{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:15:14Z","timestamp":1779164114334,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci Eng Ethics"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s11948-012-9411-6","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T14:47:38Z","timestamp":1351090058000},"page":"1141-1164","source":"Crossref","is-referenced-by-count":43,"title":["Midstream Modulation in Biotechnology Industry: Redefining What is \u2018Part of the Job\u2019 of Researchers in Industry"],"prefix":"10.1007","volume":"19","author":[{"given":"Steven M.","family":"Flipse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten C. A.","family":"van der Sanden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Osseweijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"issue":"4","key":"9411_CR1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/09537320902819247","volume":"21","author":"J Alegre","year":"2009","unstructured":"Alegre, J., Chiva, R., & Lapiedra, R. (2009). Measuring innovation in long product development cycle industries: An insight in biotechnology. Technology Analysis & Strategic Management, 21(4), 535\u2013546.","journal-title":"Technology Analysis & Strategic Management"},{"key":"9411_CR2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1382-6689(99)00009-5","volume":"7","author":"A Barling","year":"1999","unstructured":"Barling, A., De Vriend, H., Cornelese, J. A., Ekstrand, B., Hecker, E. F. F., Howlett, J., et al. (1999). The social aspects of food biotechnology: A European view. Environmental Toxicology and Pharmacology, 7, 85\u201393.","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"9411_CR3","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.respol.2007.03.002","volume":"36","author":"JEL Bercovitz","year":"2007","unstructured":"Bercovitz, J. E. L., & Feldman, M. P. (2007). Fishing upstream: Firm innovation strategy and university research alliances. Research Policy, 36, 930\u2013948.","journal-title":"Research Policy"},{"key":"9411_CR4","volume-title":"The quest for responsibility","author":"MAP Bovens","year":"1998","unstructured":"Bovens, M. A. P. (1998). The quest for responsibility (1st ed.). Cambridge: Cambridge University Press.","edition":"1"},{"key":"9411_CR5","unstructured":"Calleja-Lopez, A. & Fisher, E. (2009). Dialogues from the Lab: Contemporary Maieutics for Socio-Technical Inquiry. Proceedings of Society for Philosophy and Technology, University of Twente, The Netherlands. July 7-10 2009."},{"issue":"1","key":"9411_CR6","first-page":"5","volume":"20","author":"MS Carolan","year":"2007","unstructured":"Carolan, M. S. (2007). The precautionary principle and traditional risk assessment: Rethinking how we assess and mitigate environmental threats organization. Environment, 20(1), 5\u201324.","journal-title":"Environment"},{"issue":"2","key":"9411_CR7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/0306312702032002003","volume":"32","author":"HM Collins","year":"2002","unstructured":"Collins, H. M., & Evans, R. (2002). The third wave of science studies: Studies of expertise and experience. Social Studies of Science, 32(2), 235\u2013296.","journal-title":"Social Studies of Science"},{"issue":"4","key":"9411_CR8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s11948-011-9323-x","volume":"17","author":"S Conley","year":"2011","unstructured":"Conley, S. (2011). Engagement agents in the making: On the front lines of socio-technical integration. commentary on: \u2018Constructing productive engagement: Pre-engagement tools for emerging technologies\u2019. Science and Engineering Ethics, 17(4), 715\u2013721.","journal-title":"Science and Engineering Ethics"},{"issue":"3","key":"9411_CR9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1108\/14601060010322301","volume":"3","author":"AJ Cozijnsen","year":"2000","unstructured":"Cozijnsen, A. J., Vrakking, W. J., & Van Ijzerloo, M. (2000). Success and failure of 50 innovation projects in Dutch companies. European Journal of Innovation Management, 3(3), 150\u2013159.","journal-title":"European Journal of Innovation Management"},{"key":"9411_CR10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/(SICI)1097-0266(199910)20:10<953::AID-SMJ59>3.0.CO;2-3","volume":"20","author":"DM DeCarolis","year":"1999","unstructured":"DeCarolis, D. M., & Deeds, D. L. (1999). The impact of stocks and flows of organizational knowledge on firm performance: An empirical investigation of the biotechnology industry. Strategic Management Journal, 20, 953\u2013968.","journal-title":"Strategic Management Journal"},{"issue":"6","key":"9411_CR11","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1177\/0963662510363054","volume":"20","author":"A Delgado","year":"2010","unstructured":"Delgado, A., Kj\u00f8lberg, K. L., & Wickson, F. (2010). Public engagement coming of age: From theory to practice in STS encounters with nanotechnology. Public Understanding of Science, 20(6), 826\u2013845.","journal-title":"Public Understanding of Science"},{"key":"9411_CR12","unstructured":"Doorn, N. (2011). Exploring responsibility rationales in research and development. Science, Technology & Human Values, Online, pp 1\u201330."