{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T14:35:24Z","timestamp":1775658924200,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Theory Biosci."],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s12064-013-0182-7","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T05:35:30Z","timestamp":1368509730000},"page":"1-21","source":"Crossref","is-referenced-by-count":8,"title":["Information theory, gene expression, and combinatorial regulation: a quantitative analysis"],"prefix":"10.1007","volume":"133","author":[{"given":"J\u00fcrgen","family":"Jost","sequence":"first","affiliation":[]},{"given":"Klaus","family":"Scherrer","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"182_CR1","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1126\/science.287.5461.2185","volume":"287","author":"D Adams M.","year":"2000","unstructured":"Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Rubin GM, Venter JC (2000) The genome sequence of Drosophila melanogaster. Science 287:2185\u20132195","journal-title":"Science"},{"key":"182_CR2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00019052-200406000-00015","volume":"17","author":"A Aguzzi","year":"2004","unstructured":"Aguzzi A, Miele G (2004) Recent advances in prion biology. Curr Opin Neurol 17:337\u2013342","journal-title":"Curr Opin Neurol"},{"key":"182_CR3","doi-asserted-by":"crossref","unstructured":"Ashby WR (1956) An introduction to cybernetics. Chapman and Hall, London","DOI":"10.5962\/bhl.title.5851"},{"key":"182_CR4","unstructured":"Banerjee A, Jost J (2007) Laplacian spectrum and protein\u2013protein interaction networks. eprint arXiv 0705.3373"},{"key":"182_CR5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature09000","volume":"465","author":"Y Barash","year":"2010","unstructured":"Barash Y, Calarco JA, Gao W, Pan Q, Wang X, Shai O, Blencowe BJ, Frey BJ (2010) Deciphering the splicing code. Nature 465:53\u201359","journal-title":"Nature"},{"key":"182_CR6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0022-2836(72)90519-0","volume":"63","author":"ML Birnstiel","year":"1972","unstructured":"Birnstiel ML, Sells BH, Purdom IF (1972) Kinetic complexity of RNA molecules. J Mol Biol 63:21\u201339","journal-title":"J Mol Biol"},{"key":"182_CR7","unstructured":"Casarrubea D (2013) A new mouse model with gain of iron regulatory protein 1 function. PhD thesis, Heidelberg University"},{"key":"182_CR8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrg1990","volume":"8","author":"K Chen","year":"2007","unstructured":"Chen K, Rajewsky N (2007) The evolution of gene regulation by transcription factors and microRNAs\u2014review. Nat Rev Genet 8:93\u2013103","journal-title":"Nat Rev Genet"},{"key":"182_CR9","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1093\/nar\/27.15.3219","volume":"27","author":"M Deutsch","year":"1999","unstructured":"Deutsch M, Long MY (1999) Intron and exon structures of eukaryotic model organisms. Nucleic Acids Res 27:3219\u20133228","journal-title":"Nucleic Acids Res"},{"key":"182_CR10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","volume":"489","author":"S Djebali","year":"2012","unstructured":"Djebali S et\u00a0al (2012) Landscape of transcription in human cells. Nature 489:101\u2013108","journal-title":"Nature"},{"key":"182_CR11","doi-asserted-by":"crossref","unstructured":"Edstrom J (1964) The role of chromosomes in development. Academic Press, New York, p. 137","DOI":"10.1016\/B978-0-12-395727-6.50012-8"},{"key":"182_CR12","doi-asserted-by":"crossref","unstructured":"Project Consortium ENCODE (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447:779\u2013961. doi: 10.1038\/nature05874","DOI":"10.1038\/nature05874"},{"key":"182_CR13","unstructured":"http:\/\/www.gencodegenes.org\/releases\/14.html"},{"key":"182_CR14","doi-asserted-by":"crossref","unstructured":"Hamkalo BA, Miller OL, Bakken AH (1974) Ultrastructure of active eukaryotic genomes. In: cold spring