{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T21:45:23Z","timestamp":1765143923098,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J CARS"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>This research aimed to develop an innovative method for designing and fabricating nasal prostheses that reduces anaplastologist expertise dependency while maintaining quality and appearance, allowing patients to regain their normal facial appearance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The method involved statistical shape modeling using a morphable face model and 3D data acquired through optical scanning or CT. An automated design process generated patient-specific fits and appearances using regular prosthesis materials and 3D printing of molds. Manual input was required for specific case-related details.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The developed method met all predefined requirements, replacing analog impression-making and offering compatibility with various data acquisition methods. Prostheses created through this method exhibited equivalent aesthetics to conventionally fabricated ones while reducing the skill dependency typically associated with prosthetic design and fabrication.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This method provides a promising approach for both temporary and definitive nasal prostheses, with the potential for remote prosthesis fabrication in areas lacking anaplastology care. While new skills are required for data acquisition and algorithm control, these technologies are increasingly accessible. Further clinical studies will help validate its effectiveness, and ongoing technological advancements may lead to even more advanced and skill-independent prosthesis fabrication methods in the future.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11548-024-03206-y","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T17:01:50Z","timestamp":1717693310000},"page":"2279-2285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Computer-aided design and fabrication of nasal prostheses: a semi-automated algorithm using statistical shape modeling"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-7037","authenticated-orcid":false,"given":"T.","family":"Bannink","sequence":"first","affiliation":[]},{"given":"M.","family":"de Ridder","sequence":"additional","affiliation":[]},{"given":"S.","family":"Bouman","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-6707","authenticated-orcid":false,"given":"M. J. A.","family":"van Alphen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8257-7422","authenticated-orcid":false,"given":"R. L. P.","family":"van Veen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-6743","authenticated-orcid":false,"given":"M. W. M.","family":"van den Brekel","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1700-5743","authenticated-orcid":false,"given":"M. B.","family":"Karakulluk\u00e7u","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"issue":"5","key":"3206_CR1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1080\/09687599.2018.1454300","volume":"33","author":"G Yaron","year":"2018","unstructured":"Yaron G, Meershoek A, Widdershoven G, Slatman J (2018) Recognizing difference: in\/visibility in the everyday life of individuals with facial limb absence. Disabil Soc 33(5):743\u2013762. https:\/\/doi.org\/10.1080\/09687599.2018.1454300","journal-title":"Disabil Soc"},{"issue":"2","key":"3206_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10746-017-9426-8","volume":"40","author":"G Yaron","year":"2017","unstructured":"Yaron G, Meershoek A, Widdershoven G, van den Brekel M, Slatman J (2017) Facing a disruptive face: embodiment in the everyday experiences of \u201cdisfigured\u201d individuals. Hum Stud 40(2):285\u2013307. https:\/\/doi.org\/10.1007\/s10746-017-9426-8","journal-title":"Hum Stud"},{"issue":"4","key":"3206_CR3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.bjoms.2015.09.011","volume":"54","author":"M Wondergem","year":"2016","unstructured":"Wondergem M, Lieben G, Bouman S, van den Brekel MW, Lohuis PJ (2016) Patients\u2019 satisfaction with facial prostheses. Br J Oral Maxillofac Surg 54(4):394\u2013399. https:\/\/doi.org\/10.1016\/j.bjoms.2015.09.011","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"3","key":"3206_CR4","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jormas.2019.10.003","volume":"121","author":"TH Farook","year":"2020","unstructured":"Farook TH, Jamayet NB, Abdullah JY, Rajion ZA, Alam MK (2020) A systematic review of the computerized tools and digital techniques applied to fabricate nasal, auricular, orbital and ocular prostheses