{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:19:12Z","timestamp":1780463952797,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SA 3461\/2-1"],"award-info":[{"award-number":["SA 3461\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerium f\u00fcr Wissenschaft und Wirtschaft, Land Sachsen-Anhalt (DE), Forschungscampus STIMULATE","award":["I 117"],"award-info":[{"award-number":["I 117"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J CARS"],"published-print":{"date-parts":[[2021,11]]},"abstract":"Abstract<\/jats:title>\n Purpose<\/jats:title>\n Intracranial aneurysms are local dilations of brain vessels. Their rupture, as well as their treatment, is associated with high risk of morbidity and mortality. In this work, we propose shape indices for aneurysm ostia for the rupture risk assessment of intracranial aneurysms.<\/jats:p>\n <\/jats:sec>\n Methods<\/jats:title>\n We analyzed 84 middle cerebral artery bifurcation aneurysms (27 ruptured and 57 unruptured) and their ostia, with respect to their size and shape. We extracted 3D models of the aneurysms and vascular trees. A semi-automatic approach was used to separate the aneurysm from its parent vessel and to reconstruct the ostium. We used known indices to quantitatively describe the aneurysms. For the ostium, we present new shape indices: the 2D Undulation Index (UI$$_\\mathrm{2D}$$<\/jats:tex-math>\n \n \n \n 2<\/mml:mn>\n D<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>), the 2D Ellipticity Index (EI$$_\\mathrm{2D}$$<\/jats:tex-math>\n \n \n \n 2<\/mml:mn>\n D<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>) and the 2D Noncircularity Index (NCI$$_\\mathrm{2D}$$<\/jats:tex-math>\n \n \n \n 2<\/mml:mn>\n D<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>). Results were analyzed using the Student t<\/jats:italic> test, the Mann\u2013Whitney U<\/jats:italic> test and a correlation analysis between indices of the aneurysms and their ostia.<\/jats:p>\n <\/jats:sec>\n Results<\/jats:title>\n Of the indices, none was significantly associated with rupture status. Most aneurysms have an NCI$$_\\mathrm{2D}$$<\/jats:tex-math>\n \n \n \n 2<\/mml:mn>\n D<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> below 0.2. Of the aneurysms that have an NCI$$_\\mathrm{2D}$$<\/jats:tex-math>\n \n \n \n 2<\/mml:mn>\n D<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> above 0.5, only one is ruptured, which indicates that ruptured aneurysms often have a circular-shaped ostium. Furthermore, the ostia of ruptured aneurysms tend to have a smaller area, which is also correlated with the aneurysm\u2019s size. While also other variables were significantly correlated, strong linear correlations can only be seen between the area of the ostium with the aneurysm\u2019s volume and surface.<\/jats:p>\n <\/jats:sec>\n Conclusion<\/jats:title>\n The proposed shape indices open up new possibilities to quantitatively describe and compare ostia, which can be beneficial for rupture risk assessment and subsequent treatment decision. Additionally, this work shows that the ostium area and the size of the aneurysm are correlated. Further longitudinal studies are necessary to analyze whether stable and unstable aneurysms can be distinguished by their ostia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s11548-021-02469-z","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T10:03:31Z","timestamp":1629281011000},"page":"1977-1984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Definition and extraction of 2D shape indices of intracranial aneurysm necks for rupture risk assessment"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4124-3132","authenticated-orcid":false,"given":"Sarah","family":"Mittenentzwei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Beuing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-0545","authenticated-orcid":false,"given":"Belal","family":"Neyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Erol","family":"Sandalcioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9826-9478","authenticated-orcid":false,"given":"Bernhard","family":"Preim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-7917","authenticated-orcid":false,"given":"Sylvia","family":"Saalfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"issue":"3","key":"2469_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.tjem.2018.08.001","volume":"18","author":"H