{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:34:01Z","timestamp":1770971641039,"version":"3.50.1"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Theory Biosci."],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s12064-018-0266-5","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T10:20:43Z","timestamp":1531218043000},"page":"155-168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bioenergetics of life, disease and death phenomena"],"prefix":"10.1007","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2590-6688","authenticated-orcid":false,"given":"Andrzej","family":"Kasperski","sequence":"first","affiliation":[]},{"given":"Renata","family":"Kasperska","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"issue":"19","key":"266_CR1","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1038\/sj.emboj.7600819","volume":"24","author":"G Achanta","year":"2005","unstructured":"Achanta G, Sasaki R, Feng L, Carew JS et al (2005) Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. EMBO J 24(19):3482\u20133492","journal-title":"EMBO J"},{"key":"266_CR2","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/j.1440-1746.2012.07200.x","volume":"27","author":"S Al-Sohaily","year":"2012","unstructured":"Al-Sohaily S, Biankin A, Leong R, Kohonen-Corish M et al (2012) Molecular pathways in colorectal cancer. J Gastroen Hepatol 27:1423\u20131431","journal-title":"J Gastroen Hepatol"},{"key":"266_CR3","unstructured":"Alvergne A, Jenkinson C, Faurie C (2016) Evolutionary thinking in medicine from research to policy and practice, 1st edn, Chapter 13, Why Chemotherapy Does Not Work: Cancer Genome Evolution and the Illusion of Oncogene Addiction. Springer International Publishing (Verlag)"},{"issue":"9","key":"266_CR4","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","volume":"25","author":"P Anand","year":"2008","unstructured":"Anand P, Kunnumakara AB, Sundaram C, Harikumar KB et al (2008) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25(9):2097\u20132116","journal-title":"Pharm Res"},{"issue":"2","key":"266_CR5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.mehy.2014.05.001","volume":"83","author":"G Bagkos","year":"2014","unstructured":"Bagkos G, Koufopoulos K, Piperi C (2014) A new model for mitochondrial membrane potential production and storage. Med Hypotheses 83(2):175\u2013181","journal-title":"Med Hypotheses"},{"issue":"2","key":"266_CR6","doi-asserted-by":"crossref","first-page":"dju405","DOI":"10.1093\/jnci\/dju405","volume":"107","author":"SG Baker","year":"2015","unstructured":"Baker SG (2015) A cancer theory kerfuffle can lead to new lines of research. JNCI J Natl Cancer I 107(2):dju405","journal-title":"JNCI J Natl Cancer I"},{"key":"266_CR7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1574-6976.2001.tb00570.x","volume":"25","author":"BM Bakker","year":"2001","unstructured":"Bakker BM, Overkamp KM, van Maris AJA, K\u00f6tter P et al (2001) Stoichiometry and compartmentation of NADH metabolism in Saccharomyces cerevisiae. FEMS Microbiol Rev 25:15\u201337","journal-title":"FEMS Microbiol Rev"},{"issue":"Pt 6","key":"266_CR8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1042\/bst0311441","volume":"31","author":"L Behrend","year":"2003","unstructured":"Behrend L, Henderson G, Zwacka RM (2003) Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 31(Pt 6):1441\u20131444","journal-title":"Biochem Soc Trans"},{"issue":"6900","key":"266_CR9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/418823a","volume":"418","author":"R Bernards","year":"2002","unstructured":"Bernards R, Weinberg RA (2002) A progression puzzle. Nature 418(6900):823","journal-title":"Nature"},{"issue":"1","key":"266_CR10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ccr.2006.10.020","volume":"11","author":"S Bonnet","year":"2007","unstructured":"Bonnet S, Archer SL, Allalunis-Turner J, Haromy A et al (2007) A mitochondria-K\u2009+\u2009channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11(1):37\u201351","journal-title":"Cancer Cell"},{"issue":"1\u20132","key":"266_CR11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0022-1759(00)00178-2","volume":"240","author":"DA Bradbury","year":"2000","unstructured":"Bradbury DA, Simmons TD, Slater KJ, Crouch SP (2000) Measurement of the ADP:ATP ratio in human leukaemic cell lines can be used as an indicator of cell viability, necrosis and apoptosis. J Immunol Methods 240(1\u20132):79\u201392","journal-title":"J Immunol Methods"},{"key":"266_CR12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/1471-2407-14-331","volume":"14","author":"BLDM Br\u00fccher","year":"2014","unstructured":"Br\u00fccher BLDM, Jamall IS (2014) Epistemology of the origin of cancer: a new paradigm. BMC Cancer 14:331","journal-title":"BMC Cancer"},{"issue":"16","key":"266_CR13","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1016\/S0021-9258(19)68900-3","volume":"256","author":"E Bustamante","year":"1981","unstructured":"Bustamante E, Morris HP, Pedersen PL (1981) Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 256(16):8699\u20138704","journal-title":"J Biol Chem"},{"key":"266_CR14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/255197a0","volume":"255","author":"J Cairns","year":"1975","unstructured":"Cairns J (1975) Mutation selection and the natural history of cancer. Nature 255:197\u2013200","journal-title":"Nature"},{"key":"266_CR15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2407-10-3","volume":"10","author":"P Calabrese","year":"2010","unstructured":"Calabrese P, Shibata D (2010) A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer 10:3","journal-title":"BMC Cancer"},{"issue":"1","key":"266_CR16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.canlet.2008.02.029","volume":"266","author":"JS Clerkin","year":"2008","unstructured":"Clerkin JS, Naughton R, Quiney C, Cotter TG (2008) Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett 266(1):30\u201336","journal-title":"Cancer Lett"},{"key":"266_CR17","volume-title":"The cell: a molecular approach","author":"GM Cooper","year":"2000","unstructured":"Cooper GM (2000) The cell: a molecular approach, 2nd edn. Sinauer Associates, Sunderland","edition":"2"},{"key":"266_CR18","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1529\/biophysj.104.041749","volume":"87","author":"S Cortassa","year":"2004","unstructured":"Cortassa S, Aon MA, Winslow RL, O\u2019Rourke B (2004) A mitochondrial oscillator dependent on reactive oxygen species. Biophys J 87:2060\u20132073","journal-title":"Biophys J"},{"key":"266_CR19","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.cell.2012.02.032","volume":"148","author":"RJ Berardinis De","year":"2012","unstructured":"De Berardinis RJ, Thompson CB (2012) Cellular metabolism and disease: what do metabolic outliers teach us? Cell 148:1132\u20131144","journal-title":"Cell"},{"issue":"9","key":"266_CR20","doi-asserted-by":"crossref","first-page":"093101","DOI":"10.1063\/1.5000713","volume":"27","author":"C Draghi","year":"2017","unstructured":"Draghi C, Viger L, Denis F, Letellier C (2017) How the growth rate of host cells affects cancer risk in a deterministic way. Chaos 27(9):093101","journal-title":"Chaos"},{"issue":"2","key":"266_CR21","first-page":"24","volume":"22","author":"J Erenpreisa","year":"2014","unstructured":"Erenpreisa J (2014) Cancer is ontogenetically pre-programmed. MEDIC 22(2):24\u201327","journal-title":"MEDIC"},{"key":"266_CR22","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.68582","volume-title":"Senescence - Physiology or Pathology","author":"Jekaterina Erenpreisa","year":"2017","unstructured":"Erenpreisa J, Salmina K, Cragg MS (2017) Accelerated senescence of cancer stem cells: a failure to thrive or a route to survival? senescence\u2014physiology or pathology, Dorszewska J. (Ed.), InTech. https:\/\/doi.org\/10.5772\/intechopen.68582"},{"issue":"6","key":"266_CR23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2006.04.023","volume":"9","author":"VR Fantin","year":"2006","unstructured":"Fantin VR, St-Pierre J, Leder P (2006) Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9(6):425\u2013434","journal-title":"Cancer Cell"},{"issue":"8","key":"266_CR24","doi-asserted-by":"crossref","first-page":"526","DOI":"10.5732\/cjc.011.10018","volume":"30","author":"VC Fogg","year":"2011","unstructured":"Fogg VC, Lanning NJ, MacKeigan JP (2011) Mitochondria in cancer: at the crossroads of life and death. Chin J Cancer 30(8):526\u2013539","journal-title":"Chin J Cancer"},{"key":"266_CR25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","volume":"147","author":"Y Fuchs","year":"2011","unstructured":"Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147:742\u2013758","journal-title":"Cell"},{"key":"266_CR26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.mehy.2012.06.015","volume":"79","author":"MJ Gonzalez","year":"2012","unstructured":"Gonzalez MJ, Miranda Massari JR, Duconge J, Riordan NH et al (2012) The bio-energetic theory of carcinogenesis. Med Hypotheses 79:433\u2013439","journal-title":"Med Hypotheses"},{"issue":"2","key":"266_CR27","first-page":"84","volume":"31","author":"MJ Gonzalez","year":"2016","unstructured":"Gonzalez MJ, Miranda-Massari JR, Duconge J (2016) The bio-energetic theory of carcinogenesis: the origin of cancer revisited. JOM 31(2):84\u201389","journal-title":"JOM"},{"key":"266_CR28","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1093\/carcin\/bgv039","volume":"36","author":"WH Goodson 3rd","year":"2015","unstructured":"Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M et al (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis 36:S254\u2013S296","journal-title":"Carcinogenesis"},{"key":"266_CR29","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.cdd.4401231","volume":"10","author":"E Gottlieb","year":"2003","unstructured":"Gottlieb E, Armour SM, Harris MH, Thompson CB (2003) Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ 10:709\u2013717","journal-title":"Cell Death