{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:41:36Z","timestamp":1759178496605,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006209","name":"Radboud University Medical Center","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006209","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J CARS"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Radiofrequency ablation (RFA) can be associated with local recurrences in the treatment of liver tumors. Data obtained at our center for an earlier multinational multicenter trial regarding an in-house developed simulation software were re-evaluated in order to analyze whether the software was able to predict local recurrences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty-seven RFA ablations for either primary or secondary hepatic tumors were included. Colorectal liver metastases were shown in 14 patients and hepatocellular carcinoma in 13 patients. Overlap of the simulated volume and the tumor volume was automatically generated and defined as positive predictive value (PPV) and additionally visually assessed. Local recurrence during follow-up was defined as gold standard. Sensitivity and specificity were calculated using the visual assessment and gold standard.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean tumor size was 18\u00a0mm (95% CI 15\u201321\u00a0mm). Local recurrence occurred in 5 patients. The PPV of the simulation showed a mean of 0.89 (0.84\u20130.93 95% CI). After visual assessment, 9 incomplete ablations were observed, of which 4 true positives and 5 false positives for the detection of an incomplete ablation. The sensitivity and specificity were, respectively, 80% and 77% with a correct prediction in 78% of cases. No significant correlation was found between size of the tumor and PPV (Pearson Correlation 0.10; <jats:italic>p<\/jats:italic>\u2009=\u20090.62) or between PPV and recurrence rates (Pearson Correlation 0.28; <jats:italic>p<\/jats:italic>\u2009=\u20090.16).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The simulation software shows promise in estimating the completeness of liver RFA treatment and predicting local recurrence rates, but could not be performed real-time. Future improvements in the field of registration could improve results and provide a possibility for real-time implementation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11548-021-02394-1","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T13:03:15Z","timestamp":1620738195000},"page":"1051-1057","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Software-based planning of ultrasound and CT-guided percutaneous radiofrequency ablation in hepatic tumors"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-0392","authenticated-orcid":false,"given":"M. J.","family":"van Amerongen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mariappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Voglreiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. F. M.","family":"Jenniskens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pollari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kolesnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Moche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"F\u00fctterer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"2394_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1200\/JCO.2009.23.4450","volume":"28","author":"SL Wong","year":"2010","unstructured":"Wong SL, Mangu PB, Choti MA et al (2010) American Society of Clinical Oncology 2009 clinical evidence review on radiofrequency ablation of hepatic metastases from colorectal cancer. J Clin Oncol 28:493\u2013508","journal-title":"J Clin Oncol"},{"key":"2394_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/medicina46010002","volume":"46","author":"T Vanagas","year":"2010","unstructured":"Vanagas T, Gulbinas A, Pundzius J, Barauskas G (2010) Radiofrequency ablation of liver tumors (I): biological background. Medicina (Kaunas) 46:13\u201317","journal-title":"Medicina (Kaunas)"},{"key":"2394_CR3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000367740","volume":"4","author":"TW Kang","year":"2015","unstructured":"Kang TW, Rhim H (2015) Recent advances in tumor ablation for hepatocellular carcinoma. Liver Cancer 4:176\u2013187","journal-title":"Liver Cancer"},{"key":"2394_CR4","doi-asserted-by":"crossref","unstructured":"Riemsma RP, Bala MM, Wolff R, Kleijnen J (2013) Percutaneous ethanol injection for liver metastases. Cochrane Database Syst Rev 5:Cd008717","DOI":"10.1002\/14651858.CD008717.pub2"},{"key":"2394_CR5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1055\/s-0035-1564706","volume":"32","author":"G Narayanan","year":"2015","unstructured":"Narayanan G (2015) Irreversible electroporation Semin Intervent Radiol 32:349\u2013355","journal-title":"Irreversible electroporation Semin Intervent Radiol"},{"key":"2394_CR6","doi-asserted-by":"publisher","first-page":"e252","DOI":"10.1111\/j.1463-1318.2011.02695.x","volume":"13","author":"S