{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:56:00Z","timestamp":1762606560560},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroinform"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s12021-015-9267-4","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T06:35:01Z","timestamp":1428474901000},"page":"443-458","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Automatic Dendritic Length Quantification for High Throughput Screening of Mature Neurons"],"prefix":"10.1007","volume":"13","author":[{"given":"Timothy","family":"Smafield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkat","family":"Pasupuleti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Huganir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"9267_CR1","unstructured":"Al-Ali, H., Blackmore, M., Bixby, J. L., & Lemmon, V. P. (2013). High content screening with primary neurons. In Assay Guidance Manual. Bethesda: Eli Lilly & Company and the National Center for Advancing Translational Sciences."},{"issue":"2","key":"9267_CR2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1109\/TITB.2002.1006304","volume":"6","author":"KA Al-Kofahi","year":"2002","unstructured":"Al-Kofahi, K. A., Lasek, S., Szarowski, D. H., Pace, C. J., Nagy, G., Turner, J. N., et al. (2002). Rapid automated three-dimensional tracing of neurons from confocal image stacks. IEEE Transactions on Information Technology in Biomedicine, 6(2), 171\u2013187.","journal-title":"IEEE Transactions on Information Technology in Biomedicine"},{"issue":"10","key":"9267_CR3","first-page":"981","volume":"10","author":"L Becker","year":"1986","unstructured":"Becker, L., Armstrong, D., & Chan, F. (1986). Dendritic atrophy in children with Down\u2019s syndrome. Annals of Neurology, 10(10), 981\u2013991.","journal-title":"Annals of Neurology"},{"key":"9267_CR4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0006-8993(89)90144-3","volume":"494","author":"GJ Brewer","year":"1989","unstructured":"Brewer, G. J., & Cotman, C. W. (1989). Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Research, 494, 65\u201374.","journal-title":"Brain Research"},{"issue":"2","key":"9267_CR5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1109\/4233.767088","volume":"3","author":"A Can","year":"1999","unstructured":"Can, A., Shen, H., Turner, J. N., Tanenbaum, H. L., & Roysam, B. (1999). Rapid automated tracing and feature extraction from retinal fundus images. IEEE Transactions on Information Technology in Biomedicine, 3(2), 125\u2013138.","journal-title":"IEEE Transactions on Information Technology in Biomedicine"},{"key":"9267_CR6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF01386390","volume":"1","author":"EW Dijkstra","year":"1959","unstructured":"Dijkstra, E. W. (1959). A note on two problems in connexion with graphs. Numerische Mathematik, 1, 269\u2013271.","journal-title":"Numerische Mathematik"},{"key":"9267_CR7","first-page":"75","volume":"5","author":"R Dunkle","year":"2003","unstructured":"Dunkle, R. (2003). Role of image informatics in accelerating drug discovery and development. Drug Discovery World, 5, 75\u201382.","journal-title":"Drug Discovery World"},{"key":"9267_CR8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-3806(02)00642-9","volume":"141","author":"CJ Faherty","year":"2003","unstructured":"Faherty, C. J., Kerley, D., & Smeyne, R. J. (2003). A Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. Developmental Brain Research, 141, 55\u201361.","journal-title":"Developmental Brain Research"},{"key":"9267_CR9","first-page":"21","volume":"5","author":"S Fox","year":"2003","unstructured":"Fox, S. (2003). Accommodating Cells in HTS. Drug Discovery World, 5, 21\u201330.","journal-title":"Drug Discovery World"},{"issue":"3","key":"9267_CR10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1145\/28869.28874","volume":"34","author":"ML Fredman","year":"1987","unstructured":"Fredman, M. L., & Tarjan, R. E. (1987). Fibonacci heaps and their uses in improved network optimization algorithms. Journal of the Association for Computing Machinery, 34(3), 596\u2013615.","journal-title":"Journal of the Association for Computing Machinery"},{"key":"9267_CR11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroscience.2012.04.044","volume":"251","author":"J