{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T20:00:25Z","timestamp":1759694425585},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s13721-014-0071-0","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T15:41:49Z","timestamp":1414078909000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In silico epigenetic profiling of hypermethylated genes in non-small cell lung cancer"],"prefix":"10.1007","volume":"3","author":[{"given":"Anshika Nikita","family":"Singh","sequence":"first","affiliation":[]},{"given":"Satendra","family":"Singh","sequence":"additional","affiliation":[]},{"given":"Pramod Wasudev","family":"Ramteke","sequence":"additional","affiliation":[]},{"given":"Budhayash","family":"Gautam","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"71_CR1","doi-asserted-by":"crossref","first-page":"29S","DOI":"10.1378\/chest.07-1347","volume":"132","author":"AJ Alberg","year":"2007","unstructured":"Alberg AJ, Ford JG, Samet JM (2007) Epidemiology of lung cancer: ACCP evidence based clinical practice guidelines (2nd edition). Chest 132:29S\u201355S","journal-title":"Chest"},{"key":"71_CR2","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1038\/sj.onc.1204455","volume":"20","author":"J Brabender","year":"2001","unstructured":"Brabender J, Henning U, Kathleen DD, Ralf M, Paul MS, Reginald VL, Kumari W, Christopher EL, JiMin P, Stephen JM, Peter VD (2001) Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. Oncogene 20:3528\u20133532","journal-title":"Oncogene"},{"key":"71_CR3","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1183\/09031936.01.00275301","volume":"18","author":"E Brambilla","year":"2001","unstructured":"Brambilla E, Travis WD, Colby TV (2001) The new World Health Organization classification of lung tumours. Eur Respir J 18:1059\u20131068","journal-title":"Eur Respir J"},{"key":"71_CR4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature05610","volume":"446","author":"C Greenman","year":"2007","unstructured":"Greenman C, Stephens P, Smith R (2007) Patterns of somatic mutation in human cancer genomes. Nature 446:153\u2013158","journal-title":"Nature"},{"issue":"1","key":"71_CR5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/nar\/29.1.270","volume":"29","author":"C Grunau","year":"2001","unstructured":"Grunau C, Eric R, Rosenthal E, Roizes G (2001) MethDB- a public database for DNA methylation data. Nucleic Acids Res 29(1):270\u2013274","journal-title":"Nucleic Acids Res"},{"key":"71_CR6","first-page":"589","volume":"27","author":"R Hakem","year":"2008","unstructured":"Hakem R (2008) DNA-damage repair; the good, the bad, and the ugly. J Embryol 27:589\u2013605","journal-title":"J Embryol"},{"key":"71_CR7","first-page":"D836","volume":"36","author":"XM He","year":"2008","unstructured":"He XM, Chang SH, Zhang JJ, Zhao Q, Xiang HZ, Wang J (2008) MethyCancer: the database of human DNA methylation and cancer. Nucleic Acids Res 36:D836\u2013D841","journal-title":"Nucleic Acids Res"},{"key":"71_CR8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM (2011) Global cancer statistics. Cancer J Clin 61:69\u201390","journal-title":"Cancer J Clin"},{"key":"71_CR9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27\u201330","journal-title":"Nucleic Acids Res"},{"issue":"14","key":"71_CR10","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1038\/sj.onc.1204302","volume":"20","author":"DH Kim","year":"2001","unstructured":"Kim DH, Nelson HH, Wiencke JK, Christiani DC, Wain JC, Mark EJ, Kelsey KT (2001) Promoter methylation of DAP-kinase: association with advanced stage in non-small cell lung cancer. Oncogene 20(14):1765\u20131770","journal-title":"Oncogene"},{"key":"71_CR11","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1200\/JCO.2010.28.8126","volume":"28","author":"CJ Langer","year":"2010","unstructured":"Langer CJ, Besse B, Gualberto A (2010) The evolving role of histology in the management of advanced non-small-cell lung cancer. J