{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:33:54Z","timestamp":1772120034020,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["1OT3OD025349-01"],"award-info":[{"award-number":["1OT3OD025349-01"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroinform"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    With advances in microscopy and computer science, the technique of digitally reconstructing, modeling, and quantifying microscopic anatomies has become central to many fields of biological research. MBF Bioscience has chosen to openly document their digital reconstruction file format, the Neuromorphological File Specification, available at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.mbfbioscience.com\/filespecification\">www.mbfbioscience.com\/filespecification<\/jats:ext-link>\n                    (Angstman et al., 2020). The format, created and maintained by MBF Bioscience, is broadly utilized by the neuroscience community. The data format\u2019s structure and capabilities have evolved since its inception, with modifications made to keep pace with advancements in microscopy and the scientific questions raised by worldwide experts in the field. More recent modifications to the neuromorphological file format ensure it abides by the Findable, Accessible, Interoperable, and Reusable (FAIR) data principles promoted by the International Neuroinformatics Coordinating Facility (INCF; Wilkinson et al.,\n                    <jats:italic>Scientific Data, 3<\/jats:italic>\n                    , 160018,, 2016). The incorporated metadata make it easy to identify and repurpose these data types for downstream applications and investigation. This publication describes key elements of the file format and details their relevant structural advantages in an effort to encourage the reuse of these rich data files for alternative analysis or reproduction of derived conclusions.\n                  <\/jats:p>","DOI":"10.1007\/s12021-021-09530-x","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T15:01:29Z","timestamp":1633359689000},"page":"221-240","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6999-9906","authenticated-orcid":false,"given":"A. E.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-3770","authenticated-orcid":false,"given":"S. J.","family":"Tappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Angstman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. C.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Hoppes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Abdul-Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5097-1030","authenticated-orcid":false,"given":"M. L.","family":"Heal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-207X","authenticated-orcid":false,"given":"Jack R.","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"key":"9530_CR1","doi-asserted-by":"publisher","unstructured":"Abrams, M. B., Bjaalie, J. G., Das, S., Egan, G. F., Ghosh, S. S., Goscinski, W. J., Grethe, J. S., Kotaleski, J. H., Wei Ho, E. T., Kennedy, D. N., Lanyon, L. J., Leergaard, T. B., Mayberg, H. S., Milanesi, L., Mou\u010dek, R., Poline, J. B., Roy, P. K., Strother, S. C., Tang, T. B., Tiesinga, P., Wachtler, T., W\u00f3jcik, D. K., & Martone, M. E. (2021). A standards organization for open and FAIR neuroscience: the International Neuroinformatics Coordinating Facility. Neuroinform. https:\/\/doi.org\/10.1007\/s12021-020-09509-0.","DOI":"10.1007\/s12021-020-09509-0"},{"issue":"6","key":"9530_CR2","doi-asserted-by":"publisher","first-page":"101140","DOI":"10.1016\/j.isci.2020.101140","volume":"23","author":"S Achanta","year":"2020","unstructured":"Achanta, S., Gorky, J., Leung, C., Moss, A., Robbins, S., Eisenman, L., Chen, J., Tappan, S., Heal, M., Farahani, N., Huffman, T., England, S., Cheng, Z. J., Vadigepalli, R., & Schwaber, J. S. (2020). A