Differ"},{"issue":"7381","key":"266_CR30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nature10762","volume":"481","author":"M Greaves","year":"2012","unstructured":"Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481(7381):306\u2013313","journal-title":"Nature"},{"key":"266_CR31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature05610","volume":"446","author":"C Greenman","year":"2007","unstructured":"Greenman C, Stephens P, Smith R, Dalgliesh GL et al (2007) Patterns of somatic mutation in human cancer genomes. Nature 446:153\u2013158","journal-title":"Nature"},{"key":"266_CR32","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1089\/ars.2011.4414","volume":"16","author":"SC Gupta","year":"2012","unstructured":"Gupta SC, Hevia D, Patchva S, Park B et al (2012) Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Sign 16:1295\u20131322","journal-title":"Antioxid Redox Sign"},{"issue":"1","key":"266_CR33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57\u201370","journal-title":"Cell"},{"issue":"5","key":"266_CR34","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u2013674","journal-title":"Cell"},{"key":"266_CR35","doi-asserted-by":"crossref","first-page":"9861","DOI":"10.1158\/0008-5472.CAN-05-2444","volume":"65","author":"BG Heerdt","year":"2005","unstructured":"Heerdt BG, Houston MA, Augenlicht LH (2005) The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression. Cancer Res 65:9861\u20139867","journal-title":"Cancer Res"},{"key":"266_CR36","isbn-type":"print","volume-title":"Debating cancer: the paradox in cancer research","author":"HH Heng","year":"2016","unstructured":"Heng HH (2016) Debating cancer: the paradox in cancer research. World Scientific Publishing, Singapore. ISBN 978-981-4520-84-3","ISBN":"https:\/\/id.crossref.org\/isbn\/9789814520843"},{"issue":"3","key":"266_CR37","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jcp.21799","volume":"220","author":"HH Heng","year":"2009","unstructured":"Heng HH, Bremer SW, Stevens JB, Ye KJ et al (2009) Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective. J Cell Physiol 220(3):538\u2013547","journal-title":"J Cell Physiol"},{"issue":"3\u20134","key":"266_CR38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10555-013-9427-7","volume":"32","author":"HH Heng","year":"2013","unstructured":"Heng HH, Bremer SW, Stevens JB, Horne SD et al (2013) Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution. Cancer Metast Rev 32(3\u20134):325\u2013340","journal-title":"Cancer Metast Rev"},{"key":"266_CR39","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1038\/sj.onc.1207534","volume":"23","author":"J Henry-Mowatt","year":"2004","unstructured":"Henry-Mowatt J, Dive C, Martinou JC, James D (2004) Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 23:2850\u20132860","journal-title":"Oncogene"},{"key":"266_CR40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jcp.24233","volume":"228","author":"SD Horne","year":"2013","unstructured":"Horne SD, Stevens JB, Abdallah BY, Liu G et al (2013) Why imatinib remains an exception of cancer research. J Cell Physiol 228:665\u2013670","journal-title":"J Cell Physiol"},{"issue":"3","key":"266_CR41","first-page":"303","volume":"4","author":"SD Horne","year":"2015","unstructured":"Horne SD, Ye CJ, Abdallah BY, Liu G et al (2015a) Cancer genome evolution. Transl Cancer Res 4(3):303\u2013313","journal-title":"Transl Cancer Res"},{"key":"266_CR42","doi-asserted-by":"crossref","unstructured":"Horne SD, Ye CJ, Heng HH (2015b) Chromosomal instability (CIN) in cancer. eLS 1\u20139","DOI":"10.1002\/9780470015902.a0006069.pub2"},{"key":"266_CR43","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/978-1-4614-1800-9_35","volume-title":"Computational complexity: theory, techniques, and applications","author":"S Huang","year":"2012","unstructured":"Huang S, Kauffman SA (2012) Complex gene regulatory networks\u2014from structure to biological observables: cell fate determination. In: Meyers RA (ed) Computational complexity: theory, techniques, and applications. Springer, New York, pp 527\u2013560"},{"issue":"7","key":"266_CR44","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.semcdb.2009.07.003","volume":"20","author":"S Huang","year":"2009","unstructured":"Huang S, Ernberg I, Kauffman S (2009) Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective. Semin Cell Dev Biol 20(7):869\u2013876","journal-title":"Semin Cell Dev Biol"},{"issue":"5306","key":"266_CR45","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1126\/science.275.5306.1649","volume":"275","author":"K Irani","year":"1997","unstructured":"Irani K, Xia Y, Zweier JL, Sollott SJ et al (1997) Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275(5306):1649\u20131652","journal-title":"Science"},{"issue":"5876","key":"266_CR46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.1156906","volume":"320","author":"K Ishikawa","year":"2008","unstructured":"Ishikawa K, Takenaga K, Akimoto M, Koshikawa N et al (2008) ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320(5876):661\u2013664","journal-title":"Science"},{"key":"266_CR47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bbabio.2004.05.007","volume":"1658","author":"DS Izyumov","year":"2004","unstructured":"Izyumov DS, Avetisyan AV, Pletjushkina OY, Sakharov DV et al (2004) \u201cWages of fear\u201d: transient threefold decrease in intracellular ATP level imposes apoptosis. Biochim Biophys Acta 1658:141\u2013147","journal-title":"Biochim Biophys Acta"},{"key":"266_CR48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(00)81873-5","volume":"88","author":"MD Jacobson","year":"1997","unstructured":"Jacobson MD, Weil M, Raff MC (1997) Programmed cell death in animal development. Cell 88:347\u2013354","journal-title":"Cell"},{"issue":"3","key":"266_CR49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12272-015-0558-y","volume":"38","author":"H Jang","year":"2015","unstructured":"Jang H, Yang J, Lee E, Cheong JH (2015) Metabolism in embryonic and cancer stemness. Arch Pharm Res 38(3):381\u2013388","journal-title":"Arch Pharm Res"},{"key":"266_CR50","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbabio.2010.10.012","volume":"1807","author":"C Jose","year":"2011","unstructured":"Jose C, Bellance N, Rossignol R (2011) Choosing between glycolysis and oxidative phosphorylation: a tumour\u2019s dilemma. Biochim Biophys Acta 1807:552\u2013561","journal-title":"Biochim Biophys Acta"},{"key":"266_CR51","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10441-008-9050-0","volume":"56","author":"A Kasperski","year":"2008","unstructured":"Kasperski A (2008) Modelling of cells bioenergetics. Acta Biotheor 56:233\u2013247","journal-title":"Acta Biotheor"},{"issue":"2","key":"266_CR52","doi-asserted-by":"publisher","first-page":"93","DOI":"10.5455\/jib.20130227041230","volume":"2","author":"A Kasperski","year":"2013","unstructured":"Kasperski A, Kasperska R (2013) Selected disease fundamentals based on the unified cell bioenergetics. J Invest Biochem 2(2):93\u2013100. https:\/\/doi.org\/10.5455\/jib.20130227041230","journal-title":"J Invest Biochem"},{"key":"266_CR53","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/224177a0","volume":"224","author":"S Kauffman","year":"1969","unstructured":"Kauffman S (1969a) Homeostasis and differentiation in random genetic control networks. Nature 224:177\u2013178","journal-title":"Nature"},{"key":"266_CR54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0022-5193(69)90015-0","volume":"22","author":"SA Kauffman","year":"1969","unstructured":"Kauffman SA (1969b) Metabolic stability and epigenesis in randomly constructed genetic nets. J Theor Biol 22:437\u2013467","journal-title":"J Theor Biol"},{"key":"266_CR55","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0022-5193(71)90020-8","volume":"31","author":"S Kauffman","year":"1971","unstructured":"Kauffman S (1971) Differentiation of malignant to benign cells. J Theor Biol 31:429\u2013451","journal-title":"J Theor Biol"},{"key":"266_CR56","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195079517.001.0001","volume-title":"The origins of order","author":"SA Kauffman","year":"1993","unstructured":"Kauffman SA (1993) The origins of order. Oxford University Press, New York"},{"issue":"34","key":"266_CR57","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1038\/onc.2008.102","volume":"27","author":"D Komatsu","year":"2008","unstructured":"Komatsu D, Kato M, Nakayama J, Miyagawa S et al (2008) NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene 27(34):4724\u20134732","journal-title":"Oncogene"},{"key":"266_CR58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","volume":"416","author":"SS Korshunov","year":"1997","unstructured":"Korshunov SS, Skulachev VP, Starkov AA (1997) High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett 416:15\u201318","journal-title":"FEBS Lett"},{"issue":"6","key":"266_CR59","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1158\/0008-5472.CAN-07-5259","volume":"68","author":"B Kumar","year":"2008","unstructured":"Kumar B, Koul S, Khandrika L, Meacham RB et al (2008) Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 68(6):1777\u20131785","journal-title":"Cancer Res"},{"key":"266_CR60","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1042\/bj20021121","volume":"368","author":"Y Kushnareva","year":"2002","unstructured":"Kushnareva Y, Murphy AN, Andreyev A (2002) Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)1 oxidation-reduction state. Biochem J 368:545\u2013553","journal-title":"Biochem J"},{"key":"266_CR61","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1093\/carcin\/bgv031","volume":"36","author":"SA Langie","year":"2015","unstructured":"Langie SA, Koppen G, Desaulniers D, Al-Mulla F et al (2015) Causes of genome instability: the effect of low dose chemical exposures in modern society. Carcinogenesis 36:S61\u2013S88","journal-title":"Carcinogenesis"},{"key":"266_CR62","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1158\/1078-0432.CCR-0002-4","volume":"10","author":"SM