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Central to these advances has been the identification and analysis of \u201cfunctional networks\u201d, often derived from groups of pre-selected pain regions. In this study our main objective was to identify functional brain networks related to pain perception by examining whole-brain activation, avoiding the need for a priori selection of regions. We applied a data-driven technique\u2014Constrained Principal Component Analysis for fMRI (fMRI-CPCA)\u2014that identifies networks without assuming their anatomical or temporal properties. Open-source fMRI data collected during a thermal pain task (33 healthy participants) were subjected to fMRI-CPCA for network extraction, and networks were associated with pain perception by modelling subjective pain ratings as a function of network activation intensities. Three functional networks emerged: a sensorimotor response network, a salience-mediated attention network, and the default-mode network. Together, these networks constituted a brain state that explained variability in pain perception, both within and between individuals, demonstrating the potential of data-driven, whole-brain functional network techniques for the analysis of pain imaging data.<\/jats:p>","DOI":"10.1007\/s12021-021-09527-6","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T10:08:40Z","timestamp":1623146920000},"page":"155-172","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Multiple Functional Brain Networks Related to Pain Perception Revealed by fMRI"],"prefix":"10.1007","volume":"20","author":[{"given":"Matteo","family":"Damascelli","sequence":"first","affiliation":[]},{"given":"Todd S.","family":"Woodward","sequence":"additional","affiliation":[]},{"given":"Nicole","family":"Sanford","sequence":"additional","affiliation":[]},{"given":"Hafsa B.","family":"Zahid","sequence":"additional","affiliation":[]},{"given":"Ryan","family":"Lim","sequence":"additional","affiliation":[]},{"given":"Alexander","family":"Scott","sequence":"additional","affiliation":[]},{"given":"John K.","family":"Kramer","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"9527_CR1","doi-asserted-by":"crossref","unstructured":"Abdi, H., & Williams, L. 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