{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:07:49Z","timestamp":1694650069675},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,4,26]],"date-time":"2008-04-26T00:00:00Z","timestamp":1209168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Theory Biosci."],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1007\/s12064-008-0041-0","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T08:16:54Z","timestamp":1209111414000},"page":"95-105","source":"Crossref","is-referenced-by-count":6,"title":["3D Multi-agent models for protein release from PLGA spherical particles with complex inner morphologies"],"prefix":"10.1007","volume":"127","author":[{"given":"Ana","family":"Barat","sequence":"first","affiliation":[]},{"given":"Heather J.","family":"Ruskin","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Crane","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,4,26]]},"reference":[{"key":"41_CR1","unstructured":"Barat A (2006) Probabilistic methods for drug dissolution, PhD thesis, Dublin City University"},{"issue":"12","key":"41_CR2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1021\/js9604117","volume":"86","author":"RP Batycky","year":"1997","unstructured":"Batycky RP, Hanes J, Langer R, Edwards DA (1997) A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J Pharm Sci 86(12):1464\u20131477","journal-title":"J Pharm Sci"},{"key":"41_CR3","unstructured":"Charlton D, Peterson M, Spiller K, Lowman A, Torzilli P, Maher S (2006) Mechanical characterization of a Novel Scaffold for the repair of articular cartilage. Private communication"},{"key":"41_CR4","unstructured":"Feng S (2006) Chemotherapeutic engineering: polymeric nanoparticles for clinical administration of anticancer drugs. Access date: 14\/11\/2006"},{"key":"41_CR5","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1016\/S0009-2509(03)00234-3","volume":"58","author":"S Feng","year":"2003","unstructured":"Feng S, Chien S (2003) Chemotherapeutic engineering: application and further development of chemical engineering principles for chemotherapy of cancer and other diseases. Chem Eng Sci 58:4087\u20134114","journal-title":"Chem Eng Sci"},{"issue":"10","key":"41_CR6","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/aic.690411012","volume":"41","author":"A G\u00f6pferich","year":"1995","unstructured":"G\u00f6pferich A (1995) Modeling of polymer erosion in three dimensions: rotationally symmetric devices. Am Inst Chem Eng (AIChE) J 41(10):2292\u20132299","journal-title":"Am Inst Chem Eng (AIChE) J"},{"key":"41_CR7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0142-9612(96)85755-3","volume":"17","author":"A G\u00f6pferich","year":"1996","unstructured":"G\u00f6pferich A (1996) Mechanisms of polymer degradation and erosion. Biomaterials 17:103\u2013114","journal-title":"Biomaterials"},{"key":"41_CR8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(96)01533-7","volume":"44","author":"A G\u00f6pferich","year":"1997","unstructured":"G\u00f6pferich A (1997a) Bioerodible implants with programmable drug release. J Control Release 44:271\u2013281","journal-title":"J Control Release"},{"key":"41_CR9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0142-9612(96)00151-2","volume":"18","author":"A G\u00f6pferich","year":"1997","unstructured":"G\u00f6pferich A (1997b) Erosion of composite polymer matrices. Biomaterials 18:397\u2013403","journal-title":"Biomaterials"},{"key":"41_CR10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0168-3659(94)00064-2","volume":"33","author":"A G\u00f6pferich","year":"1995","unstructured":"G\u00f6pferich A, Langer R (1995) Modeling monomer release from bioerodible polymers. J Control Release 33:55\u201369","journal-title":"J Control Release"},{"issue":"4","key":"41_CR11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1208\/pt020430","volume":"2","author":"F Kang","year":"2001","unstructured":"Kang F, Singh J (2001) Effect of additives on the release of a model protein from PLGA microspheres. AAPS PharmSciTech 2(4):30","journal-title":"AAPS PharmSciTech"},{"issue":"6","key":"41_CR12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/02652040500162766","volume":"22","author":"AC Kilic","year":"2005","unstructured":"Kilic AC, Capan Y, Vural I, Gursoy RN, Dalkara T, Cuine A, Hincal AA (2005) Preparation and characterization of PLGA nanospheres for the targeted delivery of NR2B-specific antisense oligonucleotides to the NMDA receptors in the brain. Journal of Microencapsul 22(6):633\u2013641","journal-title":"J Microencapsul"},{"key":"41_CR13","first-page":"89","volume":"4","author":"JM Kisler","year":"2001","unstructured":"Kisler JM, Stevens GW, O\u2019Connor AJ (2001) Adsorption of proteins on mesoporous molecular sieves. Mater Phys Mech 4:89\u201393","journal-title":"Mater Phys