{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:37:18Z","timestamp":1761489438493,"version":"3.40.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s13721-014-0066-x","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T20:33:07Z","timestamp":1408653187000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Binding affinity analysis and ADMET prediction of epigallocatechine gallate (EGCG) derivatives for AP-1 protein: a drug target for liver cancer"],"prefix":"10.1007","volume":"3","author":[{"given":"Mamta","family":"Sagar","sequence":"first","affiliation":[]},{"given":"Rajesh Kumar","family":"Pathak","sequence":"additional","affiliation":[]},{"given":"Rishi Kumar","family":"Pandey","sequence":"additional","affiliation":[]},{"given":"Dev Bukhsh","family":"Singh","sequence":"additional","affiliation":[]},{"given":"Neetesh","family":"Pandey","sequence":"additional","affiliation":[]},{"given":"Manish Kumar","family":"Gupta","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"issue":"16","key":"66_CR1","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1200\/JCO.2008.20.6235","volume":"27","author":"AR Amin","year":"2009","unstructured":"Amin AR, Kucuk O, Khuri FR, Shin DM (2009) Perspectives for cancer prevention with natural compounds. J Clin Oncol 27(16):2712\u20132725","journal-title":"J Clin Oncol"},{"issue":"8","key":"66_CR2","doi-asserted-by":"crossref","first-page":"1535S","DOI":"10.1093\/jn\/138.8.1535S","volume":"138","author":"C Auger","year":"2008","unstructured":"Auger C, Mullen W, Hara Y, Crozier A (2008) Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy. J Nutr 138(8):1535S\u20131542S","journal-title":"J Nutr"},{"issue":"12","key":"66_CR3","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/carcin\/19.12.2201","volume":"19","author":"M Barthelman","year":"1998","unstructured":"Barthelman M, Bair WB 3rd, Stickland KK, Chen W, Timmermann BN, Valcic S, Dong Z, Bowden GT (1998) (\u2212)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity. Carcinogenesis 19(12):2201\u20132204","journal-title":"Carcinogenesis"},{"issue":"8","key":"66_CR4","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1128\/JVI.70.8.4978-4985.1996","volume":"70","author":"J Benn","year":"1996","unstructured":"Benn J, Su F, Doria M, Schneider RJ (1996) Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J Virol 70(8):4978\u20134985","journal-title":"J Virol"},{"issue":"4","key":"66_CR5","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1055\/s-0038-1656049","volume":"77","author":"A Bierhaus","year":"1997","unstructured":"Bierhaus A, Zhang Y, Quehenberger P, Luther T, Haase M, M\u00fcller M, Mackman N, Ziegler R, Nawroth PP (1997) The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B. Thromb Haemost 77(4):772\u2013782","journal-title":"Thromb Haemost"},{"issue":"1\u20132","key":"66_CR6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mrfmmm.2004.05.018","volume":"555","author":"AM Bode","year":"2004","unstructured":"Bode AM, Dong Z (2004) Targeting signal transduction pathways by chemopreventive agents. Mutat Res 555(1\u20132):33\u201351","journal-title":"Mutat Res"},{"issue":"9","key":"66_CR7","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1128\/JVI.80.9.4406-4414.2006","volume":"80","author":"MJ Bouchard","year":"2006","unstructured":"Bouchard MJ, Wang L, Schneider RJ (2006) Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol 80(9):4406\u20134414","journal-title":"J Virol"},{"issue":"13","key":"66_CR8","first-page":"3453","volume":"63","author":"TW Chung","year":"2003","unstructured":"Chung TW, Lee YC, Ko JH, Kim CH (2003) Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. Cancer Res 63(13):3453\u20133458","journal-title":"Cancer Res"},{"issue":"41","key":"66_CR9","doi-asserted-by":"crossref","first-page":"30143","DOI":"10.1074\/jbc.M702390200","volume":"282","author":"QF Collins","year":"2007","unstructured":"Collins QF, Liu HY, Pi J, Liu Z, Quon MJ, Cao W (2007) Epigallocatechin-3 gallate(EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5\u2032-AMP-activated protein kinase. J Biol Chem 282(41):30143\u201330149","journal-title":"J Biol Chem"},{"issue":"25","key":"66_CR10","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1021\/jm010960b","volume":"44","author":"G Colmenarejo","year":"2001","unstructured":"Colmenarejo G, Alvarez-Pedraglio A, Lavandera JL (2001) Cheminformatic models to predict binding affinities to human serum albumin. J Med Chem 44(25):4370\u20134378","journal-title":"J Med Chem"},{"issue":"19","key":"66_CR11","first-page":"4414","volume":"57","author":"Z Dong","year":"1997","unstructured":"Dong Z, Ma W, Huang C, Yang CS (1997) Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (\u2212)-epigallocatechin gallate, and theaflavins. Cancer Res 57(19):4414\u20134419","journal-title":"Cancer Res"},{"issue":"2","key":"66_CR12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejps.2010.06.010","volume":"41","author":"A