comprehensive integrated anatomical and molecular atlas of rat intrinsic cardiac nervous system. iScience, 23(6), 101140. https:\/\/doi.org\/10.1016\/j.isci.2020.101140.","journal-title":"iScience"},{"key":"9530_CR3","unstructured":"Angstman, P. J., Tappan, S. J., Sullivan, A. E., Thomas, G. C., Rodriguez, A., Hoppes, D. M., Abdul-Karim, M. A., Heal, M. L., Glaser, J.R. (2020). Neuromorphological File Specification (4.0). Neuromorphological File Specification. Retrieved March 23, 2020, from www.mbfbioscience.com\/filespecification"},{"issue":"1","key":"9530_CR4","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3389\/neuro.01.1.1.010.2007","volume":"1","author":"JI Arellano","year":"2007","unstructured":"Arellano, J. I., Benavides-Piccione, R., DeFelipe, J., & Yuste, R. (2007). Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies. Frontiers in Neuroscience, 1(1), 131\u2013131. https:\/\/doi.org\/10.3389\/neuro.01.1.1.010.2007.","journal-title":"Frontiers in Neuroscience"},{"issue":"35","key":"9530_CR5","doi-asserted-by":"publisher","first-page":"9247","DOI":"10.1523\/jneurosci.2055-07.2007","volume":"27","author":"GA Ascoli","year":"2007","unstructured":"Ascoli, G. A., Donohue, D. E., & Halavi, M. (2007). NeuroMorpho.Org: a central resource for neuronal morphologies. Journal of Neuroscience, 27(35), 9247\u20139251. https:\/\/doi.org\/10.1523\/jneurosci.2055-07.2007.","journal-title":"Journal of Neuroscience"},{"key":"9530_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fnana.2014.00065","volume":"8","author":"AV Blackman","year":"2014","unstructured":"Blackman, A. V., Grabuschnig, S., Legenstein, R., & Sj\u00f6str\u00f6m, P. J. (2014). A comparison of manual neuronal reconstruction from biocytin histology or 2-photon imaging: morphometry and computer modeling. Frontiers in Neuroanatomy, 8, 65. https:\/\/doi.org\/10.3389\/fnana.2014.00065.","journal-title":"Frontiers in Neuroanatomy"},{"key":"9530_CR7","unstructured":"Bray, T., Paoli, J., Sperberg-McQueen, C. M., Maler, E., & Yergeau, F. (2008). Extensible Markup Language (XML) 1.0\u00a0(Fifth Edition). W3C. Retrieved August 8, 2020, from https:\/\/www.w3.org\/TR\/2008\/REC-xml-20081126\/"},{"issue":"1\u20132","key":"9530_CR8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s0165-0270(98)00091-0","volume":"84","author":"RC Cannon","year":"1998","unstructured":"Cannon, R. C., Turner, D. A., Pyapali, G. K., & Wheal, H. V. (1998). An on-line archive of reconstructed hippocampal neurons. Journal of Neuroscience Methods, 84(1\u20132), 49\u201354. https:\/\/doi.org\/10.1016\/s0165-0270(98)00091-0.","journal-title":"Journal of Neuroscience Methods"},{"key":"9530_CR9","doi-asserted-by":"publisher","unstructured":"Cho, Y., Tsanhani, A., Sullivan, A. E., Tappan, S. J., Ardell, J. L., Shivkumar, K., & Tompkins, J. D. (2020). Atlas of mouse stellate ganglion neurons with axonal projections to the heart. (Version 1) [Data set in progress]. Blackfynn. https:\/\/doi.org\/10.26275\/atzo-uhlm.","DOI":"10.26275\/atzo-uhlm"},{"issue":"2","key":"9530_CR10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s12021-007-0003-6","volume":"5","author":"S Crook","year":"2007","unstructured":"Crook, S., Gleeson, P., Howell, F., Svitak, J., & Silver, R. A. (2007). MorphML: level 1 of the NeuroML standards for neuronal morphology data and model specification. Neuroinformatics, 5(2), 96\u2013104. https:\/\/doi.org\/10.1007\/s12021-007-0003-6.","journal-title":"Neuroinformatics"},{"key":"9530_CR11","unstructured":"EPLF Blue Brain Project. (n.d.). Neurons. EPLF Blue Brian Portal. Retrieved August 6th, 2020, from https:\/\/portal.bluebrain.epfl.ch\/resources\/models\/neurons-2\/"},{"key":"9530_CR12","unstructured":"FDI Lab. (n.d). Our Services. FDI Lab. Retrieved March 24, 2021, from https:\/\/www.fdilab.org\/services"},{"issue":"3","key":"9530_CR13","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.neuron.2013.02.036","volume":"78","author":"C F\u00f6ldy","year":"2013","unstructured":"F\u00f6ldy, C., Malenka, R. C., & S\u00fcdhof, T. C. (2013). Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron, 78(3), 498\u2013509. https:\/\/doi.org\/10.1016\/j.neuron.2013.02.036.","journal-title":"Neuron"},{"issue":"18","key":"9530_CR14","doi-asserted-by":"publisher","first-page":"6939","DOI":"10.1523\/JNEUROSCI.20-18-06939.2000","volume":"20","author":"ML Gabriele","year":"2000","unstructured":"Gabriele, M. L., Brunso-Bechtold, J. K., & Henkel, C. K. (2000). Plasticity in the development of afferent patterns in the inferior colliculus of the rat after unilateral cochlear ablation. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 20(18), 6939\u20136949. https:\/\/doi.org\/10.1523\/JNEUROSCI.20-18-06939.2000.","journal-title":"The Journal of Neuroscience: the Official Journal of the Society for Neuroscience"},{"issue":"1","key":"9530_CR15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40478-018-0647-5","volume":"7","author":"MA Gama Sosa","year":"2019","unstructured":"Gama Sosa, M. A., De Gasperi, R., Perez Garcia, G. S., Perez, G. M., Searcy, C., Vargas, D., Spencer, A., Janssen, P. L., Tschiffely, A. E., McCarron, R. M., Ache, B., Manoharan, R., Janssen, W. G., Tappan, S. J., Hanson, R. W., Gandy, S., Hof, P. R., Ahlers, S. T., & Elder, G. A. (2019). Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain. Acta Neuropathologica Communications, 7(1), 6. https:\/\/doi.org\/10.1186\/s40478-018-0647-5.","journal-title":"Acta Neuropathologica Communications"},{"issue":"6424","key":"9530_CR16","doi-asserted-by":"publisher","first-page":"eaau8302","DOI":"10.1126\/science.aau8302","volume":"363","author":"R Gao","year":"2019","unstructured":"Gao, R., Asano, S. M., Upadhyayula, S., Pisarev, I., Milkie, D. E., Liu, T. L., Singh, V., Graves, A., Huynh, G. H., Zhao, Y., Bogovic, J., Colonell, J., Ott, C. M., Zugates, C., Tappan, S., Rodriguez, A., Mosaliganti, K. R., Sheu, S. H., Pasolli, H. A., Pang, S., \u2026 Betzig, E. (2019). Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science, 363(6424), eaau8302. https:\/\/doi.org\/10.1126\/science.aau8302.","journal-title":"Science"},{"issue":"7342","key":"9530_CR17","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature09945","volume":"472","author":"S Ghosh","year":"2011","unstructured":"Ghosh, S., Larson, S. D., Hefzi, H., Marnoy, Z., Cutforth, T., Dokka, K., & Baldwin, K. K. (2011). Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons. Nature, 472(7342), 217\u2013220. https:\/\/doi.org\/10.1038\/nature09945.","journal-title":"Nature"},{"key":"9530_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1109\/TBME.1965.4502337","volume":"12","author":"EM Glaser","year":"1965","unstructured":"Glaser, E. M., & Van der loos, H. (1965). A semi-automatic computer-microscope for the analysis of neuronal morphology. IEEE Transactions on Bio-medical Engineering, 12, 22\u201331.","journal-title":"IEEE Transactions on Bio-medical Engineering"},{"issue":"5","key":"9530_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0895-6111(90)90105-k","volume":"14","author":"JR Glaser","year":"1990","unstructured":"Glaser, J. R., & Glaser, E. M. (1990). Neuron imaging with Neurolucida\u2013a PC-based system for image combining microscopy. Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society, 14(5), 307\u2013317. https:\/\/doi.org\/10.1016\/0895-6111(90)90105-k.","journal-title":"Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society"},{"key":"9530_CR20","doi-asserted-by":"publisher","unstructured":"Grethe, J. S., Bandrowski, A., Banks, D. E., Condit, C., Gupta, A., Larson, S. D., Li, Y., Ozyurt, I. B., Stagg, A. M., Whetzel, P. L., Marenco, L., Miller, P., Wang, R., Shepherd, G. M., & Martone, M. E. (2014). SciCrunch: A cooperative and collaborative data and resource discovery platform for scientific communities. Frontiers in Neuroinformatics. Conference Abstract: Neuroinformatics 2014. https:\/\/doi.org\/10.3389\/conf.fninf.2014.18.00069.","DOI":"10.3389\/conf.fninf.2014.18.00069"},{"key":"9530_CR21","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fnins.2012.00049","volume":"6","author":"M Halavi","year":"2012","unstructured":"Halavi, M., Hamilton, K. A., Parekh, R., & Ascoli, G. A. (2012). Digital reconstructions of neuronal morphology: three decades of research trends. Frontiers in Neuroscience, 6, 49. https:\/\/doi.org\/10.3389\/fnins.2012.00049.","journal-title":"Frontiers in Neuroscience"},{"issue":"2\u20133","key":"9530_CR22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12021-011-9098-x","volume":"9","author":"HY He","year":"2011","unstructured":"He, H. Y., & Cline, H. T. (2011). Diadem X: automated 4 dimensional analysis of morphological data. Neuroinformatics, 9(2\u20133), 107\u2013112. https:\/\/doi.org\/10.1007\/s12021-011-9098-x.","journal-title":"Neuroinformatics"},{"issue":"1","key":"9530_CR23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neuron.2010.08.042","volume":"68","author":"EJ Henriksen","year":"2010","unstructured":"Henriksen, E. J., Colgin, L. L., Barnes, C. A., Witter, M. P., Moser, M. B., & Moser, E. I. (2010). Spatial representation along the proximodistal axis of CA1. Neuron, 68(1), 127\u2013137. .","journal-title":"Neuron"},{"key":"9530_CR24","unstructured":"Human Brain Project. (n.d.). EBRAINS Find Data. EBRAINS. Retrieved August 6th, 2020, from https:\/\/kg.ebrains.eu\/search\/"},{"issue":"1","key":"9530_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/s0361-9230(96)00380-2","volume":"44","author":"ME Jackson","year":"1997","unstructured":"Jackson, M. E., & Cauller, L. J. (1997). Evaluation of simplified compartmental models of reconstructed neocortical neurons for use in large-scale simulations of biological neural networks. Brain Research Bulletin, 44(1), 7\u201317. https:\/\/doi.org\/10.1016\/s0361-9230(96)00380-2.","journal-title":"Brain Research Bulletin"},{"issue":"6","key":"9530_CR26","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/cercor\/11.6.558","volume":"11","author":"B Jacobs","year":"2001","unstructured":"Jacobs, B., Schall, M., Prather, M., Kapler, E., Driscoll, L., Baca, S., Jacobs, J., Ford, K., Wainwright, M., & Treml, M. (2001). Regional dendritic and spine variation in human cerebral cortex: a quantitative golgi study. Cerebral Cortex, 11(6), 558\u2013571. https:\/\/doi.org\/10.1093\/cercor\/11.6.558.","journal-title":"Cerebral Cortex"},{"issue":"6","key":"9530_CR27","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.1007\/s00429-018-1666-5","volume":"223","author":"J L\u00e1zaro","year":"2018","unstructured":"L\u00e1zaro, J., Hertel, M., Sherwood, C. C., Muturi, M., & Dechmann, D. K. N. (2018). Profound seasonal changes in brain size and architecture in the common shrew. Brain Structure & Function, 223(6), 3823\u20132840. https:\/\/doi.org\/10.1007\/s00429-018-1666-5.","journal-title":"Brain Structure & Function"},{"issue":"9","key":"9530_CR28","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1093\/cercor\/bhl127","volume":"17","author":"JV Le B\u00e9","year":"2007","unstructured":"Le B\u00e9, J. V., Silberberg, G., Wang, Y., & Markram, H. (2007). Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex. Cerebral Cortex, 17(9), 2204\u20132213. https:\/\/doi.org\/10.1093\/cercor\/bhl127.","journal-title":"Cerebral Cortex"},{"key":"9530_CR29","doi-asserted-by":"publisher","unstructured":"Leung, C., Robbins, S., Vadigepalli, R., Schwaber, J., Heal, M., Tappan, S., Huffman, T., Farahani, N., & Cheng, Z. (2020). Distribution of ICN Neurons in Male and Female 3D Reconstructed Rat Hearts (Version 1) [Data set]. Blackfynn. https:\/\/doi.org\/10.26275\/IVO4-0RZY.","DOI":"10.26275\/IVO4-0RZY"},{"key":"9530_CR30","unstructured":"MBF Bioscience. (2020). Neuron Summary (branched structure). Analysis results. Neuron Summary and Cell Body Details.https:\/\/www.mbfbioscience.com\/help\/neurolucida_explorer\/Content\/Analyze\/BranchedStructure\/neuronSumm.htm."},{"issue":"7","key":"9530_CR31","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/cyto.a.20895","volume":"77","author":"E Meijering","year":"2010","unstructured":"Meijering, E. (2010). Neuron tracing in perspective. Cytometry. Part A: the Journal of the International Society for Analytical Cytology, 77(7), 693\u2013704. https:\/\/doi.org\/10.1002\/cyto.a.20895.","journal-title":"Cytometry. Part A: the Journal of the International Society for Analytical Cytology"},{"key":"9530_CR32","doi-asserted-by":"publisher","unstructured":"Mpodozis, J., Cox, K., Shimizu, T., Bischof, H. J., Woodson, W., & Karten, H. J. (1996). GABAergic inputs to the nucleus rotundus (pulvinar inferior) of the pigeon (columba livia). The Journal of Comparative Neurology, 374(2), 204\u2013222. https:\/\/doi.org\/10.1002\/(SICI)1096-9861(19961014)374:2<204::AID-CNE4>3.0.CO;2-6.","DOI":"10.1002\/(SICI)1096-9861(19961014)374:2<204::AID-CNE4>3.0.CO;2-6"},{"key":"9530_CR33","doi-asserted-by":"publisher","first-page":"170207","DOI":"10.1038\/sdata.2017.207","volume":"5","author":"S Nanda","year":"2018","unstructured":"Nanda, S., Chen, H., Das, R., Bhattacharjee, S., Cuntz, H., Torben-Nielsen, B., Peng, H., Cox, D. N., De Schutter, E., & Ascoli, G. A. (2018). Design and implementation of multi-signal and time-varying neural reconstructions. Scientific Data, 5, 170207. https:\/\/doi.org\/10.1038\/sdata.2017.207.","journal-title":"Scientific Data"},{"issue":"9","key":"9530_CR34","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/jnr.24206","volume":"96","author":"H Nedelescu","year":"2018","unstructured":"Nedelescu, H., Abdelhack, M., & Pritchard, A. T. (2018). Regional differences in Purkinje cell morphology in the cerebellar vermis of male mice. Journal of Neuroscience Research, 96(9), 1476\u20131489. https:\/\/doi.org\/10.1002\/jnr.24206.","journal-title":"Journal of Neuroscience Research"},{"key":"9530_CR35","unstructured":"NeuroMorpho.Org. (n.d.).\u00a0Metadata. NeuroMorpho.Org. Retrieved March 9th, 2021, from http:\/\/neuromorpho.org\/MetaData.jsp"},{"issue":"1","key":"9530_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00441-014-2103-6","volume":"360","author":"R Parekh","year":"2015","unstructured":"Parekh, R., Arma\u00f1anzas, R., & Ascoli, G. A. (2015). The importance of metadata to assess information content in digital reconstructions of neuronal morphology. Cell and Tissue Research, 360(1), 121\u2013127. https:\/\/doi.org\/10.1007\/s00441-014-2103-6.","journal-title":"Cell and Tissue Research"},{"issue":"6","key":"9530_CR37","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.neuron.2013.03.008","volume":"77","author":"R Parekh","year":"2013","unstructured":"Parekh, R., & Ascoli, G. A. (2013). Neuronal morphology goes digital: a research hub for cellular and system neuroscience. Neuron, 77(6), 1017\u20131038. https:\/\/doi.org\/10.1016\/j.neuron.2013.03.008.","journal-title":"Neuron"},{"issue":"6","key":"9530_CR38","doi-asserted-by":"publisher","first-page":"e38971","DOI":"10.1371\/journal.pone.0038971","volume":"7","author":"A Pillai","year":"2012","unstructured":"Pillai, A., de Jong, D., Kanatsu, S., Krugers, H., Knapman, A., Heinzmann, J., Holsboer, F., LandgraF, R., Jo\u00ebls, M., & Touma, C. (2012). Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity. PLoS One, 7(6), e38971. https:\/\/doi.org\/10.1371\/journal.pone.0038971.","journal-title":"PLoS One"},{"issue":"3","key":"9530_CR39","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/s1385-299x(98)00055-5","volume":"3","author":"G Prusky","year":"1999","unstructured":"Prusky, G., & Arjannikova, T. (1999). Intracellular filling and reconstruction of identified neurons in fixed rat brain slices. Brain Research. Brain Research Protocols, 3(3), 313\u2013319. https:\/\/doi.org\/10.1016\/s1385-299x(98)00055-5.","journal-title":"Brain Research. Brain Research Protocols"},{"issue":"1","key":"9530_CR40","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1210\/jcem-71-1-79","volume":"71","author":"NE Rance","year":"1990","unstructured":"Rance, N. E., McMullen, N. T., Smialek, J. E., Price, D. L., & Young, W. S. III. (1990). Postmenopausal hypertrophy of neurons expressing the estrogen receptor gene in the human hypothalamus. The Journal of Clinical Endocrinology and Metabolism, 71(1), 79\u201385. https:\/\/doi.org\/10.1210\/jcem-71-1-79.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"9530_CR41","doi-asserted-by":"publisher","unstructured":"Rodriguez, A., Ehlenberger, D. B., Dickstein, D. L., Hof, P. R., & Wearne, S. L. (2008). Automated three-dimensional detection and shape classification of dendritic spines from fluorescence microscopy images. PLoS One, 3(4), e1997. https:\/\/doi.org\/10.1371\/journal.pone.0001997.","DOI":"10.1371\/journal.pone.0001997"},{"key":"9530_CR42","doi-asserted-by":"publisher","unstructured":"R\u00fcbel, O., Tritt, A., Dichter, B., Braun, T., Cain, N., Clack, N., Davidson, T. J., Dougherty, M., Fillion-Robin, J., Graddis, N., Grauer, M., Kiggins, T. J., Niu, L., Ozturk, Schroeder, W., Soltesz, I., Sommer, F. T., Svoboda, K., Lydia, N., Frank, L. M., & Bouchard, K. (2019). NWB:N 2.0: An accessible data standard for neurophysiology. bioRxiv, 523035. https:\/\/doi.org\/10.1101\/523035.","DOI":"10.1101\/523035"},{"key":"9530_CR43","doi-asserted-by":"crossref","unstructured":"Schiller, J., Schiller, Y., Stuart, G., & Sakmann, B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. Journal of Physiology, 505(3), 605\u2013616.","DOI":"10.1111\/j.1469-7793.1997.605ba.x"},{"key":"9530_CR44","unstructured":"Siek, J., Lee, L., & Lumsdaine, A. (2001). Review of Elementary Graph Theory. Boost C++ Libraries. Retrieved July 10, 2020, from https:\/\/www.boost.org\/doc\/libs\/1_73_0\/libs\/graph\/doc\/graph_theory_review.html"},{"issue":"4","key":"9530_CR45","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/cne.903560408","volume":"356","author":"DA Turner","year":"1995","unstructured":"Turner, D. A., Li, X. G., Pyapali, G. K., Ylinen, A., & Buzsaki, G. (1995). Morphometric and electrical properties of reconstructed hippocampal CA3 neurons recorded in vivo. The Journal of Comparative Neurology, 356(4), 580\u2013594. https:\/\/doi.org\/10.1002\/cne.903560408.","journal-title":"The Journal of Comparative Neurology"},{"issue":"1","key":"9530_CR46","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1038\/s41598-020-58838-2","volume":"10","author":"F Ullah","year":"2020","unstructured":"Ullah, F., Asgarov, R., Venigalla, M., Liang, H., Niedermayer, G., M\u00fcnch, G., & Gyengesi, E. (2020). Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model. Scientific Reports, 10(1), 2365. https:\/\/doi.org\/10.1038\/s41598-020-58838-2.","journal-title":"Scientific Reports"},{"issue":"1","key":"9530_CR47","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1109\/TVCG.2017.2744079","volume":"24","author":"W Usher","year":"2018","unstructured":"Usher, W., Klacansky, P., Federer, F., Bremer, P. T., Knoll, A., Yarch, J., Angelucci, A., & Pascucci, V. (2018). A virtual reality visualization tool for neuron tracing. IEEE Transactions on Visualization and Computer Graphics, 24(1), 994\u20131003. https:\/\/doi.org\/10.1109\/TVCG.2017.2744079.","journal-title":"IEEE Transactions on Visualization and Computer Graphics"},{"key":"9530_CR48","doi-asserted-by":"publisher","unstructured":"Wilkinson, M. D., Dumontier, M., Aalbersberg, I. J., Appleton, G., Axton, M., Baak, A., Blomberg, N., Boiten, J. W., da Silva Santos, L. B., Bourne, P. E., Bouwman, J., Brookes, A. J., Clark, T., Crosas, M., Dillo, I., Dumon, O., Edmunds, S., Evelo, C. T., Finkers, R., Gonzalez-Beltran, A., Gray, A. J. G., Groth, P., Goble, C., Grethe, J. S., Heringa, J., Hoen, P. A. C., \u2019t, Hooft, R., Kuhn, T., Kok, R., Kok, J., Lusher, S. J., Martone, M. E., Mons, A., Packer, P. L., Persson, B., Rocca-Serra, P., Roos, M., van Schaik, R., Sansone, S., Schultes, E., Sengstag, T., Slater, T., Strawn, G., Swertz, M. A., Thompson, M., van der Lei, J., van Mulligen, E., Velterop, J., Waagmeester, A., Wittenburg, P., Wolstencroft, K., Zhao, J., & Mons, B. (2016). The FAIR Guiding Principles for scientific data management and stewardship. Scientific Data, 3, 160018. https:\/\/doi.org\/10.1038\/sdata.2016.18.","DOI":"10.1038\/sdata.2016.18"},{"issue":"2","key":"9530_CR49","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/s0092-8674(02)00707-9","volume":"109","author":"AM Wong","year":"2002","unstructured":"Wong, A. M., Wang, J. W., & Axel, R. (2002). Spatial representation of the glomerular map in the Drosophila protocerebrum. Cell, 109(2), 229\u2013241. https:\/\/doi.org\/10.1016\/s0092-8674(02)00707-9.","journal-title":"Cell"},{"issue":"2","key":"9530_CR50","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1017\/s0952523898152148","volume":"15","author":"CC Wu","year":"1998","unstructured":"Wu, C. C., & Karten, H. J. (1998). The thalamo-hyperstriatal system is established by the time of hatching in chicks (Gallus gallus): a cholera toxin B subunit study. Visual Neuroscience, 15(2), 349\u2013358. https:\/\/doi.org\/10.1017\/s0952523898152148.","journal-title":"Visual Neuroscience"},{"issue":"1","key":"9530_CR51","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/cercor\/bht210","volume":"25","author":"L Zaborszky","year":"2015","unstructured":"Zaborszky, L., Csordas, A., Mosca, K., Kim, J., Gielow, M. R., Vadasz, C., & Nadasdy, Z. (2015). Neurons in the basal forebrain project to the cortex in a complex topographic organization that reflects corticocortical connectivity patterns: an experimental study based on retrograde tracing and 3D reconstruction. Cerebral Cortex, 25(1), 118\u2013137. https:\/\/doi.org\/10.1093\/cercor\/bht210.","journal-title":"Cerebral Cortex"}],"container-title":["Neuroinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12021-021-09530-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12021-021-09530-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12021-021-09530-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T11:42:04Z","timestamp":1672918924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12021-021-09530-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,2]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["9530"],"URL":"https:\/\/doi.org\/10.1007\/s12021-021-09530-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.22.306670","asserted-by":"object"}]},"ISSN":["1539-2791","1559-0089"],"issn-type":[{"value":"1539-2791","type":"print"},{"value":"1559-0089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,2]]},"assertion":[{"value":"1 June 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MBF Bioscience is a commercial entity, and the authors affiliated with them are company employees.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest\/Competing Interests"}}]}}