Glausier","year":"2013","unstructured":"Glausier, J., & Lewis, D. (2013). Dendritic spine pathology in schizophrenia. Neuroscience, 251, 90\u2013107.","journal-title":"Neuroscience"},{"issue":"4","key":"9267_CR12","first-page":"749","volume":"27","author":"CD Hawker","year":"2007","unstructured":"Hawker, C. D. (2007). Laboratory automation: total and subtotal. Laboratory Management, 27(4), 749\u2013770.","journal-title":"Laboratory Management"},{"key":"9267_CR13","doi-asserted-by":"crossref","unstructured":"Liu, Y. (2011). The DIADEM and beyond. Neuroinformatics, 99\u2013102.","DOI":"10.1007\/s12021-011-9102-5"},{"issue":"7","key":"9267_CR14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/cyto.a.20895","volume":"77","author":"E Meijering","year":"2010","unstructured":"Meijering, E. (2010). Neuron tracing in perspective. Cytometry. Part A, 77(7), 693\u2013704.","journal-title":"Cytometry. Part A"},{"issue":"2","key":"9267_CR15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.20022","volume":"58","author":"E Meijering","year":"2004","unstructured":"Meijering, E., Jacob, M., Sarria, J., Steiner, P., Hirling, H., & Unser, M. (2004). Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry. Part A, 58(2), 167\u2013176.","journal-title":"Cytometry. Part A"},{"key":"9267_CR16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fninf.2012.00004","volume":"6","author":"DR Myatt","year":"2012","unstructured":"Myatt, D. R., Hadlington, T., Ascoli, G. A., & Nasuto, S. J. (2012). Neuromantic - from semi-manual to semi-automatic reconstruction of neuron morphology. Frontiers in Neuroinformatics, 6, 4.","journal-title":"Frontiers in Neuroinformatics"},{"key":"9267_CR17","doi-asserted-by":"crossref","unstructured":"Narro, M. L., Yang, F., Kraft, R., Wenk, C., Efrat, A., & Restifo, L. L. (2007). NeuronMetrics: Software for semi-automated processing of cultured neuron images. Brain Research, 113b, 57\u20137 5.","DOI":"10.1016\/j.brainres.2006.10.094"},{"issue":"3","key":"9267_CR18","doi-asserted-by":"crossref","first-page":"e91744","DOI":"10.1371\/journal.pone.0091744","volume":"9","author":"TJ Nieland","year":"2014","unstructured":"Nieland, T. J., Logan, D. J., Saulnier, J., Lam, D., Johnson, C., Root, D. E., et al. (2014). High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons. PLoS ONE, 9(3), e91744.","journal-title":"PLoS ONE"},{"issue":"1","key":"9267_CR19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","volume":"9","author":"N Otsu","year":"1975","unstructured":"Otsu, N. (1975). A threshold selection method from gray-level histograms. IEEE Transactions on Systems, Man, and Cybernetics, 9(1), 62\u201366.","journal-title":"IEEE Transactions on Systems, Man, and Cybernetics"},{"issue":"3","key":"9267_CR20","first-page":"373","volume":"6","author":"S Patt","year":"1991","unstructured":"Patt, S., Gertz, H., Gerhard, L., & Cerv\u00f3s-Navarro, J. (1991). Pathological changes in dendrites of substantia nigra neurons in Parkinson\u2019s disease: a Golgi study. Histology and Histopathology, 6(3), 373\u2013380.","journal-title":"Histology and Histopathology"},{"key":"9267_CR21","doi-asserted-by":"crossref","unstructured":"Peng, H., Long, F., Zhao, T., & Myers, E. (2011). Proof-editing is The Bottleneck of 3D Neuron Reconstruction: The Problem and Solutions. Neuroinformatics.","DOI":"10.1007\/s12021-010-9090-x"},{"issue":"4","key":"9267_CR22","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nbt.1612","volume":"28","author":"H Peng","year":"2010","unstructured":"Peng, H., Ruan, Z., Long, F., Simpson, J. H., & Myers, E. W. (2010). V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets. Nature Biotechnology, 28(4), 348\u2013353.","journal-title":"Nature Biotechnology"},{"key":"9267_CR23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.npp.1301574","volume":"33","author":"C Pittenger","year":"2008","unstructured":"Pittenger, C., & Duman, R. S. (2008). Stress, depression, and neuroplasticity: a convergence. Neuropsychopharmacology Reviews, 33, 88\u2013109.","journal-title":"Neuropsychopharmacology Reviews"},{"issue":"1","key":"9267_CR24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jneumeth.2007.08.029","volume":"168","author":"M Pool","year":"2008","unstructured":"Pool, M., Thiemann, J., Bar-Or, A., & Fournier, A. E. (2008). NeuriteTracer: a novel imagej plugin for automated. Journal of Neuroscience Methods, 168(1), 134\u2013139.","journal-title":"Journal of Neuroscience Methods"},{"issue":"4","key":"9267_CR25","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/nprot.2006.313","volume":"1","author":"A Rodriguez","year":"2006","unstructured":"Rodriguez, A., Ehlenberger, D., Hof, P., & Wearne, S. (2006). Rayburst sampling, an algorithm for automated three-dimensional shape analysis from laser scanning microscopy images. Nature Protocol, 1(4), 2152\u201361.","journal-title":"Nature Protocol"},{"issue":"1","key":"9267_CR26","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-0270(00)00228-4","volume":"100","author":"LC R\u00f8nn","year":"2000","unstructured":"R\u00f8nn, L. C., Ralets, I., Hartz, B. P., Bech, M., Berezin, A., Berezin, V., et al. (2000). A simple procedure for quantification of neurite outgrowth based on stereological principles. Journal of Neuroscience Methods, 100(1), 25\u201332.","journal-title":"Journal of Neuroscience Methods"},{"issue":"5","key":"9267_CR27","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.celrep.2013.11.008","volume":"5","author":"K Sharma","year":"2013","unstructured":"Sharma, K., Choi, S.-Y., Zhang, Y., Nieland, T. J., Long, S., Li, M., et al. (2013). High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development. Cell Reports, 5(5), 1330\u201341.","journal-title":"Cell Reports"},{"key":"9267_CR28","doi-asserted-by":"crossref","unstructured":"Sternberg, S. R. (1983). Biomedical Image Processing. IEEE Computer, 22\u201334.","DOI":"10.1109\/MC.1983.1654163"},{"key":"9267_CR29","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/cyto.a.20462","volume":"71A","author":"P Vallotton","year":"2007","unstructured":"Vallotton, P., Lagerstrom, R., Sun, C., Buckley, M., Wang, D., Silva, M. D., et al. (2007). Automated analysis of neurite branching in cultured cortical neurons using HCA-Vision. Cytometry. Part A, 71A, 889\u2013895.","journal-title":"Cytometry. Part A"},{"key":"9267_CR30","first-page":"135","volume-title":"Digital image analysis of microbes: Imaging, morphometry, fluorometry and motility techniques and applications","author":"MH Wilkinson","year":"1998","unstructured":"Wilkinson, M. H. (1998). Segmentation techniques in image analysis of Microbes. In Digital image analysis of microbes: Imaging, morphometry, fluorometry and motility techniques and applications (pp. 135\u2013170). Chichester: John Wiley & Sons."},{"issue":"2","key":"9267_CR31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12021-010-9067-9","volume":"8","author":"C Wu","year":"2010","unstructured":"Wu, C., Schulte, J., Sepp, K. J., Littleton, J. T., & Hong, P. (2010). Automatic robust neurite detection and morphological analysis of neuronal cell cultures in high-content screening. Neuroinformatics, 8(2), 83\u2013100.","journal-title":"Neuroinformatics"},{"issue":"4","key":"9267_CR32","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.neuroimage.2007.01.014","volume":"35","author":"Y Zhang","year":"2007","unstructured":"Zhang, Y., Zhou, X., Alexei, D., Marta, L., Adjeroh, D., Yuan, J., et al. (2007). Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. NeuroImage, 35(4), 1502\u20131515.","journal-title":"NeuroImage"},{"key":"9267_CR33","doi-asserted-by":"crossref","unstructured":"Zuiderveld, K. (1994). Contrast limited adaptive histogram equalization. In Graphics Gems IV (pp. 474\u2013485). Princeton: Academic Press.","DOI":"10.1016\/B978-0-12-336156-1.50061-6"}],"container-title":["Neuroinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12021-015-9267-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12021-015-9267-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12021-015-9267-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T01:57:25Z","timestamp":1559440645000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12021-015-9267-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,9]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["9267"],"URL":"https:\/\/doi.org\/10.1007\/s12021-015-9267-4","relation":{},"ISSN":["1539-2791","1559-0089"],"issn-type":[{"value":"1539-2791","type":"print"},{"value":"1559-0089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,9]]}}}