for facial defect rehabilitation. J Stomatol Oral Maxillofac Surg 121(3):268\u2013277. https:\/\/doi.org\/10.1016\/j.jormas.2019.10.003","journal-title":"J Stomatol Oral Maxillofac Surg"},{"issue":"3","key":"3206_CR5","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3390\/app11030973","volume":"11","author":"CM Cristache","year":"2021","unstructured":"Cristache CM, Tudor I, Moraru L, Cristache G, Lanza A, Burlibasa M (2021) Digital workflow in maxillofacial prosthodontics\u2014an update on defect data acquisition, editing and design using open-source and commercial available software. Appl Sci 11(3):973. https:\/\/doi.org\/10.3390\/app11030973","journal-title":"Appl Sci"},{"issue":"7","key":"3206_CR6","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.3390\/ijerph18073756","volume":"18","author":"W Tanveer","year":"2021","unstructured":"Tanveer W, Ridwan-Pramana A, Molinero-Mourelle P, Koolstra JH, Forouzanfar T (2021) Systematic review of clinical applications of cad\/cam technology for craniofacial implants placement and manufacturing of nasal prostheses. Int J Environ Res Public Health 18(7):3756. https:\/\/doi.org\/10.3390\/ijerph18073756","journal-title":"Int J Environ Res Public Health"},{"issue":"1\u20132","key":"3206_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000346668","volume":"36","author":"B Reitemeier","year":"2013","unstructured":"Reitemeier B, G\u00f6tzel B, Sch\u00f6ne C, Stockmann F, M\u00fcller R, Lexmann J, Meissner H (2013) Creation and utilization of a digital database for nasal prosthesis models. Onkologie 36(1\u20132):7\u201311. https:\/\/doi.org\/10.1159\/000346668","journal-title":"Onkologie"},{"issue":"1","key":"3206_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12008-012-0159-7","volume":"7","author":"M Fantini","year":"2013","unstructured":"Fantini M, De Crescenzio F, Ciocca L (2013) Design and rapid manufacturing of anatomical prosthesis for facial rehabilitation. Int J Interact Des Manuf (IJIDeM) 7(1):51\u201362. https:\/\/doi.org\/10.1007\/s12008-012-0159-7","journal-title":"Int J Interact Des Manuf (IJIDeM)"},{"issue":"2","key":"3206_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1177\/0309364613489333","volume":"38","author":"D Palousek","year":"2014","unstructured":"Palousek D, Rosicky J, Koutny D (2014) Use of digital technologies for nasal prosthesis manufacturing. Prosthet Orthot Int 38(2):171\u2013175. https:\/\/doi.org\/10.1177\/0309364613489333","journal-title":"Prosthet Orthot Int"},{"issue":"3","key":"3206_CR10","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jpor.2019.01.004","volume":"63","author":"A Unkovskiy","year":"2019","unstructured":"Unkovskiy A, Roehler A, Huettig F, Geis-Gerstorfer J, Brom J, Keutel C, Spintzyk S (2019) Simplifying the digital workflow of facial prostheses manufacturing using a three-dimensional (3d) database: setup, development, and aspects of virtual data validation for reproduction. J Prosthodont Res 63(3):313\u2013320. https:\/\/doi.org\/10.1016\/j.jpor.2019.01.004","journal-title":"J Prosthodont Res"},{"key":"3206_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2023.02.019","author":"RY Jablonski","year":"2023","unstructured":"Jablonski RY, Malhotra T, Coward TJ, Shaw D, Bojke C, Pavitt SH, Nattress BR, Keeling AJ (2023) Digital database for nasal prosthesis design with a 3d morphable face model approach. J Prosthet Dent. https:\/\/doi.org\/10.1016\/j.prosdent.2023.02.019","journal-title":"J Prosthet Dent"},{"key":"3206_CR12","unstructured":"Basso C, Vetter T (2005) Statistically motivated 3d faces reconstruction. In: Proceedings of the 2nd International Conference on Reconstruction of Soft Facial Parts. Luchterhand Publishers, Remagen"},{"key":"3206_CR13","doi-asserted-by":"publisher","unstructured":"Blanz V, Vetter T (1999) A morphable model for the synthesis of 3d faces. In: Proceedings of the 26th annual conference on Computer graphics and interactive techniques. ACM Press\/Addison-Wesley Publishing Co. https:\/\/doi.org\/10.1145\/311535.311556","DOI":"10.1145\/311535.311556"},{"issue":"8","key":"3206_CR14","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1016\/j.bjoms.2011.02.007","volume":"49","author":"AA Mueller","year":"2011","unstructured":"Mueller AA, Paysan P, Schumacher R, Zeilhofer HF, Berg-Boerner BI, Maurer J, Vetter T, Schkommodau E, Juergens P, Schwenzer-Zimmerer K (2011) Missing facial parts computed by a morphable model and transferred directly to a polyamide laser-sintered prosthesis: an innovation study. Br J Oral Maxillofac Surg 49(8):e67-71. https:\/\/doi.org\/10.1016\/j.bjoms.2011.02.007","journal-title":"Br J Oral Maxillofac