{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:50:03Z","timestamp":1775155803134,"version":"3.50.1"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"NIH","award":["R01 DE031832- (Wang"],"award-info":[{"award-number":["R01 DE031832- (Wang"]}]},{"name":"NIH","award":["Mathew PIs)"],"award-info":[{"award-number":["Mathew PIs)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s11517-024-03077-0","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:01:55Z","timestamp":1712966515000},"page":"2409-2434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intelligent salivary biosensors for periodontitis: in vitro simulation of oral oxidative stress conditions"],"prefix":"10.1007","volume":"62","author":[{"given":"Haritha","family":"George","sequence":"first","affiliation":[]},{"given":"Yani","family":"Sun","sequence":"additional","affiliation":[]},{"given":"Junyi","family":"Wu","sequence":"additional","affiliation":[]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Russell P.","family":"Pesavento","sequence":"additional","affiliation":[]},{"given":"Mathew T.","family":"Mathew","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"3077_CR1","doi-asserted-by":"publisher","unstructured":"Rocca JP, Fornaini C, Wang Z, Tan L, Merigo E (2020) Focal Infection and Periodontitis: A Narrative Report and New Possible Approaches.\u00a0Int. J\u00a0Microbiol\u00a08875612. https:\/\/doi.org\/10.1155\/2020\/8875612","DOI":"10.1155\/2020\/8875612"},{"issue":"4","key":"3077_CR2","first-page":"241","volume":"22","author":"YH Lee","year":"2009","unstructured":"Lee YH, Wong DT (2009) Saliva: an emerging biofluid for early detection of diseases. Am J Dent 22(4):241\u2013248","journal-title":"Am J Dent"},{"issue":"4","key":"3077_CR3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-051X.1995.tb00146.x","volume":"22","author":"LA Sew\u00f3n","year":"1995","unstructured":"Sew\u00f3n LA, Karjalainen SM, Sainio M, Sepp\u00e4 O (1995) Calcium and other salivary factors in periodontitis-affected subjects prior to treatment. J Clin Periodontol 22(4):267\u2013270","journal-title":"J Clin Periodontol"},{"issue":"4","key":"3077_CR4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4103\/0972-124X.92560","volume":"15","author":"PB Patil","year":"2011","unstructured":"Patil PB, Patil BR (2011) Saliva: a diagnostic biomarker of periodontal diseases. J Indian Soc Periodontol 15(4):310\u2013317","journal-title":"J Indian Soc Periodontol"},{"issue":"4","key":"3077_CR5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/07853890.2018.1468922","volume":"50","author":"L \u00c4yr\u00e4v\u00e4inen","year":"2018","unstructured":"\u00c4yr\u00e4v\u00e4inen L et al (2018) Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status. Ann Med 50(4):333\u2013344","journal-title":"Ann Med"},{"key":"3077_CR6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.14219\/jada.archive.2006.0181","volume":"137","author":"CS Miller","year":"2006","unstructured":"Miller CS, King CP Jr, Langub MC et al (2006) Salivary biomarkers of existing periodontal disease: a cross-sectional study. J Am Dent Assoc 137:322\u2013329","journal-title":"J Am Dent Assoc"},{"key":"3077_CR7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/jcpe.12038","volume":"40","author":"N Rathnayake","year":"2012","unstructured":"Rathnayake N, \u00c5kerman S, Klinge B et al (2012) Salivary biomarkers of oral health- a cross-sectional study. J Clin Periodontol 40:140\u2013147","journal-title":"J Clin Periodontol"},{"key":"3077_CR8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-0765.1990.tb01035.x","volume":"25","author":"VJ Uitto","year":"1990","unstructured":"Uitto VJ, Suomalainen K, Sorsa T (1990) Salivary collagenase: origin, characteristics and relationship to periodontal health. J Periodontal Res 25:135\u2013142","journal-title":"J Periodontal Res"},{"key":"3077_CR9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/ard.2003.013243","volume":"63","author":"I Tchetverikov","year":"2004","unstructured":"Tchetverikov I, Ronday HK, Van El B et al (2004) MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Ann Rheum Dis 63:881\u2013883","journal-title":"Ann Rheum Dis"},{"key":"3077_CR10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1902\/jop.2009.090510","volume":"81","author":"PP Costa","year":"2010","unstructured":"Costa PP, Trevisan GL, Macedo GO et al (2010) Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes. J Periodontol 81:384\u2013391","journal-title":"J Periodontol"},{"issue":"3","key":"3077_CR11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4103\/jomfp.JOMFP_222_15","volume":"21","author":"S Gupta","year":"2017","unstructured":"Gupta S, Nayak MT, Sunitha J, Dawar G, Sinha N, Rallan NS (2017) Correlation of salivary glucose level with blood glucose level in diabetes mellitus. J Oral Maxillofac Pathol JOMFP 21(3):334\u2013339","journal-title":"J Oral Maxillofac Pathol JOMFP"},{"key":"3077_CR12","doi-asserted-by":"publisher","unstructured":"Malon RS, Sadir S, Balakrishnan M, C\u00f3rcoles EP (2014) Saliva-based biosensors: noninvasive monitoring tool for clinical diagnostics. BioMed\u00a0Res Int\u00a0962903. https:\/\/doi.org\/10.1155\/2014\/962903","DOI":"10.1155\/2014\/962903"},{"issue":"3","key":"3077_CR13","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3390\/s80314000","volume":"8","author":"D Grieshaber","year":"2008","unstructured":"Grieshaber D, MacKenzie R, V\u00f6r\u00f6s J, Reimhult E (2008) Electrochemical biosensors - sensor principles and architectures. Sensors (Basel) 8(3):1400\u20131458","journal-title":"Sensors (Basel)"},{"issue":"6","key":"3077_CR14","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","volume":"71","author":"TaeHyun Kwon","year":"2021","unstructured":"Kwon TaeHyun, Lamster IB, Levin L (2021) Current concepts in the management of periodontitis. Int Dent J 71(6):462\u2013476","journal-title":"Int Dent J"},{"key":"3077_CR15","doi-asserted-by":"crossref","unstructured":"ISSN 0020\u20136539,Sanz M, D\u2019Aiuto F, Deanfield J, Fernandez-Avil\u00e9s F (2010) European workshop in periodontal health and cardiovascular disease-scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature. Eur Heart J Suppl 12(Suppl B), B3\u201312","DOI":"10.1093\/eurheartj\/suq003"},{"key":"3077_CR16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.bdj.2014.912","volume":"217","author":"P Batchelor","year":"2014","unstructured":"Batchelor P (2014) Is periodontal disease a public health problem? Br Dent J 217:405\u2013409","journal-title":"Br Dent J"},{"key":"3077_CR17","unstructured":"Gasner NS, Schure RS (2022) Periodontal disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing"},{"issue":"2","key":"3077_CR18","first-page":"72","volume":"11","author":"MA Nazir","year":"2017","unstructured":"Nazir MA (2017) Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim) 11(2):72\u201380","journal-title":"Int J Health Sci (Qassim)"},{"key":"3077_CR19","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3389\/fphys.2017.00910","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Andrukhov O, Rausch-Fan X (2017) Oxidative stress and antioxidant system in periodontitis. Front Physiol 8:910","journal-title":"Front Physiol"},{"key":"3077_CR20","doi-asserted-by":"crossref","unstructured":"Courtois P (2021) Oral peroxidases: From antimicrobial agents to ecological actors (review). Mol Med Rep 24 (1): 500","DOI":"10.3892\/mmr.2021.12139"},{"key":"3077_CR21","doi-asserted-by":"publisher","first-page":"717843","DOI":"10.1155\/2012\/717843","volume":"2012","author":"L Zhu","year":"2012","unstructured":"Zhu L, Kreth J (2012) The role of hydrogen peroxide in environmental adaptation of oral microbial communities. Oxid Med Cell Longev 2012:717843. https:\/\/doi.org\/10.1155\/2012\/717843","journal-title":"Oxid Med Cell Longev"},{"key":"3077_CR22","doi-asserted-by":"publisher","unstructured":"Carlsson J (1987) Salivary peroxidase: an important part of our defense against oxygen toxicity.