{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:13:05Z","timestamp":1740147185703,"version":"3.37.3"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Ateneo 2014","award":["C26A14XZC8"],"award-info":[{"award-number":["C26A14XZC8"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Eng Ethics"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s11948-016-9774-1","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T09:21:54Z","timestamp":1466414514000},"page":"365-374","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biological Dual-Use Research and Synthetic Biology of Yeast"],"prefix":"10.1007","volume":"23","author":[{"given":"Angela","family":"Cirigliano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Cenciarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Malizia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Bellecci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Lioj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-245X","authenticated-orcid":false,"given":"Teresa","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,20]]},"reference":[{"issue":"6179","key":"9774_CR1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1249252","volume":"344","author":"N Annaluru","year":"2014","unstructured":"Annaluru, N., Muller, H., Mitchell, L. A., Ramalingam, S., Stracquadanio, G., Richardson, S. M., et al. (2014). Total synthesis of a functional designer eukaryotic chromosome. Science, 344(6179), 55\u201358.","journal-title":"Science"},{"issue":"6925","key":"9774_CR2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nature01479","volume":"421","author":"R Atlas","year":"2003","unstructured":"Atlas, R., Campbell, P., Cozzarelli, N. R., Curfman, G., Enquist, L., Fink, G., et al. (2003). Statement on the consideration of biodefense and biosecurity. Nature, 421(6925), 771.","journal-title":"Nature"},{"issue":"2","key":"9774_CR3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/infdis\/jit449","volume":"209","author":"JR Barash","year":"2014","unstructured":"Barash, J. R., & Arnon, S. S. (2014). A novel strain of Clostridium botulinum that produces type B and type H botulinum toxins. Journal of Infectious Diseases, 209(2), 183\u2013191.","journal-title":"Journal of Infectious Diseases"},{"key":"9774_CR4","unstructured":"Beaudoin, G. A. W. (2015). Characterization of oxidative enzymes involved in the biosynthesis of benzylisoquinoline alkaloids in opium poppy (Papaver somniferum).\u00a0Ph.D thesis, University of Calgary. Available at\u00a0 http:\/\/hdl.handle.net\/11023\/2115"},{"issue":"6069","key":"9774_CR5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1126\/science.1217994","volume":"335","author":"KI Berns","year":"2012","unstructured":"Berns, K. I., Casadevall, A., Cohen, M. L., Ehrlich, S. A., Enquist, L. W., Fitch, J. P., et al. (2012). Adaptations of avian flu virus are a cause for concern. Science, 335(6069), 660\u2013661.","journal-title":"Science"},{"issue":"6","key":"9774_CR6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nbt0607-627","volume":"25","author":"H B\u00fcgl","year":"2007","unstructured":"B\u00fcgl, H., Danner, J. P., Molinari, R. J., Mulligan, J. T., Park, H. O., Reichert, B., et al. (2007). DNA synthesis and biological security. Nature Biotechnology, 25(6), 627\u2013629.","journal-title":"Nature Biotechnology"},{"issue":"5","key":"9774_CR7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrmicro3239","volume":"12","author":"DE Cameron","year":"2014","unstructured":"Cameron, D. E., Bashor, C. J., & Collins, J. J. (2014). A brief history of synthetic biology. Nature Reviews Microbiology, 12(5), 381\u2013390.","journal-title":"Nature Reviews Microbiology"},{"key":"9774_CR8","first-page":"56","volume":"1","author":"C Charatsis","year":"2015","unstructured":"Charatsis, C. (2015). Setting the publication of \u2018dual-use research\u2019 under the export authorisation process: The H5N1 case. Strategic Trade Review, 1, 56\u201372.","journal-title":"Strategic Trade Review"},{"key":"9774_CR9","unstructured":"Collett, M. S. (2006). Impact of synthetic genomics on the threat of bioterrorism with viral agents. In Garfinkel, M.S., Endy, D., Epstein, G.L., Friedman, R.M. (Eds.), Working papers for synthetic genomics: Risks and benefits for science and society, pp. 83\u2013103."