{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:34:22Z","timestamp":1767706462155,"version":"3.37.3"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","award":["IT13597"],"award-info":[{"award-number":["IT13597"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s11517-022-02507-1","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T18:02:42Z","timestamp":1643652162000},"page":"797-810","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An unbiased algorithm for objective separation of Alzheimer\u2019s, Alzheimer\u2019s mixed with cerebrovascular symptomology, and healthy controls from one another using electrovestibulography (EVestG)"],"prefix":"10.1007","volume":"60","author":[{"given":"Zeinab A.","family":"Dastgheib","sequence":"first","affiliation":[]},{"given":"Brian J.","family":"Lithgow","sequence":"additional","affiliation":[]},{"given":"Zahra K.","family":"Moussavi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"2507_CR1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2017.96","volume":"13","author":"FM Elahi","year":"2017","unstructured":"Elahi FM, Miller BL (2017) A clinicopathological approach to the diagnosis of dementia. Nat Rev Neurol 13:457\u2013477. https:\/\/doi.org\/10.1038\/nrneurol.2017.96","journal-title":"Nat Rev Neurol"},{"key":"2507_CR2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement 7:263\u2013269. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.005","journal-title":"Alzheimers Dement"},{"key":"2507_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3389\/fneur.2020.00496","volume":"11","author":"RS Turner","year":"2020","unstructured":"Turner RS, Stubbs T, Davies DA, Albensi BC (2020) Potential new approaches for diagnosis of Alzheimer\u2019s disease and related dementias. Front Neurol 11:496. https:\/\/doi.org\/10.3389\/fneur.2020.00496","journal-title":"Front Neurol"},{"key":"2507_CR4","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack","year":"2018","unstructured":"Jack CR, Bennett DA, Blennow K et al (2018) NIA-AA Research Framework: toward a biological definition of Alzheimer\u2019s disease. Alzheimer\u2019s & Dementia 14:535\u2013562. https:\/\/doi.org\/10.1016\/j.jalz.2018.02.018","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"2507_CR5","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.3390\/jcm9113452","volume":"9","author":"K Wilczy\u0144ska","year":"2020","unstructured":"Wilczy\u0144ska K, Waszkiewicz N (2020) Diagnostic utility of selected serum dementia biomarkers: amyloid \u03b2-40, amyloid \u03b2-42, Tau protein, and YKL-40: a review. J Clin Med 9:3452. https:\/\/doi.org\/10.3390\/jcm9113452","journal-title":"J Clin Med"},{"key":"2507_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neulet.2013.03.007","volume":"541","author":"J Zhang","year":"2013","unstructured":"Zhang J, Jia J, Qin W, Wang S (2013) Combination of plasma tumor necrosis factor receptors signaling proteins, beta-amyloid and apolipoprotein E for the detection of Alzheimer\u2019s disease. Neurosci Lett 541:99\u2013104. https:\/\/doi.org\/10.1016\/j.neulet.2013.03.007","journal-title":"Neurosci Lett"},{"key":"2507_CR7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s12017-018-8513-y","volume":"20","author":"S-C Tang","year":"2018","unstructured":"Tang S-C, Yang K-C, Chen C-H et al (2018) Plasma \u03b2-amyloids and Tau proteins in patients with vascular cognitive impairment. Neuromolecular Med 20:498\u2013503. https:\/\/doi.org\/10.1007\/s12017-018-8513-y","journal-title":"Neuromolecular Med"},{"key":"2507_CR8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s12011-014-9930-x","volume":"158","author":"S Krishnan","year":"2014","unstructured":"Krishnan S, Rani P (2014) Evaluation of selenium, redox status and their association with