\u00a0J Oral Pathol\u00a016(8):412\u2013416. https:\/\/doi.org\/10.1111\/j.1600-0714.1987.tb02077.x","DOI":"10.1111\/j.1600-0714.1987.tb02077.x"},{"issue":"2","key":"3077_CR23","first-page":"215","volume":"35","author":"Z Keke","year":"2017","unstructured":"Keke Z, Xuedong Z, Xin X (2017) The origin of hydrogen peroxide in the oral cavity and its role in oral microecology balance]. Hua Xi Kou Qiang Yi Xue Za Zhi 35(2):215\u2013220","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"issue":"1","key":"3077_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s10020-020-00165-3","volume":"26","author":"J Pravda","year":"2020","unstructured":"Pravda J (2020) Hydrogen peroxide and disease: towards a unified system of pathogenesis and therapeutics. Mol Med 26(1):41. https:\/\/doi.org\/10.1186\/s10020-020-00165-3","journal-title":"Mol Med"},{"key":"3077_CR25","doi-asserted-by":"publisher","unstructured":"Maciejczyk M, Nesterowicz M, Zalewska A, Biedrzycki G, Gerreth P, Hojan K, Gerreth K (2022) Salivary Xanthine Oxidase as a Potential Biomarker in Stroke Diagnostics.\u00a0Front. Immunol 13:897413. https:\/\/doi.org\/10.3389\/fimmu.2022.897413\u00a0","DOI":"10.3389\/fimmu.2022.897413"},{"issue":"3","key":"3077_CR26","first-page":"167","volume":"7","author":"C Alexander","year":"2001","unstructured":"Alexander C, Rietschel ET (2001) Bacterial lipopolysaccharides and innate immunity. J Endotoxin Res 7(3):167\u2013202","journal-title":"J Endotoxin Res"},{"issue":"4975","key":"3077_CR27","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1126\/science.1698311","volume":"249","author":"SD Wright","year":"1990","unstructured":"Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249(4975):1431\u20131433","journal-title":"Science"},{"key":"3077_CR28","unstructured":"Wilson M (1995) Biological activities of lipopolysaccharides from oral bacteria and their relevance to the pathogenesis of chronic periodontitis.\u00a0Sci Prog\u00a078( Pt 1):19\u201334"},{"issue":"12","key":"3077_CR29","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.3390\/ijms22126242","volume":"22","author":"M Candelli","year":"2021","unstructured":"Candelli M, Franza L, Pignataro G, Ojetti V, Covino M, Piccioni A, Gasbarrini A, Franceschi F (2021) Interaction between lipopolysaccharide and gut microbiota in inflammatory bowel diseases. Int J Mol Sci 22(12):6242","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3077_CR30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","volume":"55","author":"L Qin","year":"2007","unstructured":"Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55(5):453\u2013462","journal-title":"Glia"},{"issue":"8","key":"3077_CR31","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/jcpe.12751","volume":"44","author":"JM Liljestrand","year":"2017","unstructured":"Liljestrand JM, Paju S, Buhlin K, Persson GR, Sarna S, Nieminen MS, Sinisalo J, M\u00e4ntyl\u00e4 P, Pussinen PJ (2017) Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease. J Clin Periodontol 44(8):784\u2013792","journal-title":"J Clin Periodontol"},{"key":"3077_CR32","doi-asserted-by":"crossref","unstructured":"G\u00f6lz L, Memmert S, Rath-Deschner B, J\u00e4ger A, Appel T, Baumgarten G, G\u00f6tz W, Frede S (2014) LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis Mediators Inflamm 2014:986264","DOI":"10.1155\/2014\/986264"},{"key":"3077_CR33","doi-asserted-by":"publisher","unstructured":"Siddiqui A, Deepa D, Mehrotra S, Sharma A (2021) Metabolomics in periodontal disease - A mini-review. Enviro\u00a0Dent J\u00a04(1). https:\/\/doi.org\/10.12944\/EDJ.04.01.04","DOI":"10.12944\/EDJ.04.01.04"},{"key":"3077_CR34","doi-asserted-by":"publisher","unstructured":"Lai WK, Lu YC, Hsieh CR, Wei CK, Tsai YH, Chang FR, Chan Y (2021) Developing lactic acid bacteria as an oral healthy food. Life 11(4):268. https:\/\/doi.org\/10.3390\/life11040268","DOI":"10.3390\/life11040268"},{"key":"3077_CR35","doi-asserted-by":"crossref","unstructured":"Radha S. P. Malon, Sahba Sadir, Malarvili Balakrishnan, Emma P. C\u00f3rcoles (2014) Saliva-based biosensors: non-invasive monitoring tool for clinical diagnostics. Biomed Res Int 2014 (962903): 20","DOI":"10.1155\/2014\/962903"},{"key":"3077_CR36","doi-asserted-by":"publisher","unstructured":"Ji Suk, Choi Youngnim (2015) Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. Front Cell Infect Microbiol 5.