},{"key":"9774_CR10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nchembio.1816","volume":"11","author":"WC DeLoache","year":"2015","unstructured":"DeLoache, W. C., Russ, Z. N., Narcross, L., Gonzales, A. M., Martin, V. J., & Dueber, J. E. (2015). An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. Nature Chemical Biology, 11, 465\u2013471.","journal-title":"Nature Chemical Biology"},{"issue":"2","key":"9774_CR11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/infdis\/jit450","volume":"209","author":"N Dover","year":"2014","unstructured":"Dover, N., Barash, J. R., Hill, K. K., Xie, G., & Arnon, S. S. (2014). Molecular characterization of a novel botulinum neurotoxin type H gene. Journal of Infectious Diseases, 209(2), 192\u2013202.","journal-title":"Journal of Infectious Diseases"},{"issue":"7365","key":"9774_CR12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature10403","volume":"477","author":"JS Dymond","year":"2011","unstructured":"Dymond, J. S., Richardson, S. M., Coombes, C. E., Babatz, T., Muller, H., Annaluru, N., et al. (2011). Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature, 477(7365), 471\u2013476.","journal-title":"Nature"},{"issue":"2","key":"9774_CR13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s11948-013-9450-7","volume":"20","author":"B Edwards","year":"2014","unstructured":"Edwards, B., Revill, J., & Bezuidenhout, L. (2014). From cases to capacity? A critical reflection on the role of \u2018ethical dilemmas\u2019 in the development of dual-use governance. Science and Engineering Ethics, 20(2), 571\u2013582.","journal-title":"Science and Engineering Ethics"},{"issue":"1","key":"9774_CR14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/10736700.2014.880560","volume":"21","author":"J Enia","year":"2014","unstructured":"Enia, J., & Fields, J. (2014). The relative efficacy of the biological and chemical weapon regimes. The Nonproliferation Review, 21(1), 43\u201364.","journal-title":"The Nonproliferation Review"},{"issue":"6079","key":"9774_CR15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1126\/science.336.6079.285","volume":"336","author":"M Enserink","year":"2012","unstructured":"Enserink, M. (2012). Will dutch allow \u2018export\u2019 of controversial flu study? Science, 336(6079), 285.","journal-title":"Science"},{"issue":"6155","key":"9774_CR16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1126\/science.342.6155.178","volume":"342","author":"M Enserink","year":"2013","unstructured":"Enserink, M. (2013). Dutch H5N1 ruling raises new questions. Science, 342(6155), 178.","journal-title":"Science"},{"issue":"6225","key":"9774_CR17","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.347.6225.934","volume":"347","author":"M Enserink","year":"2015","unstructured":"Enserink, M. (2015). As new botulism threat implodes, more questions. Science, 347(6225), 934\u2013935.","journal-title":"Science"},{"issue":"2","key":"9774_CR18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11024-012-9196-4","volume":"50","author":"SA Evans","year":"2012","unstructured":"Evans, S. A., & Valdivia, W. D. (2012). Export controls and the tensions between academic freedom and national security. Minerva, 50(2), 169\u2013190.","journal-title":"Minerva"},{"issue":"4","key":"9774_CR19","doi-asserted-by":"crossref","first-page":"e0124459","DOI":"10.1371\/journal.pone.0124459","volume":"10","author":"E Fossati","year":"2015","unstructured":"Fossati, E., Narcross, L., Ekins, A., Falgueyret, J. P., & Martin, V. J. (2015). Synthesis of morphinan alkaloids in Saccharomyces cerevisiae. PLoS ONE, 10(4), e0124459.","journal-title":"PLoS