Mech"},{"key":"41_CR14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0378-5173(03)00030-9","volume":"254","author":"K Kosmidis","year":"2003","unstructured":"Kosmidis K, Rinaki E, Argyrakis P, Macheras P (2003) Analysis of case ii drug transport with radial and axial release from cylinders. Int J Pharm 254:181\u2013188","journal-title":"Int J Pharm"},{"key":"41_CR15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0168-3659(00)00224-8","volume":"67","author":"X Lam","year":"2000","unstructured":"Lam X, Duenas E, Daugherty A, Levin N, Cleland J (2000) Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes. J Control Release 67:281\u2013292","journal-title":"J Control Release"},{"key":"41_CR16","unstructured":"Merkle H, Gander B, Meinel L, Walter E (2002) Novel opportunities of microparticulates for the delivery of therapeutics and vaccines, Technical report"},{"issue":"5","key":"41_CR17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-2236(98)01261-2","volume":"21","author":"C Nicholson","year":"1998","unstructured":"Nicholson C, Sychova E (1998) Extracellular space structure revealed by diffusion analysis. Trends Neurosci 21(5):207\u2013215","journal-title":"Trends Neurosci"},{"key":"41_CR18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-3659(01)00446-1","volume":"76","author":"M Sandor","year":"2001","unstructured":"Sandor M, Enscore D, Weston P, Mathiowitz E (2001) Effect of protein molecular weight on release from micron-sized PLGA microspheres. J Control Release 76:297\u2013311","journal-title":"J Control Release"},{"issue":"12","key":"41_CR19","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1023\/A:1021457911533","volume":"19","author":"J Siepmann","year":"2002","unstructured":"Siepmann J, Faisant N, Benoit J-P (2002) A new mathematical model quantifying drug release from bioerodible microparticles using Monte Carlo simulations. Pharm Res 19(12):1885\u20131893","journal-title":"Pharm Res"},{"issue":"9","key":"41_CR20","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1128\/AAC.47.9.3005-3007.2003","volume":"47","author":"Q ul Ain","year":"2003","unstructured":"ul Ain Q, Sharma S, Khuller GK (2003) Chemotherapeutic potential of orally administered poly(lactide-co-glycolide) microparticles containing isoniazid, rifampin, and pyrazinamide against experimental tuberculosis. Antimicrob Agents Chemother 47(9):3005\u20133007","journal-title":"Antimicrob Agents Chemother"},{"key":"41_CR21","unstructured":"Ungaro F, Biondi M, Indolfi L, Rosa GD, Rotonda MIL, Quaglia F, Netti P (2004) Bioactivated polymer scaffolds for tissue engineering. V Biomaterials"},{"key":"41_CR22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2005.11.021","volume":"111","author":"KD Vlugt-Wensink","year":"2006","unstructured":"Vlugt-Wensink KD, Vlugt TJ, Jiskoot W, Crommelin DJ, Verrijk R, Hennink WE (2006) Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations. J Control Release 111:117\u2013127","journal-title":"J Control Release"},{"issue":"10","key":"41_CR23","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/jps.10463","volume":"92","author":"M Zhang","year":"2003","unstructured":"Zhang M, Yang Z, Chow L-L, Wang C-H (2003) Simulation of drug release from biodegradable polymeric microspheres with bulk and surface erosions. J Pharm Sci 92(10):2040\u20132056","journal-title":"J Pharm Sci"},{"issue":"12","key":"41_CR24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2006.03.018","volume":"113","author":"A Zhao","year":"2006","unstructured":"Zhao A, Rodgers V (2006) Using TEM to couple transient protein distribution and release for PLGA microparticles for potential use as vaccine delivery vehicles. J Control Release 113(12):15\u201322","journal-title":"J Control Release"},{"key":"41_CR25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0142-9612(96)85757-7","volume":"17","author":"K Zygourakis","year":"1996","unstructured":"Zygourakis K, Markenscoff PA (1996) Computer-aided design of bioerodible devices with optimal release characteristics: a cellular automata approach. Biomaterials 17:125\u2013135","journal-title":"Biomaterials"}],"container-title":["Theory in Biosciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12064-008-0041-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12064-008-0041-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12064-008-0041-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T03:33:20Z","timestamp":1559446400000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12064-008-0041-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,26]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["41"],"URL":"https:\/\/doi.org\/10.1007\/s12064-008-0041-0","relation":{},"ISSN":["1431-7613","1611-7530"],"issn-type":[{"value":"1431-7613","type":"print"},{"value":"1611-7530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,26]]}}}