plasma amyloid\/tau in Alzheimer\u2019s disease. Biol Trace Elem Res 158:158\u2013165. https:\/\/doi.org\/10.1007\/s12011-014-9930-x","journal-title":"Biol Trace Elem Res"},{"key":"2507_CR9","doi-asserted-by":"publisher","first-page":"P293","DOI":"10.1016\/j.jalz.2016.06.529","volume":"12","author":"W Qian","year":"2016","unstructured":"Qian W, Schweizer T, Munoz D, Fischer CE (2016) Misdiagnosis of Alzheimer\u2019s disease: inconsistencies between clinical diagnosis and neuropathological confirmation. Alzheimer\u2019s & Dementia 12:P293\u2013P293. https:\/\/doi.org\/10.1016\/j.jalz.2016.06.529","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"2507_CR10","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/NEN.0b013e31824b211b","volume":"71","author":"TG Beach","year":"2012","unstructured":"Beach TG, Monsell SE, Phillips LE, Kukull W (2012) Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005\u20132010. J Neuropathol Exp Neurol 71:266\u2013273. https:\/\/doi.org\/10.1097\/NEN.0b013e31824b211b","journal-title":"J Neuropathol Exp Neurol"},{"key":"2507_CR11","doi-asserted-by":"publisher","first-page":"908915","DOI":"10.1155\/2014\/908915","volume":"2014","author":"L Rizzi","year":"2014","unstructured":"Rizzi L, Rosset I, Roriz-Cruz M (2014) Global epidemiology of dementia: Alzheimer\u2019s and vascular types. Biomed Res Int 2014:908915. https:\/\/doi.org\/10.1155\/2014\/908915","journal-title":"Biomed Res Int"},{"key":"2507_CR12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/35040009","volume":"1","author":"MP Mattson","year":"2000","unstructured":"Mattson MP (2000) Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 1:120\u2013130. https:\/\/doi.org\/10.1038\/35040009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2507_CR13","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","volume":"80","author":"C Iadecola","year":"2013","unstructured":"Iadecola C (2013) The pathobiology of vascular dementia. Neuron 80:844\u201366. https:\/\/doi.org\/10.1016\/j.neuron.2013.10.008","journal-title":"Neuron"},{"key":"2507_CR14","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1590\/1980-57642016dn11-040005","volume":"11","author":"N Custodio","year":"2017","unstructured":"Custodio N, Montesinos R, Lira D et al (2017) Mixed dementia: a review of the evidence. Dement Neuropsychol 11:364\u2013370. https:\/\/doi.org\/10.1590\/1980-57642016dn11-040005","journal-title":"Dement Neuropsychol"},{"key":"2507_CR15","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1001\/archneur.1975.00490510088009","volume":"32","author":"VC Hachinski","year":"1975","unstructured":"Hachinski VC, Iliff LD, Zilhka E et al (1975) Cerebral blood flow in dementia. Arch Neurol 32:632\u2013637. https:\/\/doi.org\/10.1001\/archneur.1975.00490510088009","journal-title":"Arch Neurol"},{"key":"2507_CR16","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1136\/jnnp.48.11.1085","volume":"48","author":"PK Molsa","year":"1985","unstructured":"Molsa PK, Paljarvi L, Rinne JO et al (1985) Validity of clinical diagnosis in dementia: a prospective clinicopathological study. J Neurol Neurosurg Psychiatry 48:1085\u20131090. https:\/\/doi.org\/10.1136\/jnnp.48.11.1085","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2507_CR17","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1212\/wnl.43.2.250","volume":"43","author":"GC Rom\u00e1n","year":"1993","unstructured":"Rom\u00e1n GC, Tatemichi TK, Erkinjuntti T et al (1993) Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurol 43:250\u2013260. https:\/\/doi.org\/10.1212\/wnl.43.2.250","journal-title":"Neurol"},{"key":"2507_CR18","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1212\/WNL.49.3.690","volume":"49","author":"G Gold","year":"1997","unstructured":"Gold