{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:39:01Z","timestamp":1740166741564,"version":"3.37.3"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007087","name":"University of Isfahan","doi-asserted-by":"crossref","award":["97886\/90"],"award-info":[{"award-number":["97886\/90"]}],"id":[{"id":"10.13039\/501100007087","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Netw Model Anal Health Inform Bioinforma"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s13721-016-0112-y","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T12:36:25Z","timestamp":1454070985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In silico vaccine design against type 1 diabetes based on molecular modeling of coxsackievirus B4 epitopes"],"prefix":"10.1007","volume":"5","author":[{"given":"Mahsa","family":"Taherzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abolghasem","family":"Esmaeili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad Reza","family":"Ganjalikhany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"112_CR1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2105-5-51","volume":"5","author":"S Ahmad","year":"2004","unstructured":"Ahmad S, Gromiha M, Fawareh H, Sarai A (2004) ASAView: database and tool for solvent accessibility representation in proteins. BMC Bioinform 5:51","journal-title":"BMC Bioinform"},{"key":"112_CR2","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1172\/JCI117567","volume":"94","author":"MA Atkinson","year":"1994","unstructured":"Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK (1994) Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Investig 94:2125","journal-title":"J Clin Investig"},{"key":"112_CR3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1210\/edrv-15-4-516","volume":"15","author":"JF Bach","year":"1994","unstructured":"Bach JF (1994) Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 15:516\u2013542","journal-title":"Endocr Rev"},{"key":"112_CR4","doi-asserted-by":"crossref","first-page":"828","DOI":"10.4239\/wjd.v6.i6.828","volume":"6","author":"CS Bergamin","year":"2015","unstructured":"Bergamin CS, Dib SA (2015) Enterovirus and type 1 diabetes: What is the matter? World J Diabetes 6:828","journal-title":"World J Diabetes"},{"key":"112_CR5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2249.2002.01842.x","volume":"128","author":"M Blomqvist","year":"2002","unstructured":"Blomqvist M et al (2002) Rotavirus infections and development of diabetes-associated autoantibodies during the first 2\u00a0years of life. Clin Exp Immunol 128:511\u2013515","journal-title":"Clin Exp Immunol"},{"key":"112_CR6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1586\/eci.10.91","volume":"7","author":"T Boettler","year":"2011","unstructured":"Boettler T, von Herrath M (2011) Protection against or triggering of Type 1 diabetes? Different roles for viral infections. Expert Rev Clin Immunol 7:45\u201353","journal-title":"Expert Rev Clin Immunol"},{"key":"112_CR7","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jcc.20290","volume":"26","author":"DA Case","year":"2005","unstructured":"Case DA et al (2005) The Amber biomolecular simulation programs. J Comput Chem 26:1668\u20131688","journal-title":"J Comput Chem"},{"key":"112_CR8","volume-title":"AMBER 2015","author":"D Case","year":"2015","unstructured":"Case D et al (2015) AMBER 2015. University of California, San Francisco"},{"key":"112_CR9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00726-006-0485-9","volume":"33","author":"J Chen","year":"2007","unstructured":"Chen J, Liu H, Yang J, Chou KC (2007) Prediction of linear B-cell epitopes using amino acid pair antigenicity scale. Amino Acids 33:423\u2013428","journal-title":"Amino Acids"},{"key":"112_CR10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12250-011-3159-4","volume":"26","author":"P Chen","year":"2011","unstructured":"Chen P, Rayner S, Hu KH (2011) Advances of bioinformatics tools applied in virus epitopes prediction. Virologica Sinica 26:1\u20137","journal-title":"Virologica