ONE"},{"key":"9774_CR20","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.aac9373","volume":"349","author":"S Galanie","year":"2015","unstructured":"Galanie, S., Thodey, K., Trenchard, I. J., Interrante, M. F., & Smolke, C. D. (2015). Complete biosynthesis of opioids in yeast. Science, 349, 1095\u20131100.","journal-title":"Science"},{"issue":"5987","key":"9774_CR21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.1190719","volume":"329","author":"DG Gibson","year":"2010","unstructured":"Gibson, D. G., Glass, J. I., Lartigue, C., Noskov, V. N., Chuang, R. Y., Algire, M. A., et al. (2010). Creation of a bacterial cell controlled by a chemically synthesized genome. Science, 329(5987), 52\u201356.","journal-title":"Science"},{"issue":"7499","key":"9774_CR22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/509168a","volume":"509","author":"DG Gibson","year":"2014","unstructured":"Gibson, D. G., & Venter, J. C. (2014). Synthetic biology: Construction of a yeast chromosome. Nature, 509(7499), 168\u2013169.","journal-title":"Nature"},{"key":"9774_CR23","volume-title":"H5N1: A case study for dual-use research","author":"GK Gronvall","year":"2013","unstructured":"Gronvall, G. K. (2013). H5N1: A case study for dual-use research. New York, NY: Council on Foreign Relations."},{"issue":"1","key":"9774_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2859-4-33","volume":"4","author":"C Gurkan","year":"2005","unstructured":"Gurkan, C., & Ellar, D. J. (2005). Recombinant production of bacterial toxins and their derivatives in the methylotrophic yeast Pichia pastoris. Microbial Cell Factories, 4(1), 1.","journal-title":"Microbial Cell Factories"},{"issue":"6088","key":"9774_CR25","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1126\/science.1213362","volume":"336","author":"S Herfst","year":"2012","unstructured":"Herfst, S., Schrauwen, E. J., Linster, M., Chutinimitkul, S., de Wit, E., Munster, V. J., et al. (2012). Airborne transmission of influenza A\/H5N1 virus between ferrets. Science, 336(6088), 1534\u20131541.","journal-title":"Science"},{"issue":"9","key":"9774_CR26","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/embor.2013.116","volume":"14","author":"P Herrlich","year":"2013","unstructured":"Herrlich, P. (2013). The responsibility of the scientist. EMBO Reports, 14(9), 759\u2013764.","journal-title":"EMBO Reports"},{"issue":"2","key":"9774_CR27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/infdis\/jit528","volume":"209","author":"DC Hooper","year":"2014","unstructured":"Hooper, D. C., & Hirsch, M. S. (2014). Novel Clostridium botulinum toxin and dual use research of concern issues. Journal of Infectious Diseases, 209(2), 167.","journal-title":"Journal of Infectious Diseases"},{"issue":"7","key":"9774_CR28","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/embor.2012.80","volume":"13","author":"P Hunter","year":"2012","unstructured":"Hunter, P. (2012). H5N1 infects the biosecurity debate. EMBO Reports, 13(7), 604\u2013607.","journal-title":"EMBO Reports"},{"issue":"7403","key":"9774_CR29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature10831","volume":"486","author":"M Imai","year":"2012","unstructured":"Imai, M., Watanabe, T., Hatta, M., Das, S. C., Ozawa, M., Shinya, K., et al. (2012). Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA\/H1N1 virus in ferrets. Nature, 486(7403), 420\u2013428.","journal-title":"Nature"},{"issue":"3","key":"9774_CR30","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1128\/JVI.75.3.1205-1210.2001","volume":"75","author":"RJ Jackson","year":"2001","unstructured":"Jackson, R. J., Ramsay, A. J., Christensen, C. D., Beaton, S., Hall, D. F., & Ramshaw, I. A. (2001). Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. Journal of Virology, 75(3), 1205\u20131210.","journal-title":"Journal of Virology"},{"key":"9774_CR31","doi-asserted-by":"crossref","unstructured":"Kalb, S. R., Baudys, J., Raphael, B. H., Dykes, J. K., Luquez, C., Maslanka, S. E., & Barr, J. R. (2015). Functional characterization of botulinum neurotoxin serotype H as a hybrid of known serotypes F and A (BoNT F\/A). Analytical Chemistry, 87(7), 3911\u20133917.","DOI":"10.1021\/ac504716v"},{"issue":"1S","key":"9774_CR32","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1038\/embor.2009.119","volume":"10","author":"A Kelle","year":"2009","unstructured":"Kelle, A. (2009). Synthetic biology and biosecurity. EMBO Reports, 10(1S), S23\u2013S27.","journal-title":"EMBO Reports"},{"issue":"3","key":"9774_CR33","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s11948-012-9365-8","volume":"19","author":"A Kelle","year":"2013","unstructured":"Kelle, A. (2013). Beyond patchwork precaution in the dual-use governance of synthetic biology. Science and Engineering Ethics, 19(3), 1121\u20131139.","journal-title":"Science and Engineering Ethics"},{"key":"9774_CR34","volume-title":"Prohibiting chemical and biological weapons: Multilateral regimes and their evolution","author":"A Kelle","year":"2014","unstructured":"Kelle, A. (2014). Prohibiting chemical and biological weapons: Multilateral regimes and their evolution. Incorporated: Lynne Rienner Publishers."},{"issue":"9","key":"9774_CR35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1467-8519.2008.00695.x","volume":"22","author":"F Kuhlau","year":"2008","unstructured":"Kuhlau, F., Eriksson, S., Evers, K., & H\u00f6glund, A. T. (2008). Taking due care: Moral obligations in dual use research. Bioethics, 22(9), 477\u2013487.","journal-title":"Bioethics"},{"issue":"3","key":"9774_CR36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2174\/092986611794578314","volume":"18","author":"M Kumar Singh","year":"2011","unstructured":"Kumar Singh, M., Kumar Dhaked, R., Singh, P., Gupta, P., & Singh, L. (2011). Characterization of LC-HCC fusion protein of botulinum neurotoxin type A. Protein and Peptide Letters, 18(3), 295\u2013304.","journal-title":"Protein and Peptide Letters"},{"issue":"5498","key":"9774_CR500","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1126\/science.1173759","volume":"325","author":"C Lartigue","year":"2009","unstructured":"Lartigue, C., Vashee, S., Algire, M. A., Chuang, R. Y., Benders, G. A., Ma, L., et al. (2009). Creating bacterial strains from genomes that have been cloned and engineered in yeast. Science, 325(5948), 1693\u20131696.","journal-title":"Science"},{"key":"9774_CR37","doi-asserted-by":"publisher","unstructured":"Liu, B., Shi, D., Chang, S., Gong, X., Yu, Y., Sun, Z., & Wu, J. (2015). Characterization and immunological activity of different forms of recombinant secreted Hc of botulinum neurotoxin serotype B products expressed in yeast. Scientific Reports, 5, 7678. doi: 10.1038\/srep07678 .","DOI":"10.1038\/srep07678"},{"issue":"4","key":"9774_CR38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11948-007-9043-4","volume":"13","author":"S Miller","year":"2007","unstructured":"Miller, S., & Selgelid, M. J. (2007). Ethical and philosophical consideration of the dual-use dilemma in the biological sciences. Science and Engineering Ethics, 13(4), 523\u2013580.","journal-title":"Science and Engineering Ethics"},{"key":"9774_CR39","unstructured":"National Research Council (2004). Biotechnology research in an age of terrorism. Committee on research standards and practices to prevent the destructive application of biotechnology. Washington, D.C.: National Academies Press."},{"issue":"7552","key":"9774_CR40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/521281a","volume":"521","author":"KA Oye","year":"2015","unstructured":"Oye, K. A., Lawson, J. C., & Bubela, T. (2015). Drugs: Regulate \u2018home-brew\u2019 opiates. Nature, 521(7552), 281.","journal-title":"Nature"},{"issue":"7446","key":"9774_CR41","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature12051","volume":"496","author":"CJ Paddon","year":"2013","unstructured":"Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., et al. (2013). High-level semi-synthetic production of the potent antimalarial