G, Giannakopoulos P, Montes-Paixao C et al (1997) Sensitivity and specificity of newly proposed clinical criteria for possible vascular dementia. Neurology 49:690\u2013694. https:\/\/doi.org\/10.1212\/WNL.49.3.690","journal-title":"Neurology"},{"key":"2507_CR19","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1007\/s10439-012-0526-3","volume":"40","author":"B Lithgow","year":"2012","unstructured":"Lithgow B (2012) A methodology for detecting field potentials from the external ear canal: NEER and EVestG. Ann Biomed Eng 40:1835\u20131850. https:\/\/doi.org\/10.1007\/s10439-012-0526-3","journal-title":"Ann Biomed Eng"},{"key":"2507_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s40846-018-0398-6","volume":"39","author":"B Blakley","year":"2019","unstructured":"Blakley B, Suleiman A, Rutherford G et al (2019) EVestG recordings are vestibuloacoustic signals. J Med Biol Eng 39:213\u2013217. https:\/\/doi.org\/10.1007\/s40846-018-0398-6","journal-title":"J Med Biol Eng"},{"key":"2507_CR21","doi-asserted-by":"publisher","unstructured":"Moussavi Z, Suleiman A, Rutherford G, et al (2019) A pilot randomised double-blind study of the tolerability and efficacy of repetitive transcranial magnetic stimulation on persistent post-concussion syndrome. Sci Rep 9:. https:\/\/doi.org\/10.1038\/s41598-019-41923-6","DOI":"10.1038\/s41598-019-41923-6"},{"key":"2507_CR22","doi-asserted-by":"publisher","unstructured":"Suleiman A, Lithgow B, Dastgheib Z, et al (2017) Quantitative measurement of post-concussion syndrome using electrovestibulography. Sci Rep 7:. https:\/\/doi.org\/10.1038\/s41598-017-15487-2","DOI":"10.1038\/s41598-017-15487-2"},{"key":"2507_CR23","doi-asserted-by":"publisher","unstructured":"Suleiman A, Lithgow B, Mansouri B, Moussavi Z (2018) Investigating the validity and reliability of electrovestibulography (EVestG) for detecting post-concussion syndrome (PCS) with and without comorbid depression. Sci Rep 8:. https:\/\/doi.org\/10.1038\/s41598-018-32808-1","DOI":"10.1038\/s41598-018-32808-1"},{"key":"2507_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jns.2015.03.050","volume":"353","author":"BJ Lithgow","year":"2015","unstructured":"Lithgow BJ, Shoushtarian M (2015) Parkinson\u2019s disease: disturbed vestibular function and levodopa. J Neurol Sci 353:49\u201358. https:\/\/doi.org\/10.1016\/j.jns.2015.03.050","journal-title":"J Neurol Sci"},{"key":"2507_CR25","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s11517-012-0890-z","volume":"50","author":"ZA Dastgheib","year":"2012","unstructured":"Dastgheib ZA, Lithgow B, Moussavi Z (2012) Diagnosis of Parkinson\u2019s disease using electrovestibulography. Med Biol Eng Comput 50:483\u2013491. https:\/\/doi.org\/10.1007\/s11517-012-0890-z","journal-title":"Med Biol Eng Comput"},{"key":"2507_CR26","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1007\/s10439-015-1441-1","volume":"44","author":"ZA Dastgheib","year":"2016","unstructured":"Dastgheib ZA, Lithgow B, Blakely B, Moussavi Z (2016) Application of vestibular spontaneous response as a diagnostic aid for Meniere\u2019s disease. Ann Biomed Eng 44:1672\u20131684. https:\/\/doi.org\/10.1007\/s10439-015-1441-1","journal-title":"Ann Biomed Eng"},{"key":"2507_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40463-015-0065-7","volume":"44","author":"ZA Dastgheib","year":"2015","unstructured":"Dastgheib ZA, Lithgow B, Blakley B, Moussavi Z (2015) A new diagnostic vestibular evoked response. J Otolaryngol Head Neck Surg 44:14. https:\/\/doi.org\/10.1186\/s40463-015-0065-7","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"2507_CR28","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40463-014-0052-4","volume":"43","author":"B Blakley","year":"2014","unstructured":"Blakley B, Dastgheib ZA, Lithgow