Sinica"},{"key":"112_CR11","doi-asserted-by":"crossref","first-page":"a007682","DOI":"10.1101\/cshperspect.a007682","volume":"2","author":"KT Coppieters","year":"2012","unstructured":"Coppieters KT, Boettler T, von Herrath M (2012) Virus infections in type 1 diabetes. Cold Spring Harb Perspect Med 2:a007682","journal-title":"Cold Spring Harb Perspect Med"},{"key":"112_CR12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1399-5448.2011.00790.x","volume":"13","author":"O Diaz-Horta","year":"2012","unstructured":"Diaz-Horta O, Baj A, Maccari G, Salvatoni A, Toniolo A (2012) Enteroviruses and causality of type 1 diabetes: how close are we? Pediatr Diabetes 13:92\u201399","journal-title":"Pediatr Diabetes"},{"key":"112_CR13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jmr.893","volume":"21","author":"Y EL-Manzalawy","year":"2008","unstructured":"EL-Manzalawy Y, Dobbs D, Honavar V (2008) Predicting linear B-cell epitopes using string kernels. J Mol Recognit 21:243\u2013255","journal-title":"J Mol Recognit"},{"key":"112_CR14","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/JVI.55.3.836-839.1985","volume":"55","author":"EA Emini","year":"1985","unstructured":"Emini EA, Hughes JV, Perlow D, Boger J (1985) Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol 55:836\u2013839","journal-title":"J Virol"},{"key":"112_CR15","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"U Essmann","year":"1995","unstructured":"Essmann U, Perera L, Berkowitz ML, Darden T, Lee H, Pedersen LG (1995) A smooth particle mesh Ewald method. J Chem Phys 103:8577\u20138593","journal-title":"J Chem Phys"},{"key":"112_CR16","doi-asserted-by":"crossref","unstructured":"Florea L, Halldorsson B, Kohlbacher O, Schwartz R, Hoffman S, Istrail S (2003) Epitope prediction algorithms for peptide-based vaccine design. In: Bioinformatics Conference, 2003. CSB 2003. Proceedings of the 2003 IEEE, 2003. IEEE, pp 17\u201326","DOI":"10.1109\/CSB.2003.1227293"},{"key":"112_CR17","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00125-008-1099-4","volume":"51","author":"E Gale","year":"2008","unstructured":"Gale E (2008) Congenital rubella: citation virus or viral cause of type 1 diabetes? Diabetologia 51:1559\u20131566","journal-title":"Diabetologia"},{"key":"112_CR18","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/bmj.3.5671.631","volume":"3","author":"D Gamble","year":"1969","unstructured":"Gamble D, Taylor K (1969) Seasonal incidence of diabetes mellitus. Bmj 3:631\u2013633","journal-title":"Bmj"},{"key":"112_CR19","doi-asserted-by":"crossref","first-page":"e40327","DOI":"10.1371\/journal.pone.0040327","volume":"7","author":"MR Ganjalikhany","year":"2012","unstructured":"Ganjalikhany MR, Ranjbar B, Taghavi AH, Moghadam TT (2012) Functional motions of Candida antarctica lipase B: a survey through open-close conformation. PloS One 7:e40327","journal-title":"PloS One"},{"key":"112_CR20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00018-012-1042-1","volume":"70","author":"L Ghazarian","year":"2013","unstructured":"Ghazarian L, Diana J, Simoni Y, Beaudoin L, Lehuen A (2013) Prevention or acceleration of type 1 diabetes by viruses. Cell Mol Life Sci 70:239\u2013255","journal-title":"Cell Mol Life Sci"},{"key":"112_CR21","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"N Guex","year":"1997","unstructured":"Guex N, Peitsch MC (1997) SWISS-MODEL and the Swiss-Pdb viewer: an environment for comparative protein modeling. Electrophoresis 18:2714\u20132723","journal-title":"Electrophoresis"},{"key":"112_CR22","first-page":"218590","volume":"2010","author":"Y He","year":"2010","unstructured":"He Y, Rappuoli R, De Groot AS, Chen RT (2010) Emerging vaccine informatics. J BioMed Biotchnol 2010:218590","journal-title":"J BioMed Biotchnol"},{"key":"112_CR23","first-page":"279","volume":"6","author":"D Hober","year":"2010","unstructured":"Hober D, Sauter P (2010) Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host nature reviews. Endocrinology 