Dube","year":"2010","unstructured":"Dube A, Nicolazzo JA, Larson I (2010) Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (\u2212)-epigallocatechin gallate. Eur J Pharm Sci 41(2):219\u2013225","journal-title":"Eur J Pharm Sci"},{"issue":"7","key":"66_CR13","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"RA Friesner","year":"2004","unstructured":"Friesner RA, Banks JL, Murphy RB, Halgren TA, Klicic JJ, Mainz DT, Repasky MP, Knoll EH, Shelley M, Perry JK, Shaw DE, Francis P, Shenkin PS (2004) Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem 47(7):1739\u20131749","journal-title":"J Med Chem"},{"issue":"21","key":"66_CR14","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"RA Friesner","year":"2006","unstructured":"Friesner RA, Murphy RB, Repasky MP, Frye LL, Greenwood JR, Halgren TA, Sanschagrin PC, Mainz DT (2006) Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. J Med Chem 49(21):6177\u20136196","journal-title":"J Med Chem"},{"issue":"11","key":"66_CR15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s004320050321","volume":"125","author":"H Fujiki","year":"1999","unstructured":"Fujiki H (1999) Two stages of cancer prevention with green tea. J Cancer Res Clin Oncol 125(11):589\u2013597","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"66_CR16","first-page":"91","volume":"24","author":"H Fujiki","year":"2000","unstructured":"Fujiki H, Suganuma M, Okabe S, Sueoka E, Suga K, Imai K, Nakachi K (2000) A new concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive agents (\u2212)-epigallocatechin gallate and green tea\u2013a review. Cancer Detect Prev 24(1):91\u201399","journal-title":"Cancer Detect Prev"},{"issue":"7","key":"66_CR17","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","volume":"47","author":"TA Halgren","year":"2004","unstructured":"Halgren TA, Murphy RB, Friesner RA, Beard HS, Frye LL, Pollard WT, Banks JL (2004) Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J Med Chem 47(7):1750\u20131759","journal-title":"J Med Chem"},{"issue":"3","key":"66_CR18","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1128\/MCB.18.3.1562","volume":"18","author":"I Haviv","year":"1998","unstructured":"Haviv I, Shamay M, Doitsh G, Shaul Y (1998) Hepatitis B virus pX targets TFIIB in transcription coactivation. Mol Cell Biol 18(3):1562\u20131569","journal-title":"Mol Cell Biol"},{"issue":"1","key":"66_CR19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4049\/jimmunol.0903742","volume":"185","author":"E Hong Byun","year":"2010","unstructured":"Hong Byun E, Fujimura Y, Yamada K, Tachibana H (2010) TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. J Immunol 185(1):33\u201345","journal-title":"J Immunol"},{"issue":"3","key":"66_CR20","first-page":"813","volume":"51","author":"MT Huang","year":"1991","unstructured":"Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH (1991) Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res 51(3):813\u2013819","journal-title":"Cancer Res"},{"issue":"13","key":"66_CR21","first-page":"3053","volume":"59","author":"C Huang","year":"1999","unstructured":"Huang C, Ma WY, Li J, Dong Z (1999) Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway. Cancer Res 59(13):3053\u20133058","journal-title":"Cancer Res"},{"issue":"6","key":"66_CR22","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1006\/pmed.1997.0242","volume":"26","author":"K Imai","year":"1997","unstructured":"Imai K, Suga K, Nakachi K (1997) Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med 26(6):769\u2013775","journal-title":"Prev Med"},{"issue":"11","key":"66_CR23","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0960-894X(00)00172-4","volume":"10","author":"WL Jorgensen","year":"2000","unstructured":"Jorgensen WL, Duffy EM (2000) Prediction of drug solubility from Monte Carlo simulations. Bioorg Med Chem Lett 10(11):1155\u20131158","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"66_CR24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0169-409X(02)00008-X","volume":"54","author":"WL Jorgensen","year":"2002","unstructured":"Jorgensen WL, Duffy EM (2002) Prediction of drug solubility from structure. Adv Drug Deliv Rev 54(3):355\u2013366","journal-title":"Adv Drug Deliv Rev"},{"key":"66_CR25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2741\/e363","volume":"4","author":"J Kanwar","year":"2012","unstructured":"Kanwar J, Taskeen M, Mohammad I, Huo C, Chan TH, Dou QP (2012) Recent advances on tea polyphenols. Front Biosci (Elite Ed) 4:111\u2013131","journal-title":"Front Biosci (Elite Ed)"},{"key":"66_CR26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","volume":"9","author":"M Karin","year":"1997","unstructured":"Karin M, Liu ZG, Zandi E (1997) AP-1 function and regulation. Curr Opin Cell Biol 9:240\u2013246","journal-title":"Curr Opin Cell Biol"},{"issue":"3","key":"66_CR27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/carcin\/18.3.497","volume":"18","author":"SK