B, Moussavi Z (2014) Preliminary report: neural firing patterns specific for Meniere\u2019s disease. J Otolaryngol Head Neck Surg 43:52. https:\/\/doi.org\/10.1186\/s40463-014-0052-4","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"2507_CR29","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3109\/15622975.2015.1014410","volume":"16","author":"BJ Lithgow","year":"2015","unstructured":"Lithgow BJ, Garrett AL, Moussavi ZM et al (2015) Major depression and electrovestibulography. World J Biol Psychiatry 16:334\u2013350. https:\/\/doi.org\/10.3109\/15622975.2015.1014410","journal-title":"World J Biol Psychiatry"},{"key":"2507_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15622975.2019.1599143","volume":"20","author":"B Lithgow","year":"2019","unstructured":"Lithgow B, Moussavi Z, Fitzgerald P (2019) Quantitative separation of the depressive phase of bipolar disorder and major depressive disorder using electrovestibulography. The World Journal of Biological Psychiatry 20:1\u201335. https:\/\/doi.org\/10.1080\/15622975.2019.1599143","journal-title":"The World Journal of Biological Psychiatry"},{"key":"2507_CR31","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00406-018-0935-x","volume":"269","author":"BJ Lithgow","year":"2019","unstructured":"Lithgow BJ, Moussavi Z, Gurvich C et al (2019) Bipolar disorder in the balance. Eur Arch Psychiatry Clin Neurosci 269:761\u2013775. https:\/\/doi.org\/10.1007\/s00406-018-0935-x","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2507_CR32","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.2174\/1567205016666190816114838","volume":"16","author":"EX Wei","year":"2019","unstructured":"Wei EX, Oh ES, Harun A et al (2019) Increased prevalence of vestibular loss in mild cognitive impairment and Alzheimer\u2019s disease. Curr Alzheimer Res 16:1143\u20131150. https:\/\/doi.org\/10.2174\/1567205016666190816114838","journal-title":"Curr Alzheimer Res"},{"key":"2507_CR33","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00221-002-1267-6","volume":"148","author":"M Dieterich","year":"2003","unstructured":"Dieterich M, Bense S, Stephan T et al (2003) fMRI signal increases and decreases in cortical areas during small-field optokinetic stimulation and central fixation. Exp Brain Res 148:117\u2013127. https:\/\/doi.org\/10.1007\/s00221-002-1267-6","journal-title":"Exp Brain Res"},{"key":"2507_CR34","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/BF00227958","volume":"112","author":"E Vitte","year":"1996","unstructured":"Vitte E, Derosier C, Caritu Y et al (1996) Activation of the hippocampal formation by vestibular stimulation: a functional magnetic resonance imaging study. Exp Brain Res 112:523\u2013526. https:\/\/doi.org\/10.1007\/BF00227958","journal-title":"Exp Brain Res"},{"key":"2507_CR35","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.anl.2016.01.006","volume":"43","author":"YJ Seo","year":"2016","unstructured":"Seo YJ, Kim J, Kim SH (2016) The change of hippocampal volume and its relevance with inner ear function in Meniere\u2019s disease patients. Auris Nasus Larynx 43:620\u2013625. https:\/\/doi.org\/10.1016\/j.anl.2016.01.006","journal-title":"Auris Nasus Larynx"},{"key":"2507_CR36","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1093\/brain\/awh617","volume":"128","author":"T Brandt","year":"2005","unstructured":"Brandt T, Schautzer F, Hamilton DA et al (2005) Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain 128:2732\u20132741. https:\/\/doi.org\/10.1093\/brain\/awh617","journal-title":"Brain"},{"key":"2507_CR37","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s11517-021-02409-8","volume":"59","author":"BJ Lithgow","year":"2021","unstructured":"Lithgow BJ, Dastgheib Z, Anssari N et al (2021) Physiological