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We hypothesize that influence of ligament pre-tension on strain and relative joint movement is morphologically sex-specific and more pronounced than effects of body weight. Finite element models were developed from CTs of a larger cohort (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009818) for typical male (TMJ) and typical female joint (TFJ) geometries. For different loading scenarios, stresses were higher in TFJ than TMJ for same pre-tension, only considering sex-specific morphology. Loading in antero-posterior direction caused highest stresses and relative movement. Ligament pre-tension was most sensitive with mean sensitivity factor (change output [%]\/change input [%]): 71.04\/33.64 for translation, 43.09\/4.02 for rotation, 2.11\/\u2009\u2212\u20098.97 for stress for TFJ\/TMJ respectively. Mean sensitivity factor of ligament stiffness was\u2009\u2212\u20091.14\/\u2009\u2212\u20091.06 for translation,\u2009\u2212\u20090.90\/\u2009\u2212\u20090.89 for rotation and 0.17\/0.13 for stress, while mean sensitivity of load intensity was 1.09\/1.10 for translation, 0.91\/0.88 for rotation and 0.54\/0.58 for stress for TFJ\/TMJ respectively. Relative motion was more sensitive to parameter variations than stress. The hypothesis was confirmed: influence of ligament pre-tension on stress but especially relative joint movement of SIJ is morphologically sex-specific and larger than body weight effects. As this may play a crucial role in pain development, ligament pre-tension must be verified in situ in the future.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>Sacro-iliac joint models are determined by ligament laxity: stiffness &amp; pretension. Our analyses show the relative effect of parameter assumptions on modeling results. A substantial preload or pretension changes joint stability \/ mobility and stress. The influence of ligament pre-tension on stress and relative joint mobility of the sacro-iliac joint was larger than load intensity (bodyweight of patient) in our modelling set-up. Evaluation of the specific ligament pretension is imperative for patient-specific finite element models.<\/jats:p>","DOI":"10.1007\/s11517-025-03396-w","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:51:03Z","timestamp":1750143063000},"page":"3321-3333","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ligament pre-tension determines outcome in sacroiliac joint in silicon modelling"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-3948","authenticated-orcid":false,"given":"Mark","family":"Heyland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Sch\u00f6mig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daven","family":"Maikath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Deppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Pumberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg N.","family":"Duda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Ziegeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Damm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"3396_CR1","doi-asserted-by":"publisher","first-page":"789629","DOI":"10.3389\/fbioe.2022.789629","volume":"10","author":"A Bender","year":"2022","unstructured":"Bender A, Damm P, Hommel H, Duda GN (2022) Overstretching expectations may endanger the success of the \u201cMillennium Surgery.\u201d Front Bioeng Biotechnol 10:789629","journal-title":"Front Bioeng Biotechnol"},{"issue":"5","key":"3396_CR2","doi-asserted-by":"publisher","first-page":"e0155612","DOI":"10.1371\/journal.pone.0155612","volume":"11","author":"G Bergmann","year":"2016","unstructured":"Bergmann G, Bender A, Dymke J, Duda G, Damm P (2016) Standardized loads acting in hip implants. 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