harbor symposia on quantitative biology, vol 38, pp 915\u2013919","DOI":"10.1101\/SQB.1974.038.01.093"},{"key":"182_CR15","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nature03154","volume":"432","author":"L Hillier","year":"2004","unstructured":"Hillier L, LaDeana W et\u00a0al (2004) Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432:695\u2013716","journal-title":"Nature"},{"key":"182_CR16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF00286047","volume":"62","author":"Y Hotta","year":"1977","unstructured":"Hotta Y, Chandley AC, Stern H (1977) Biochemical analysis of meiosis in the male mouse. Chromosoma 62:255\u2013268","journal-title":"Chromosoma"},{"key":"182_CR17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/269240a0","volume":"269","author":"Y Hotta","year":"1977","unstructured":"Hotta Y, Chandley AC, Stern H (1977) Meiotic crossing-over in lily and mouse. Nature 269:240\u2013242","journal-title":"Nature"},{"key":"182_CR18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0012-1606(82)90246-9","volume":"93","author":"M-T Imaizumi-Scherrer","year":"1982","unstructured":"Imaizumi-Scherrer M-T, Maundrell K, Civelli O, Scherrer K (1982) Transcriptional and post-transcriptional regulation in duck erythroblasts. Dev Biol 93:126\u2013138","journal-title":"Dev Biol"},{"key":"182_CR19","doi-asserted-by":"crossref","unstructured":"International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409:860\u2013921","DOI":"10.1038\/35057062"},{"key":"182_CR20","doi-asserted-by":"crossref","unstructured":"Lara FJ (1987) Gene amplification in Rhynchosciara (1955\u20131987). Mem Inst Oswaldo Cruz 82(Suppl 3):125\u2013128","DOI":"10.1590\/S0074-02761987000700023"},{"key":"182_CR21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.molcel.2010.07.012","volume":"39","author":"MP Mayer","year":"2010","unstructured":"Mayer MP (2010) Gymnastics of molecular chaperones\u2014review. Mol Cell 39:321\u2013331","journal-title":"Mol Cell"},{"key":"182_CR22","doi-asserted-by":"crossref","unstructured":"Moreau J, Matyash-Smirniaguina L, Scherrer K (1981) Systematic punctuation of eukaryotic DNA by AT-rich sequences. Proc Natl Acad Sci USA 78:1341\u20131345","DOI":"10.1073\/pnas.78.3.1341"},{"key":"182_CR23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0022-5193(03)00028-6","volume":"222","author":"R Pastor-Satorras","year":"2003","unstructured":"Pastor-Satorras R, Smith E, Sole RV (2003) Evolving protein interaction networks through gene duplication. J Theor Biol 222:199\u2013210","journal-title":"J Theor Biol"},{"key":"182_CR24","doi-asserted-by":"crossref","unstructured":"Razin SV, Farrell CM, Recillas-Targa F (2003) Genomic domains and regulatory elements operating at the domain level. Int Rev Cytol 226:63\u2013125","DOI":"10.1016\/S0074-7696(03)01002-7"},{"key":"182_CR25","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/jcb.20066","volume":"92","author":"SV Razin","year":"2004","unstructured":"Razin SV, Rynditch A, Borunova V, Ioudinkova E, Smalko V, Scherrer K (2004) The 33\u00a0kb transcript of the chicken alpha-globin gene domain is part of the nuclear matrix. J Cell Biochem 92:445\u2013457","journal-title":"J Cell Biochem"},{"key":"182_CR26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0079-6603(08)60918-6","volume":"19","author":"W Salser","year":"1976","unstructured":"Salser W, Browne F, Clarke P, Heindell H, Higuchi R, Paddock G, Roberts J, Studnicka G, Zakar P (1976) Determination of globin mRNA sequences and their insertion into bacterial plasmids. Prog Nucleic Acid Res Mol Biol 19:177\u2013204","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"182_CR27","unstructured":"Scherrer K (1980) Cascade regulation: a model of integrative control of gene expression in eukaryotic cells and organisms. In: Kolodny GM (ed) Eukaryotic gene regulation, vol 1. CRC Press Inc., Boca Raton, pp 57\u2013129"},{"issue":"2","key":"182_CR28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF01115994","volume":"9","author":"K