},{"issue":"3","key":"9411_CR13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/0270467610372112","volume":"30","author":"N Doorn","year":"2010","unstructured":"Doorn, N., & Fahlquist, J. N. (2010). Responsibility in engineering: Toward a new role for engineering ethicists. Bulletin of Science Technology Society, 30(3), 222\u2013230.","journal-title":"Bulletin of Science Technology Society"},{"key":"9411_CR14","unstructured":"DSM (2012). Our company: Corporate website. Available at http:\/\/www.dsm.com\/en_US\/cworld\/public\/about\/pages\/Our_company.jsp . Accessed 16 April 2012."},{"key":"9411_CR15","unstructured":"European Commission. (2011a). Horizon 2020: The framework programme for research and innovation. Communication from the Commission to the European Parliament, the Council, the European Economic and Social Commisttee and the Committee of the Regions, pp 1\u201314."},{"key":"9411_CR16","unstructured":"European Commission. (2011b). Analysis part I: Investment and performance in R&D: Investing in the future. Innovation Union Competitiveness report 2011, 41\u2013154. Available at http:\/\/ec.europa.eu\/research\/innovation-union\/pdf\/competitiveness-report\/2011\/part_1.pdf , Accessed 16 April 2012."},{"key":"9411_CR17","unstructured":"European Group on Ethics in Science and New Technologies to the European Commission. (2007). Opinion on the ethical aspects of nanomedicine: Opinion No. 21, Available at http:\/\/ec.europa.eu\/bepa\/european-group-ethics\/docs\/publications\/opinion_21_nano_en.pdf , Accessed 16 April 2012."},{"key":"9411_CR18","first-page":"3","volume":"14","author":"E Fisher","year":"2006","unstructured":"Fisher, E. (2006). Embedded nanotechnology policy research. Ogmius, 14, 3\u20134.","journal-title":"Ogmius"},{"key":"9411_CR19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11569-007-0016-5","volume":"1","author":"E Fisher","year":"2007","unstructured":"Fisher, E. (2007). Ethnographic invention: Probing the capacity of laboratory decisions. Nanoethics, 1, 155\u2013165.","journal-title":"Nanoethics"},{"issue":"4","key":"9411_CR20","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s11948-011-9331-x","volume":"17","author":"E Fisher","year":"2011","unstructured":"Fisher, E. (2011). Public science and technology scholars: Engaging whom? Science and Engineering Ethics, 17(4), 607\u2013620.","journal-title":"Science and Engineering Ethics"},{"key":"9411_CR21","doi-asserted-by":"crossref","unstructured":"Fisher, E., & Mahajan, R. L. (2006). Midstream modulation of nanotechnology research in an academic laboratory. Proceedings of ASME international mechanical engineering congress and exposition (IMECE) 2006 in Chicago, Illinois, pp 1\u20137.","DOI":"10.1115\/IMECE2006-14790"},{"key":"9411_CR22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.7551\/mitpress\/9780262014724.003.0010","volume-title":"Trading zones and interactional expertise: Creating new kinds of collaboration","author":"E Fisher","year":"2010","unstructured":"Fisher, E., & Mahajan, R. L. (2010). Embedding the humanities in engineering: Art, dialogue, and a laboratory. In M. E. Gorman (Ed.), Trading zones and interactional expertise: Creating new kinds of collaboration (pp. 209\u2013230). Boston: MIT Press."},{"issue":"6","key":"9411_CR23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/0270467606295402","volume":"26","author":"E Fisher","year":"2006","unstructured":"Fisher, E., Mahajan, R. L., & Mitcham, C. (2006). Midstream modulation of technology: Governance from within. Bulletin of Science, Technology & Society, 26(6), 485\u2013496.","journal-title":"Bulletin of Science, Technology & Society"},{"key":"9411_CR24","unstructured":"Fisher, E. & Miller, C. (2009) Contextualizing the engineering laboratory. In S.H. Christensen, M. Meganck, B. Delahousse, B. (Eds.), Engineering in context (pp. 369\u2013381). Palo Alto: Academica Press."