separation of Alzheimer\u2019s disease and Alzheimer\u2019s disease with significant levels of cerebrovascular symptomology and healthy controls. Med Biol Eng Comput 59:1597\u20131610. https:\/\/doi.org\/10.1007\/s11517-021-02409-8","journal-title":"Med Biol Eng Comput"},{"key":"2507_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s0378-5955(99)00110-0","volume":"136","author":"TA Jones","year":"1999","unstructured":"Jones TA, Jones SM (1999) Short latency compound action potentials from mammalian gravity receptor organs. Hear Res 136:75\u201385. https:\/\/doi.org\/10.1016\/s0378-5955(99)00110-0","journal-title":"Hear Res"},{"key":"2507_CR39","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.heares.2010.03.091","volume":"267","author":"DJ Brown","year":"2010","unstructured":"Brown DJ, Patuzzi RB (2010) Evidence that the compound action potential (CAP) from the auditory nerve is a stationary potential generated across dura mater. Hear Res 267:12\u201326. https:\/\/doi.org\/10.1016\/j.heares.2010.03.091","journal-title":"Hear Res"},{"key":"2507_CR40","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/0014-4886(83)90313-8","volume":"80","author":"AR M\u00f8ller","year":"1983","unstructured":"M\u00f8ller AR (1983) On the origin of the compound action potentials (N1, N2) of the cochlea of the rat. Exp Neurol 80:633\u2013644. https:\/\/doi.org\/10.1016\/0014-4886(83)90313-8","journal-title":"Exp Neurol"},{"key":"2507_CR41","doi-asserted-by":"publisher","first-page":"396","DOI":"10.4161\/cam.28802","volume":"8","author":"D-E Xu","year":"2014","unstructured":"Xu D-E, Zhang W-M, Yang ZZ et al (2014) Amyloid precursor protein at node of Ranvier modulates nodal formation. Cell Adh Migr 8:396\u2013403. https:\/\/doi.org\/10.4161\/cam.28802","journal-title":"Cell Adh Migr"},{"key":"2507_CR42","doi-asserted-by":"publisher","first-page":"12048","DOI":"10.1074\/jbc.M114.617092","volume":"290","author":"C Liu","year":"2015","unstructured":"Liu C, Tan FCK, Xiao Z-C, Dawe GS (2015) Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression. J Biol Chem 290:12048\u201312057. https:\/\/doi.org\/10.1074\/jbc.M114.617092","journal-title":"J Biol Chem"},{"key":"2507_CR43","doi-asserted-by":"publisher","first-page":"e0134385","DOI":"10.1371\/journal.pone.0134385","volume":"10","author":"J Mayordomo-Cava","year":"2015","unstructured":"Mayordomo-Cava J, Yajeya J, Navarro-L\u00f3pez JD, Jim\u00e9nez-D\u00edaz L (2015) Amyloid-\u03b2 (25\u201335) modulates the expression of GirK and KCNQ channel genes in the hippocampus. PLoS ONE 10:e0134385. https:\/\/doi.org\/10.1371\/journal.pone.0134385","journal-title":"PLoS ONE"},{"key":"2507_CR44","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener 14:32. https:\/\/doi.org\/10.1186\/s13024-019-0333-5","journal-title":"Mol Neurodegener"},{"key":"2507_CR45","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1162\/153244303322753616","volume":"3","author":"I Guyon","year":"2003","unstructured":"Guyon I, Elisseeff A (2003) An introduction of variable and feature selection. J Machine Learning Research Special Issue on Variable and Feature Selection 3:1157\u20131182. https:\/\/doi.org\/10.1162\/153244303322753616","journal-title":"J Machine Learning Research Special Issue on Variable and Feature Selection"},{"key":"2507_CR46","unstructured":"Hastie T, Tibshirani R, Friedman J (2009) The elements of statistical learning: data mining, inference, and prediction, Second Edition. Springer Science & Business Media"},{"key":"2507_CR47","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V et al (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53:695\u2013699. https:\/\/doi.org\/10.1111\/j.1532-5415.2005.53221.x","journal-title":"J Am Geriatr