Akoglu","year":"2018","unstructured":"Akoglu H (2018) Users guide to correlation coefficients. Turk J Emerg Med 18(3):91\u201393. https:\/\/doi.org\/10.1016\/j.tjem.2018.08.001","journal-title":"Turk J Emerg Med"},{"key":"2469_CR2","unstructured":"Aneurisk-Team: AneuriskWeb project website, http:\/\/ecm2.mathcs.emory.edu\/ aneuriskweb. Web Site (2012)"},{"issue":"11","key":"2469_CR3","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s11517-008-0420-1","volume":"46","author":"L Antiga","year":"2008","unstructured":"Antiga L, Piccinelli M, Botti L, Ene-Iordache B, Remuzzi A, Steinman DA (2008) An image-based modeling framework for patient-specific computational hemodynamics. Med Biol Eng Comput 46(11):1097","journal-title":"Med Biol Eng Comput"},{"issue":"10","key":"2469_CR4","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1007\/s00701-003-0124-0","volume":"145","author":"J Beck","year":"2003","unstructured":"Beck J, Rohde S, el Beltagy M, Zimmermann M, Berkefeld J, Seifert V, Raabe A (2003) Difference in configuration of ruptured and unruptured intracranial aneurysms determined by biplanar digital subtraction angiography. Acta Neurochir 145(10):861\u2013865. https:\/\/doi.org\/10.1007\/s00701-003-0124-0","journal-title":"Acta Neurochir"},{"issue":"3","key":"2469_CR5","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1148\/radiol.13120099","volume":"267","author":"T Becske","year":"2013","unstructured":"Becske T, Kallmes DF, Saatci I, McDougall CG, Szikora I, Lanzino G, Moran CJ, Woo HH, Lopes DK, Berez AL, Cher DJ, Siddiqui AH, Levy EI, Albuquerque FC, Fiorella DJ, Berentei Z, Mar\u0151sfoi M, Cekirge SH, Nelson PK (2013) Pipeline for uncoilable or failed aneurysms: Results from a multicenter clinical trial. Radiology 267(3):858\u2013868. https:\/\/doi.org\/10.1148\/radiol.13120099","journal-title":"Radiology"},{"key":"2469_CR6","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2307\/2346101","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate\u2014a practical and powerful approach to multiple testing. J R Stat Soc Ser B 57:289\u2013300. https:\/\/doi.org\/10.2307\/2346101","journal-title":"J R Stat Soc Ser B"},{"issue":"8","key":"2469_CR7","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1161\/strokeaha.117.017391","volume":"48","author":"P Bijlenga","year":"2017","unstructured":"Bijlenga P, Gondar R, Schilling S, Morel S, Hirsch S, Cuony J, Corniola MV, Perren F, R\u00fcfenacht D, Schaller K (2017) PHASES score for the management of intracranial aneurysm. Stroke 48(8):2105\u20132112. https:\/\/doi.org\/10.1161\/strokeaha.117.017391","journal-title":"Stroke"},{"issue":"11","key":"2469_CR8","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1161\/strokeaha.108.521617","volume":"39","author":"L Boussel","year":"2008","unstructured":"Boussel L, Rayz V, McCulloch C, Martin A, Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D (2008) Aneurysm growth occurs at region of low wall shear stress. Stroke 39(11):2997\u20133002. https:\/\/doi.org\/10.1161\/strokeaha.108.521617","journal-title":"Stroke"},{"issue":"4","key":"2469_CR9","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1136\/neurintsurg-2016-012327","volume":"9","author":"W Brinjikji","year":"2017","unstructured":"Brinjikji W, Chung BJ, Jimenez C, Putman C, Kallmes DF, Cebral JR (2017) Hemodynamic differences between unstable and stable unruptured aneurysms independent of size and location: a pilot study. J Neurointervent Surg 9(4):376\u2013380","journal-title":"J Neurointervent Surg"},{"issue":"8","key":"2469_CR10","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.3174\/ajnr.a1633","volume":"30","author":"W Brinjikji","year":"2009","unstructured":"Brinjikji W, Cloft H, Kallmes D (2009) Difficult aneurysms for endovascular treatment: Overwide or undertall? Am J Neuroradiol 30(8):1513\u20131517. https:\/\/doi.org\/10.3174\/ajnr.a1633","journal-title":"Am J