Pathak","year":"2011","unstructured":"Pathak S, Jones R, Tang JM et al (2011) Ablative therapies for colorectal liver metastases: a systematic review. Colorectal Dis 13:e252-265","journal-title":"Colorectal Dis"},{"key":"2394_CR7","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.hpb.2017.05.011","volume":"19","author":"MJ van Amerongen","year":"2017","unstructured":"van Amerongen MJ, Jenniskens SFM, van den Boezem PB, Futterer JJ, de Wilt JHW (2017) Radiofrequency ablation compared to surgical resection for curative treatment of patients with colorectal liver metastases - a meta-analysis. HPB (Oxford) 19:749\u2013756","journal-title":"HPB (Oxford)"},{"key":"2394_CR8","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1148\/radiol.2017162756","volume":"287","author":"XL Xu","year":"2018","unstructured":"Xu XL, Liu XD, Liang M, Luo BM (2018) Radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma: systematic review of randomized controlled trials with meta-analysis and trial sequential analysis. Radiology 287:461\u2013472","journal-title":"Radiology"},{"key":"2394_CR9","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.ejso.2006.01.006","volume":"32","author":"P Hildebrand","year":"2006","unstructured":"Hildebrand P, Leibecke T, Kleemann M et al (2006) Influence of operator experience in radiofrequency ablation of malignant liver tumours on treatment outcome. Eur J Surg Oncol 32:430\u2013434","journal-title":"Eur J Surg Oncol"},{"key":"2394_CR10","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.1245\/s10434-014-3738-y","volume":"21","author":"CH Liu","year":"2014","unstructured":"Liu CH, Yu CY, Chang WC, Dai MS, Hsiao CW, Chou YC (2014) Radiofrequency ablation of hepatic metastases: factors influencing local tumor progression. Ann Surg Oncol 21:3090\u20133095","journal-title":"Ann Surg Oncol"},{"key":"2394_CR11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/02656730600609122","volume":"22","author":"Z Liu","year":"2006","unstructured":"Liu Z, Ahmed M, Weinstein Y, Yi M, Mahajan RL, Goldberg SN (2006) Characterization of the RF ablation-induced \u201coven effect\u201d: the importance of background tissue thermal conductivity on tissue heating. Int J Hyperthermia 22:327\u2013342","journal-title":"Int J Hyperthermia"},{"key":"2394_CR12","first-page":"2913","volume":"15","author":"F Primavesi","year":"2018","unstructured":"Primavesi F, Swierczynski S, Klieser E et al (2018) Thermographic real-time-monitoring of surgical radiofrequency and microwave ablation in a perfused porcine liver model. Oncol Lett 15:2913\u20132920","journal-title":"Oncol Lett"},{"key":"2394_CR13","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/s41598-017-18899-2","volume":"8","author":"P Voglreiter","year":"2018","unstructured":"Voglreiter P, Mariappan P, Pollari M et al (2018) RFA Guardian: comprehensive simulation of radiofrequency ablation treatment of liver tumors. Sci Rep 8:787","journal-title":"Sci Rep"},{"key":"2394_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06411-5","author":"M Moche","year":"2019","unstructured":"Moche M, Busse H, Futterer JJ et al (2019) Clinical evaluation of in silico planning and real-time simulation of hepatic radiofrequency ablation (ClinicIMPPACT Trial). Eur Radiol. https:\/\/doi.org\/10.1007\/s00330-019-06411-5","journal-title":"Eur Radiol"},{"key":"2394_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.conctc.2017.08.004","volume":"8","author":"M Reinhardt","year":"2017","unstructured":"Reinhardt M, Brandmaier P, Seider D et al (2017) A prospective development study of software-guided radio-frequency ablation of primary and secondary liver tumors: Clinical intervention modelling, planning and proof for ablation cancer treatment (ClinicIMPPACT). Contemp Clin Trials Commun 8:25\u201332","journal-title":"Contemp Clin Trials Commun"},{"key":"2394_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11548-016-1469-1","volume":"12","author":"P Mariappan","year":"2017","unstructured":"Mariappan P, Weir P, Flanagan R et al (2017) GPU-based RFA simulation for minimally invasive cancer treatment of liver tumours. Int J Comput Assist Radiol Surg 12:59\u201368","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"2394_CR17","doi-asserted-by":"publisher","first-page":"3718","DOI":"10.1002\/mp.12332","volume":"44","author":"G Gunay","year":"2017","unstructured":"Gunay G, Luu MH, Moelker A, van Walsum T, Klein S (2017) Semiautomated registration of pre- and intraoperative CT for image-guided percutaneous liver tumor ablation interventions. Med Phys 44:3718\u20133725","journal-title":"Med Phys"},{"key":"2394_CR18","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1016\/j.acra.2010.06.004","volume":"17","author":"H Elhawary","year":"2010","unstructured":"Elhawary H, Oguro S, Tuncali K et al (2010) Multimodality non-rigid image registration for planning, targeting and monitoring during CT-guided percutaneous liver tumor