Clin Oncol 28:5311\u20135320","journal-title":"J Clin Oncol"},{"issue":"21","key":"71_CR12","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","volume":"23","author":"MA Larkin","year":"2007","unstructured":"Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23(21):2947\u20132948","journal-title":"Bioinformatics"},{"issue":"1","key":"71_CR13","first-page":"836","volume":"36","author":"M Ongenaert","year":"2008","unstructured":"Ongenaert M, Leander VN, Tim DM, Gerben M, Bekaert S, Wim VC (2008) PubMeth: a cancer methylation database combining text-mining and expert annotation. Nucleic Acids Res 36(1):836\u2013841","journal-title":"Nucleic Acids Res"},{"key":"71_CR14","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1038\/sj.onc.1205802","volume":"21","author":"H Osada","year":"2002","unstructured":"Osada H, Takahashi T (2002) Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. Oncogene 21:7421\u20137434","journal-title":"Oncogene"},{"key":"71_CR15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/bmj.321.7257.323","volume":"321","author":"R Peto","year":"2000","unstructured":"Peto R, Darby S, Deo H (2000) Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. Br Med J 321:323\u2013329","journal-title":"Br Med J"},{"issue":"1","key":"71_CR16","first-page":"116","volume":"1","author":"T Phillips","year":"2008","unstructured":"Phillips T (2008) The role of methylation in gene expression. Nat Educ 1(1):116","journal-title":"Nat Educ"},{"issue":"5","key":"71_CR17","doi-asserted-by":"crossref","first-page":"e64364","DOI":"10.1371\/journal.pone.0064364","volume":"8","author":"R Purohit","year":"2013","unstructured":"Purohit R, Kumar A (2013) Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain. PLoS One 8(5):e64364","journal-title":"PLoS One"},{"issue":"4","key":"71_CR18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12539-009-0043-8","volume":"1","author":"R Purohit","year":"2009","unstructured":"Purohit R, Sethumadhavan R (2009) Structural basis for the resilience of Darunavir (TMC114) resistance major flap mutations of HIV-1 protease. Interdiscip Sci 1(4):320\u2013328","journal-title":"Interdiscip Sci"},{"issue":"4","key":"71_CR19","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00894-010-0785-6","volume":"17","author":"R Purohit","year":"2001","unstructured":"Purohit R, Rajendran V, Sethumadhavan R (2001) Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and Isoniazid susceptibility: an in silico analysis. J Mol Model 17(4):869\u2013877","journal-title":"J Mol Model"},{"issue":"1","key":"71_CR20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/07391102.2011.10507379","volume":"29","author":"R Purohit","year":"2011","unstructured":"Purohit R, Rajendran V, Sethumadhavan R (2011) Studies on adaptability of binding residues and flap region of TMC-114 resistance HIV-1 protease mutants. J Biomol Struct Dyn 29(1):137\u2013152","journal-title":"J Biomol Struct Dyn"},{"issue":"2","key":"71_CR21","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00726-011-1108-7","volume":"43","author":"V Rajendran","year":"2012","unstructured":"Rajendran V, Purohit R, Sethumadhavan R (2012) In silico investigation of molecular mechanism of laminopathy caused by a point mutation (R482W) in lamin A\/C protein. Amino Acids 43(2):603\u2013615","journal-title":"Amino Acids"},{"key":"71_CR22","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/modpathol.2011.92","volume":"24","author":"N Rekhtman","year":"2011","unstructured":"Rekhtman N, Ang DC, Sima CS (2011) Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens. Mod Pathol 24:1348\u20131359","journal-title":"Mod Pathol"},{"issue":"ii","key":"71_CR23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/annonc\/mdj910","volume":"17","author":"G Rosti","year":"2006","unstructured":"Rosti G, Bevilacqua G, Bidoli P (2006) Small cell lung cancer. Ann Oncol 17(ii):5\u201310","journal-title":"Ann