Neuroradiol"},{"issue":"3","key":"2469_CR11","doi-asserted-by":"publisher","first-page":"500","DOI":"10.3174\/ajnr.a5531","volume":"39","author":"A Chien","year":"2018","unstructured":"Chien A, Xu M, Yokota H, Scalzo F, Morimoto E, Salamon N (2018) Nonsphericity index and size ratio identify morphologic differences between growing and stable aneurysms in a longitudinal study of 93 cases. Am J Neuroradiol 39(3):500\u2013506. https:\/\/doi.org\/10.3174\/ajnr.a5531","journal-title":"Am J Neuroradiol"},{"issue":"3","key":"2469_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00234-018-2135-9","volume":"61","author":"FJ Detmer","year":"2018","unstructured":"Detmer FJ, Chung BJ, Jimenez C, Hamzei-Sichani F, Kallmes D, Putman C, Cebral JR (2018) Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location. Neuroradiology 61(3):275\u2013284. https:\/\/doi.org\/10.1007\/s00234-018-2135-9","journal-title":"Neuroradiology"},{"key":"2469_CR13","doi-asserted-by":"crossref","unstructured":"Detmer FJ, Chung BJ, Mut F, Slawski M, Hamzei-Sichani F, Putman C, Jim\u00e9nez C, Cebral JR (2018) Development and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics. Int J Comput Assist Radiol Surg 13(11):1767\u20131779","DOI":"10.1007\/s11548-018-1837-0"},{"issue":"2","key":"2469_CR14","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1227\/01.neu.0000316847.64140.81","volume":"63","author":"S Dhar","year":"2008","unstructured":"Dhar S, Tremmel M, Mocco J, Kim M, Yamamoto J, Siddiqui AH, Hopkins LN, Meng H (2008) Morphology parameters for intracranial aneurysm rupture risk assessment. Neurosurgery 63(2):185\u2013197. https:\/\/doi.org\/10.1227\/01.neu.0000316847.64140.81","journal-title":"Neurosurgery"},{"key":"2469_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1214\/09-ss051","volume":"4","author":"MP Fay","year":"2010","unstructured":"Fay MP, Proschan MA (2010) Wilcoxon\u2013Mann\u2013Whitney or t-test? On assumptions for hypothesis tests and multiple interpretations of decision rules. Stat Surv 4:1\u201339. https:\/\/doi.org\/10.1214\/09-ss051","journal-title":"Stat Surv"},{"issue":"6","key":"2469_CR16","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1097\/00006123-200112000-00006","volume":"49","author":"TR Forget","year":"2001","unstructured":"Forget TR, Benitez R, Veznedaroglu E, Sharan A, Mitchell W, Silva M, Rosenwasser RH (2001) A review of size and location of ruptured intracranial aneurysms. Neurosurgery 49(6):1322\u20131326. https:\/\/doi.org\/10.1097\/00006123-200112000-00006","journal-title":"Neurosurgery"},{"issue":"1","key":"2469_CR17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/s1474-4422(13)70263-1","volume":"13","author":"JP Greving","year":"2014","unstructured":"Greving JP, Wermer MJH, Brown RD, Morita A, Juvela S, Yonekura M, Ishibashi T, Torner JC, Nakayama T, Rinkel GJE, Algra A (2014) Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol 13(1):59\u201366. https:\/\/doi.org\/10.1016\/s1474-4422(13)70263-1","journal-title":"Lancet Neurol"},{"key":"2469_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s41016-018-0138-3","author":"CQ Huang","year":"2018","unstructured":"Huang CQ, Kang DZ, Yu LH, Zheng SF, Yao PS, Lin YX, Lin ZY (2018) The classification of intracranial aneurysm neck: a single center research experience. Chin Neurosurg J. https:\/\/doi.org\/10.1186\/s41016-018-0138-3","journal-title":"Chin Neurosurg J"},{"issue":"1","key":"2469_CR19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1161\/STROKEAHA.108.521674","volume":"40","author":"T Ishibashi","year":"2008","unstructured":"Ishibashi T, Murayama Y, Urashima M, Saguchi T, Ebara M, Arakawa H, Irie K, Takao H, Abe T (2008) Unruptured intracranial aneurysms\u2014incidence of rupture and risk factors. Stroke 40(1):313\u2013316. https:\/\/doi.org\/10.1161\/STROKEAHA.108.521674","journal-title":"Stroke"},{"issue":"4","key":"2469_CR20","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1161\/strokeaha.117.020342","volume":"49","author":"R Jabbarli","year":"2018","unstructured":"Jabbarli R, Dinger TF, Oppong MD, Pierscianek D, Dammann P, Wrede KH, Kaier K, K\u00f6hrmann M, Forsting M, Kleinschnitz C, Sure U (2018) Risk factors for and clinical consequences of multiple intracranial