},{"issue":"7","key":"9411_CR25","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0016-3287(93)90022-L","volume":"25","author":"SO Funtowicz","year":"1993","unstructured":"Funtowicz, S. O., & Ravetz, J. R. (1993). Science for the post-normal age. Futures, 25(7), 739\u2013755.","journal-title":"Futures"},{"issue":"1\u20132","key":"9411_CR26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0160-791X(01)00047-1","volume":"24","author":"DH Guston","year":"2002","unstructured":"Guston, D. H., & Sarewitz, D. (2002). Real-time technology assessment. Technology in Society, 24(1\u20132), 93\u2013109.","journal-title":"Technology in Society"},{"issue":"5","key":"9411_CR27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3152\/030234209X442034","volume":"36","author":"LK Hessels","year":"2009","unstructured":"Hessels, L. K., Van Lente, H., & Smits, R. (2009). In search of relevance: The changing contract between science and society. Science and Public Policy, 36(5), 387\u2013401.","journal-title":"Science and Public Policy"},{"issue":"4","key":"9411_CR28","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s11948-011-9302-2","volume":"17","author":"S Jasanoff","year":"2011","unstructured":"Jasanoff, S. (2011). Constitutional moments in governing science and technology. Science and Engineering Ethics, 17(4), 621\u2013638.","journal-title":"Science and Engineering Ethics"},{"issue":"2","key":"9411_CR30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11569-011-0119-x","volume":"5","author":"F Lucivero","year":"2011","unstructured":"Lucivero, F., Swierstra, T., & Boenink, M. (2011). Assessing expectations: Towards a toolbox for an ethics of emerging technologies. NanoEthics, 5(2), 129\u2013141.","journal-title":"NanoEthics"},{"issue":"1","key":"9411_CR31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5465\/amr.2001.4011987","volume":"26","author":"A McWilliams","year":"2001","unstructured":"McWilliams, A., & Siegel, D. (2001). Corporate social responsibility: A theory of the firm perspective. The Academy of Management Review, 26(1), 117\u2013127.","journal-title":"The Academy of Management Review"},{"issue":"2","key":"9411_CR32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11569-011-0118-y","volume":"5","author":"D Patra","year":"2011","unstructured":"Patra, D. (2011). Responsible development of nanoscience and nanotechnology: Contextualizing socio-technical integration into the nanofabrication laboratories in the USA. NanoEthics, 5(2), 143\u2013157.","journal-title":"NanoEthics"},{"key":"9411_CR33","unstructured":"PBL Netherlands Environmental Assessment Agency. (2012). Sustainability of biomass in a bio-based economy, pp 1\u201322."},{"issue":"6","key":"9411_CR34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/0270467609349047","volume":"29","author":"B Penders","year":"2009","unstructured":"Penders, B., Verbakel, J. M. A., & Nelis, A. (2009). The social study of corporate science: A research manifesto. Bulletin of Science Technology Society, 29(6), 439\u2013446.","journal-title":"Bulletin of Science Technology Society"},{"issue":"2","key":"9411_CR35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-1-61779-052-2_22","volume":"726","author":"R Phelps","year":"2011","unstructured":"Phelps, R., & Fisher, E. (2011). Legislating the laboratory? Promotion and precaution in a nanomaterials company. Methods in Molecular Biology, 726(2), 339\u2013358.","journal-title":"Methods in Molecular Biology"},{"key":"9411_CR36","first-page":"82","volume-title":"Reflexive governance for sustainable development","author":"A Rip","year":"2006","unstructured":"Rip, A. (2006). A co-evolutionary approach to reflexive governance\u2013and its ironies. In J. Voss, D. Bauknecht, & R. Kemp (Eds.), Reflexive governance for sustainable development (pp. 82\u2013100). Cheltenham: Edward Elgar."},{"issue":"1","key":"9411_CR38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1037\/0003-066X.55.1.68","volume":"55","author":"R Ryan","year":"2000","unstructured":"Ryan, R., & Deci, E. L. (2000). Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. American Psychologist, 55(1), 68\u201378.","journal-title":"American Psychologist"},{"issue":"2\u20133","key":"9411_CR39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0040-1625(96)00180-1","volume":"54","author":"J Schot","year":"1997","unstructured":"Schot, J., & Rip, A. (1997). The past and future of constructive technology assessment. Technological Forecasting and Social Change, 54(2\u20133), 251\u2013268.","journal-title":"Technological Forecasting and Social Change"},{"issue":"4","key":"9411_CR40","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s11948-011-9317-8","volume":"17","author":"D Schuurbiers","year":"2011","unstructured":"Schuurbiers, D. (2011). What happens in the lab does not stay in the lab: Applying midstream modulation to enhance critical reflection in the laboratory. Science and Engineering Ethics, 17(4), 769\u2013788.","journal-title":"Science and Engineering Ethics"},{"issue":"5","key":"9411_CR41","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/embor.2009.80","volume":"10","author":"D Schuurbiers","year":"2009","unstructured":"Schuurbiers, D., & Fisher, E. (2009). Lab-scale intervention. EMBO reports Science & Society Series on Convergence