\u00a0\u00a0https:\/\/doi.org\/10.3389\/fcimb.2015.00065","DOI":"10.3389\/fcimb.2015.00065"},{"issue":"10 Suppl","key":"3077_CR37","doi-asserted-by":"crossref","first-page":"6S","DOI":"10.14219\/jada.archive.2012.0341","volume":"143","author":"WV Giannobile","year":"2012","unstructured":"Giannobile WV (2012) Salivary diagnostics for periodontal diseases. J Am Dent Assoc 143(10 Suppl):6S-11S","journal-title":"J Am Dent Assoc"},{"issue":"3","key":"3077_CR38","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/jcm10030379","volume":"10","author":"I Luchian","year":"2021","unstructured":"Luchian I, Moscalu M, Goriuc A, Nucci L, Tatarciuc M, Martu I, Covasa M (2021) Using salivary MMP-9 to successfully quantify periodontal inflammation during orthodontic treatment. J Clin Med 10(3):379","journal-title":"J Clin Med"},{"issue":"2022","key":"3077_CR39","first-page":"3664516","volume":"24","author":"S Reddahi","year":"2022","unstructured":"Reddahi S, Bouziane A, Rida S, Tligui H, Ennibi O (2022) Salivary biomarkers in periodontitis patients: a pilot study. Int J Dent 24(2022):3664516","journal-title":"Int J Dent"},{"key":"3077_CR40","first-page":"53","volume":"7","author":"KY How","year":"2016","unstructured":"How KY, Song KP, Chan KG (2016) Porphyromonas gingivalis: an overview of periodontopathic pathogen below the gum line. Front Microbiol 7:53","journal-title":"Front Microbiol"},{"issue":"3 Suppl 1","key":"3077_CR41","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1875-595X.1998.tb00717.x","volume":"48","author":"G Menassa","year":"1998","unstructured":"Menassa G, Van Dyke TE (1998) Periodontal diagnosis: current status and future directions. Int Dent J 48(3 Suppl 1):275\u2013281","journal-title":"Int Dent J"},{"issue":"8","key":"3077_CR42","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/JPER.21-0120","volume":"92","author":"FA Scannapieco","year":"2021","unstructured":"Scannapieco FA, Dongari-Bagtzoglou A (2021) Dysbiosis revisited: understanding the role of the oral microbiome in the pathogenesis of gingivitis and periodontitis: a critical assessment. J Periodontol 92(8):1071\u20131078","journal-title":"J Periodontol"},{"issue":"2","key":"3077_CR43","doi-asserted-by":"publisher","first-page":"149","DOI":"10.4103\/0974-777X.56251","volume":"1","author":"R Saini","year":"2009","unstructured":"Saini R, Marawar PP, Shete S, Saini S (2009) Periodontitis, a true infection. J Glob Infect Dis 1(2):149\u2013150. https:\/\/doi.org\/10.4103\/0974-777X.56251","journal-title":"J Glob Infect Dis"},{"issue":"1","key":"3077_CR44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","volume":"84","author":"FSC Sczepanik","year":"2000","unstructured":"Sczepanik FSC, Grossi ML, Casati M, Goldberg M, Glogauer M, Fine N, Tenenbaum HC (2000) Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way. Periodontol 84(1):45\u201368","journal-title":"Periodontol"},{"issue":"23","key":"3077_CR45","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.3390\/ijms21239149","volume":"21","author":"C Ransy","year":"2020","unstructured":"Ransy C, Vaz C, Lomb\u00e8s A, Bouillaud F (2020) Use of H2O2 to cause oxidative stress, the catalase issue. Int J Mol Sci 21(23):9149","journal-title":"Int J Mol Sci"},{"key":"3077_CR46","doi-asserted-by":"crossref","first-page":"1029806","DOI":"10.3389\/froh.2022.1029806","volume":"3","author":"S Zaric","year":"2022","unstructured":"Zaric S, Strachan A, Kurushima Y, Dong A, McIlwaine C, Harrington Z, Nibali L, Foey A, Ide M (2022) Evaluating clinical utility of subgingival and salivary endotoxin activity levels as periodontal biomarkers. Front Oral Health 3:1029806","journal-title":"Front Oral Health"},{"key":"3077_CR47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0003-2670(00)80215-9","volume":"245","author":"G Palleschi","year":"1991","unstructured":"Palleschi G, Faridnia MH, Lubrano GJ, Guilbault GG (1991) Determination of lactate in human saliva with an electrochemical enzyme probe. Anal Chim Acta 245:151\u2013157","journal-title":"Anal Chim Acta"},{"key":"3077_CR48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","volume":"21","author":"G Hajishengallis","year":"2021","unstructured":"Hajishengallis G, Chavakis T (2021) Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol 21:426\u2013440","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"3077_CR49","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/jpm13020166","volume":"13","author":"G Viglianisi","year":"2023","unstructured":"Viglianisi G, Tartaglia GM, Santonocito S, Amato M, Polizzi A, Mascitti M, Isola G (2023) The emerging role of salivary oxidative stress biomarkers as prognostic markers of periodontitis: new insights for a personalized approach in dentistry. J Pers Med 13(2):166","journal-title":"J Pers Med"},{"key":"3077_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1680\/jsuin.16.00023","volume":"5","author":"B Patel","year":"2017","unstructured":"Patel B, Duran A, Gurman P, Auciello O, Barao V, Campbell S, Sukotjo C, Mathew M (2017) Ultrananocrystalline diamond (UNCD) coatings for dental implant applications: electrochemical characteristics. Surf Innov 5:1\u201331. https:\/\/doi.org\/10.1680\/jsuin.16.00023","journal-title":"Surf Innov"},{"issue":"4","key":"3077_CR51","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1021\/ar500456w","volume":"48","author":"K Hsieh","year":"2015","unstructured":"Hsieh K, Ferguson BS, Eisenstein M, Plaxco KW, Soh HT (2015) Integrated electrochemical microsystems for genetic detection of pathogens at the point of care. Acc Chem Res 48(4):911\u2013920","journal-title":"Acc Chem Res"},{"issue":"20","key":"3077_CR52","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1021\/acs.analchem.5b03121","volume":"87","author":"BY Ng","year":"2015","unstructured":"Ng BY, Xiao W, West NP, Wee EJ, Wang Y, Trau M (2015) Rapid, Single-cell electrochemical detection of mycobacterium tuberculosis using colloidal gold nanoparticles. Anal Chem 87(20):10613\u201310618","journal-title":"Anal Chem"},{"issue":"3","key":"3077_CR53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/CMR.00120-13","volume":"27","author":"A Ahmed","year":"2014","unstructured":"Ahmed A, Rushworth JV, Hirst NA, Millner PA (2014) Biosensors for whole-cell bacterial detection. Clin Microbiol Rev 27(3):631\u2013646","journal-title":"Clin Microbiol Rev"},{"issue":"11","key":"3077_CR54","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/elan.200390114","volume":"15","author":"E Katz","year":"2003","unstructured":"Katz E, Willner I (2003) Probing biomolecular interactions at conductive and semiconductive surfaces by impedance spectroscopy: routes to impedimetric immunosensors, dna-sensors, and enzyme biosensors. Electroanalysis 15(11):913\u2013947","journal-title":"Electroanalysis"},{"key":"3077_CR55","doi-asserted-by":"publisher","unstructured":"Forster RJ, Walsh DA (2005) VOLTAMMETRY | Overview, Encyclopedia of Analytical Science (2nd edn), Elsevier 181\u2013188. https:\/\/doi.org\/10.1016\/B0-12-369397-7\/00646-4","DOI":"10.1016\/B0-12-369397-7\/00646-4"},{"key":"3077_CR56","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1021\/cr068076m","volume":"108","author":"RL McCreery","year":"2008","unstructured":"McCreery RL (2008) Advanced carbon electrode materials for molecular electrochemistry. Chem Rev 108:2646\u20132687","journal-title":"Chem Rev"},{"key":"3077_CR57","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1039\/D2LC00552B","volume":"23","author":"M Zamani","year":"2023","unstructured":"Zamani M, Klapperich CM, Furst AL (2023) Recent advances in gold electrode fabrication for low-resource setting biosensing. Lab Chip 23:1410","journal-title":"Lab Chip"},{"key":"3077_CR58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jmbbm.2011.11.004","volume":"8","author":"MT Mathew","year":"2012","unstructured":"Mathew MT et al (2012) What is the role of lipopolysaccharide on the tribocorrosive behavior of