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This study evaluated bone and soft tissue stress in CAI contrasted with copers and non-injured participants during a cutting task. Integrating scanned 3D foot shapes and free-form deformation, sixty-six personalized finite element foot models were developed. Computed Achilles tendon forces and measured regional plantar pressure were applied as boundary loading conditions for simulation. It was observed that the primary group differences in foot stress occurred during midstance and heel-off phases of the cutting task. Specifically, healthy individuals had significantly higher stress in the talus and soft tissue around the talus compared to CAI participants. In contrast, CAI participants had significantly higher stress in the cuneiforms and lateral forefoot bones during mid-stance and push-off phases. CAI participants appeared to adopt a protective strategy by transferring greater force to the lateral forefoot at the heel-off phase while lowering stress around the talus, which may be associated with pain relief near the ankle. These findings suggest further attention should be placed on internal stress in CAI at the push-off phase with implications for long-term foot adaptation.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s11517-024-03276-9","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T21:51:03Z","timestamp":1736977863000},"page":"1507-1519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Foot tissue stress in chronic ankle instability during the stance phase of cutting"],"prefix":"10.1007","volume":"63","author":[{"given":"Peimin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanzhen","family":"Cen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangliang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaodong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"3276_CR1","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1177\/0363546516628870","volume":"44","author":"C Doherty","year":"2016","unstructured":"Doherty C, Bleakley C, Hertel J et al (2016) Recovery from a first-time lateral ankle sprain and the predictors of chronic ankle instability. 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