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In combination with 4D flow fields acquired with phase-contrast (PC) MRI, hemodynamic information can be extracted to enhance the analysis by providing direct measurements in the larger arteries or patient-specific boundary conditions. Hence, a registration between both modalities is required.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>To combine TOF and PC-MRI data, we developed a hybrid registration approach. Vessels and their centerlines are segmented from the TOF data. The centerline is fit to the intensity ridges of the lower resolved PC-MRI data, which provides temporal information. We used a metric that utilizes a scaled sum of weighted intensities and gradients on the normal plane. The registration is then guided by decoupled local affine transformations. It is applied hierarchically following the branching order of the vessel tree.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A landmark validation over Monte Carlo simulations yielded an average mean squared error of 184.73\u00a0mm and an average Hausdorff distance of 15.20\u00a0mm. The hierarchical traversal that transforms child vessels with their parents registers even small vessels not detectable in the PC-MRI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The presented work combines high-resolution tomographic information from 7T TOF-MRI and measured flow data from 4D 7T PC-MRI scan for the arteries of the brain. This enables usage of patient-specific flow parameters for realistic simulations, thus supporting research in areas such as cerebral small vessel disease. Automatization and free deformations can help address the limiting error measures in the future.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11548-023-02836-y","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T04:37:06Z","timestamp":1674275826000},"page":"837-844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A hybrid hierarchical strategy for registration of 7T TOF-MRI to 7T PC-MRI intracranial vessel data"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-6918","authenticated-orcid":false,"given":"Lena","family":"Spitz","sequence":"first","affiliation":[]},{"given":"Franziska","family":"Gaidzik","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Stucht","sequence":"additional","affiliation":[]},{"given":"Hendrik","family":"Mattern","sequence":"additional","affiliation":[]},{"given":"Bernhard","family":"Preim","sequence":"additional","affiliation":[]},{"given":"Sylvia","family":"Saalfeld","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"issue":"1","key":"2836_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1532-429X-13-19","volume":"13","author":"MP Hartung","year":"2011","unstructured":"Hartung MP, Grist TM, Fran\u00e7ois CJ (2011) Magnetic resonance angiography: current status and future directions. 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Written informed consent was obtained from all subjects before the scans. In clinical research and practice, multimodal image data or different sequences are required for answering diagnostic and research questions. Depending on the data and artifacts, co-registration can be error-prone and often requires highly adapted algorithms.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}