titanium? J Mech Behav Biomed Mater 8:71\u201385","journal-title":"J Mech Behav Biomed Mater"},{"issue":"1","key":"3077_CR59","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/bios10010002","volume":"10","author":"P Sondhi","year":"2019","unstructured":"Sondhi P, Maruf MHU, Stine KJ (2019) Nanomaterials for biosensing lipopolysaccharide. Biosensors (Basel) 10(1):2. https:\/\/doi.org\/10.3390\/bios10010002","journal-title":"Biosensors (Basel)"},{"issue":"3","key":"3077_CR60","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.3390\/s120302456","volume":"12","author":"ZH Ibupoto","year":"2012","unstructured":"Ibupoto ZH, Shah SM, Khun K, Willander M (2012) Electrochemical L-lactic acid sensor based on immobilized ZnO nanorods with lactate oxidase. Sensors (Basel) 12(3):2456\u20132466. https:\/\/doi.org\/10.3390\/s120302456","journal-title":"Sensors (Basel)"},{"key":"3077_CR61","doi-asserted-by":"crossref","unstructured":"Ben-Hur A, Weston J (2010) A user\u2019s guide to support vector machines. In: Carugo O, Eisenhaber F (eds) Data mining techniques for the life sciences. Methods in Molecular Biology (Methods and Protocols), Vol 609 Humana Press 223\u2013239","DOI":"10.1007\/978-1-60327-241-4_13"},{"key":"3077_CR62","doi-asserted-by":"crossref","unstructured":"Sch\u00f6lkopf B, Tsuda K, and Vert J-P (2004) Kernel methods in computational biology. MIT Press series on Computational Molecular Biology (July 16, 2004)","DOI":"10.7551\/mitpress\/4057.001.0001"},{"key":"3077_CR63","unstructured":"Choi RY, Coyner AS, Kalpathy-Cramer J, Chiang MF, Campbell JP (2020) Transl Vis Sci Technol 9:14"},{"key":"3077_CR64","doi-asserted-by":"crossref","first-page":"12701","DOI":"10.1038\/s41598-019-49185-y","volume":"9","author":"H Stevenson","year":"2019","unstructured":"Stevenson H, Bacon A, Joseph KM et al (2019) A rapid response electrochemical biosensor for detecting Thc In saliva. Sci Rep 9:12701","journal-title":"Sci Rep"},{"key":"3077_CR65","unstructured":"Reddy J, Gayathri R, Gayathri R, Priya V (2018) Variation in salivary pH and buffering capacity of saliva in normal and diabetes mellitus patients - A pilot study. Drug\u00a0Invent\u00a0Today 10:895\u2013898"},{"key":"3077_CR66","doi-asserted-by":"publisher","first-page":"8941876","DOI":"10.1155\/2020\/8941876","volume":"2020","author":"J de S\u00e1","year":"2020","unstructured":"de S\u00e1 J, Vieira F, Aroso CM, Cardoso M, Mendes JM, Silva AS (2020) The influence of saliva pH on the fracture resistance of three complete denture base acrylic resins. Int J Dent 2020:8941876. https:\/\/doi.org\/10.1155\/2020\/8941876","journal-title":"Int J Dent"},{"issue":"2","key":"3077_CR67","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.cct.2004.12.008","volume":"26","author":"C Drake","year":"2005","unstructured":"Drake C, Levine RA (2005) Sensitivity, specificity and other diagnostic measures with multiple sites per unit. Contemp Clin Trials 26(2):252\u2013259. https:\/\/doi.org\/10.1016\/j.cct.2004.12.008","journal-title":"Contemp Clin Trials"},{"issue":"3","key":"3077_CR68","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1651-2227.2006.00180.x","volume":"96","author":"AK Akobeng","year":"2007","unstructured":"Akobeng AK (2007) Understanding diagnostic tests 1: sensitivity, specificity and predictive values. Acta Paediatr 96(3):338\u2013341. https:\/\/doi.org\/10.1111\/j.1651-2227.2006.00180.x","journal-title":"Acta Paediatr"},{"key":"3077_CR69","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","volume":"143","author":"JA Hanley","year":"1982","unstructured":"Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143:29\u201336","journal-title":"Radiology"},{"key":"3077_CR70","doi-asserted-by":"publisher","first-page":"670670","DOI":"10.3389\/fphar.2021.670670","volume":"12","author":"S Seo","year":"2021","unstructured":"Seo S, Kim Y, Han HJ, Son WC, Hong ZY, Sohn I, Shim J, Hwang C (2021) Predicting successes and failures of clinical trials with outer product-based convolutional neural network. Front Pharmacol 