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With any tracking system technology and a patient\/target-specific registration marker configuration, submillimetric target registration error (TRE), high-precise application accuracy for single or multiple anatomical targets in image-guided neurosurgery or ENT surgery is realized.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The system utilizes the advantages of marker-based registration technique and allows to perform automatized patient registration using on the device attached and with patient scanned four fiducial markers. The best possible sensor\/marker positions around the patient\u2019s head are determined for single or multiple region(s) of interest (target\/s) in the anatomy. Once brought at the predetermined positions the device can be operated with any tracking system for registration purposes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Targeting accuracy was evaluated quantitatively at various target positions on a phantom skull. The target registration error (TRE) was measured on individual targets using an electromagnetic tracking system. The overall averaged TRE was 0.22 \u00b1 0.08 mm for intraoperative measurements.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>An automatized patient registration system using optimized patient-\/target-specific marker configurations is proposed. High-precision and user-error-free intraoperative surgical navigation with minimum number of registration markers and sensors is realized. The targeting accuracy is significantly improved in minimally invasive neurosurgical and ENT interventions.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11548-024-03135-w","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T07:02:06Z","timestamp":1715756526000},"page":"2371-2380","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Noctopus: a novel device and method for patient registration and navigation in image-guided cranial surgery"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6695-2885","authenticated-orcid":false,"given":"Yusuf","family":"\u00d6zbek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"B\u00e1rdosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Freysinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"issue":"4","key":"3135_CR1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1109\/42.611354","volume":"16","author":"CR Maurer","year":"1997","unstructured":"Maurer CR, Fitzpatrick JM, Wang MY, Galloway RL, Maciunas RJ, Allen GS (1997) Registration of head volume images using implantable fiducial markers. 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