cryoablation. Acad Radiol 17:1334\u20131344","journal-title":"Acad Radiol"},{"key":"2394_CR19","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2020-0033","author":"J Schaible","year":"2020","unstructured":"Schaible J, Pregler B, Verloh N et al (2020) Improvement of the primary efficacy of microwave ablation of malignant liver tumors by using a robotic navigation system. Radiol Oncol. https:\/\/doi.org\/10.2478\/raon-2020-0033","journal-title":"Radiol Oncol"},{"key":"2394_CR20","doi-asserted-by":"publisher","first-page":"e1952","DOI":"10.1002\/rcs.1952","volume":"15","author":"P Liu","year":"2019","unstructured":"Liu P, Qin J, Duan B et al (2019) Overlapping radiofrequency ablation planning and robot-assisted needle insertion for large liver tumors. Int J Med Robot 15:e1952","journal-title":"Int J Med Robot"},{"key":"2394_CR21","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ejrad.2018.06.006","volume":"105","author":"T Hiraki","year":"2018","unstructured":"Hiraki T, Matsuno T, Kamegawa T et al (2018) Robotic insertion of various ablation needles under computed tomography guidance: accuracy in animal experiments. Eur J Radiol 105:162\u2013167","journal-title":"Eur J Radiol"},{"key":"2394_CR22","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s11548-015-1286-y","volume":"11","author":"LP Beyer","year":"2016","unstructured":"Beyer LP, Pregler B, Niessen C et al (2016) Robot-assisted microwave thermoablation of liver tumors: a single-center experience. Int J Comput Assist Radiol Surg 11:253\u2013259","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"2394_CR23","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1007\/s00330-011-2314-0","volume":"22","author":"R Bale","year":"2012","unstructured":"Bale R, Widmann G, Schullian P et al (2012) Percutaneous stereotactic radiofrequency ablation of colorectal liver metastases. Eur Radiol 22:930\u2013937","journal-title":"Eur Radiol"},{"key":"2394_CR24","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1007\/s00270-011-0200-4","volume":"35","author":"G Widmann","year":"2012","unstructured":"Widmann G, Schullian P, Haidu M, Bale R (2012) Stereotactic radiofrequency ablation (SRFA) of liver lesions: technique effectiveness, safety, and interoperator performance. Cardiovasc Intervent Radiol 35:570\u2013580","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2394_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07409-0","author":"P Schullian","year":"2020","unstructured":"Schullian P, Johnston E, Laimer G et al (2020) Frequency and risk factors for major complications after stereotactic radiofrequency ablation of liver tumors in 1235 ablation sessions: a 15-year experience. Eur Radiol. https:\/\/doi.org\/10.1007\/s00330-020-07409-0","journal-title":"Eur Radiol"},{"key":"2394_CR26","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1213\/ANE.0b013e318212b851","volume":"112","author":"J Raiten","year":"2011","unstructured":"Raiten J, Elkassabany N, Gao W, Mandel JE (2011) Novel uses of high frequency ventilation outside the operating room. Anesth Analg 112:1110\u20131113","journal-title":"Anesth Analg"},{"key":"2394_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1177\/153303460600500102","volume":"5","author":"P Fritz","year":"2006","unstructured":"Fritz P, Kraus HJ, D\u00f6lken W, M\u00fchlnickel W, M\u00fcller-Nolte F, Hering W (2006) Technical note: gold marker implants and high-frequency jet ventilation for stereotactic, single-dose irradiation of liver tumors. Technol Cancer Res Treat 5:9\u201314","journal-title":"Technol Cancer Res Treat"}],"container-title":["International Journal of Computer Assisted Radiology and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-021-02394-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11548-021-02394-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-021-02394-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T10:53:12Z","timestamp":1622458392000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11548-021-02394-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,11]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2394"],"URL":"https:\/\/doi.org\/10.1007\/s11548-021-02394-1","relation":{},"ISSN":["1861-6410","1861-6429"],"issn-type":[{"type":"print","value":"1861-6410"},{"type":"electronic","value":"1861-6429"}],"subject":[],"published":{"date-parts":[[2021,5,11]]},"assertion":[{"value":"23 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no Conflict of interest or any disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All included patients were informed, consented and signed an informed consent form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All included patients were informed, consented and signed an informed consent form.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publications"}},{"value":"Approval was given by our institutional review board (CMO region Arnhem-Nijmegen; NL54334.091.15).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}