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Navigated ultrasound provides the surgeon with reconstructed views of ultrasound data, but no commercial system presently permits its integration with other essential non-imaging-based intraoperative monitoring modalities such as intraoperative neuromonitoring. Such a system would be particularly useful in skull base neurosurgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We established functional and technical requirements of an integrated multi-modality IGS system tailored for skull base surgery with the ability to incorporate: (1) preoperative MRI data and associated 3D volume reconstructions, (2) real-time intraoperative neurophysiological data and (3) live reconstructed 3D ultrasound. We created an open-source software platform to integrate with readily available commercial hardware. We tested the accuracy of the system\u2019s ultrasound navigation and reconstruction using a polyvinyl alcohol phantom model and simulated the use of the complete navigation system in a clinical operating room using a patient-specific phantom model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Experimental validation of the system\u2019s navigated ultrasound component demonstrated accuracy of <jats:inline-formula><jats:alternatives><jats:tex-math>$$&lt;4.5\\,\\hbox {mm}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                    <mml:mrow>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>4.5<\/mml:mn>\n                      <mml:mspace\/>\n                      <mml:mtext>mm<\/mml:mtext>\n                    <\/mml:mrow>\n                  <\/mml:math><\/jats:alternatives><\/jats:inline-formula> and a frame rate of 25 frames per second. Clinical simulation confirmed that system assembly was straightforward, could be achieved in a clinically acceptable time of <jats:inline-formula><jats:alternatives><jats:tex-math>$$&lt;15\\,\\hbox {min}$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                    <mml:mrow>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>15<\/mml:mn>\n                      <mml:mspace\/>\n                      <mml:mtext>min<\/mml:mtext>\n                    <\/mml:mrow>\n                  <\/mml:math><\/jats:alternatives><\/jats:inline-formula> and performed with a clinically acceptable level of accuracy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We present an integrated open-source research platform for multi-modality IGS. The present prototype system was tailored for neurosurgery and met all minimum design requirements focused on skull base surgery. Future work aims to optimise the system further by addressing the remaining target requirements.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11548-021-02374-5","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T20:18:04Z","timestamp":1620073084000},"page":"1347-1356","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Integrated multi-modality image-guided navigation for neurosurgery: open-source software platform using state-of-the-art clinical hardware"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0291-348X","authenticated-orcid":false,"given":"Jonathan","family":"Shapey","sequence":"first","affiliation":[]},{"given":"Thomas","family":"Dowrick","sequence":"additional","affiliation":[]},{"given":"R\u00e9mi","family":"Delaunay","sequence":"additional","affiliation":[]},{"given":"Eleanor C.","family":"Mackle","sequence":"additional","affiliation":[]},{"given":"Stephen","family":"Thompson","sequence":"additional","affiliation":[]},{"given":"Mirek","family":"Janatka","sequence":"additional","affiliation":[]},{"given":"Roland","family":"Guichard","sequence":"additional","affiliation":[]},{"given":"Anastasis","family":"Georgoulas","sequence":"additional","affiliation":[]},{"given":"David","family":"P\u00e9rez-Su\u00e1rez","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Bradford","sequence":"additional","affiliation":[]},{"given":"Shakeel R.","family":"Saeed","sequence":"additional","affiliation":[]},{"given":"S\u00e9bastien","family":"Ourselin","sequence":"additional","affiliation":[]},{"given":"Matthew J.","family":"Clarkson","sequence":"additional","affiliation":[]},{"given":"Tom","family":"Vercauteren","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"issue":"1","key":"2374_CR1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00701-018-3747-x","volume":"161","author":"A Alomari","year":"2019","unstructured":"Alomari A, Jaspers C, Reinbold WD, Feldkamp J, Knappe UJ (2019) Use of intraoperative intracavitary (direct-contact) ultrasound for resection control in transsphenoidal surgery for pituitary tumors: evaluation of a microsurgical series. 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