{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:54:15Z","timestamp":1782521655244,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100022242","name":"Botnar Research Centre for Child Health, University of Basel","doi-asserted-by":"publisher","award":["11724"],"award-info":[{"award-number":["11724"]}],"id":[{"id":"10.13039\/501100022242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["205321 205008"],"award-info":[{"award-number":["205321 205008"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J CARS"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Presurgical orthopedic plates are widely used for the treatment of cleft lip and palate, which is the most common craniofacial birth defect. For the traditional plate fabrication, an impression is taken under airway-endangering conditions, which recent digital alternatives overcome via intraoral scanners. However, these alternatives demand proficiency in 3D modeling software in addition to the generally required clinical knowledge of plate design.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We address these limitations with a data-driven and fully automated digital pipeline, endowed with a graphical user interface. The pipeline adopts a deep learning model to landmark raw intraoral scans of arbitrary mesh topology and orientation, which guides the nonrigid surface registration subsequently employed to segment the scans. The plates that are individually fit to these segmented scans are 3D-printable and offer optional customization.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>With the distance to the alveolar ridges closely centered around the targeted 0.1\u00a0mm, our pipeline computes tightly fitting plates in less than 3\u00a0min. The plates were approved in 12 out of 12 cases by two cleft care professionals in a printed-model-based evaluation. Moreover, since the pipeline was implemented in clinical routine in two hospitals, 19 patients have been undergoing treatment utilizing our automated designs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results demonstrate that our automated pipeline meets the high precision requirements of the medical setting employed in cleft lip and palate care while substantially reducing the design time and required clinical expertise, which could facilitate access to this presurgical treatment, especially in low-income countries.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11548-023-02858-6","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T10:01:28Z","timestamp":1680516088000},"page":"1119-1125","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Automated and data-driven plate computation for presurgical cleft lip and palate treatment"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7277-2515","authenticated-orcid":false,"given":"Till N.","family":"Schnabel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baran","family":"G\u00f6zc\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Gotardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Lingens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dorda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frawa","family":"Vetterli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Emhemmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Nalabothu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriko","family":"Lill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benito K.","family":"Benitez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas A.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Solenthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,2]]},"reference":[{"key":"2858_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000337464","volume":"16","author":"PA Mossey","year":"2012","unstructured":"Mossey PA, Modell B (2012) Epidemiology of oral clefts 2012: an international perspective. Front Oral Biol 16:1\u201318. https:\/\/doi.org\/10.1159\/000337464","journal-title":"Front Oral Biol"},{"key":"2858_CR2","first-page":"66","volume":"10","author":"B Mishra","year":"2010","unstructured":"Mishra B, Singh AK, Zaidi J, Singh GK, Agrawal R, Kumar V (2010) Presurgical nasoalveolar molding for correction of cleft lip nasal deformity: experience from northern India. Eplasty 10:66","journal-title":"Eplasty"},{"key":"2858_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2147\/CCIDE.S129598","volume":"9","author":"I Alzain","year":"2017","unstructured":"Alzain I, Batwa W, Cash A, Murshid ZA (2017) Presurgical cleft lip and palate orthopedics: an overview. Clin Cosmet Investig Dent 9:53\u201359. https:\/\/doi.org\/10.2147\/CCIDE.S129598","journal-title":"Clin Cosmet Investig Dent"},{"issue":"7","key":"2858_CR4","first-page":"1422","volume":"92","author":"BH Grayson","year":"1993","unstructured":"Grayson BH, Cutting C, Wood R (1993) Preoperative columella lengthening in bilateral cleft lip and palate. Plast Reconstr Surg 92(7):1422\u20131423","journal-title":"Plast Reconstr Surg"},{"issue":"01","key":"2858_CR5","doi-asserted-by":"publisher","first-page":"035","DOI":"10.1055\/s-0039-1684106","volume":"07","author":"TG Lodhi","year":"2019","unstructured":"Lodhi TG, Patil SKB, Bahetwar SKK, Sharma AB, Ninawe NS, Dolas AR (2019) Fabrication of feeding plate in cleft palate patient: a case report. Dent J Adv Stud 07(01):035\u2013037. https:\/\/doi.org\/10.1055\/s-0039-1684106","journal-title":"Dent J Adv Stud"},{"issue":"4","key":"2858_CR6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1179\/bjo.22.4.299","volume":"22","author":"RA Chate","year":"1995","unstructured":"Chate RA (1995) A report on the hazards encountered when taking neonatal cleft palate impressions (1983\u20131992). Br J Orthod 22(4):299\u2013307. https:\/\/doi.org\/10.1179\/bjo.22.4.299","journal-title":"Br J Orthod"},{"issue":"3","key":"2858_CR7","first-page":"251","volume":"21","author":"K-F Krey","year":"2018","unstructured":"Krey K-F, Ratzmann A, Metelmann PH, Hartmann M, Ruge S, Korda\u00df B (2018) Fully digital workflow for presurgical orthodontic plate in cleft lip and palate patients. Int J Comput Dent 21(3):251\u2013259","journal-title":"Int J Comput Dent"},{"key":"2858_CR8","unstructured":"Xepapadeas