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Japan\u2019s Brain Dock system, an MRI-based brain healthcare screening program developed uniquely in Japan, provides a valuable infrastructure for large-scale neuroimaging-based risk assessment. Importantly, structural MRI biomarkers can be influenced by lifestyle improvements, such as quitting smoking and reducing alcohol consumption, as well as by the treatment of lifestyle-related diseases, including diabetes and hypertension. Overall, this review highlights the potential of neuroimaging-informed approaches to identify at-risk drivers and to support targeted preventive strategies, thereby contributing to both brain healthcare program and traffic safety in aging societies.<\/jats:p>","DOI":"10.1007\/s13177-025-00601-w","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:21:16Z","timestamp":1766395276000},"page":"85-95","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural Brain Biomarker on Driving Safety in Healthy Older Adults: An MRI-Based Review"],"prefix":"10.1007","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-9220","authenticated-orcid":false,"given":"Kaechang","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handityo Aulia","family":"Putra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"issue":"22","key":"601_CR1","doi-asserted-by":"publisher","first-page":"11802","DOI":"10.3390\/ijerph182211802","volume":"18","author":"D Lin","year":"2021","unstructured":"Lin, D., Cui, J.: Transport and mobility needs for an ageing society from a policy perspective: review and implications. 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