6:279\u2013289","journal-title":"Endocrinology"},{"key":"112_CR24","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/prot.21123","volume":"65","author":"V Hornak","year":"2006","unstructured":"Hornak V, Abel R, Okur A, Strockbine B, Roitberg A, Simmerling C (2006) Comparison of multiple Amber force fields and development of improved protein backbone parameters. Proteins Struct Funct Bioinform 65:712\u2013725","journal-title":"Proteins Struct Funct Bioinform"},{"key":"112_CR25","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.2337\/diab.43.10.1260","volume":"43","author":"J Hou","year":"1994","unstructured":"Hou J, Said C, Franchi D, Dockstader P, Chatterjee NK (1994) Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients. Diabetes 43:1260\u20131266","journal-title":"Diabetes"},{"key":"112_CR26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1743-422X-10-113","volume":"10","author":"S Idrees","year":"2013","unstructured":"Idrees S, Ashfaq UA (2013) Structural analysis and epitope prediction of HCV E1 protein isolated in Pakistan: an in silico approach. Virol J 10:113","journal-title":"Virol J"},{"key":"112_CR27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.diabet.2008.05.008","volume":"34","author":"H Jaidane","year":"2008","unstructured":"Jaidane H, Hober D (2008) Role of coxsackievirus B4 in the pathogenesis of type 1 diabetes. Diabetes Metab 34:537\u2013548","journal-title":"Diabetes Metab"},{"key":"112_CR28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0022-2836(78)90408-4","volume":"125","author":"J Janin","year":"1978","unstructured":"Janin J, Wodak S, Levitt M, Maigret B (1978) Conformation of amino acid side-chains in proteins. J Mol Biol 125:357\u2013386","journal-title":"J Mol Biol"},{"key":"112_CR29","first-page":"212","volume":"72","author":"P Karplus","year":"1985","unstructured":"Karplus P, Schulz G (1985) Prediction of chain flexibility in proteins Naturwissenschaften 72:212\u2013213","journal-title":"Prediction of chain flexibility in proteins Naturwissenschaften"},{"key":"112_CR30","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2337\/diacare.23.10.1516","volume":"23","author":"M Karvonen","year":"2000","unstructured":"Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J (2000) Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 23:1516\u20131526","journal-title":"Diabetes Care"},{"key":"112_CR31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1172\/JCI115573","volume":"89","author":"D Kaufman","year":"1992","unstructured":"Kaufman D, Erlander M, Clare-Salzler M, Atkinson M, Maclaren N, Tobin A (1992) Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 89:283","journal-title":"J Clin Invest"},{"key":"112_CR32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","volume":"276","author":"A Kolaskar","year":"1990","unstructured":"Kolaskar A, Tongaonkar PC (1990) A semi-empirical method for prediction of antigenic determinants on protein antigens. FEBS Lett 276:172\u2013174","journal-title":"FEBS Lett"},{"key":"112_CR33","doi-asserted-by":"crossref","first-page":"e1002829","DOI":"10.1371\/journal.pcbi.1002829","volume":"8","author":"JV Kringelum","year":"2012","unstructured":"Kringelum JV, Lundegaard C, Lund O, Nielsen M (2012) Reliable B cell epitope predictions: impacts of method development and improved benchmarking. PLoS Comput Biol 8:e1002829","journal-title":"PLoS Comput Biol"},{"key":"112_CR34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","volume":"2","author":"JE Larsen","year":"2006","unstructured":"Larsen JE, Lund O, Nielsen M (2006) Improved method for predicting linear B-cell epitopes. Immunome Res 2:2","journal-title":"Immunome Res"},{"key":"112_CR35","doi-asserted-by":"crossref","first-page":"D355","DOI":"10.1093\/nar\/gkn860","volume":"37","author":"RA Laskowski","year":"2009","unstructured":"Laskowski RA (2009) PDBsum new things. Nucleic acids Res 37:D355\u2013D359","journal-title":"Nucleic acids Res"},{"key":"112_CR36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"RA Laskowski","year":"1993","unstructured":"Laskowski