12:670670. https:\/\/doi.org\/10.3389\/fphar.2021.670670","journal-title":"Front Pharmacol"},{"key":"3077_CR71","doi-asserted-by":"publisher","first-page":"1130229","DOI":"10.3389\/fonc.2023.1130229","volume":"13","author":"HH Rashidi","year":"2023","unstructured":"Rashidi HH, Albahra S, Robertson S, Tran NK, Hu B (2023) Common statistical concepts in the supervised machine learning arena. Front Oncol 13:1130229. https:\/\/doi.org\/10.3389\/fonc.2023.1130229","journal-title":"Front Oncol"},{"issue":"1","key":"3077_CR72","doi-asserted-by":"publisher","first-page":"5979","DOI":"10.1038\/s41598-022-09954-8","volume":"12","author":"SA Hicks","year":"2022","unstructured":"Hicks SA, Str\u00fcmke I, Thambawita V, Hammou M, Riegler MA, Halvorsen P, Parasa S (2022) On evaluation metrics for medical applications of artificial intelligence. Sci Rep 12(1):5979. https:\/\/doi.org\/10.1038\/s41598-022-09954-8","journal-title":"Sci Rep"},{"key":"3077_CR73","doi-asserted-by":"publisher","unstructured":"Fernandes LL, Pachec VB, Borges L, Athwal HK, de Paula Eduardo F, Bezinelli L, Correa L, Jimenez M, Dame-Teixeira N, Lombaert IMA, Heller D (2020) Saliva in the diagnosis of COVID-19: A review and new research directions.\u00a0J Dent Res\u00a099(13):1435\u20131443. https:\/\/doi.org\/10.1177\/0022034520960070","DOI":"10.1177\/0022034520960070"},{"issue":"2020","key":"3077_CR74","doi-asserted-by":"crossref","first-page":"119117","DOI":"10.1016\/j.lfs.2021.119117","volume":"273","author":"SA Abid","year":"2021","unstructured":"Abid SA et al (2021) Biosensors as a future diagnostic approach for COVID-19. Life Sci 273(2020):119117","journal-title":"Life Sci"},{"key":"3077_CR75","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1235","volume":"24","author":"N Rifai","year":"2006","unstructured":"Rifai N, Gillette M, Carr S (2006) Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 24:971\u2013983","journal-title":"Nat Biotechnol"},{"key":"3077_CR76","doi-asserted-by":"publisher","unstructured":"Dong T, Matos Pires NM, Yang Z, Jiang Z (2023) Advances in electrochemical biosensors based on nanomaterials for protein biomarker detection in Saliva. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10(6):e2205429. https:\/\/doi.org\/10.1002\/advs.202205429","DOI":"10.1002\/advs.202205429"},{"key":"3077_CR77","doi-asserted-by":"crossref","first-page":"714370","DOI":"10.3389\/fcell.2021.714370","volume":"9","author":"SA Sinenko","year":"2021","unstructured":"Sinenko SA, Starkova TY, Kuzmin AA, Tomilin AN (2021) Physiological signaling functions of reactive oxygen species in stem cells: from flies to man. Front Cell Dev Biol 9:714370","journal-title":"Front Cell Dev Biol"},{"key":"3077_CR78","doi-asserted-by":"publisher","unstructured":"Martins SG, Zilh\u00e3o R, Thorsteinsd\u00f3ttir S, Carlos AR (2021) Linking oxidative stress and DNA damage to changes in the expression of extracellular matrix components.\u00a0Front Genet\u00a012:673002. https:\/\/doi.org\/10.3389\/fgene.2021.673002","DOI":"10.3389\/fgene.2021.673002"},{"key":"3077_CR79","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.3899\/jrheum.091451","volume":"37","author":"H Su","year":"2010","unstructured":"Su H, Baron M, Benarroch M, Velly AM, Gravel S, Schipper HM, Gornitsky M (2010) Altered salivary redox homeostasis in patients with systemic sclerosis. J Rheumatol 37:1858\u20131863","journal-title":"J Rheumatol"},{"key":"3077_CR80","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1051\/ocl\/2020025","volume":"27","author":"M Caroff","year":"2020","unstructured":"Caroff M, Novikov A (2020) Lipopolysaccharides: structure, function and bacterial identifications. OCL 27:31","journal-title":"OCL"},{"key":"3077_CR81","doi-asserted-by":"publisher","unstructured":"Kobayashi R, Hashizume-Takizawa T, Kurita-Ochiai T (2021) Lactic acid bacteria prevent both periodontitis and atherosclerosis exacerbated by periodontitis in spontaneously hyperlipidemic mice.