Larson","year":"2004","unstructured":"Larson SM (2004) Positron emission tomography-based molecular imaging in human cancer: exploring the link between hypoxia and accelerated glucose metabolism. Clin Cancer Res 10:2203\u20132204","journal-title":"Clin Cancer Res"},{"issue":"5","key":"266_CR63","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","volume":"44","author":"GY Liou","year":"2010","unstructured":"Liou GY, Storz P (2010) Reactive oxygen species in cancer. Free Radic Res 44(5):479\u2013496","journal-title":"Free Radic Res"},{"key":"266_CR64","unstructured":"Liu SS, Huang JP (1996) Co-existence of \u201creactive oxygen species\u201d with Q-cycle and proton cycle in respiratory chain of mitochondria. In: Parker L, Traber MG, Xin WJ (eds) Proceedings of the international symposium on natural antioxidants. molecular mechanisms and health effects. AOCS, Champaighn, p 511\u201329"},{"issue":"2","key":"266_CR65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ddmod.2007.10.005","volume":"4","author":"W Lu","year":"2007","unstructured":"Lu W, Ogasawara MA, Huang P (2007) Models of reactive oxygen species in cancer. Drug Discov Today Dis Models 4(2):67\u201373","journal-title":"Drug Discov Today Dis Models"},{"issue":"7\u20138","key":"266_CR66","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.bbabio.2008.03.027","volume":"1777","author":"KG Lyamzaev","year":"2008","unstructured":"Lyamzaev KG, Nepryakhina OK, Saprunova VB, Bakeeva LE et al (2008) Novel mechanism of elimination of malfunctioning mitochondria (mitoptosis): formation of mitoptotic bodies and extrusion of mitochondrial material from the cell. BBA Bioenergetics 1777(7\u20138):817\u2013825","journal-title":"BBA Bioenergetics"},{"issue":"2","key":"266_CR67","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molcel.2015.12.002","volume":"61","author":"I Mart\u00ednez-Reyes","year":"2016","unstructured":"Mart\u00ednez-Reyes I, Diebold LP, Kong H, Schieber M et al (2016) TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions. Mol Cell 61(2):199\u2013209","journal-title":"Mol Cell"},{"issue":"6","key":"266_CR68","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1742-4658.2007.05686.x","volume":"274","author":"R Moreno-S\u00e1nchez","year":"2007","unstructured":"Moreno-S\u00e1nchez R, Rodr\u00edguez-Enr\u00edquez S, Mar\u00edn-Hern\u00e1ndez A, Saavedra E (2007) Energy metabolism in tumor cells. FEBS J 274(6):1393\u20131418","journal-title":"FEBS J"},{"key":"266_CR69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","volume":"417","author":"MP Murphy","year":"2009","unstructured":"Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417:1\u201313","journal-title":"Biochem J"},{"key":"266_CR70","volume-title":"Lehninger principles of biochemistry","author":"DL Nelson","year":"2008","unstructured":"Nelson DL, Lehninger AL, Cox MM (2008) Lehninger principles of biochemistry. W.H. Freeman, New York"},{"key":"266_CR71","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-0767-3","volume-title":"Bioreaction engineering principles","author":"J Nielsen","year":"2003","unstructured":"Nielsen J, Villadsen J, Lid\u00e9n G (2003) Bioreaction engineering principles, 2nd edn. Springer Science + Business Media, New York","edition":"2"},{"key":"266_CR72","doi-asserted-by":"crossref","first-page":"41817","DOI":"10.1074\/jbc.M207690200","volume":"277","author":"M Noda","year":"2002","unstructured":"Noda M, Yamashita S, Takahashi N, Eto K et al (2002) Switch to anaerobic glucose metabolism with NADH accumulation in the \u00df-cell model of mitochondrial diabetes: characteristics of \u00dfHC9 cells deficient in mitochondrial DNA transcription. J Biol Chem 277:41817\u201341826","journal-title":"J Biol Chem"},{"key":"266_CR73","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1128\/JB.182.10.2823-2830.2000","volume":"182","author":"KM Overkamp","year":"2000","unstructured":"Overkamp KM, Bakker BM, Kotter P (2000) In vivo analysis of the mechanisms for oxidation of cytosolic NADH by Saccharomyces cerevisiae mitochondria. J Bacteriol 182:2823\u20132830","journal-title":"J Bacteriol"},{"issue":"4","key":"266_CR74","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/1534735407309760","volume":"6","author":"BP Patel","year":"2007","unstructured":"Patel BP, Rawal UM, Dave TK, Rawal RM et al (2007) Lipid peroxidation, total antioxidant status, and total thiol levels predict overall survival in patients with oral squamous cell carcinoma. Integr Cancer Ther 6(4):365\u2013372","journal-title":"Integr Cancer Ther"},{"key":"266_CR75","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/B978-0-12-416618-9.00016-9","volume":"542","author":"S Patergnani","year":"2014","unstructured":"Patergnani S, Baldassari F, De Marchi E, Karkucinska-Wieckowska A et al (2014) Methods to monitor and compare mitochondrial and glycolytic ATP production. Methods Enzymol 542:313\u2013332","journal-title":"Methods