AB, Klein N, Weise C, Frank K, Arand J, Wiechers C, Poets CF, Koos B, Spintzyk S (2019) Digitaler workflow zur herstellung von gaumenabdeckplatten. Quintessenz Zahntechnik 45:1242\u20131250"},{"issue":"2","key":"2858_CR9","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/SCS.0000000000006258","volume":"31","author":"X Gong","year":"2020","unstructured":"Gong X, Dang R, Xu T, Yu Q, Zheng J (2020) Full digital workflow of nasoalveolar molding treatment in infants with cleft lip and palate. J Craniofac Surg 31(2):367\u2013371. https:\/\/doi.org\/10.1097\/SCS.0000000000006258","journal-title":"J Craniofac Surg"},{"key":"2858_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/children9081261","author":"P Zarean","year":"2022","unstructured":"Zarean P, Zarean P, Thieringer FM, Mueller AA, Kressmann S, Erismann M, Sharma N, Benitez BK (2022) A point-of-care digital workflow for 3d printed passive presurgical orthopedic plates in cleft care. Children. https:\/\/doi.org\/10.3390\/children9081261","journal-title":"Children"},{"issue":"1","key":"2858_CR11","doi-asserted-by":"publisher","first-page":"11845","DOI":"10.1038\/s41598-018-29959-6","volume":"8","author":"FD Grill","year":"2018","unstructured":"Grill FD, Ritschl LM, Bauer FX, Rau A, Gau D, Roth M, Eblenkamp M, Wolff K-D, Loeffelbein DJ (2018) A semi-automated virtual workflow solution for the design and production of intraoral molding plates using additive manufacturing: the first clinical results of a pilot-study. Sci Rep 8(1):11845. https:\/\/doi.org\/10.1038\/s41598-018-29959-6","journal-title":"Sci Rep"},{"issue":"5","key":"2858_CR12","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1109\/TBME.2019.2934907","volume":"67","author":"J Schiebl","year":"2019","unstructured":"Schiebl J, Bauer FX, Grill F, Loeffelbein DJ (2019) RapidNAM: algorithm for the semi-automated generation of nasoalveolar molding device designs for the presurgical treatment of bilateral cleft lip and palate. IEEE Trans Biomed Eng 67(5):1263\u20131271. https:\/\/doi.org\/10.1109\/TBME.2019.2934907","journal-title":"IEEE Trans Biomed Eng"},{"key":"2858_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040962","author":"P Nalabothu","year":"2020","unstructured":"Nalabothu P, Benitez BK, Dalstra M, Verna C, Mueller AA (2020) Three-dimensional morphological changes of the true cleft under passive presurgical orthopaedics in unilateral cleft lip and palate: a retrospective cohort study. J Clin Med. https:\/\/doi.org\/10.3390\/jcm9040962","journal-title":"J Clin Med"},{"key":"2858_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/3507905","volume":"41","author":"N Sharp","year":"2022","unstructured":"Sharp N, Attaiki S, Crane K, Ovsjanikov M (2022) Diffusionnet: discretization agnostic learning on surfaces. ACM Trans Graph 41:1\u201316. https:\/\/doi.org\/10.1145\/3507905","journal-title":"ACM Trans Graph"},{"key":"2858_CR15","unstructured":"Carotenuto L (2022) Three dimensional facial landmark detection in 3d photos. Master\u2019s thesis, Radboud University. https:\/\/www.ai-for-health.nl\/projects\/3d-landmark-detection. Accessed 19 Aug 2022"},{"issue":"1","key":"2858_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/BF02291478","volume":"40","author":"JC Gower","year":"1975","unstructured":"Gower JC (1975) Generalized procrustes analysis. Psychometrika 40(1):33\u201351. https:\/\/doi.org\/10.1007\/BF02291478","journal-title":"Psychometrika"},{"key":"2858_CR17","doi-asserted-by":"publisher","unstructured":"Amberg B, Romdhani S, Vetter T (2007) Optimal step nonrigid icp algorithms for surface registration. In: IEEE conference on computer vision and pattern recognition (CVPR), pp 1\u20138. https:\/\/doi.org\/10.1109\/CVPR.2007.383165","DOI":"10.1109\/CVPR.2007.383165"},{"issue":"2","key":"2858_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s11263-017-1009-7","volume":"126","author":"J Booth","year":"2018","unstructured":"Booth J, Roussos A, Ponniah A, Dunaway D, Zafeiriou S (2018) Large scale 3d morphable models. Int J Comput Vis 126(2):233\u2013254. https:\/\/doi.org\/10.1007\/s11263-017-1009-7","journal-title":"Int J Comput Vis"},{"issue":"3","key":"2858_CR19","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.archoralbio.2005.07.007","volume":"51","author":"A Hohoff","year":"2006","unstructured":"Hohoff A, Stamm T, Meyer U, Wiechmann D, Ehmer U (2006) Objective growth monitoring of the maxilla in full term infants. Arch Oral Biol 51(3):222\u2013235. https:\/\/doi.org\/10.1016\/j.archoralbio.2005.07.007","journal-title":"Arch Oral Biol"},{"key":"2858_CR20","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/cgf.14502","volume":"41","author":"B Deng","year":"2022","unstructured":"Deng B, Yao Y, Dyke R, Zhang J (2022) A survey of non-rigid 3d registration. Comput Graph Forum 41:559\u2013589. https:\/\/doi.org\/10.1111\/cgf.14502","journal-title":"Comput Graph Forum"}],"container-title":["International Journal of Computer Assisted Radiology and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-023-02858-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11548-023-02858-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-023-02858-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T14:40:29Z","timestamp":1687358429000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11548-023-02858-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,2]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["2858"],"URL":"https:\/\/doi.org\/10.1007\/s11548-023-02858-6","relation":{},"ISSN":["1861-6429"],"issn-type":[{"value":"1861-6429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,2]]},"assertion":[{"value":"25 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The collection and further use of the clinical data received the IRB approval by Ethikkommission Nordwest- und Zentralschweiz (EKNZ) on March 5th, 2020 (Protocol Number 2020-00388) and was registered on  (identifier NCT04342234).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The parents have given their consent for the use of the image material presented in Fig.\u00a0.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Content for publication"}}]}}