\u00a0J Periodontal Res\u00a056(4):753\u2013760. https:\/\/doi.org\/10.1111\/jre.12874","DOI":"10.1111\/jre.12874"},{"key":"3077_CR82","doi-asserted-by":"publisher","unstructured":"Shimada A, Noda M, Matoba Y, Kumagai T, Kozai K, Sugiyama M (2015) Oral lactic acid bacteria related to the occurrence and\/or progression of dental caries in Japanese preschool children.\u00a0Biosci\u00a0Microbiota Food Health 34(2):29\u201336. https:\/\/doi.org\/10.12938\/bmfh.2014-015","DOI":"10.12938\/bmfh.2014-015"},{"key":"3077_CR83","doi-asserted-by":"publisher","unstructured":"Cui F, Yue Y, Zhang Y, Zhang Z, Zhou HS (2020) Advancing biosensors with machine learning. ACS sensors 5(11):3346\u20133364. https:\/\/doi.org\/10.1021\/acssensors.0c01424","DOI":"10.1021\/acssensors.0c01424"},{"issue":"3","key":"3077_CR84","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5005\/jcdp-9-3-72","volume":"9","author":"PV de Almeida","year":"2008","unstructured":"de Almeida PV, Gr\u00e9gio AM, Machado MA, de Lima AA, Azevedo LR (2008) Saliva composition and functions: a comprehensive review. J Contemp Dent Pract 9(3):72\u201380","journal-title":"J Contemp Dent Pract"},{"issue":"12","key":"3077_CR85","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.3390\/cryst12121797","volume":"12","author":"Miros\u0142aw Ga\u0142\u0105zka","year":"2022","unstructured":"Ga\u0142\u0105zka Miros\u0142aw, Osiecka-Drewniak Natalia (2022) Electric conductivity and electrode polarization as markers of phase transitions. Crystals 12(12):1797. https:\/\/doi.org\/10.3390\/cryst12121797","journal-title":"Crystals"},{"issue":"1","key":"3077_CR86","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1567-5394(01)00110-4","volume":"54","author":"F Bordi","year":"2001","unstructured":"Bordi F, Cametti C, Gili T (2001) Reduction of the contribution of electrode polarization effects in the radiowave dielectric measurements of highly conductive biological cell suspensions. Bioelectrochemistry 54(1):53\u201361. https:\/\/doi.org\/10.1016\/S1567-5394(01)00110-4","journal-title":"Bioelectrochemistry"},{"issue":"3","key":"3077_CR87","doi-asserted-by":"publisher","first-page":"e0248786","DOI":"10.1371\/journal.pone.0248786","volume":"16","author":"S Holm","year":"2021","unstructured":"Holm S, Holm T, Martinsen \u00d8G (2021) Simple circuit equivalents for the constant phase element. PLoS ONE 16(3):e0248786. https:\/\/doi.org\/10.1371\/journal.pone.0248786","journal-title":"PLoS ONE"},{"key":"3077_CR88","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.snb.2018.04.108","volume":"269","author":"A Soni","year":"2018","unstructured":"Soni A, Surana RK, Jha SK (2018) Smartphone based optical biosensor for the detection of urea in saliva. Sens Actuators B Chem 269:346\u2013353","journal-title":"Sens Actuators B Chem"},{"key":"3077_CR89","doi-asserted-by":"publisher","first-page":"96","DOI":"10.9790\/0853-1169699","volume":"11","author":"V Madalli","year":"2013","unstructured":"Madalli V (2013) Saliva-a diagnostic tool. IOSR Journal of Dental and Medical Sciences 11:96\u201399. https:\/\/doi.org\/10.9790\/0853-1169699","journal-title":"IOSR Journal of Dental and Medical Sciences"},{"key":"3077_CR90","doi-asserted-by":"publisher","unstructured":"Maciejczyk M, Bielas M, Zalewska A, Gerreth K (2021) Salivary biomarkers of oxidative stress and inflammation in stroke patients: from basic research to clinical practice.\u00a0Oxidative Med Cell Longev\u00a05545330. https:\/\/doi.org\/10.1155\/2021\/5545330","DOI":"10.1155\/2021\/5545330"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-024-03077-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11517-024-03077-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-024-03077-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T11:17:21Z","timestamp":1722338241000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11517-024-03077-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,13]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3077"],"URL":"https:\/\/doi.org\/10.1007\/s11517-024-03077-0","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,13]]},"assertion":[{"value":"26 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}