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All patients have given their written informed consent in agreement and after approval by the local ethics committee of the University of Bonn (Bonn, Germany). The human samples, used in this work, were anonymized, and all patient-related data and unique identifiers were removed. Mice experiments have been performed as described previously []. All animal experiments were approved by the local government authorities (LANUV, NRW, Germany) and performed according to the institutional and national guidelines for the care and use of laboratory animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}]}}