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The quantification of accumulated edema may have potential clinical benefits. This work focuses on accurately estimating the amount of edema non-invasively using abdominal CT scans, with minimal false positives. However, edema segmentation is challenging due to the complex appearance of edema and the lack of manually annotated volumes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:bold>Methods:<\/jats:bold>\n            <\/jats:title>\n            <jats:p>We propose a weakly supervised approach for edema segmentation using initial edema labels from the current state-of-the-art method for edema segmentation (Intensity Prior), along with labels of surrounding tissues as anatomical priors. A multi-class 3D nnU-Net was employed as the segmentation network, and training was performed using an iterative annotation workflow.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:bold>Results:<\/jats:bold>\n            <\/jats:title>\n            <jats:p>We evaluated segmentation accuracy on a test set of 25 patients with edema. The average Dice Similarity Coefficient of the proposed method was similar to Intensity Prior (61.5% vs. 61.7%; <jats:inline-formula>\n                <jats:alternatives>\n                  <jats:tex-math>$$p=0.83$$<\/jats:tex-math>\n                  <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                    <mml:mrow>\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.83<\/mml:mn>\n                    <\/mml:mrow>\n                  <\/mml:math>\n                <\/jats:alternatives>\n              <\/jats:inline-formula>). However, the proposed method reduced the average False Positive Rate significantly, from 1.8% to 1.1% (<jats:inline-formula>\n                <jats:alternatives>\n                  <jats:tex-math>$$p&lt;0.001$$<\/jats:tex-math>\n                  <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                    <mml:mrow>\n                      <mml:mi>p<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.001<\/mml:mn>\n                    <\/mml:mrow>\n                  <\/mml:math>\n                <\/jats:alternatives>\n              <\/jats:inline-formula>). Edema volumes computed using automated segmentation had a strong correlation with manual annotation (<jats:inline-formula>\n                <jats:alternatives>\n                  <jats:tex-math>$$R^2=0.87$$<\/jats:tex-math>\n                  <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                    <mml:mrow>\n                      <mml:msup>\n                        <mml:mi>R<\/mml:mi>\n                        <mml:mn>2<\/mml:mn>\n                      <\/mml:msup>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.87<\/mml:mn>\n                    <\/mml:mrow>\n                  <\/mml:math>\n                <\/jats:alternatives>\n              <\/jats:inline-formula>).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:bold>Conclusion:<\/jats:bold>\n            <\/jats:title>\n            <jats:p>Weakly supervised learning using 3D multi-class labels and iterative annotation is an efficient way to perform high-quality edema segmentation with minimal false positives. Automated edema segmentation can produce edema volume estimates that are highly correlated with manual annotation. The proposed approach is promising for clinical applications to monitor anasarca using estimated edema volumes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11548-024-03262-4","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:01:56Z","timestamp":1726272116000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Subcutaneous edema segmentation on abdominal CT using multi-class labels and iterative annotation"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-1142","authenticated-orcid":false,"given":"Sayantan","family":"Bhadra","sequence":"first","affiliation":[]},{"given":"Jianfei","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Ronald M.","family":"Summers","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"3262_CR1","volume-title":"Anasarca, StatPearls","author":"S Kattula","year":"2021","unstructured":"Kattula S, Avula A, Baradhi K (2021) Anasarca, StatPearls. 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His lab received research support from PingAn. The authors have no additional Conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the IRB of the National Institutes of Health and was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The need for written informed consent was waived by the IRB.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}