orcid":false,"given":"Michael","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph-Eckhard","family":"Heyde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-0195","authenticated-orcid":false,"given":"Stephan","family":"Schoenfelder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"issue":"2","key":"2465_CR1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S1350-4533(98)00001-0","volume":"20","author":"P Augat","year":"1998","unstructured":"Augat P, Link T, Lang TF, Lin JC, Majumdar S, Genant HK (1998) Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations. 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The body donor program is regulated by the Saxonian Death and Funeral Act of 1994 (third section, paragraph 18, item 8).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Conflict of interest"}}]}}