aneurysms. Stroke 49(4):848\u2013855. https:\/\/doi.org\/10.1161\/strokeaha.117.020342","journal-title":"Stroke"},{"issue":"2","key":"2469_CR21","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1109\/tbme.2019.2918921","volume":"67","author":"T Jerman","year":"2020","unstructured":"Jerman T, Chien A, Pernus F, Likar B, Spiclin Z (2020) Automated cutting plane positioning for intracranial aneurysm quantification. IEEE Trans Biomed Eng 67(2):577\u2013587. https:\/\/doi.org\/10.1109\/tbme.2019.2918921","journal-title":"IEEE Trans Biomed Eng"},{"issue":"3","key":"2469_CR22","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1136\/svn-2016-000027","volume":"1","author":"B Jiang","year":"2016","unstructured":"Jiang B, Paff M, Colby GP, Coon AL, Lin LM (2016) Cerebral aneurysm treatment: modern neurovascular techniques. BMJ 1(3):93\u2013100. https:\/\/doi.org\/10.1136\/svn-2016-000027","journal-title":"BMJ"},{"issue":"5","key":"2469_CR23","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1136\/neurintsurg-2014-011182","volume":"7","author":"C Karmonik","year":"2014","unstructured":"Karmonik C, Diaz O, Klucznik R, Grossman RG, Zhang YJ, Britz G, Lv N, Huang Q (2014) Quantitative comparison of hemodynamic parameters from steady and transient CFD simulations in cerebral aneurysms with focus on the aneurysm ostium. J NeuroIntervent Surg 7(5):367\u2013372. https:\/\/doi.org\/10.1136\/neurintsurg-2014-011182","journal-title":"J NeuroIntervent Surg"},{"issue":"2","key":"2469_CR24","first-page":"141","volume":"9","author":"A Keedy","year":"2006","unstructured":"Keedy A (2006) An overview of intracranial aneurysms. McGill J Med MJM 9(2):141","journal-title":"McGill J Med MJM"},{"key":"2469_CR25","doi-asserted-by":"publisher","unstructured":"Kretschmer T (ed) (2017) Zerebrale Aneurysmen und Gef\u00e4\u00dfmalformationen. Springer, Berlin. https:\/\/doi.org\/10.1007\/978-3-662-50478-9","DOI":"10.1007\/978-3-662-50478-9"},{"issue":"3","key":"2469_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1109\/MCG.2018.032421654","volume":"38","author":"M Meuschke","year":"2018","unstructured":"Meuschke M, G\u00fcnther T, Wickenh\u00f6fer R, Gross M, Preim B, Lawonn K (2018) Management of cerebral aneurysm descriptors based on an automatic ostium extraction. IEEE Comput Gr Appl 38(3):58\u201372","journal-title":"IEEE Comput Gr Appl"},{"key":"2469_CR27","doi-asserted-by":"publisher","unstructured":"Nadgir R, Yousem DM (2017) Cerebral aneurysms. Requisit Neuroradiol. https:\/\/doi.org\/10.1002\/9781118782934","DOI":"10.1002\/9781118782934"},{"key":"2469_CR28","doi-asserted-by":"publisher","unstructured":"Niemann U, Berg P, Niemann A, Beuing O, Preim B, Spiliopoulou M, Saalfeld S (2018) Rupture status classification of intracranial aneurysms using morphological parameters. In: 2018 IEEE 31st international symposium on computer-based medical systems (CBMS). IEEE (2018). https:\/\/doi.org\/10.1109\/cbms.2018.00016","DOI":"10.1109\/cbms.2018.00016"},{"issue":"2","key":"2469_CR29","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3174\/ajnr.A5953","volume":"40","author":"N Paliwal","year":"2019","unstructured":"Paliwal N, Tutino V, Shallwani H, Beecher J, Damiano R, Shakir H, Atwal G, Fennell V, Natarajan S, Levy E, Siddiqui A, Davies J, Meng H (2019) Ostium ratio and neck ratio could predict the outcome of sidewall intracranial aneurysms treated with flow diverters. Am J Neuroradiol 40(2):288\u2013294. https:\/\/doi.org\/10.3174\/ajnr.A5953","journal-title":"Am J Neuroradiol"},{"issue":"2","key":"2469_CR30","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3171\/jns.2005.102.2.0355","volume":"102","author":"ML Raghavan","year":"2009","unstructured":"Raghavan ML, Ma B, Harbaugh RE (2009) Quantified aneurysm shape and rupture risk. J Neurosurg 102(2):355\u2013362. https:\/\/doi.org\/10.3171\/jns.2005.102.2.0355","journal-title":"J Neurosurg"},{"key":"2469_CR31","doi-asserted-by":"publisher","first-page":"e541","DOI":"10.1016\/j.wneu.2018.07.208","volume":"119","author":"H Rajabzadeh-Oghaz","year":"2018","unstructured":"Rajabzadeh-Oghaz H, Varble N, Shallwani H, Tutino VM, Mowla A, Shakir HJ, Vakharia K, Atwal GS, Siddiqui AH, Davies JM, Meng