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Biochemical reaction systems are typically studied using the language and tools of graph theory. However, graph representations only describe pairwise interactions between molecular species and so are not well suited to modelling complex sets of reactions that may involve numerous reactants and\/or products. Here, we make use of a recently developed hypergraph theory of chemical reactions that naturally allows for higher-order interactions to explore the geometry and quantify functional redundancy in biochemical reactions systems. Our results constitute a general theory of automorphisms for oriented hypergraphs and describe the effect of automorphism group structure on hypergraph Laplacian spectra.<\/jats:p>","DOI":"10.1007\/s12064-021-00353-7","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T16:06:10Z","timestamp":1626365170000},"page":"265-277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Geometry and symmetry in biochemical reaction systems"],"prefix":"10.1007","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-6479","authenticated-orcid":false,"given":"Raffaella","family":"Mulas","sequence":"first","affiliation":[]},{"given":"Rub\u00e9n J.","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[]},{"given":"Ben D.","family":"MacArthur","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"353_CR1","unstructured":"Andreotti E, Mulas R Signless Normalized Laplacian for Hypergraphs. 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