Soc"},{"key":"2507_CR48","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1192\/bjp.134.4.382","volume":"134","author":"SA Montgomery","year":"1979","unstructured":"Montgomery SA, \u00c5sberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382\u2013389. https:\/\/doi.org\/10.1192\/bjp.134.4.382","journal-title":"Br J Psychiatry"},{"key":"2507_CR49","unstructured":"Dastgheib, Zeinab (2016) The use of spontaneous vestibular response for diagnosis of Meniere\u2019s disease. Ph.D. dissertation, Biomedical Engineering Program, Dept. Elec. & Comp. Engineering, University of Manitoba"},{"key":"2507_CR50","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s11517-015-1251-5","volume":"53","author":"C Kumaragamage","year":"2015","unstructured":"Kumaragamage C, Lithgow B, Moussavi Z (2015) A new low-noise signal acquisition protocol and electrode placement for electrocochleography (ECOG) recordings. Med Biol Eng Comput 53:499\u2013509. https:\/\/doi.org\/10.1007\/s11517-015-1251-5","journal-title":"Med Biol Eng Comput"},{"key":"2507_CR51","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1121\/1.398477","volume":"86","author":"DF Dolan","year":"1989","unstructured":"Dolan DF, Xi L, Nuttall AL (1989) Characterization of an EPSP-like potential recorded remotely from the round window. J Acoust Soc Am 86:2167\u20132171. https:\/\/doi.org\/10.1121\/1.398477","journal-title":"J Acoust Soc Am"},{"key":"2507_CR52","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S0378-5955(96)00149-9","volume":"102","author":"MG van Emst","year":"1996","unstructured":"van Emst MG, Klis SFL, Smoorenburg GF (1996) 4-Aminopyridine effects on summating potentials in the guinea pig. Hear Res 102:70\u201380. https:\/\/doi.org\/10.1016\/S0378-5955(96)00149-9","journal-title":"Hear Res"},{"key":"2507_CR53","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2307\/3001968","volume":"1","author":"F Wilcoxon","year":"1945","unstructured":"Wilcoxon F (1945) Individual comparisons by ranking methods. Biometrics Bulletin 1:80\u201383. https:\/\/doi.org\/10.2307\/3001968","journal-title":"Biometrics Bulletin"},{"key":"2507_CR54","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1007\/978-3-642-04898-2_641","volume-title":"International Encyclopedia of Statistical Science","author":"D Kalpi\u0107","year":"2011","unstructured":"Kalpi\u0107 D, Hlupi\u0107 N, Lovri\u0107 M (2011) Student\u2019s t-tests. In: Lovric M (ed) International Encyclopedia of Statistical Science. Springer, Berlin, Heidelberg, pp 1559\u20131563"},{"key":"2507_CR55","volume-title":"An introduction to statistical learning: with applications in R","author":"G James","year":"2014","unstructured":"James G, Witten D, Hastie T, Tibshirani R (2014) An introduction to statistical learning: with applications in R. Springer Publishing Company, Incorporated"},{"key":"2507_CR56","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-021-02421-y","author":"A Elwali","year":"2021","unstructured":"Elwali A, Moussavi Z (2021) A feature reduction and selection algorithm for improved obstructive sleep apnea classification process. Med Biol Eng Comput. https:\/\/doi.org\/10.1007\/s11517-021-02421-y","journal-title":"Med Biol Eng Comput"},{"key":"2507_CR57","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/bs.irn.2016.04.001","volume":"128","author":"C Contet","year":"2016","unstructured":"Contet C, Goulding SP, Kuljis DA, Barth AL (2016) BK channels in the central nervous system. Int Rev Neurobiol 128:281\u2013342. https:\/\/doi.org\/10.1016\/bs.irn.2016.04.001","journal-title":"Int Rev Neurobiol"},{"key":"2507_CR58","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fncel.2019.00027","volume":"13","author":"JJ Gutzmann","year":"2019","unstructured":"Gutzmann JJ, Lin L, Hoffman DA (2019) Functional coupling