Oncol"},{"key":"71_CR24","first-page":"1357","volume":"11","author":"VEA Russo","year":"1996","unstructured":"Russo VEA (1996) Epigenetic mechanisms of gene regulation. Genes Dev 11:1357\u20131492","journal-title":"Genes Dev"},{"key":"71_CR25","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1158\/1078-0432.CCR-04-2378","volume":"11","author":"AM Safar","year":"2005","unstructured":"Safar AM, Horace S, Xiaobo S (2005) Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res 11:4400\u20134405","journal-title":"Clin Cancer Res"},{"key":"71_CR26","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.1038\/sj.onc.1205832","volume":"21","author":"PG Shields","year":"2002","unstructured":"Shields PG (2002) Molecular epidemiology of smoking and lung cancer. Oncogene 21:6870\u20136876","journal-title":"Oncogene"},{"issue":"3","key":"71_CR27","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1158\/0008-5472.CAN-05-2625","volume":"66","author":"S Toyooka","year":"2006","unstructured":"Toyooka S, Tokumo M, Shigematsu H, Matsuo K, Asano H, Tomii K, Ichihara S, Suzuki M, Aoe M, Date H, Gazdar AF, Shimizu N (2006) Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers. Cancer Res 66(3):1371\u20131375","journal-title":"Cancer Res"},{"key":"71_CR28","first-page":"12","volume":"1","author":"WD Travis","year":"2004","unstructured":"Travis WD, Brambilla E, Muller-Hermelink HK (2004) Pathology and genetics: tumors of the lung, pleura, thymus and heart. Int Agency Res Cancer 1:12\u2013124","journal-title":"Int Agency Res Cancer"},{"issue":"2","key":"71_CR29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lungcan.2004.08.003","volume":"47","author":"JA Tsou","year":"2005","unstructured":"Tsou JA, Shen LY, Siegmund KD, Long TI, Laird PW, Seneviratne CK, Koss MN, Pass HI, Hagen JA, Laird-Offringa IA (2005) Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung. Lung Cancer 47(2):193\u2013204","journal-title":"Lung Cancer"},{"issue":"1","key":"71_CR30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3816\/CLC.2006.n.031","volume":"8","author":"D Vallb\u00f6hmer","year":"2006","unstructured":"Vallb\u00f6hmer D, Brabender J, Yang D, Schneider PM, Metzger R, Danenberg KD, H\u00f6lscher AH, Danenberg PV (2006) DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value. Clin Lung Cancer 8(1):39\u201344","journal-title":"Clin Lung Cancer"},{"key":"71_CR31","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nm1087","volume":"10","author":"B Vogelstein","year":"2004","unstructured":"Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789\u2013799","journal-title":"Nat Med"},{"key":"71_CR32","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1158\/1078-0432.CCR-04-0652","volume":"10","author":"J Wang","year":"2004","unstructured":"Wang J, Lee JJ, Wang L, Liu DD, Lu C, Fan YH, Hong WK, Mao L (2004) Value of p16INK4A and RASSF1 promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer. Clin Cancer Res 10:6119\u20136125","journal-title":"Clin Cancer Res"},{"key":"71_CR33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","volume":"13","author":"J Ye","year":"2012","unstructured":"Ye J, Coulouris G, Zaretskaya I, Cutcutache I, Rozen S, Madden T (2012) Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. BMC Bioinformatics 13:134","journal-title":"BMC Bioinformatics"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-014-0071-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13721-014-0071-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-014-0071-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T15:07:24Z","timestamp":1565968044000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13721-014-0071-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["71"],"URL":"https:\/\/doi.org\/10.1007\/s13721-014-0071-0","relation":{},"ISSN":["2192-6662","2192-6670"],"issn-type":[{"value":"2192-6662","type":"print"},{"value":"2192-6670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,24]]},"article-number":"71"}}