Katiyar","year":"1997","unstructured":"Katiyar SK, Mohan RR, Agarwal R, Mukhtar H (1997) Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols. Carcinogenesis 18(3):497\u2013502","journal-title":"Carcinogenesis"},{"issue":"9","key":"66_CR28","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1021\/jf000386x","volume":"48","author":"K Kida","year":"2000","unstructured":"Kida K, Suzuki M, Matsumoto N, Nanjo F, Hara Y (2000) Identification of biliary metabolites of (\u2212)-epigallocatechin gallate in rats. J Agric Food Chem 48(9):4151\u20134155","journal-title":"J Agric Food Chem"},{"issue":"2B","key":"66_CR29","first-page":"747","volume":"24","author":"HS Kim","year":"2004","unstructured":"Kim HS, Kim MH, Jeong M, Hwang YS, Lim SH, Shin BA, Ahn BW, Jung YD (2004) EGCG blocks tumor promoter-induced MMP-9 expression via suppression of MAPK and AP-1 activation in human gastric AGS cells. Anticancer Res 24(2B):747\u2013753","journal-title":"Anticancer Res"},{"issue":"7","key":"66_CR30","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"EH Knoll","year":"2004","unstructured":"Knoll EH, Shelley M, Perry JK, Shaw DE, Francis P, Shenkin PS (2004) Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem 47(7):1739\u20131749","journal-title":"J Med Chem"},{"issue":"8","key":"66_CR31","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/jn\/134.8.1948","volume":"134","author":"JD Lambert","year":"2004","unstructured":"Lambert JD, Hong J, Kim DH, Mishin VM, Yang CS (2004) Piperine enhances the bioavailability of the tea polyphenol (\u2212)-epigallocatechin-3-gallate in mice. J Nutr 134(8):1948\u20131952","journal-title":"J Nutr"},{"key":"66_CR32","first-page":"1025","volume":"11","author":"MJ Lee","year":"2002","unstructured":"Lee MJ, Maliakal P, Chen L, Meng X, Bondoc FY, Prabhu S, Lambert G, Mohr S, Yang CS (2002) Pharmacokinetics of tea catechins after ingestion of green tea and (\u2212)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomark Prev 11:1025\u20131032","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"4","key":"66_CR33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/mc.20377","volume":"47","author":"J Li","year":"2008","unstructured":"Li J, Zhang D, Stoner GD, Huang C (2008) Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Mol Carcinog 47(4):286\u2013294","journal-title":"Mol Carcinog"},{"issue":"11","key":"66_CR34","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.1021\/jf200203n","volume":"59","author":"N Li","year":"2011","unstructured":"Li N, Taylor LS, Mauer LJ (2011) Degradation kinetics of catechins in green tea powder: effects of temperature and relative humidity. J Agric Food Chem 59(11):6082\u20136090","journal-title":"J Agric Food Chem"},{"issue":"2","key":"66_CR35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/eurheartj\/ehl442","volume":"28","author":"M Lorenz","year":"2007","unstructured":"Lorenz M, Jochmann N, von Krosigk A, Martus P, Baumann G, Stangl K, Stangl V (2007) Addition of milk prevents vascular protective effects of tea. Eur Heart J 28(2):219\u2013223","journal-title":"Eur Heart J"},{"issue":"5","key":"66_CR36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1124\/dmd.31.5.572","volume":"31","author":"H Lu","year":"2003","unstructured":"Lu H, Meng X, Yang CS (2003) Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (\u2212)-epigallocatechin gallate. Drug Metab Dispos 31(5):572\u2013579","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"66_CR37","first-page":"53","volume":"16","author":"Y Matsumoto","year":"2012","unstructured":"Matsumoto Y, Kaihatsu K, Nishino K, Ogawa M, Kato N, Yamaguchi A (2012) Antibacterial and antifungal activities of new acylated derivatives of epigallocatechin gallate. Front Microbiol 16(3):53","journal-title":"Front Microbiol"},{"issue":"9","key":"66_CR38","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.3390\/ijms12095592","volume":"12","author":"D Mereles","year":"2011","unstructured":"Mereles D, Hunstein W (2011) Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises? Int J Mol Sci 12(9):5592\u20135603","journal-title":"Int J Mol Sci"},{"key":"66_CR40","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3181\/00379727-220-44372","volume":"220","author":"H Mukhtar","year":"1999","unstructured":"Mukhtar H, Ahmad N (1999) Mechanism of cancer chemopreventive activity of green tea. Proc Soc Exp Biol Med 220:234\u2013238","journal-title":"Proc Soc Exp Biol Med"},{"issue":"10","key":"66_CR41","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1093\/carcin\/21.10.1885","volume":"21","author":"M Nomura","year":"2000","unstructured":"Nomura M, Ma W-Y, Chen N, Bode AM, Dong Z (2000) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-\u03baB activation by tea polyphenols, (\u2212)-epigallocatechin gallate and theaflavins. Carcinogenesis 