Scherrer","year":"1989","unstructured":"Scherrer K (1989) A unified matrix hypothesis of DNA-directed morphogenesis, protodynamism and growth control. Biosci Rep 9(2):157\u2013188","journal-title":"Biosci Rep"},{"key":"182_CR29","unstructured":"Scherrer K (2010) The genon-concept and the transcription factor cycle (TFC) hypothesis. Abstr Book A 045:112"},{"key":"182_CR30","doi-asserted-by":"crossref","unstructured":"Scherrer K, Jost J (2007) The gene and the genon concept: a functional and information-theoretic analysis. Mol Syst Biol 3:87","DOI":"10.1038\/msb4100123"},{"key":"182_CR31","doi-asserted-by":"crossref","unstructured":"Scherrer K, Jost J (2007) The genon concept: gene storage and expression in view of information theoretic analysis. Theory Biosci. doi: 10.1007\/s12064-007-0012-x .","DOI":"10.1007\/s12064-007-0012-x"},{"key":"182_CR32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jcp.1040720413","volume":"72","author":"K Scherrer","year":"1968","unstructured":"Scherrer K, Marcaud L (1968) Messenger RNA in avian erythroblasts at the transcriptional and translational levels and the problem of regulation in animal cells. J Cell Physiol 72:181\u2013212","journal-title":"J Cell Physiol"},{"key":"182_CR33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/science.1084354","volume":"300","author":"M Snyder","year":"2003","unstructured":"Snyder M, Gerstein M (2003) Genomics. Defining genes in the genomics era. Science 300:258\u2013260","journal-title":"Science"},{"key":"182_CR34","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1016\/S0021-9258(19)34036-0","volume":"265","author":"E Theil","year":"1990","unstructured":"Theil E (1990) Regulation of ferritin and transferrin receptor mRNAs. JBC 265:4771\u20134774","journal-title":"JBC"},{"key":"182_CR35","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S1357-2725(99)00080-1","volume":"31","author":"A Thompson","year":"1999","unstructured":"Thompson A, Rogers J, Leedman P (1999) Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation. Review. Int J Biochem Cell Biol 31:1139\u20131152","journal-title":"Int J Biochem Cell Biol"},{"key":"182_CR36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00778736","volume":"7","author":"A Vincent","year":"1981","unstructured":"Vincent A, Goldenberg S, Standart N, Civelli O, Imaizumi-Scherrer MT, Maundrell K, Scherrer K (1981) Potential role of mRNP proteins in cytoplasmic control of gene expression in duck erythroblasts. Mol Biol Rep 7:71\u201381","journal-title":"Mol Biol Rep"},{"key":"182_CR37","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/oxfordjournals.molbev.a003913","volume":"18","author":"A Wagner","year":"2001","unstructured":"Wagner A (2001) The yeast protein interaction network evolves rapidly and contains few redundant duplicate genes. Mol Biol Evol 18:1283\u20131292","journal-title":"Mol Biol Evol"},{"key":"182_CR38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1098\/rspb.2002.2269","volume":"270","author":"A Wagner","year":"2003","unstructured":"Wagner A (2003) How the global structure of protein interaction networks evolves. Proc R Soc B: Biol Sci 270:457\u2013466","journal-title":"Proc R Soc B: Biol Sci"}],"container-title":["Theory in Biosciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12064-013-0182-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12064-013-0182-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12064-013-0182-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T23:44:39Z","timestamp":1645055079000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12064-013-0182-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["182"],"URL":"https:\/\/doi.org\/10.1007\/s12064-013-0182-7","relation":{},"ISSN":["1431-7613","1611-7530"],"issn-type":[{"value":"1431-7613","type":"print"},{"value":"1611-7530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,15]]}}}