artemisinin. Nature, 496(7446), 528\u2013532.","journal-title":"Nature"},{"issue":"3","key":"9774_CR42","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s11948-014-9519-y","volume":"20","author":"J Rath","year":"2014","unstructured":"Rath, J., Ischi, M., & Perkins, D. (2014). Evolution of different dual-use concepts in international and national law and its implications on research ethics and governance. Science and Engineering Ethics, 20(3), 769\u2013790.","journal-title":"Science and Engineering Ethics"},{"issue":"2","key":"9774_CR43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/hast.156","volume":"43","author":"DA Relman","year":"2013","unstructured":"Relman, D. A. (2013). The increasingly compelling moral responsibilities of life scientists. Hastings Center Report, 43(2), 34\u201335.","journal-title":"Hastings Center Report"},{"issue":"1","key":"9774_CR44","doi-asserted-by":"crossref","first-page":"e1001253","DOI":"10.1371\/journal.ppat.1001253","volume":"7","author":"JE Suk","year":"2011","unstructured":"Suk, J. E., Zmorzynska, A., Hunger, I., Biederbick, W., Sasse, J., Maidhof, H., & Semenza, J. C. (2011). Dual-use research and technological diffusion: Reconsidering the bioterrorism threat spectrum. PLoS Pathogens, 7(1), e1001253.","journal-title":"PLoS Pathogens"},{"key":"9774_CR45","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nchembio.1613","volume":"10","author":"K Thodey","year":"2014","unstructured":"Thodey, K., Galanie, S., & Smolke, C. D. (2014). A microbial biomanufacturing platform for natural and semisynthetic opioids. Nature Chemical Biology, 10, 837\u2013844.","journal-title":"Nature Chemical Biology"},{"volume-title":"Innovation, dual use, and security: Managing the risks of emerging biological and chemical technologies","year":"2012","key":"9774_CR46","unstructured":"Tucker, J. B. (Ed.). (2012). Innovation, dual use, and security: Managing the risks of emerging biological and chemical technologies. Cambridge, MA: MIT Press."},{"issue":"1","key":"9774_CR47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/embor.2012.195","volume":"14","author":"C Uhlenhaut","year":"2013","unstructured":"Uhlenhaut, C., Burger, R., & Schaade, L. (2013). Protecting society. EMBO Reports, 14(1), 25\u201330.","journal-title":"EMBO Reports"},{"issue":"4","key":"9774_CR48","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s11948-011-9266-2","volume":"18","author":"K Bruggen van der","year":"2012","unstructured":"van der Bruggen, K. (2012). Possibilities, intentions and threats: Dual use in the life sciences reconsidered. Science and Engineering Ethics, 18(4), 741\u2013756.","journal-title":"Science and Engineering Ethics"},{"key":"9774_CR49","doi-asserted-by":"crossref","unstructured":"Webster, R. G. (2012). Mammalian-transmissible H5N1 influenza: The dilemma of dual-use research. MBio, 3(1), e00005-12.13.","DOI":"10.1128\/mBio.00005-12"},{"key":"9774_CR50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/485013a","volume":"485","author":"E Yong","year":"2012","unstructured":"Yong, E. (2012). Mutant-flu paper published. Nature, 485, 13\u201314.","journal-title":"Nature"}],"container-title":["Science and Engineering Ethics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11948-016-9774-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11948-016-9774-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11948-016-9774-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11948-016-9774-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T20:02:23Z","timestamp":1568059343000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11948-016-9774-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,20]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["9774"],"URL":"https:\/\/doi.org\/10.1007\/s11948-016-9774-1","relation":{},"ISSN":["1353-3452","1471-5546"],"issn-type":[{"type":"print","value":"1353-3452"},{"type":"electronic","value":"1471-5546"}],"subject":[],"published":{"date-parts":[[2016,6,20]]}}}