H (2018) Computer-assisted three-dimensional morphology evaluation of intracranial aneurysms. World Neurosurg 119:e541\u2013e550. https:\/\/doi.org\/10.1016\/j.wneu.2018.07.208","journal-title":"World Neurosurg"},{"issue":"2","key":"2469_CR32","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3171\/2015.2.jns142265","volume":"124","author":"M Ramachandran","year":"2016","unstructured":"Ramachandran M, Retarekar R, Raghavan ML, Berkowitz B, Dickerhoff B, Correa T, Lin S, Johnson K, Hasan D, Ogilvy C, Rosenwasser R, Torner J, Bogason E, Stapleton CJ, Harbaugh RE (2016) Assessment of image-derived risk factors for natural course of unruptured cerebral aneurysms. J Neurosurg 124(2):288\u2013295. https:\/\/doi.org\/10.3171\/2015.2.jns142265","journal-title":"J Neurosurg"},{"issue":"6","key":"2469_CR33","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1161\/01.str.0000073841.88563.e9","volume":"34","author":"J Raymond","year":"2003","unstructured":"Raymond J, Guilbert F, Weill A, Georganos SA, Juravsky L, Lambert A, Lamoureux J, Chagnon M, Roy D (2003) Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke 34(6):1398\u20131403. https:\/\/doi.org\/10.1161\/01.str.0000073841.88563.e9","journal-title":"Stroke"},{"issue":"11","key":"2469_CR34","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s00234-010-0804-4","volume":"53","author":"CW Ryu","year":"2010","unstructured":"Ryu CW, Kwon OK, Koh JS, Kim EJ (2010) Analysis of aneurysm rupture in relation to the geometric indices: aspect ratio, volume, and volume-to-neck ratio. Neuroradiology 53(11):883\u2013889. https:\/\/doi.org\/10.1007\/s00234-010-0804-4","journal-title":"Neuroradiology"},{"issue":"11","key":"2469_CR35","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1007\/s11548-018-1848-x","volume":"13","author":"S Saalfeld","year":"2018","unstructured":"Saalfeld S, Berg P, Niemann A, Luz M, Preim B, Beuing O (2018) Semiautomatic neck curve reconstruction for intracranial aneurysm rupture risk assessment based on morphological parameters. Int J Comput Assist Radiol Surg 13(11):1781\u20131793. https:\/\/doi.org\/10.1007\/s11548-018-1848-x","journal-title":"Int J Comput Assist Radiol Surg"},{"issue":"3","key":"2469_CR36","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3174\/ajnr.A6413","volume":"41","author":"T Su","year":"2020","unstructured":"Su T, Reymond P, Brina O, Bouillot P, Machi P, Delattre B, Jin L, L\u00f6vblad K, Vargas M (2020) Large neck and strong ostium inflow as the potential causes for delayed occlusion of unruptured sidewall intracranial aneurysms treated by flow diverter. Am J Neuroradiol 41(3):488\u2013494. https:\/\/doi.org\/10.3174\/ajnr.A6413","journal-title":"Am J Neuroradiol"},{"issue":"6","key":"2469_CR37","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.acra.2012.02.012","volume":"19","author":"SC Wong","year":"2012","unstructured":"Wong SC, Nawawi O, Ramli N, Kadir KAA (2012) Benefits of 3d rotational DSA compared with 2d DSA in the evaluation of intracranial aneurysm. Acad Radiol 19(6):701\u2013707. https:\/\/doi.org\/10.1016\/j.acra.2012.02.012","journal-title":"Acad Radiol"}],"container-title":["International Journal of Computer Assisted Radiology and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-021-02469-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11548-021-02469-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-021-02469-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T13:10:12Z","timestamp":1636722612000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11548-021-02469-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["2469"],"URL":"https:\/\/doi.org\/10.1007\/s11548-021-02469-z","relation":{},"ISSN":["1861-6410","1861-6429"],"issn-type":[{"value":"1861-6410","type":"print"},{"value":"1861-6429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]},"assertion":[{"value":"11 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors Sarah Mittenentzwei, Oliver Beuing, Belal Neyazi, I. Erol Sandalcioglu, Naomi Larsen, Bernhard Preim and Sylvia Saalfeld declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"For this type of study, formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}