of Cav23 and BK potassium channels regulates action potential repolarization and short-term plasticity in the mouse hippocampus. Front Cell Neurosci 13:27. https:\/\/doi.org\/10.3389\/fncel.2019.00027","journal-title":"Front Cell Neurosci"},{"key":"2507_CR59","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3389\/fnmol.2018.00258","volume":"11","author":"AS Kshatri","year":"2018","unstructured":"Kshatri AS, Gonzalez-Hernandez A, Giraldez T (2018) Physiological roles and therapeutic potential of Ca2+ activated potassium channels in the nervous system. Front Mol Neurosci 11:258. https:\/\/doi.org\/10.3389\/fnmol.2018.00258","journal-title":"Front Mol Neurosci"},{"key":"2507_CR60","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/s1808-8694(15)31001-6","volume":"72","author":"LL de Moraes Marchiori","year":"2006","unstructured":"de Moraes Marchiori LL, de Almeida Rego Filho E, Matsuo T (2006) Hypertension as a factor associated with hearing loss. Braz J Otorhinolaryngol 72:533\u2013540. https:\/\/doi.org\/10.1016\/s1808-8694(15)31001-6","journal-title":"Braz J Otorhinolaryngol"},{"key":"2507_CR61","unstructured":"Zeigelboim BS, Jurkiewicz AL, Klagenberg KF, et al (2006) Vestibular evaluation in patients with systemic arterial hypertension: a preliminary study. http:\/\/arquivosdeorl.org.br\/additional\/acervo_eng.asp?Id=381. Accessed 14 Oct 2020"},{"key":"2507_CR62","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S1808-8694(15)31312-4","volume":"71","author":"CAS Maia","year":"2005","unstructured":"Maia CAS, de Campos CAH (2005) Diabetes mellitus as etiological factor of hearing loss. Braz J Otorhinolaryngol 71:208\u2013214. https:\/\/doi.org\/10.1016\/S1808-8694(15)31312-4","journal-title":"Braz J Otorhinolaryngol"},{"key":"2507_CR63","unstructured":"M.D DA Neuropathology. https:\/\/neuropathology-web.org\/chapter6\/chapter6aMs.html. Accessed 19 Oct 2020"},{"key":"2507_CR64","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1749-6632.1959.tb49311.x","volume":"81","author":"AF Huxley","year":"1959","unstructured":"Huxley AF (1959) Ion movements during nerve activity. Ann N Y Acad Sci 81:221\u2013246. https:\/\/doi.org\/10.1111\/j.1749-6632.1959.tb49311.x","journal-title":"Ann N Y Acad Sci"},{"key":"2507_CR65","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1113\/jphysiol.1952.sp004718","volume":"116","author":"AL Hodgkin","year":"1952","unstructured":"Hodgkin AL, Huxley AF (1952) The components of membrane conductance in the giant axon of Loligo. J Physiol 116:473\u2013496","journal-title":"J Physiol"},{"key":"2507_CR66","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","volume":"117","author":"AL Hodgkin","year":"1952","unstructured":"Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500\u2013544","journal-title":"J Physiol"}],"container-title":["Medical &amp; Biological Engineering &amp; Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-022-02507-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11517-022-02507-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-022-02507-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T06:18:42Z","timestamp":1645078722000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11517-022-02507-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2507"],"URL":"https:\/\/doi.org\/10.1007\/s11517-022-02507-1","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"type":"print","value":"0140-0118"},{"type":"electronic","value":"1741-0444"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"27 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author Brian Lithgow has less than 0.5% shares in company NeuralDX Pty. Ltd. No other authors have any conflict of interest<b>.<\/b>","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}