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In this study, we introduce CAPE (Continuous Automatic PWV Estimation), an innovative framework for near real-time cf-PWV estimation based on beat-to-beat analysis of laser-Doppler vibrometry (LDV) signals. CAPE integrates automatic fiducial point detection, systematic signal quality control, and a cross-channel strategy to provide a highly reliable assessment of cf-PWV. The framework was evaluated using LDV signals acquired from 100 patients with mild to moderate essential hypertension, using a multichannel laser vibrometry system. CAPE calculates cf-PWV as the ratio of carotid-femoral distance to pulse transit time (PTT), which is the delay between carotid and femoral fiducial points. These points are detected using template-matching on the second derivative of LDV displacement signals. Signal quality in CAPE is ensured through an integrated quality assessment based on the number of automatically detected carotid-femoral peaks, which assigns confidence scores (acceptable or excellent) to the PWV measurements. When validated against the gold-standard applanation tonometry, CAPE achieved a mean bias of 0.25\u2009\u00b1\u20090.77\u00a0m\/s, demonstrating high reliability and precision. The optimized framework estimates cf-PWV in 3\u00a0s, making CAPE ideal for clinical applications requiring real-time cardiovascular assessment.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s11517-025-03417-8","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:12:49Z","timestamp":1753863169000},"page":"3709-3724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-time beat-to-beat pulse wave velocity estimation: a quality-driven approach using laser Doppler vibrometry"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-2654","authenticated-orcid":false,"given":"Silvia","family":"Seoni","sequence":"first","affiliation":[]},{"given":"Patrick","family":"Segers","sequence":"additional","affiliation":[]},{"given":"Simeon","family":"Beeckman","sequence":"additional","affiliation":[]},{"given":"Massimo","family":"Salvi","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[]},{"given":"Smriti","family":"Badhwar","sequence":"additional","affiliation":[]},{"given":"Rosa Maria","family":"Bruno","sequence":"additional","affiliation":[]},{"given":"Yanlu","family":"Li","sequence":"additional","affiliation":[]},{"given":"Soren","family":"Aasmul","sequence":"additional","affiliation":[]},{"given":"Nilesh","family":"Madhu","sequence":"additional","affiliation":[]},{"given":"Filippo","family":"Molinari","sequence":"additional","affiliation":[]},{"given":"Umberto","family":"Morbiducci","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"issue":"1","key":"3417_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1161\/01.RES.20.1.99","volume":"20","author":"H Wolinsky","year":"1967","unstructured":"Wolinsky H, Glagov S (1967) A lamellar unit of aortic medial structure and function in mammals. 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