RA, MacArthur MW, Moss DS, Thornton JM (1993) PROCHECK: a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26:283\u2013291","journal-title":"J Appl Crystallogr"},{"key":"112_CR37","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1046\/j.1365-2249.1996.60771.x","volume":"104","author":"M L\u00f6nnrot","year":"1996","unstructured":"L\u00f6nnrot M, Hy\u00f6ty H, Knip M, Roivainen M, Kulmala P, Leinikki P, \u00c5kerblom H (1996) Antibody cross-reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD65) and 2C protein of coxsackievirus B4. Clin Exp Immunol 104:398\u2013405","journal-title":"Clin Exp Immunol"},{"key":"112_CR38","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2337\/diab.38.4.534","volume":"38","author":"N MacLaren","year":"1989","unstructured":"MacLaren N, Schatz D, Drash A, Grave G (1989) Initial pathogenic events in IDDM. Diabetes 38:534\u2013538","journal-title":"Diabetes"},{"key":"112_CR39","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.7314\/APJCP.2012.13.7.3053","volume":"13","author":"M Mahdavi","year":"2012","unstructured":"Mahdavi M, Mohabatkar H, Keyhanfar M, Jafarian A, Dehkordi MR (2012) Linear and Conformational B Cell Epitope Prediction of the HER 2 ECD-Subdomain III by in silico Methods. Asian Pac J Cancer Prev 13:3053\u20133059","journal-title":"Asian Pac J Cancer Prev"},{"key":"112_CR40","first-page":"602","volume":"8","author":"H Mohabatkar","year":"2007","unstructured":"Mohabatkar H (2007) Prediction of epitopes and structural properties of Iranian HPV-16 E6 by bioinformatics methods. Asian Pac J Cancer Prev 8:602\u2013606","journal-title":"Asian Pac J Cancer Prev"},{"key":"112_CR41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2008.02.011","volume":"131","author":"AR Movahedi","year":"2008","unstructured":"Movahedi AR, Hampson DJ (2008) New ways to identify novel bacterial antigens for vaccine development. Vet Microbiol 131:1\u201313","journal-title":"Vet Microbiol"},{"key":"112_CR42","doi-asserted-by":"crossref","first-page":"e20020","DOI":"10.1371\/journal.pone.0020020","volume":"6","author":"S Nair","year":"2011","unstructured":"Nair S, Kukreja N, Singh BP, Arora N (2011) Identification of B cell epitopes of alcohol dehydrogenase allergen of Curvularia lunata. PloS One 6:e20020","journal-title":"PloS One"},{"key":"112_CR43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1471-2105-8-238","volume":"8","author":"M Nielsen","year":"2007","unstructured":"Nielsen M, Lundegaard C, Lund O (2007) Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method. BMC Bioinform 8:238","journal-title":"BMC Bioinform"},{"key":"112_CR44","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1021\/bi00367a013","volume":"25","author":"J Parker","year":"1986","unstructured":"Parker J, Guo D, Hodges R (1986) New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites. Biochemistry 25:5425\u20135432","journal-title":"Biochemistry"},{"key":"112_CR45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-2478(93)90072-A","volume":"36","author":"JL Pellequer","year":"1993","unstructured":"Pellequer JL, Westhof E, Van Regenmortel MH (1993) Correlation between the location of antigenic sites and the prediction of turns in proteins. Immunol Lett 36:83\u201399","journal-title":"Immunol Lett"},{"key":"112_CR46","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1371\/journal.pbio.0030091","volume":"3","author":"B Peters","year":"2005","unstructured":"Peters B et al (2005) The immune epitope database and analysis resource: from vision to blueprint. PLoS Biol 3:e91","journal-title":"PLoS Biol"},{"key":"112_CR47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-3233(03)66002-X","volume":"66","author":"JW Ponder","year":"2003","unstructured":"Ponder JW, Case DA (2003) Force fields for protein simulations. Adv Protein Chem 66:27\u201385","journal-title":"Adv Protein Chem"},{"key":"112_CR48","first-page":"301","volume":"623","author":"P Ponnuswamy","year":"1980","unstructured":"Ponnuswamy P, Prabhakaran M, Manavalan P (1980) Hydrophobic packing and spatial arrangement of amino acid residues in globular proteins Biochimica et Biophysica Acta (BBA)-Protein. Structure\u00a0623:301\u2013316","journal-title":"Structure"},{"key":"112_CR49","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2105-9-514","volume":"9","author":"J Ponomarenko","year":"2008","unstructured":"Ponomarenko J, Bui HH, Li W, Fusseder N, Bourne PE, Sette A, Peters B (2008) ElliPro: a new structure-based tool for the prediction of antibody epitopes. BMC Bioinform 9:514","journal-title":"BMC Bioinform"},{"key":"112_CR50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/prot.22540","volume":"77","author":"S Raman","year":"2009","unstructured":"Raman S et al (2009) Structure prediction for CASP8 with all-atom refinement using Rosetta. Proteins Struct Funct Bioinform 77:89\u201399","journal-title":"Proteins Struct Funct Bioinform"},{"key":"112_CR51","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/bmj.318.7185.698","volume":"318","author":"MJ Redondo","year":"1999","unstructured":"Redondo MJ, Rewers M, Yu L, Garg S, Pilcher CC, Elliott RB, Eisenbarth GS (1999) Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study. Bmj 318:698\u2013702","journal-title":"Bmj"},{"key":"112_CR52","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s11892-010-0139-x","volume":"10","author":"M Roivainen","year":"2010","unstructured":"Roivainen M, Klingel K (2010) Virus infections and type 1 diabetes risk. Curr DiabRep 10:350\u2013356","journal-title":"Curr DiabRep"},{"key":"112_CR53","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"JP Ryckaert","year":"1977","unstructured":"Ryckaert JP, Ciccotti G, Berendsen HJ (1977) Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes. J Comput Phys 23:327\u2013341","journal-title":"J Comput Phys"},{"key":"112_CR54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-3-540-30220-9_16","volume-title":"Artificial immune systems","author":"S Saha","year":"2004","unstructured":"Saha S, Raghava G (2004) BcePred: Prediction of continuous B-cell epitopes in antigenic sequences using physico-chemical properties. Artificial immune systems. Springer, Berlin, pp 197\u2013204"},{"key":"112_CR55","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","volume":"65","author":"S Saha","year":"2006","unstructured":"Saha S, Raghava G (2006) Prediction of continuous B-cell epitopes in an antigen using recurrent neural network Proteins: structure. Funct Bioinform 65:40\u201348","journal-title":"Funct Bioinform"},{"key":"112_CR56","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/wcms.1121","volume":"3","author":"R Salomon-Ferrer","year":"2013","unstructured":"Salomon-Ferrer R, Case DA, Walker RC (2013) An overview of the Amber biomolecular simulation package. Wiley Interdiscip Rev Comput Mole Sci 3:198\u2013210","journal-title":"Wiley Interdiscip Rev Comput Mole Sci"},{"key":"112_CR57","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s001250050683","volume":"40","author":"N Schloot","year":"1997","unstructured":"Schloot N, Roep B, Wegmann D, Yu L, Wang T, Eisenbarth G (1997) T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects. Diabetologia 40:332\u2013338","journal-title":"Diabetologia"},{"key":"112_CR58","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0198-8859(01)00223-3","volume":"62","author":"N Schloot","year":"2001","unstructured":"Schloot N, Willemen S, Duinkerken G, Drijfhout J, De Vries R, Roep B (2001) Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart. Hum Immunol 62:299\u2013309","journal-title":"Hum Immunol"},{"key":"112_CR59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1099-0895(199803)14:1<3::AID-DMR206>3.0.CO;2-T","volume":"14","author":"DB Schranz","year":"1998","unstructured":"Schranz DB, Lernmark \u00c5 (1998) Immunology in diabetes: an update. Metab Rev 14:3\u201329","journal-title":"Metab Rev"},{"key":"112_CR60","first-page":"42","volume":"4","author":"V Sharma","year":"2009","unstructured":"Sharma V, Kalim S, Srivastava MK, Nanda S, Mishra S (2009) Oxidative stress and coxsackievirus infections as mediators of beta cell damage: a review. Sci Res Essays 4:42\u201358","journal-title":"Sci Res Essays"},{"key":"112_CR61","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.str.2013.08.005","volume":"21","author":"Y Song","year":"2013","unstructured":"Song Y et al (2013) High-resolution comparative modeling with RosettaCM. Structure\u00a021:1735\u20131742","journal-title":"Structure"},{"key":"112_CR62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2337\/diab.35.2.139","volume":"35","author":"S Srikanta","year":"1986","unstructured":"Srikanta S, Ricker A, McCulloch D, Soeldner J, Eisenbarth G, Palmer J (1986) Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus. Diabetes 35:139\u2013142","journal-title":"Diabetes"},{"key":"112_CR63","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1373\/clinchem.2010.148221","volume":"57","author":"AK Steck","year":"2011","unstructured":"Steck AK, Rewers MJ (2011) Genetics of type 1 diabetes. Clin Chem 57:176\u2013185","journal-title":"Clin Chem"},{"key":"112_CR64","doi-asserted-by":"crossref","first-page":"W612","DOI":"10.1093\/nar\/gkp417","volume":"37","author":"J Sun","year":"2009","unstructured":"Sun J et al (2009) SEPPA: a computational server for spatial epitope prediction of protein antigens. Nucleic Acids Res 37:W612\u2013W616","journal-title":"Nucleic Acids Res"},{"key":"112_CR65","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.virusres.2010.02.017","volume":"150","author":"EL Tan","year":"2010","unstructured":"Tan EL, Wong APY, Poh CL (2010) Development of potential antiviral strategy against coxsackievirus B4. Virus Res 150:85\u201392","journal-title":"Virus Res"},{"key":"112_CR66","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1084\/jem.180.5.1979","volume":"180","author":"J Tian","year":"1994","unstructured":"Tian J, Lehmann PV, Kaufman DL (1994) T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med 180:1979\u20131984","journal-title":"J Exp Med"},{"key":"112_CR67","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/viro.2000.0446","volume":"274","author":"R Varela-Calvino","year":"2000","unstructured":"Varela-Calvino R, Sgarbi G, Arif S, Peakman M (2000) T-Cell reactivity to the P2C nonstructural protein of a diabetogenic strain of coxsackievirus B4. Virology 274:56\u201364","journal-title":"Virology"},{"key":"112_CR68","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s001250050864","volume":"41","author":"G Vreugdenhil","year":"1998","unstructured":"Vreugdenhil G, Geluk A, Ottenhoff T, Melchers W, Roep B, Galama J (1998) Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule. Diabetologia 41:40\u201346","journal-title":"Diabetologia"},{"key":"112_CR69","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/(SICI)1096-9071(199910)59:2<256::AID-JMV21>3.0.CO;2-H","volume":"59","author":"GR Vreugdenhil","year":"1999","unstructured":"Vreugdenhil GR, Batstra MR, Aanstoot HJ, Melchers WJ, Galama J (1999) Analysis of antibody responses against Coxsackie virus B4 protein 2C and the diabetes autoantigen GAD65. J Med Virol 59:256\u2013261","journal-title":"J Med Virol"}],"container-title":["Network Modeling Analysis in Health Informatics and Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-016-0112-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13721-016-0112-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-016-0112-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13721-016-0112-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T16:08:15Z","timestamp":1600099695000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13721-016-0112-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,29]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["112"],"URL":"https:\/\/doi.org\/10.1007\/s13721-016-0112-y","relation":{},"ISSN":["2192-6662","2192-6670"],"issn-type":[{"type":"print","value":"2192-6662"},{"type":"electronic","value":"2192-6670"}],"subject":[],"published":{"date-parts":[[2016,1,29]]},"article-number":"5"}}