Enzymol"},{"issue":"6","key":"266_CR76","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.200512100","volume":"175","author":"H Pelicano","year":"2006","unstructured":"Pelicano H, Xu RH, Du M, Feng L et al (2006) Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanizm. J Cell Biol 175(6):913\u2013923","journal-title":"J Cell Biol"},{"issue":"16","key":"266_CR77","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2174\/1381612043384411","volume":"10","author":"S Pervaiz","year":"2004","unstructured":"Pervaiz S, Clement MV (2004) Tumor intracellular redox status and drug resistance-serendipity or a causal relationship? Curr Pharm Design 10(16):1969\u20131977","journal-title":"Curr Pharm Design"},{"issue":"7047","key":"266_CR78","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature03688","volume":"436","author":"DC Radisky","year":"2005","unstructured":"Radisky DC, Levy DD, Littlepage LE, Liu H et al (2005) Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436(7047):123\u2013127","journal-title":"Nature"},{"issue":"5","key":"266_CR79","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00369712","volume":"6","author":"C Ratledge","year":"1991","unstructured":"Ratledge C (1991) Yeast physiology\u2014a micro-synopsis. Bioprocess Eng 6(5):195\u2013203","journal-title":"Bioprocess Eng"},{"issue":"5","key":"266_CR80","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1054\/drup.2001.0213","volume":"4","author":"IB Roninson","year":"2001","unstructured":"Roninson IB, Broude EV, Chang BD (2001) If not apoptosis, then what? treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Update 4(5):303\u2013313","journal-title":"Drug Resist Update"},{"key":"266_CR81","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2174\/1389450111007011341","volume":"11","author":"AV Roschke","year":"2010","unstructured":"Roschke AV, Kirsch IR (2010) Targeting karyotypic complexity and chromosomal instability of cancer cells. Curr Drug Targets 11:1341\u20131350","journal-title":"Curr Drug Targets"},{"issue":"13","key":"266_CR82","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.yexcr.2010.04.030","volume":"316","author":"K Salmina","year":"2010","unstructured":"Salmina K, Jankevics E, Huna A, Perminov D et al (2010) Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells. Exp Cell Res 316(13):2099\u20132112","journal-title":"Exp Cell Res"},{"key":"266_CR83","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1111\/j.1742-4658.2012.08644.x","volume":"279","author":"CR Santos","year":"2012","unstructured":"Santos CR, Schulze A (2012) Lipid metabolism in cancer. FEBS J 279:2610\u20132623","journal-title":"FEBS J"},{"issue":"1","key":"266_CR84","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0090-8258(88)90293-4","volume":"31","author":"BU Sevin","year":"1988","unstructured":"Sevin BU, Peng ZL, Perras JP, Ganjei P et al (1988) Application of an ATP-bioluminescence assay in human tumor chemosensitivity testing. Gynecol Oncol 31(1):191\u2013204","journal-title":"Gynecol Oncol"},{"key":"266_CR85","doi-asserted-by":"crossref","unstructured":"Seyfried TN (2011) Mitochondrial glutamine fermentation enhances ATP synthesis in murine glioblastoma cells. In: Proceedings of the 102nd annual meeting of the American association of cancer research, Orlando","DOI":"10.1158\/1538-7445.AM2011-985"},{"key":"266_CR86","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-7075-7-7","volume":"7","author":"TN Seyfried","year":"2010","unstructured":"Seyfried TN, Shelton LM (2010) Cancer as a metabolic disease. Nutri Metab (Lond) 7:7","journal-title":"Nutri Metab (Lond)"},{"key":"266_CR87","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S0033583500005795","volume":"29","author":"VP Skulachev","year":"1996","unstructured":"Skulachev VP (1996) Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q Rev Biophys 29:169\u2013202","journal-title":"Q Rev Biophys"},{"issue":"2","key":"266_CR88","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12038-013-9403-y","volume":"39","author":"C Sonnenschein","year":"2014","unstructured":"Sonnenschein C, Soto AM, Rangarajan A, Kulkarni P (2014) Competing views on cancer. J. Bioscience 39(2):281\u2013302","journal-title":"Bioscience"},{"key":"266_CR89","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1471-4159.2003.01908.x","volume":"86","author":"AA Starkov","year":"2003","unstructured":"Starkov AA, Fiskum G (2003) Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J Neurochem 86:1101\u20131107","journal-title":"J Neurochem"},{"issue":"3\u20134","key":"266_CR90","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10555-013-9428-6","volume":"32","author":"JB Stevens","year":"2013","unstructured":"Stevens JB, Horne SD, Abdallah BY, Ye CJ et al (2013) Chromosomal instability and transcriptome dynamics in cancer. Cancer Metast Rev 32(3\u20134):391\u2013402","journal-title":"Cancer Metast Rev"},{"key":"266_CR91","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1204040","volume":"331","author":"MR Stratton","year":"2011","unstructured":"Stratton MR (2011) Exploring the genomes of cancer cells: progress and promise. Science 331:1553\u20131558","journal-title":"Science"},{"key":"266_CR92","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/978-1-61779-382-0_12","volume":"810","author":"JM Suski","year":"2012","unstructured":"Suski JM, Lebiedzinska M, Bonora M, Pinton P et al (2012) Relation between mitochondrial membrane potential and ROS formation. Methods Mol Biol 810:183\u2013205","journal-title":"Methods Mol Biol"},{"issue":"4","key":"266_CR93","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.mco.0000232894.28674.30","volume":"9","author":"JV Swinnen","year":"2006","unstructured":"Swinnen JV, Brusselmans K, Verhoeven G (2006) Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care 9(4):358\u2013365","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"6","key":"266_CR94","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01516207","volume":"4","author":"A Szent-Gy\u00f6rgyi","year":"1973","unstructured":"Szent-Gy\u00f6rgyi A (1973) Bioelectronics and cancer. J Bioenerg Biomembr 4(6):533\u2013562","journal-title":"J Bioenerg Biomembr"},{"issue":"2\u20138","key":"266_CR95","first-page":"1","volume":"1","author":"GP Szigeti","year":"2017","unstructured":"Szigeti GP, Szasz O, Hegyi G (2017) Connections between Warburg\u2019s and Szentgyorgyi\u2019s approach about the causes of cancer. J Neoplasm 1(2\u20138):1\u201313","journal-title":"J Neoplasm"},{"issue":"7","key":"266_CR96","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.celrep.2017.04.061","volume":"19","author":"S Tabata","year":"2017","unstructured":"Tabata S, Yamamoto M, Goto H, Hirayama A et al (2017) Thymidine catabolism as a metabolic strategy for cancer survival. Cell Rep 19(7):1313\u20131321","journal-title":"Cell Rep"},{"issue":"12","key":"266_CR97","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1091\/mbc.e11-11-0926","volume":"23","author":"HL Tang","year":"2012","unstructured":"Tang HL, Tang HM, Mak KH, Hu S et al (2012) Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response. Mol Biol Cell 23(12):2240\u20132252","journal-title":"Mol Biol Cell"},{"issue":"2","key":"266_CR98","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/mnfr.201400485","volume":"59","author":"L Tao","year":"2015","unstructured":"Tao L, Park JY, Lambert JD (2015) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling. Mol Nutr Food Res 59(2):203\u2013211","journal-title":"Mol Nutr Food Res"},{"issue":"8","key":"266_CR99","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/ars.2007.1957","volume":"10","author":"D Trachootham","year":"2008","unstructured":"Trachootham D, Lu W, Ogasawara MA, Nilsa RD et al (2008a) Redox regulation of cell survival. Antioxid Redox Sign 10(8):1343\u20131374","journal-title":"Antioxid Redox Sign"},{"issue":"5","key":"266_CR100","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1182\/blood-2008-04-149815","volume":"112","author":"D Trachootham","year":"2008","unstructured":"Trachootham D, Zhang H, Zhang W, Feng L et al (2008b) Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism. Blood 112(5):1912\u20131922","journal-title":"Blood"},{"issue":"7","key":"266_CR101","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","volume":"8","author":"D Trachootham","year":"2009","unstructured":"Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8(7):579\u2013591","journal-title":"Nat Rev Drug Discov"},{"key":"266_CR102","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","volume":"552","author":"JF Turrens","year":"2003","unstructured":"Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552:335\u2013344","journal-title":"J Physiol"},{"issue":"1","key":"266_CR103","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2008.02.044","volume":"266","author":"M Ushio-Fukai","year":"2008","unstructured":"Ushio-Fukai M, Nakamura Y (2008) Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett 266(1):37\u201352","journal-title":"Cancer Lett"},{"issue":"46","key":"266_CR104","doi-asserted-by":"crossref","first-page":"75235","DOI":"10.18632\/oncotarget.12118","volume":"7","author":"A Vazquez-Martin","year":"2016","unstructured":"Vazquez-Martin A, Anatskaya OV, Giuliani A, Erenpreisa J et al (2016) Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature. Oncotarget 7(46):75235\u201375260","journal-title":"Oncotarget"},{"key":"266_CR105","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","volume":"39","author":"DC Wallace","year":"2005","unstructured":"Wallace DC (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 39:359\u2013407","journal-title":"Annu Rev Genet"},{"key":"266_CR106","volume-title":"The metabolism of tumours: investigations from the Kaiser Wilhelm Institute for Biology. Berlin\u2013Dahlem","author":"OH Warburg","year":"1930","unstructured":"Warburg OH (1930) The metabolism of tumours: investigations from the Kaiser Wilhelm Institute for Biology. Berlin\u2013Dahlem. Arnold