Surg"},{"key":"3206_CR15","unstructured":"Zardawi FM, Xiao K, Noort Rv, Yates JM (2015) Mechanical properties of 3d printed facial prostheses compared to silicone polymer prostheses. Eur Sci J ESJ 11(12)"},{"key":"3206_CR16","doi-asserted-by":"crossref","unstructured":"Xiao K, Wuerger SM, Mostafa F, Sohaib A, Yates JM (2016) Colour image reproduction for 3d printing facial prostheses. In: Shishkovsky IV (ed) New trends in 3d printing, IntechOpen","DOI":"10.5772\/63339"},{"issue":"2","key":"3206_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.prosdent.2017.11.007","volume":"120","author":"A Unkovskiy","year":"2018","unstructured":"Unkovskiy A, Spintzyk S, Brom J, Huettig F, Keutel C (2018) Direct 3d printing of silicone facial prostheses: a preliminary experience in digital workflow. J Prosthet Dent 120(2):303\u2013308. https:\/\/doi.org\/10.1016\/j.prosdent.2017.11.007","journal-title":"J Prosthet Dent"},{"issue":"1","key":"3206_CR18","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/jopr.13001","volume":"28","author":"A Nuseir","year":"2019","unstructured":"Nuseir A, Hatamleh MMd, Alnazzawi A, Al-Rabab\u2019ah M, Kamel B, Jaradat E (2019) Direct 3d printing of flexible nasal prosthesis: Optimized digital workflow from scan to fit. J Prosthodont 28(1):10\u201314. https:\/\/doi.org\/10.1111\/jopr.13001","journal-title":"J Prosthodont"},{"issue":"5","key":"3206_CR19","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1007\/s00170-018-2831-y","volume":"100","author":"AM Abdullah","year":"2019","unstructured":"Abdullah AM, Mohamad D, Din TNDT, Yahya S, Akil HM, Rajion ZA (2019) Fabrication of nasal prosthesis utilising an affordable 3d printer. Int J Adv Manuf Technol 100(5):1907\u20131912. https:\/\/doi.org\/10.1007\/s00170-018-2831-y","journal-title":"Int J Adv Manuf Technol"},{"key":"3206_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2020.02.021","author":"A Unkovskiy","year":"2020","unstructured":"Unkovskiy A, Wahl E, Huettig F, Keutel C, Spintzyk S (2020) Multimaterial 3d printing of a definitive silicone auricular prosthesis: An improved technique. J Prosthet Dent. https:\/\/doi.org\/10.1016\/j.prosdent.2020.02.021","journal-title":"J Prosthet Dent"},{"key":"3206_CR21","doi-asserted-by":"publisher","unstructured":"Gerig T, Morel-Forster A, Blumer C, Egger B, L\u00fcthi M, Sch\u00f6nborn S, Vetter T (2018) Morphable face models - an open framework. In: 2018 13th IEEE International Conference on Automatic Face & Gesture Recognition (FG 2018), pp 75\u201382. https:\/\/doi.org\/10.1109\/FG.2018.00021","DOI":"10.1109\/FG.2018.00021"},{"key":"3206_CR22","doi-asserted-by":"publisher","unstructured":"Paysan P, Knothe R, Amberg B, Romdhani S, Vetter T (2009) A 3d face model for pose and illumination invariant face recognition. In: 2009 Sixth IEEE International Conference on Advanced Video and Signal Based Surveillance, pp 296\u2013301. https:\/\/doi.org\/10.1109\/AVSS.2009.58","DOI":"10.1109\/AVSS.2009.58"},{"issue":"8","key":"3206_CR23","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1109\/TPAMI.2017.2739743","volume":"40","author":"M L\u00fcthi","year":"2018","unstructured":"L\u00fcthi M, Gerig T, Jud C, Vetter T (2018) Gaussian process morphable models. IEEE Trans Pattern Anal Mach Intell 40(8):1860\u20131873. https:\/\/doi.org\/10.1109\/TPAMI.2017.2739743","journal-title":"IEEE Trans Pattern Anal Mach Intell"}],"container-title":["International Journal of Computer Assisted Radiology and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-024-03206-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11548-024-03206-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-024-03206-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T16:23:31Z","timestamp":1730910211000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11548-024-03206-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":23,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["3206"],"URL":"https:\/\/doi.org\/10.1007\/s11548-024-03206-y","relation":{},"ISSN":["1861-6429"],"issn-type":[{"type":"electronic","value":"1861-6429"}],"subject":[],"published":{"date-parts":[[2024,6,6]]},"assertion":[{"value":"24 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare relevant to this article\u2019s content.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved (IRBd21-154) by the institutional research ethics committee of the Netherlands Cancer Institute. It was performed according to the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all participants in the study. The authors affirm that human research participants provided informed consent to publish the images in figure(s).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}