Research, 10(5), 424\u2013427.","journal-title":"EMBO reports Science & Society Series on Convergence Research"},{"issue":"2","key":"9411_CR42","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/embor.2008.253","volume":"10","author":"P Stegmaier","year":"2009","unstructured":"Stegmaier, P. (2009). The rock \u2018n\u2019 roll of knowledge co-production. EMBO reports Science & Society Series on Convergence Research, 10(2), 114\u2013119.","journal-title":"EMBO reports Science & Society Series on Convergence Research"},{"issue":"3","key":"9411_CR43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/0162243905285844","volume":"31","author":"T Swierstra","year":"2006","unstructured":"Swierstra, T., & Jelsma, J. (2006). Responsibility without moralism in techno scientific design practice. Science Technology Human Values, 31(3), 309\u2013332.","journal-title":"Science Technology Human Values"},{"key":"9411_CR44","unstructured":"Thoreau, F. (2010). The \u2018interpretive flexibility\u2019 of nanotechnologies in context: The case of a leading R&D center in Flanders, Belgium. SpiraL working paper series, pp 1\u201369. Available at http:\/\/www.spiral.ulg.ac.be\/uploads\/wpapers\/Spiral_WP2010-01_THOREAU.pdf , Accessed 16 April 2012."},{"issue":"3","key":"9411_CR45","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/09537320050130615","volume":"12","author":"I Poel Van de","year":"2000","unstructured":"Van de Poel, I. (2000). On the role of outsiders in technical development. Technology Analysis & Strategic Management, 12(3), 383\u2013397.","journal-title":"Technology Analysis & Strategic Management"},{"issue":"1","key":"9411_CR46","first-page":"49","volume":"32","author":"I Poel Van de","year":"2001","unstructured":"Van de Poel, I. (2001). The transformation of technological regimes. Research Policy, 32(1), 49\u201368.","journal-title":"Research Policy"},{"issue":"1","key":"9411_CR47","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11948-008-9079-0","volume":"15","author":"S Burg Van der","year":"2009","unstructured":"Van der Burg, S. (2009). Imagining the future of photoacoustic mammography. Science and Engineering Ethics, 15(1), 97\u2013110.","journal-title":"Science and Engineering Ethics"},{"key":"9411_CR48","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/0162243907301004","volume":"32","author":"A Webster","year":"2007","unstructured":"Webster, A. (2007). Crossing boundaries: social sciences in the policy room. Science, Technology and Human Values, 32, 458\u2013478.","journal-title":"Science, Technology and Human Values"},{"key":"9411_CR49","first-page":"22","volume-title":"The future of technology assessment","author":"J Wilsdon","year":"2005","unstructured":"Wilsdon, J. (2005). Paddling upstream: New currents in European technology assessment. In M. Rodemeyer, D. Sarewitz, & J. Wilsdon (Eds.), The future of technology assessment (pp. 22\u201329). Washington, DC: Woodrow Wilson International Center for Scholars."},{"issue":"6","key":"9411_CR50","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/jme.2007.020578","volume":"33","author":"L Wolpert","year":"2007","unstructured":"Wolpert, L. (2007). Is cell science dangerous? Journal on Medical Ethics, 33(6), 345\u2013348.","journal-title":"Journal on Medical Ethics"},{"issue":"3","key":"9411_CR51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/03063127030333005","volume":"33","author":"B Wynne","year":"2003","unstructured":"Wynne, B. (2003). Seasick on the third wave? Subverting the hegemony or propositionalism: Response to Collins and Evans. Social Studies of Science, 33(3), 401\u2013418.","journal-title":"Social Studies of Science"},{"issue":"4","key":"9411_CR52","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s11948-011-9316-9","volume":"17","author":"B Wynne","year":"2011","unstructured":"Wynne, B. (2011). Lab work goes social, and vice versa: Strategising public engagement processes. Science and Engineering Ethics, 17(4), 791\u2013800.","journal-title":"Science and Engineering Ethics"}],"container-title":["Science and Engineering Ethics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11948-012-9411-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11948-012-9411-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11948-012-9411-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T23:38:10Z","timestamp":1562283490000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11948-012-9411-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,25]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["9411"],"URL":"https:\/\/doi.org\/10.1007\/s11948-012-9411-6","relation":{},"ISSN":["1353-3452","1471-5546"],"issn-type":[{"value":"1353-3452","type":"print"},{"value":"1471-5546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,25]]}}}