Constable, London"},{"key":"266_CR107","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.124.3215.269","volume":"124","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956a) On respiratory impairment in cancer cells. Science 124:269\u2013270","journal-title":"Science"},{"key":"266_CR108","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O (1956b) On the origin of cancer cells. Science 123:309\u2013314","journal-title":"Science"},{"issue":"1\u20132","key":"266_CR109","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cell.2016.11.042","volume":"168","author":"Y Wei","year":"2017","unstructured":"Wei Y, Chiang WC, Sumpter R, Mishra P et al (2017) Prohibitin 2 is an inner mitochondrial membrane mitophagy receptor. Cell 168(1\u20132):224\u2013238","journal-title":"Cell"},{"issue":"6","key":"266_CR110","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3961\/jpmph.2010.43.6.459","volume":"43","author":"E Weiderpass","year":"2010","unstructured":"Weiderpass E (2010) Lifestyle and cancer risk. J Prev Med Public Health 43(6):459\u2013471","journal-title":"J Prev Med Public Health"},{"key":"266_CR111","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/carcin\/bgn104","volume":"29","author":"RA Weinberg","year":"2008","unstructured":"Weinberg RA (2008) Mechanisms of malignant progression. Carcinogenesis 29:1092\u20131095","journal-title":"Carcinogenesis"},{"issue":"23","key":"266_CR112","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1007\/s00018-009-0099-y","volume":"66","author":"F Weinberg","year":"2009","unstructured":"Weinberg F, Chandel NS (2009) Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci 66(23):3663\u20133673","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"266_CR113","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4155\/fmc.12.190","volume":"5","author":"S Wen","year":"2013","unstructured":"Wen S, Zhu D, Huang P (2013) Targeting cancer cell mitochondria as a therapeutic approach. Future Med Chem 5(1):53\u201367","journal-title":"Future Med Chem"},{"key":"266_CR114","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.2174\/0929867311320999165","volume":"20","author":"Y Yang","year":"2013","unstructured":"Yang Y, Karakhanova S, Werner J, Bazhin AV (2013) Reactive oxygen species in cancer biology and anticancer therapy. Curr Med Chem 20:3677\u20133692","journal-title":"Curr Med Chem"},{"key":"266_CR115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1749-6632.2009.05093.x","volume":"1188","author":"Y Yaniv","year":"2010","unstructured":"Yaniv Y, Juhaszova M, Nuss HB, Wang S et al (2010) Matching ATP supply and demand in mammalian heart: in vivo, in vitro, and in silico perspectives. Ann NY Acad Sci 1188:133\u2013142","journal-title":"Ann NY Acad Sci"},{"key":"266_CR116","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4172\/2157-2518.1000165","volume":"5","author":"Y Yao","year":"2014","unstructured":"Yao Y, Dai W (2014) Genomic instability and cancer. J Carcinog Mutagen 5:165. https:\/\/doi.org\/10.4172\/2157-2518.1000165","journal-title":"J Carcinog Mutagen"},{"issue":"1","key":"266_CR117","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphotobiol.2008.12.010","volume":"95","author":"Q Yu","year":"2009","unstructured":"Yu Q, Heikal AA (2009) Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell level. J Photoch Photobio B 95(1):46\u201357","journal-title":"J Photoch Photobio B"},{"key":"266_CR118","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1084\/jem.182.2.367","volume":"182","author":"N Zamzami","year":"1995","unstructured":"Zamzami N, Marchetti P, Castedo M, Decaudin D et al (1995) Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182:367\u2013377","journal-title":"J Exp Med"},{"key":"266_CR119","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.med.49.1.407","volume":"49","author":"BR Zetter","year":"1998","unstructured":"Zetter BR (1998) Angiogenesis and tumor metastasis. Annu Rev Med 49:407\u2013424","journal-title":"Annu Rev Med"},{"key":"266_CR120","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","volume":"94","author":"DB Zorov","year":"2014","unstructured":"Zorov DB, Juhaszova M, Sollott SJ (2014) Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 94:909\u2013950","journal-title":"Physiol Rev"}],"container-title":["Theory in Biosciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12064-018-0266-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12064-018-0266-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12064-018-0266-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T02:05:30Z","timestamp":1720404330000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12064-018-0266-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":120,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["266"],"URL":"https:\/\/doi.org\/10.1007\/s12064-018-0266-5","relation":{},"ISSN":["1431-7613","1611-7530"],"issn-type":[{"value":"1431-7613","type":"print"},{"value":"1611-7530","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,10]]},"assertion":[{"value":"22 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}