21(10):1885\u20131890","journal-title":"Carcinogenesis"},{"issue":"6","key":"66_CR42","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/ijc.20668","volume":"113","author":"BK Prusty","year":"2005","unstructured":"Prusty BK, Das BC (2005) Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Int J Cancer 113(6):951\u2013960","journal-title":"Int J Cancer"},{"issue":"2","key":"66_CR43","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1021\/jf9032975","volume":"58","author":"S Roowi","year":"2010","unstructured":"Roowi S, Stalmach A, Mullen W, Lean ME, Edwards CA, Crozier A (2010) Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans. J Agric Food Chem 58(2):1296\u20131304","journal-title":"J Agric Food Chem"},{"issue":"8","key":"66_CR44","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/art.10443","volume":"46","author":"R Singh","year":"2002","unstructured":"Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM (2002) Epigallocatechin-3-gallate inhibits interleukin-1 beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. Arthritis Rheum 46(8):2079\u20132086","journal-title":"Arthritis Rheum"},{"issue":"1","key":"66_CR45","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0736-0266(02)00089-X","volume":"21","author":"R Singh","year":"2003","unstructured":"Singh R, Ahmed S, Malemud CJ, Goldberg VM, Haqqi TM (2003) Epigallocatechin-3-gallate selectively inhibits interleukin-1 beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes. J Orthop Res 21(1):102\u2013109","journal-title":"J Orthop Res"},{"issue":"Suppl 1","key":"66_CR46","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1002\/mnfr.200800169","volume":"53","author":"A Stalmach","year":"2009","unstructured":"Stalmach A, Troufflard S, Serafini M, Crozier A (2009) Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Mol Nutr Food Res 53(Suppl 1):S44\u2013S53","journal-title":"Mol Nutr Food Res"},{"issue":"1\u20132","key":"66_CR47","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1383-5742(99)00057-5","volume":"428","author":"Y Surh","year":"1999","unstructured":"Surh Y (1999) Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res 428(1\u20132):305\u2013327","journal-title":"Mutat Res"},{"issue":"31","key":"66_CR48","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1002\/anie.200701276","volume":"46","author":"H Tanaka","year":"2007","unstructured":"Tanaka H, Miyoshi H, Chuang YC, Ando Y, Takahashi T (2007) Solid-phase synthesis of epigallocatechin gallate derivatives. Angew Chem Int Ed Engl 46(31):5934\u20135937","journal-title":"Angew Chem Int Ed Engl"},{"issue":"15","key":"66_CR49","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1021\/jf070519f","volume":"55","author":"S Vyas","year":"2007","unstructured":"Vyas S, Sharma M, Sharma PD, Singh TV (2007) Design, semisynthesis, and evaluation of O-acyl derivatives of (\u2212)-epigallocatechin-3-gallate as antitumor agents. J Agric Food Chem 55(15):6319\u20136324","journal-title":"J Agric Food Chem"},{"issue":"6","key":"66_CR50","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1073\/pnas.91.6.2230","volume":"91","author":"XW Wang","year":"1994","unstructured":"Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC (1994) Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 91(6):2230\u20132234","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5240","key":"66_CR51","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","volume":"270","author":"Z Xia","year":"1995","unstructured":"Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270(5240):1326\u20131331","journal-title":"Science"},{"issue":"2","key":"66_CR52","first-page":"4725","volume":"130","author":"CS Yang","year":"2000","unstructured":"Yang CS, Chung JY, Yang G, Chhabra SK, Lee MJ (2000) Tea and tea polyphenols in cancer prevention. J Nutr 130(2):4725\u20134785","journal-title":"J Nutr"},{"issue":"3","key":"66_CR53","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0026-895X(24)12615-6","volume":"60","author":"F Yang","year":"2001","unstructured":"Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, Varilek GW (2001) The green tea polyphenol (\u2212)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60(3):528\u2013533","journal-title":"Mol Pharmacol"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-014-0066-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13721-014-0066-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-014-0066-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T09:13:16Z","timestamp":1746349996000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13721-014-0066-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,19]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["66"],"URL":"https:\/\/doi.org\/10.1007\/s13721-014-0066-x","relation":{},"ISSN":["2192-6662","2192-6670"],"issn-type":[{"type":"print","value":"2192-6662"},{"type":"electronic","value":"2192-6670"}],"subject":[],"published":{"date-parts":[[2014,8,19]]},"article-number":"66"}}